Principles in Stem Cell Biology (GEN 506)
Available Spring 2020, Now Open to Undergraduate Students!
Team taught by UofR researchers actively working in the field of stem cell research, this course is an excellent opportunity for students to prepare for a future career in regenerative medicine, industry or graduate research. Or simply come to learn about one of the major revolutions in modern medicine!
This course is designed to cover: (1) basic principles in stem cell science, (2) the role of stem cell dysfunction in disease, (3) potential therapeutic applications of stem cells, (4) principles of embryonic stem cell and iPSC research and (5) managing the transition from the laboratory to the clinic. The course is structured by combining lectures and Journal Club-style group discussions. The course will be accompanied by “Essentials of Stem Cell Biology” (R. Lanza Ed.). Two take home exams and Journal Club participation will be the basis of student evaluations.
A solid foundation in cell biology, biochemistry and/or molecular biology is needed. Please contact the course director with questions: chris_proschel@urmc.rochester.edu
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GEN 506
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Draft Schedule
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Spring 2020
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1/16/20
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Introduction
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Introduction: Terminology and Definitions
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1/21/20
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Stem cell concepts
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Stemness, assymetric division and the control of self-renewal
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1/23/20
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Stem cell concepts
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JC
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1/28/20
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Stem cell concepts
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iPS and related technologies
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1/30/20
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Stem cell concepts
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Epigenetic control of differentiation
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2/4/20
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Tissue stem cells
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JC
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2/6/20
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Tissue stem cells
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Mesenchymal Stem Cells
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2/11/20
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Tissue stem cells
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Stem cells of the CNS
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2/13/20
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Tissue stem cells
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Satellite Cells
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2/18/20
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Tissue stem cells
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Progressive lineage restriction: the hematopoetic system
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2/20/20
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Tissue stem cells
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Microenvironmental Control of Hematopoetic Stem Cells
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2/25/20
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Tissue stem cells
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JC
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2/27/20
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Tissue stem cells
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Invertebrate models of stem cell biology
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3/3/20
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Tissue stem cells
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Mesenchymal and Periosteal stem cells
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3/5/20
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Tissue stem cells
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Germ cell stem cells
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3/10/20
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Tissue stem cells
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Stem Cells and Lung Development and Repair
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3/12/20
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Tissue stem cells
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iPSC models of retinal degeneration
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3/17/20
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Stem cells & pathology
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Developmental syndromes and stem cell deficiencies
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3/20/20
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Stem cells & pathology
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Cancer stem cells, Inc.
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3/24/20
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Stem cells & pathology
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JC
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3/26/20
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Stem cells & pathology
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Targeted cell-replacement: stem cells vs predifferentiation
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3/31/20
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Therapeutic Applications
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JC
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4/2/20
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Therapeutic Applications
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Stem cells for cardiac repair and disease modelling
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4/7/20
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Therapeutic Applications
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JC
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4/9/20
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Therapeutic Applications
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Stem Cells for CNS Therapy
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4/14/20
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Therapeutic Applications
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Smart implants: biomaterials and stem cells
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4/16/20
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Therapeutic Applications
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Stem Cells for Tendon Repair
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4/21/20
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Therapeutic Applications
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JC
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4/23/20
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Therapeutic Applications
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Stem cells Inc. et al. (Stem cells and Industry)
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4/28/20
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Stem Cells and Society
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The ethics of stem cell technology.
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