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Anderson Lab

Welcome to the Anderson Lab

Our lab investigates the regulatory pathways that control striated muscle development and function, and how defects in those pathways can give rise to human disease. The development of striated muscle is controlled by conserved networks of regulatory proteins and noncoding RNAs that coordinate the expression of genes involved in muscle growth, morphogenesis, differentiation and contractility.

Our research focuses on the role of muscle-enriched RNA-binding proteins and long noncoding RNAs (lncRNAs) as novel regulators of muscle development and disease. Unexpectedly, we’ve found that many annotated lncRNAs, in fact, encode small functional proteins, called micropeptides, which play important roles in regulating intracellular signaling. By investigating the function of these regulatory proteins and noncoding RNAs, we aim to uncover novel insights into the regulatory mechanisms important for muscle biology.  Our lab utilizes and generates a variety of biochemical and cell-based assays and both gain- and loss-of-function mouse models.

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Douglas M. Anderson, Ph.D.

Douglas M. Anderson, Ph.D.
Principal Investigator

Lab Members
Research Projects

Publications

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View All Publications
    1. Lynch CA
    2. Acosta SA
    3. Anderson DM
    4. Rogers GE
    5. Wilson-Rawls J
    6. Rawls A
    The Transcription Factor Mohawk Facilitates Skeletal Muscle Repair via Modulation of the Inflammatory Environment; Int J Mol Sci 25. 2024 Jan 01.
    1. Hassel GA
    2. eflová J
    3. Cho EE
    4. Blair SN
    5. Van Raamsdonk CD
    6. Anderson DM
    7. Robia SL
    8. Makarewich CA
    Another-regulin regulates cardiomyocyte calcium handling via integration of neuroendocrine signaling with SERCA2a activity; J Mol Cell Cardiol. 2024 Jan 01.
    1. Lindley S
    2. Subbaiah K
    3. Priyanka F
    4. Poosala P
    5. Ma Y
    6. Jalinous L
    7. West JA
    8. Richardson W
    9. Thomas TN
    10. Anderson DM
    Ribozyme-activated mRNA Trans-ligation Enables Large Gene Delivery to Treat Muscular Dystrophies; Science; Vol 386, pp. 762-767. 2024 Jan 01.
    1. Anderson KM
    2. Anderson DM
    LncRNAs at the heart of development and disease; . 2022 Jan 01.
    1. Anderson DM
    2. Anderson KM
    3. Nelson BR
    4. McAnally JR
    5. Bezprozvannaya S
    6. Shelton JM
    7. Bassel-Duby R
    8. Olson EN
    A myocardin-adjacent lncRNA balances SRF-dependent gene transcription in the heart.; Genes & Development; Vol 35, pp. 835-840. 2021 Jan 01.
    1. Anderson DM
    2. Cannavino J
    3. Li H
    4. Anderson KM
    5. Nelson BR
    6. McAnally J
    7. Bezprozvannaya S
    8. Liu Y
    9. Lin W
    10. Liu N
    11. Bassel-Duby R
    12. Olson EN
    Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.; Proceedings of the National Academy of Sciences of the United States of America; Vol 113(31). 2016 Aug 02.

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Affiliations

Contact Us

  Anderson Lab
601 Elmwood Ave
Box CVRI
Rochester, NY 14642

 (585) 276-7726