URMC / Cardiovascular Research Institute / Research / Berk Lab / Publications Recent Publications Berk BCPereira AVizcarra VSProschel CHsu CG Spinal Cord Injury Enhances Lung Inflammation and Exacerbates Immune Response After Acute Lung Injury.; bioRxiv : the preprint server for biology. 2024 Aug 22. Maneix LIakova PLee CGMoree SELu XDatar GKHill CTSpooner EKing JCKSykes DBSaez BDi Stefano BChen XKrause DSSahin ETsai FTFGoodell MABerk BCScadden DTCatic A Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing.; Nature cell biology. 2024 Mar 29. Zhang JBerk BCHsu CG A Natural Metabolite and Inhibitor of the NLRP3 Inflammasome: 4-hydroxynonenal.; Journal of cellular immunology; Vol 6(2), pp. 76-81. 2024. Hsu CGLi WSowden MChávez CLBerk BC Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages.; Cellular & molecular immunology. 2023 Jan 04. Hsu CGChávez CLZhang CSowden MYan CBerk BC The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis.; Cell death and differentiation. 2022 Mar 09. Meghwani HBerk BC MST1 Kinase-Cx43-YAP/TAZ Pathway Mediates Disturbed Flow Endothelial Dysfunction.; Circulation research; Vol 131(9), pp. 765-767. 2022 Jan 13. Luo LZhang YHsu CKorshunov VALong XKnight PABerk BCYan C Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodeling.; Cardiovascular research. 2021 Sep 22. Hsu CGFazal FRahman ABerk BCYan C Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation.; Journal of immunology (Baltimore, Md. : 1950). 2021 Jun 11. Wines-Samuelson MChowdhury SBerk BC Nck1 is a critical adaptor between proatherogenic blood flow, inflammation, and atherosclerosis.; The Journal of clinical investigation. 2020 Jul 13. Korshunov VASmolock EMWines-Samuelson MEFaiyaz AMickelsen DMQuinn BPan CDugbartey GJYan CDoyley MMLusis AJBerk BC Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling.; Journal of the American Heart Association; Vol 9(10). 2020 May 18. Korshunov VAQuinn BFaiyaz AAhmed RSowden MPDoyley MMBerk BC Strain-selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains.; British journal of pharmacology; Vol 176(15). 2019 Aug. Dugbartey GJQuinn BLuo LMickelsen DMTure SKMorrell CNCzyzyk JDoyley MMYan CBerk BCKorshunov VA The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.; The American journal of pathology. 2019 Jun 17. Carmo LSDBerk BCHarrison DG NOX5 as a therapeutic target in cerebral ischemic injury.; The Journal of clinical investigation; Vol 130. 2019 Mar 18. Plekhanova OParfyonova YBeloglazova IBerk BCTkachuk V Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator.; Frontiers in physiology; Vol 10. 2019. Xue CSowden MPBerk BC Extracellular and Intracellular Cyclophilin A, Native and Post-Translationally Modified, Show Diverse and Specific Pathological Roles in Diseases.; Arteriosclerosis, thrombosis, and vascular biology. 2018 Mar 29. Xue CSowden MBerk BC Extracellular Cyclophilin A, Especially Acetylated, Causes Pulmonary Hypertension by Stimulating Endothelial Apoptosis, Redox Stress, and Inflammation.; Arteriosclerosis, thrombosis, and vascular biology. 2017 Apr 27. Majumder SZhu GXu XSenchanthisai SJiang DLiu HXue CWang XCoia HCui ZSmolock EMLibby RTBerk BCPang J G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.; Cell reports; Vol 17(10). 2016 Dec 06. Perrucci GLStraino SCorlianò MScopece ANapolitano MBerk BCLombardi FPompilio GCapogrossi MCNigro P Cyclophilin A modulates bone marrow-derived CD117(+) cells and enhances ischemia-induced angiogenesis via the SDF-1/CXCR4 axis.; International journal of cardiology; Vol 212. 2016 Jun 1. Heo KSBerk BCAbe JI Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events.; Antioxidants & redox signaling. 2016 Apr 5. Shi XO'Neill MMMacDonnell SBrookes PSYan CBerk BC The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.; Journal of cardiovascular pharmacology and therapeutics; Vol 21(2). 2016 Mar. Simons MAlitalo KAnnex BHAugustin HGBeam CBerk BCByzova TCarmeliet PChilian WCooke JPDavis GEEichmann AIruela-Arispe MLKeshet ESinusas AJRuhrberg CWoo YJDimmeler S State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association.; Circulation research; Vol 116(11). 2015 May 22. Burke RMBerk BC The Role of PB1 Domain Proteins in Endothelial Cell Dysfunction and Disease.; Antioxidants & redox signaling; Vol 22(14). 2015 May 10. Sheu TJZhou WFan JZhou HZuscik MJXie CYin GBerk BC Decreased BMP2 signal in GIT1 knockout mice slows bone healing.; Molecular and cellular biochemistry; Vol 397(1-2). 2014 Dec. Abe JBerk BC Novel mechanisms of endothelial mechanotransduction.; Arteriosclerosis, thrombosis, and vascular biology; Vol 34(11). 2014 Nov. Smolock EMBurke RMWang CThomas TBatchu SNQiu XZettel MFujiwara KBerk BCKorshunov VA Intima modifier locus 2 controls endothelial cell activation and vascular permeability.; Physiological genomics; Vol 46(17). 2014 Sep 1. Wang LSoe NNSowden MXu YModjeski KBaskaran PKim YSmolock EMMorrell CNBerk BC Cyclophilin A is an important mediator of platelet function by regulating integrin αIIbβ3 bidirectional signalling.; Thrombosis and haemostasis; Vol 111(5). 2014 May 05. Spindel ONBurke RMYan CBerk BC Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation.; Circulation research; Vol 114(7). 2014 Mar 28. Soe NNSowden MBaskaran PKim YNigro PSmolock EMBerk BC Acetylation of cyclophilin A is required for its secretion and vascular cell activation.; Cardiovascular research; Vol 101(3). 2014 Mar 01. Majumder SSowden MPGerber SAThomas TChristie CKMohan AYin GLord EMBerk BCPang J G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.; Arteriosclerosis, thrombosis, and vascular biology; Vol 34(2). 2014 Feb. Yin GSheu TJMenon PPang JHo HCShi SXie CSmolock EYan CZuscik MJBerk BC Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.; PloS one; Vol 9(2). 2014. Soe NNSowden MBaskaran PSmolock EMKim YNigro PBerk BC Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells.; Arteriosclerosis, thrombosis, and vascular biology; Vol 33(9). 2013 Sep. Abe JBerk BC Atheroprone flow activation of the sterol regulatory element binding protein 2 and nod-like receptor protein 3 inflammasome mediates focal atherosclerosis.; Circulation; Vol 128(6). 2013 Aug 6. Abe JBerk BC Cezanne paints inflammation by regulating ubiquitination.; Circulation research; Vol 112(12). 2013 Jun 7. Smolock EMMachleder DEKorshunov VABerk BC Identification of a genetic locus on chromosome 11 that regulates leukocyte infiltration in mouse carotid artery.; Arteriosclerosis, thrombosis, and vascular biology; Vol 33(5). 2013 May. Pang JXu XWang XMajumder SWang JKorshunov VABerk BC G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration.; Arteriosclerosis, thrombosis, and vascular biology; Vol 33(5). 2013 May. Park SYShi XPang JYan CBerk BC Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.; Arteriosclerosis, thrombosis, and vascular biology; Vol 33(4). 2013 Apr. Kim GYNigro PFujiwara KAbe JBerk BC p62 binding to protein kinase C ζ regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cells.; Arteriosclerosis, thrombosis, and vascular biology; Vol 32(12). 2012 Dec. Smolock EMKorshunov VAGlazko GQiu XGerloff JBerk BC Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation.; Circulation; Vol 126(20). 2012 Nov 13. Bell RDWinkler EASingh ISagare APDeane RWu ZHoltzman DMBetsholtz CArmulik ASallstrom JBerk BCZlokovic BV Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.; Nature; Vol 485(7399). 2012 May 16. Spindel ONYan CBerk BC Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling.; Arteriosclerosis, thrombosis, and vascular biology; Vol 32(5). 2012 May. Spindel ONWorld CBerk BC Thioredoxin interacting protein: redox dependent and independent regulatory mechanisms.; Antioxidants & redox signaling; Vol 16(6). 2012 Mar 15. Wang XQNigro PWorld CFujiwara KYan CBerk BC Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.; Circulation research; Vol 110(4). 2012 Feb 17. Spindel ONBerk BC Redox redux: protecting the ischemic myocardium.; The Journal of clinical investigation; Vol 122(1). 2012 Jan. Pang JXu XGetman MRShi XBelmonte SLMichaloski HMohan ABlaxall BCBerk BC G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart.; Journal of molecular and cellular cardiology; Vol 51(5). 2011 Nov. Nigro PAbe JBerk BC Flow shear stress and atherosclerosis: a matter of site specificity.; Antioxidants & redox signaling; Vol 15(5). 2011 Sep 1. Shi XYan CNadtochiy SMAbe JBrookes PSBerk BC p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.; Journal of molecular and cellular cardiology; Vol 51(2). 2011 Aug. Satoh KBerk BCShimokawa H Vascular-derived reactive oxygen species for homeostasis and diseases.; Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society; Vol 25(2). 2011 Aug 1. World CSpindel ONBerk BC Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-α: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species.; Arteriosclerosis, thrombosis, and vascular biology; Vol 31(8). 2011 Aug. Heo KSLee HNigro PThomas TLe NTChang EMcClain CReinhart-King CAKing MRBerk BCFujiwara KWoo CHAbe J PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.; The Journal of cell biology; Vol 193(5). 2011 May 30. Satoh KNigro PZeidan ASoe NNJaffré FOikawa MO'Dell MRCui ZMenon PLu YMohan AYan CBlaxall BCBerk BC Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice.; Arteriosclerosis, thrombosis, and vascular biology; Vol 31(5). 2011 May. Nigro PSatoh KO'Dell MRSoe NNCui ZMohan AAbe JAlexis JDSparks JDBerk BC Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice.; The Journal of experimental medicine; Vol 208(1). 2011 Jan 17. Satoh KShimokawa HBerk BC Cyclophilin A: promising new target in cardiovascular therapy.; Circulation journal : official journal of the Japanese Circulation Society; Vol 74(11). 2010 Nov. Menon PYin GSmolock EMZuscik MJYan CBerk BC GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.; Journal of cellular physiology; Vol 225(3). 2010 Nov. Wang JYin GMenon PPang JSmolock EMYan CBerk BC Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells.; Arteriosclerosis, thrombosis, and vascular biology; Vol 30(10). 2010 Oct. Nigro PAbe JWoo CHSatoh KMcClain CO'Dell MRLee HLim JHLi JDHeo KSFujiwara KBerk BC PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.; Blood; Vol 116(11). 2010 Sep 16. Cavet MESmolock EMMenon PKonishi AKorshunov VABerk BC Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB.; Hypertension; Vol 56(1). 2010 Jul. Jeon KIXu XAizawa TLim JHJono HKwon DSAbe JBerk BCLi JDYan C Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism.; Proceedings of the National Academy of Sciences of the United States of America; Vol 107(21). 2010 May 25. Menon PDeane RSagare ALane SMZarcone TJO'Dell MRYan CZlokovic BVBerk BC Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.; Brain research; Vol 1317. 2010 Mar 4. Satoh KNigro PBerk BC Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A.; Antioxidants & redox signaling; Vol 12(5). 2010 Mar 1. Zhang NCai WYin GNagel DJBerk BC GIT1 is a novel MEK1-ERK1/2 scaffold that localizes to focal adhesions.; Cell biology international; Vol 34(1). 2010 Jan. Massett MPFan RBerk BC Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice.; Physiological genomics; Vol 40(1). 2009 Dec 30. Xie SLee YFKim EChen LMNi JFang LYLiu SLin SJAbe JBerk BHo FMChang C TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation.; Proceedings of the National Academy of Sciences of the United States of America; Vol 106(32). 2009 Aug 11. Satoh KNigro PMatoba TO'Dell MRCui ZShi XMohan AYan CAbe JIllig KABerk BC Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms.; Nature medicine; Vol 15(6). 2009 Jun. Pan SWorld CJKovacs CJBerk BC Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.; Arteriosclerosis, thrombosis, and vascular biology; Vol 29(6). 2009 Jun. Pang JHoefen RPryhuber GSWang JYin GWhite RJXu XO'Dell MRMohan AMichaloski HMassett MPYan CBerk BC G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development.; Circulation; Vol 119(11). 2009 Mar 24. Ibrahim JBerk BC Flow-mediated vascular remodeling in hypertension: relation to hemodyamics.; Stroke; a journal of cerebral circulation; Vol 40(2). 2009 Feb. Wang JTaba YPang JYin GYan CBerk BC GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma.; Arteriosclerosis, thrombosis, and vascular biology; Vol 29(2). 2009 Feb. Alexis JDWang NChe WLerner-Marmarosh NSahni AKorshunov VAZou YDing BYan CBerk BCAbe J Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells.; Circulation research; Vol 104(1). 2009 Jan 2. Plekhanova OBerk BCBashtrykov PBrooks AITkachuk VParfyonova Y Oligonucleotide microarrays reveal regulated genes related to inward arterial remodeling induced by urokinase plasminogen activator.; Journal of vascular research; Vol 46(3). 2009. Korshunov VABerk BC Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid.; Arteriosclerosis, thrombosis, and vascular biology; Vol 29(1). 2009 Jan. Berk BC Flow-Mediated Vascular Remodeling in Hypertension. Relation to Hemodyamics.; Stroke. 2009 Jan 01. Cavet MEPang JYin GBerk BC An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 22(10). 2008 Oct. Reinhart-King CFujiwara KBerk BC Chapter 2 physiologic stress-mediated signaling in the endothelium.; Methods Enzymology; Vol 443, pp. 25-44. 2008 Jan 01. Satoh KMatoba TSuzuki JO'Dell MRNigro PCui ZMohan APan SLi LJin ZGYan CAbe JBerk BC Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation.; Circulation; Vol 117(24). 2008 Jun 17. Li LTatake RJNatarajan KTaba YGarin GTai CLeung ESurapisitchat JYoshizumi MYan CAbe JBerk BC Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells.; Biochemical and biophysical research communications; Vol 370(1). 2008 May 23. Cavet MESmolock EMOzturk OHWorld CPang JKonishi ABerk BC Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells.; Arteriosclerosis, thrombosis, and vascular biology; Vol 28(5). 2008 May. Pang JYan CNatarajan KCavet MEMassett MPYin GBerk BC GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.; Arteriosclerosis, thrombosis, and vascular biology; Vol 28(5). 2008 May. Korshunov VABerk BC Smooth muscle apoptosis and vascular remodeling.; Current opinion in hematology; Vol 15(3). 2008 May. Mathews MTBerk BC PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.; Arteriosclerosis, thrombosis, and vascular biology; Vol 28(4). 2008 Apr. Berk BC Atheroprotective signaling mechanisms activated by steady laminar flow in endothelial cells.; Circulation; Vol 117(8). 2008 Feb 26. Satoh KBerk BC Circulating smooth muscle progenitor cells: novel players in plaque stability.; Cardiovascular research; Vol 77(3). 2008 Feb 1. Reinhart-King CAFujiwara KBerk BC Physiologic stress-mediated signaling in the endothelium.; Methods in enzymology; Vol 443. 2008. Korshunov VADaul MMassett MPBerk BC Axl mediates vascular remodeling induced by deoxycorticosterone acetate-salt hypertension.; Hypertension; Vol 50(6). 2007 Dec. Korshunov VASchwartz SMBerk BC Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon.; Arteriosclerosis, thrombosis, and vascular biology; Vol 27(8). 2007 Aug. Garin GAbe JMohan ALu WYan CNewby ACRhaman ABerk BC Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing.; Circulation research; Vol 101(1). 2007 Jul 6. Wang JPan SBerk BC Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner.; Arteriosclerosis, thrombosis, and vascular biology; Vol 27(6). 2007 Jun. Berk BCFujiwara KLehoux S ECM remodeling in hypertensive heart disease.; The Journal of clinical investigation; Vol 117(3). 2007 Mar. Pan SBerk BC Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: key role for glutaredoxin in the death pathway.; Circulation research; Vol 100(2). 2007 Feb 2. Berk BC Novel approaches to treat oxidative stress and cardiovascular diseases.; Transactions of the American Clinical and Climatological Association; Vol 118. 2007. Chen CKorshunov VAMassett MPYan CBerk BC Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways.; Journal of vascular research; Vol 44(6). 2007. World CJYamawaki HBerk BC Thioredoxin in the cardiovascular system.; Journal of molecular medicine (Berlin, Germany); Vol 84(12). 2006 Dec. Garin GBerk BC Flow-mediated signaling modulates endothelial cell phenotype.; Endothelium : journal of endothelial cell research; Vol 13(6). 2006 Nov. Barker TAMassett MPKorshunov VAMohan AMKennedy AJBerk BC Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade.; Hypertension; Vol 48(5). 2006 Nov. Miano JMBerk BC HDAC7 supports vascular integrity.; Nature medicine; Vol 12(9). 2006 Sep. Plekhanova OSMen'shikov MYBashtrykov PPBerk BCTkachuk VAParfenova EV Urokinase induces ROS production in vascular smooth muscle cells.; Bulletin of experimental biology and medicine; Vol 142(3). 2006 Sep. Korshunov VAMohan AMGeorger MABerk BC Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling.; Circulation research; Vol 98(11). 2006 Jun 9. Maekawa NAbe JShishido TItoh SDing BSharma VKSheu SSBlaxall BCBerk BC Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury.; Circulation; Vol 113(21). 2006 May 30. Hoefen RJBerk BC The multifunctional GIT family of proteins.; Journal of cell science; Vol 119(Pt 8). 2006 Apr 15. Itoh SDing BShishido TLerner-Marmarosh NWang NMaekawa NBerk BCTakeishi YYan CBlaxall BCAbe J Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.; Circulation; Vol 113(14). 2006 Apr 11. Menshikov MPlekhanova OCai HChalupsky KParfyonova YBashtrikov PTkachuk VBerk BC Urokinase plasminogen activator stimulates vascular smooth muscle cell proliferation via redox-dependent pathways.; Arteriosclerosis, thrombosis, and vascular biology; Vol 26(4). 2006 Apr.