URMC / Cardiovascular Research Institute / Research / Morrell Lab / Publications

Recent Publications

1. Liang C
2. Malik S
3. He M
4. Groom L
5. Ture SK
6. O'Connor TN
7. Morrell CN
8. Dirksen RT
Compound heterozygous RYR1-RM mouse model reveals disease pathomechanisms and muscle adaptations to promote postnatal survival.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 38(20), pp. e70120. 2024 Oct.
1. Li C
2. Ture SK
3. Nieves-Lopez B
4. Blick-Nitko SK
5. Maurya P
6. Livada AC
7. Stahl TJ
8. Kim M
9. Pietropaoli AP
10. Morrell CN
Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function.; Circulation research. 2024 Mar 08.
1. Akkipeddi SMK
2. Rahmani R
3. Schartz D
4. Chittaranjan S
5. Ellens NR
6. Kohli GS
7. Bhalla T
8. Mattingly TK
9. Welle K
10. Morrell CN
11. Bender MT
Stroke emboli from patients with atrial fibrillation enriched with neutrophil extracellular traps.; Research and practice in thrombosis and haemostasis; Vol 8(2), pp. 102347. 2024 Feb 15.
1. Li C
2. Morrell CN
Commentary on "Desialylated Platelets Maintain Immune Quiescence through Regulating Kupffer Cells".; Research (Washington, D.C.); Vol 6, pp. 0279. 2023 Dec 12.
1. O'Reilly D
2. Murphy CA
3. Moore CM
4. Ní Áinle F
5. Gormley IC
6. Morrell CN
7. Curley A
8. Mc Callion N
9. Maguire P
Markers of platelet activation foR identification of late onset sEpsis in infaNTs: PARENT study protocol.; Pediatric research; Vol 95(3), pp. 852-856. 2023 Sep 27.
1. Maurya P
2. Ture SK
3. Li C
4. Scheible KM
5. McGrath KE
6. Palis J
7. Morrell CN
Transfusion of Adult, but Not Neonatal, Platelets Promotes Monocyte Trafficking in Neonatal Mice.; Arteriosclerosis, thrombosis, and vascular biology. 2023 Mar 23.
1. Livada AC
2. Pariser DN
3. Morrell CN
Megakaryocytes in the lung: History and future perspectives.; Research and practice in thrombosis and haemostasis; Vol 7(2), pp. 100053. 2023 Jan 19.
1. Morrell CN
2. Mix D
3. Aggarwal A
4. Bhandari R
5. Godwin M
6. Owens Iii AP
7. Lyden SP
8. Doyle A
9. Krauel K
10. Rondina MT
11. Mohan A
12. Lowenstein CJ
13. Shim S
14. Stauffer S
15. Josyula VP
16. Ture SK
17. Yule DI
18. Wagner Iii LE
19. Ashton JM
20. Elbadawi A
21. Cameron SJ
Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms.; The Journal of clinical investigation. 2022 Mar 24.
1. Hilt ZT
2. Ture SK
3. Mohan A
4. Arne A
5. Morrell CN
Platelet-derived β2m regulates age related monocyte/macrophage functions.; Aging; Vol 11. 2019 Dec 18.
1. Morrell CN
2. Hilt ZT
3. Pariser DN
4. Maurya P
PAD4 and von Willebrand Factor Link Inflammation and Thrombosis.; Circulation research; Vol 125(5). 2019 Aug 16.
1. Dugbartey GJ
2. Quinn B
3. Luo L
4. Mickelsen DM
5. Ture SK
6. Morrell CN
7. Czyzyk J
8. Doyley MM
9. Yan C
10. Berk BC
11. Korshunov VA
The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.; The American journal of pathology. 2019 Jun 17.
1. Bennett JA
2. Ture SK
3. Schmidt RA
4. Mastrangelo MA
5. Cameron SJ
6. Terry LE
7. Yule DI
8. Morrell CN
9. Lowenstein CJ
Acetylcholine inhibits platelet activation.; The Journal of pharmacology and experimental therapeutics. 2019 Feb 14.
1. Hilt ZT
2. Pariser DN
3. Ture SK
4. Mohan A
5. Quijada P
6. Asante A
7. Cameron SJ
8. Sterling JA
9. Merkel AR
10. Johanson AL
11. Jenkins JL
12. Small EM
13. McGrath KE
14. Palis J
15. Elliott MR
16. Morrell CN
Platelet-derived β2M regulates monocyte inflammatory responses.; JCI insight. 2019 Jan 31.
1. Morrell CN
2. Pariser DN
3. Hilt ZT
4. Vega Ocasio D
The Platelet Napoleon Complex-Small Cells, but Big Immune Regulatory Functions.; Annual review of immunology. 2018 Nov 28.
1. Cameron SJ
2. Mix DS
3. Ture SK
4. Schmidt RA
5. Mohan A
6. Pariser D
7. Stoner MC
8. Shah P
9. Chen L
10. Zhang H
11. Field DJ
12. Modjeski KL
13. Toth S
14. Morrell CN
Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype.; Arteriosclerosis, thrombosis, and vascular biology. 2018 May 03.
1. Schmidt RA
2. Morrell CN
3. Ling FS
4. Simlote P
5. Fernandez G
6. Rich DQ
7. Adler D
8. Gervase J
9. Cameron SJ
The platelet phenotype in patients with ST-segment elevation myocardial infarction is different from non-ST-segment elevation myocardial infarction.; Translational research : the journal of laboratory and clinical medicine; Vol 195. 2018 May.
1. Yang M
2. Kholmukhamedov A
3. Schulte ML
4. Cooley BC
5. Scoggins NO
6. Wood JP
7. Cameron SJ
8. Morrell CN
9. Jobe SM
10. Silverstein RL
Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo.; Blood advances; Vol 2(21). 2018 Jan 13.
1. Chapman LM
2. Ture SK
3. Field DJ
4. Morrell CN
miR-451 limits CD4+ T cell proliferative responses to infection in mice.; Immunologic research; Vol 65(4). 2017 Aug.
1. Yang M
2. Cooley BC
3. Li W
4. Chen Y
5. Vasquez-Vivar J
6. Scoggins NO
7. Cameron SJ
8. Morrell CN
9. Silverstein RL
Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions.; Blood; Vol 129(21). 2017 May 25.
1. Croft DP
2. Cameron SJ
3. Morrell CN
4. Lowenstein CJ
5. Ling F
6. Zareba W
7. Hopke PK
8. Utell MJ
9. Thurston SW
10. Thevenet-Morrison K
11. Evans KA
12. Chalupa D
13. Rich DQ
Associations between ambient wood smoke and other particulate pollutants and biomarkers of systemic inflammation, coagulation and thrombosis in cardiac patients.; Environmental research; Vol 154. 2017 Apr.
1. Morrell CN
Platelets: killers of parasites or patients?; Blood; Vol 129(12). 2017 Mar 23.
1. Zhu QM
2. Ko KA
3. Ture S
4. Mastrangelo MA
5. Chen MH
6. Johnson AD
7. O'Donnell CJ
8. Morrell CN
9. Miano JM
10. Lowenstein CJ
Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice.; Arteriosclerosis, thrombosis, and vascular biology; Vol 37(2). 2017 Feb.
1. Field DJ
2. Aggrey-Amable AA
3. Blick SK
4. Ture SK
5. Johanson A
6. Cameron SJ
7. Roy S
8. Morrell CN
Platelet factor 4 increases bone marrow B cell development and differentiation.; Immunologic research; Vol 65(5). 2017 Jan.
1. Batchu SN
2. Hughson A
3. Wadosky KM
4. Morrell CN
5. Fowell DJ
6. Korshunov VA
Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension.; Arteriosclerosis, thrombosis, and vascular biology. 2016 Jun 30.
1. Xu S
2. Liu B
3. Yin M
4. Koroleva M
5. Mastrangelo M
6. Ture S
7. Morrell CN
8. Zhang DX
9. Fisher EA
10. Jin ZG
A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis.; Oncotarget; Vol 7(25). 2016 Jun 21.
1. Modjeski KL
2. Levy SC
3. Ture SK
4. Field DJ
5. Shi G
6. Ko K
7. Zhu Q
8. Morrell CN
Glutamate Receptor Interacting Protein 1 Regulates CD4(+) CTLA-4 Expression and Transplant Rejection.; American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons; Vol 16(5). 2016 May.
1. Lannan KL
2. Refaai MA
3. Ture SK
4. Morrell CN
5. Blumberg N
6. Phipps RP
7. Spinelli SL
Resveratrol preserves the function of human platelets stored for transfusion.; British journal of haematology; Vol 172(5). 2016 Mar.
1. Jackson JW
2. Singh MV
3. Singh VB
4. Jones LD
5. Davidson GA
6. Ture S
7. Morrell CN
8. Schifitto G
9. Maggirwar SB
Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis.; PloS one; Vol 11(6). 2016.
1. Modjeski KL
2. Ture SK
3. Field DJ
4. Cameron SJ
5. Morrell CN
Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation.; PloS one; Vol 11(9). 2016.
1. Batchu SN
2. Xia J
3. Ko KA
4. Doyley MM
5. Abe J
6. Morrell CN
7. Korshunov VA
Axl modulates immune activation of smooth muscle cells in vein graft remodeling.; American journal of physiology. Heart and circulatory physiology; Vol 309(6). 2015 Sep 15.
1. Spitalnik SL
2. Triulzi D
3. Devine DV
4. Dzik WH
5. Eder AF
6. Gernsheimer T
7. Josephson CD
8. Kor DJ
9. Luban NL
10. Roubinian NH
11. Mondoro T
12. Welniak LA
13. Zou S
14. Glynn S
2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.; Transfusion; Vol 55(9). 2015 Sep.
1. Cameron SJ
2. Ture SK
3. Mickelsen D
4. Chakrabarti E
5. Modjeski KL
6. McNitt S
7. Seaberry M
8. Field DJ
9. Le NT
10. Abe J
11. Morrell CN
Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion.; Circulation; Vol 132(1). 2015 Jul 7.
1. Cameron SJ
2. Morrell CN
3. Bao C
4. Swaim AF
5. Rodriguez A
6. Lowenstein CJ
A Novel Anti-Inflammatory Effect for High Density Lipoprotein.; PloS one; Vol 10(12). 2015.
1. Morrell CN
Understanding platelets in malaria infection.; Current opinion in hematology; Vol 21(5). 2014 Sep.
1. Wang L
2. Soe NN
3. Sowden M
4. Xu Y
5. Modjeski K
6. Baskaran P
7. Kim Y
8. Smolock EM
9. Morrell CN
10. Berk BC
Cyclophilin A is an important mediator of platelet function by regulating integrin αIIbβ3 bidirectional signalling.; Thrombosis and haemostasis; Vol 111(5). 2014 May 05.
1. Morrell CN
2. Aggrey AA
3. Chapman LM
4. Modjeski KL
Emerging roles for platelets as immune and inflammatory cells.; Blood; Vol 123(18). 2014 May 1.
1. Metcalf Pate KA
2. Lyons CE
3. Dorsey JL
4. Queen SE
5. Adams RJ
6. Morrell CN
7. Mankowski JL
TGFβ-Mediated Downregulation of Thrombopoietin Is Associated With Platelet Decline in Asymptomatic SIV Infection.; Journal of acquired immune deficiency syndromes (1999); Vol 65(5). 2014 Apr 15.
1. Modjeski KL
2. Morrell CN
Small cells, big effects: the role of platelets in transplant vasculopathy.; Journal of thrombosis and thrombolysis; Vol 37(1). 2014 Jan.
1. Shi G
2. Field DJ
3. Long X
4. Mickelsen D
5. Ko KA
6. Ture S
7. Korshunov VA
8. Miano JM
9. Morrell CN
Platelet factor 4 mediates vascular smooth muscle cell injury responses.; Blood; Vol 121(21). 2013 May 23.
1. Aggrey AA
2. Srivastava K
3. Ture S
4. Field DJ
5. Morrell CN
Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria.; Journal of immunology (Baltimore, Md. : 1950); Vol 190(9). 2013 May 1.
1. Chapman LM
2. Aggrey AA
3. Field DJ
4. Srivastava K
5. Ture S
6. Yui K
7. Topham DJ
8. Baldwin WM
9. Morrell CN
Platelets present antigen in the context of MHC class I.; Journal of immunology (Baltimore, Md. : 1950); Vol 189(2). 2012 Jul 15.
1. Morrell CN
2. Maggirwar SB
Recently recognized platelet agonists.; Current opinion in hematology; Vol 18(5). 2011 Sep.
1. Shi G
2. Morrell CN
Platelets as initiators and mediators of inflammation at the vessel wall.; Thrombosis research; Vol 127(5). 2011 May.
1. Morrell CN
2. Srivastava K
3. Swaim A
4. Lee MT
5. Chen J
6. Nagineni C
7. Hooks JJ
8. Detrick B
Beta interferon suppresses the development of experimental cerebral malaria.; Infection and immunity; Vol 79(4). 2011 Apr.
1. Davidson DC
2. Hirschman MP
3. Spinelli SL
4. Morrell CN
5. Schifitto G
6. Phipps RP
7. Maggirwar SB
Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals.; Journal of immunology (Baltimore, Md. : 1950); Vol 186(1). 2011 Jan 1.
1. Morrell CN
Immunomodulatory mediators in platelet transfusion reactions.; Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program; Vol 2011. 2011.
1. Ombrello C
2. Block RC
3. Morrell CN
Our expanding view of platelet functions and its clinical implications.; Journal of cardiovascular translational research; Vol 3(5). 2010 Oct.
1. Srivastava K
2. Field DJ
3. Aggrey A
4. Yamakuchi M
5. Morrell CN
Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria.; PloS one; Vol 5(5). 2010.
1. Steele BM
2. Harper MT
3. Macaulay IC
4. Morrell CN
5. Perez-Tamayo A
6. Foy M
7. Habas R
8. Poole AW
9. Fitzgerald DJ
10. Maguire PB
Canonical Wnt signaling negatively regulates platelet function.; Proceedings of the National Academy of Sciences of the United States of America; Vol 106(47). 2009 Nov 24.
1. Sun H
2. Swaim A
3. Herrera JE
4. Becker D
5. Becker L
6. Srivastava K
7. Thompson LE
8. Shero MR
9. Perez-Tamayo A
10. Suktitipat B
11. Mathias R
12. Contractor A
13. Faraday N
14. Morrell CN
Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation.; Circulation research; Vol 105(6). 2009 Sep 11.
1. Jeong Y
2. Chaupin DF
3. Matsushita K
4. Yamakuchi M
5. Cameron SJ
6. Morrell CN
7. Lowenstein CJ
Aldosterone activates endothelial exocytosis.; Proceedings of the National Academy of Sciences of the United States of America; Vol 106(10). 2009 Mar 10.
1. Srivastava K
2. Cockburn IA
3. Swaim A
4. Thompson LE
5. Tripathi A
6. Fletcher CA
7. Shirk EM
8. Sun H
9. Kowalska MA
10. Fox-Talbot K
11. Sullivan D
12. Zavala F
13. Morrell CN
Platelet factor 4 mediates inflammation in experimental cerebral malaria.; Cell host & microbe; Vol 4(2). 2008 Aug 14.
1. Morrell CN
2. Sun H
3. Ikeda M
4. Beique JC
5. Swaim AM
6. Mason E
7. Martin TV
8. Thompson LE
9. Gozen O
10. Ampagoomian D
11. Sprengel R
12. Rothstein J
13. Faraday N
14. Huganir R
15. Lowenstein CJ
Glutamate mediates platelet activation through the AMPA receptor.; The Journal of experimental medicine; Vol 205(3). 2008 Mar 17.
1. Shi C
2. Parker AR
3. Hua L
4. Morrell CN
5. Lee SC
6. Bandaru V
7. Dumler JS
8. Wu TC
9. Eshleman JR
Anti-gene padlocks eliminate Escherichia coli based on their genotype.; The Journal of antimicrobial chemotherapy; Vol 61(2). 2008 Feb.
1. Yamakuchi M
2. Ferlito M
3. Morrell CN
4. Matsushita K
5. Fletcher CA
6. Cao W
7. Lowenstein CJ
Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor.; Methods in molecular biology (Clifton, N.J.); Vol 440. 2008.
1. Morrell CN
2. Mason EA
3. Martin TV
4. Swaim AM
5. Ballard M
6. Murata K
7. Baldwin WM
Alloantibodies to MHC Induce Platelet-Endothelial Cell Interactions; Circulation Research; Vol 102(7), pp. 777-785. 2008 Jan 01.
1. Matsushita K
2. Morrell CN
3. Mason RJ
4. Yamakuchi M
5. Khanday FA
6. Irani K
7. Lowenstein CJ
Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor.; The Journal of cell biology; Vol 170(1). 2005 Jul 4.
1. Morrell CN
2. Matsushita K
3. Lowenstein CJ
A novel inhibitor of N-ethylmaleimide-sensitive factor decreases leukocyte trafficking and peritonitis.; The Journal of pharmacology and experimental therapeutics; Vol 314(1). 2005 Jul.
1. Yamakuchi M
2. Greer JJ
3. Cameron SJ
4. Matsushita K
5. Morrell CN
6. Talbot-Fox K
7. Baldwin WM
8. Lefer DJ
9. Lowenstein CJ
HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size.; Circulation research; Vol 96(11). 2005 Jun 10.
1. Matsushita K
2. Morrell CN
3. Lowenstein CJ
A novel class of fusion polypeptides inhibits exocytosis.; Molecular pharmacology; Vol 67(4). 2005 Apr.
1. Morrell CN
2. Matsushita K
3. Chiles K
4. Scharpf RB
5. Yamakuchi M
6. Mason RJ
7. Bergmeier W
8. Mankowski JL
9. Baldwin WM
10. Faraday N
11. Lowenstein CJ
Regulation of platelet granule exocytosis by S-nitrosylation.; Proceedings of the National Academy of Sciences of the United States of America; Vol 102(10). 2005 Mar 8.
1. Matsushita K
2. Yamakuchi M
3. Morrell CN
4. Ozaki M
5. O'Rourke B
6. Irani K
7. Lowenstein CJ
Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis.; Blood; Vol 105(1). 2005 Jan 1.
1. Bhatia R
2. Matsushita K
3. Yamakuchi M
4. Morrell CN
5. Cao W
6. Lowenstein CJ
Ceramide triggers Weibel-Palade body exocytosis.; Circulation research; Vol 95(3). 2004 Aug 6.
1. Matsushita K
2. Morrell CN
3. Lowenstein CJ
Sphingosine 1-phosphate activates Weibel-Palade body exocytosis.; Proceedings of the National Academy of Sciences of the United States of America; Vol 101(31). 2004 Aug 3.
1. Matsushita K
2. Morrell CN
3. Cambien B
4. Yang SX
5. Yamakuchi M
6. Bao C
7. Hara MR
8. Quick RA
9. Cao W
10. O'Rourke B
11. Lowenstein JM
12. Pevsner J
13. Wagner DD
14. Lowenstein CJ
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor.; Cell; Vol 115(2). 2003 Oct 17.
1. Chen WY
2. Zeng X
3. Carter MG
4. Morrell CN
5. Chiu Yen RW
6. Esteller M
7. Watkins DN
8. Herman JG
9. Mankowski JL
10. Baylin SB
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors.; Nature genetics; Vol 33(2). 2003 Feb.
1. Morrell CN
2. Volk MV
3. Mankowski JL
A carcinoid tumor in the gallbladder of a dog.; Veterinary pathology; Vol 39(6). 2002 Nov.
1. Mathiowitz E
2. Jacob JS
3. Jong YS
4. Carino GP
5. Chickering DE
6. Chaturvedi P
7. Santos CA
8. Vijayaraghavan K
9. Montgomery S
10. Bassett M
11. Morrell C
Biologically erodable microspheres as potential oral drug delivery systems.; Nature; Vol 386(6623). 1997 Mar 27.
1. Chickering DE
2. Jacob JS
3. Desai M
4. Harrison WP
5. Morrell CN
6. Chatuverdi P
7. Mathiowitz E
Bioadhesive Microspheres: III. An In Vivo Transit and Bioavailability Study of Drug-Loaded Alginate and Poly(Fumaric-co-Sebacic Anhydride) Microspheres; Journal of Controlled Release; Vol 48, pp. 35-46. 1997 Jan 01.