ECG Core Laboratory
The ECG Core Laboratory (ECL) has been involved in quantitative electrocardiology services and research activities for over 30 years under the leadership of Jean-Philippe Couderc, PhD and Wojciech Zareba, MD, PhD. The table below illustrates wide array of ECG technologies with numerous standard and investigational ECG analyses performed for numerous NIH- and corporate-sponsored clinical studies and clinical trials.
ECG Technologies with Clinical Applications Exercised by our ECG Core Lab
|
ECG Recording |
Parameters |
Prior and Current Studies* |
|
Standard ECG (paper copy and digital) |
Clinical diagnosis, Individuals ECG parameters |
LQTS, ARVC, MSSMI, MPIP, MDPIT, MADIT, MADIT II, MADIT-CRT, MADIT-CHIC, MADIT-SICD, RAID, M2RISK, MARVEN, Drug Studies: DIPHENHYDRAMINE, FLECAINIDE, SOTALOL, MOXIFLOXACINE, RANOLAZINE, |
|
Short-term Holter recordings 5-20 minutes |
SAECG, HRV, PDR, QTV, |
LQTS, ARVC, LQTS Emotion, Drug Studies, MADIT II, MADIT-CRT, Air-Pollution Studies, Methylmercury studies, THEW, MARVEN, |
|
Holter recordings |
Atrial arrhythmias, ventricular arrhythmias, HRV, QTV, HRT, AF burden |
MADIT II, MADIT-CRT, M2RISK, LQTS, ARVC, Air-Pollution Studies, Methylmercury studies, MARVEN, Drug studies, THEW, ANTHEM, SOLVE-CRT |
|
Long-term patches 7-14 days |
AF burden, ventricular arrhythmias |
CAMAFIB, ARVC Flecainide |
|
Pacemakers /Defibrillators |
Atrial arrhythmia burden, Ventricular arrhythmia burden, ICD therapies, HRV, activity |
HARMONY, MADIT, MADIT II, MADIT-CRT, MADIT-RIT, MADIT-CHIC, MADIT-SICD, RAID, ARVC, LQTS-ICD, MARVEN |
* List of prior and ongoing studies could be accessed here.
Over several years of conducting NIH, HEI, EPA, and industry sponsored large clinical studies and trials, the ECL has developed profound expertise in the central coordination and analysis of ECG recordings for internal studies and for external researchers and sponsors. Our ECL has been validated as FDA compliant vendor of ECG-oriented and implantable devices–oriented services.
In addition to standard analyses of ECGs and long-term recordings focused on identifying abnormal ECG patterns and presence of atrial and ventricular arrhythmias our ECG Core Lab is a leader in innovation in electrocardiology with particular emphasis on computerized analyses of ventricular repolarization and QRS signal processing.
Our experience with processing and adjudicating pacemaker and ICD interrogations served numerous studies and trials that have changed the medicine. Our unique infrastructure, FDA-compliant environment, and expertise supports state-of-the-art research activities.
Our list of current and future sponsors include: Boston-Scientific, Pfizer, Gilead, Medtronic, AMPS LLC, Global Instrumentation, BioSign GmbH, Biomedical Systems and iCardiac Technologies, Inc., Angel Medical Systems Inc, AstraZeneca, Biosigna, BSP Biological Signal Processing LTD, Cardio-QT Ltd., Cardiocore, GE-HealthCare Inc., Medial Research, Mortara Instrument, Philips Healthcare Inc.. , Philips Healthcare Inc., Roche ltd, SAIT, Samsung Advanced Institute of Technology, Schiller America Inc.