UR CTSI Incubator: The Bugs in Your Gut Could Make You Weak in the Knees
A new study, born out of a UR CTSI Incubator project, challenges old views by suggesting the gut microbiome is a key culprit behind osteoarthritis in people who are obese; not excess mechanical wear and tear on joints. Remarkably, a common prebiotic supplement altered the obese microbiome and protected against osteoarthritis.
2015 CTSI Incubator: The Gut Microbiome Affects Musculoskeletal Health
Members of the 2015 CTSI Incubator project team presented results at the Orthopaedic Research Society Annual Meeting this week that suggest manipulating the gut microbiome in obese animals can slow osteoarthritis and speed healing after fracture.
CTSI Fostered Development of Drug that Extends Effectiveness of HIV Therapy
2011 CTSI Incubator awardees have made new discoveries stemming from their Incubator project. A drug originally tested for its ability to treat HIV associated dementia, also surprisingly prolongs the effectiveness of HIV drugs and helps cells get rid of cellular “trash”, like viruses.