Multiple Myeloma: Stages
What does stage of a cancer mean?
The stage of a cancer is how much and how far the cancer has spread in your body.
Your healthcare provider uses exams and tests to find your cancer stage. The stage
is one of the most important things to know when deciding how to treat cancer.
How is multiple myeloma staged?
Different systems are used to stage multiple myeloma. The most common system is the
Revised International Staging System (R-ISS).
R-ISS is based on these four lab test results for the person with multiple myeloma:
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How much beta-2 microglobulin (B2M) is in the blood?
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How much albumin is in the blood?
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How much lactate dehydrogenase (LDH) is in the blood?
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What are the DNA changes in the myeloma cells? (This is called cytogenetics.)
What are the stages of multiple myeloma?
The R-ISS divides multiple myeloma into three stages:
Stage I includes myelomas with all of the following:
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B2M is less than 3.5 mg/L
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Albumin is 3.5 g/dL or higher
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LDH level is normal
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The myeloma cells don't have any high-risk chromosome changes
Stage II includes all myelomas that don't fall into stage I or stage III.
Stage III includes myelomas with a B2M of 5.5 mg/L or greater, plus at least one of the following:
Other factors
Along with the stage of a myeloma, other factors can also affect a person's outlook
(prognosis). For instance, people who are younger tend to do better than those who
are older. People who have better kidney function also tend to do better than those
whose kidneys are damaged by the myeloma.
Talking with your healthcare provider
Once your cancer is staged, your healthcare provider will talk with you about what
the stage means for your treatment. Ask any questions you have. Make sure to talk
about your concerns.