Primary Bone Cancer: Diagnosis
If your healthcare provider thinks you might have primary bone cancer (cancer that
starts in your bones), you will need certain exams and tests to be sure. Diagnosing
bone cancer starts with your healthcare provider asking you questions. You'll be asked
about your health history, symptoms, risk factors, and family history of disease.
A physical exam will be done.
What tests might I need?
You may need one or more of these tests:
X-rays and other imaging tests
An X-ray of the bone is usually the first test done if your healthcare provider thinks
you might have a primary bone cancer. Most bone cancers show up on X-rays. The tumor
often gives the bone a ragged look. Or it may form a hole in the bone.
X-rays can often show the size, location, and shape of a primary bone tumor. If the
tumor looks like cancer, you might need other imaging tests, like an MRI (magnetic
resonance imaging) or a CT (computed tomography) scan, to get a better look at the
tumor.
Your healthcare provider can often tell if a bone tumor is likely cancer based on
how it looks on an X-ray or other imaging tests. But a biopsy of the tumor is needed
to know for sure.
Blood tests
Blood tests might be done to measure the levels of some substances in your body, such
as alkaline phosphatase. Levels of this substance are often high in people who have
recently broken a bone or who have bone cancer. This test may not be accurate in children
and teens, who can have high levels because their bones are still growing. Other blood
tests can be done to help improve the accuracy of this test and to get an idea of
your overall health.
Biopsy
A biopsy is the only sure way to tell if you have bone cancer. A biopsy can also help
find out if the tumor is a primary or secondary bone cancer. A secondary bone cancer
has spread to the bone from cancer that started in another part of the body.
Your healthcare provider can do a bone biopsy in one of two ways:
Your biopsy should be done by a healthcare provider who has special training in diagnosing
and treating bone tumors.
Surgical biopsy
A surgical biopsy is also called an open bone biopsy. This is a minor surgery because
a small cut is made in the skin over the tumor. This allows the healthcare provider
to take a tiny piece of tissue from the bone tumor, which is called a sample.
Before the biopsy, tell your healthcare provider if you are taking any blood-thinners.
You might be told to stop taking these medicines a few days before the biopsy.
Young children need general anesthesia, which makes them sleep and not feel pain during
the surgery. Most adults also get general anesthesia before a surgical biopsy. Some
people can be awake for the procedure. They only need medicine to numb the skin around
the area.
During the biopsy, the healthcare provider cuts through your skin to take out a small
part of the tumor. In some cases, the whole tumor is removed. But this must be carefully
planned and is not often done. A healthcare provider called a pathologist will examine
the removed bone tissue. It will be tested for cancer cells.
Needle biopsy
Needle biopsies can be done in one of two ways:
-
Fine needle biopsy
-
Core needle biopsy
Before any needle biopsy, tell your healthcare provider if you are taking any blood-thinners.
You might be told to stop taking these medicines a few days before the procedure.
In most cases, a local numbing medicine will be injected over the biopsy site. You
might also get medicine in a vein to make you feel relaxed or sleepy.
If the tumor is near the surface of your body, the healthcare provider can aim the
needle by feeling the tumor. If the tumor is too deep to feel, computed tomography
(CT) might be used to guide the needle to the tumor. The CT scan takes pictures of
the inside of your body. The healthcare provider can then see where the needle is
going on a computer screen.
Fine needle biopsy. A fine needle biopsy uses a very tiny, hollow needle. The needle is put into the
tumor and small amounts of fluid and tissue are taken out. A fine needle biopsy isn’t
used very often for bone tumors because it's hard to get enough tissue for testing.
The procedure normally takes only 10 to 15 minutes. The healthcare provider looks
at the samples right away to make sure enough cells were taken.
Core needle biopsy. With a core needle biopsy, the healthcare provider uses a large needle to remove
a small plug, or core, of tissue. The tissue removed is often enough to diagnose any
type of tumor.
During the biopsy, you may feel some pressure and mild pain. But it's important to
stay still. You'll have a small amount of bleeding where the needle goes through your
skin. Pressure will be held over the needle hole until the bleeding stops. Then the
area will be cleaned and covered with a bandage.
Getting your test results
It usually takes about a week for biopsy results to come back. Waiting for the results
can be stressful. But it's important to get the correct diagnosis. When your healthcare
provider has the results, they will contact you. Your provider will talk with you
about other tests you may need if primary bone cancer is found. Make sure you understand
the results and what follow-up you need.