Colorectal Cancer: Introduction
What is cancer?
Cancer starts when cells in the body change (mutate) and grow out of control. To help
you understand what happens when you have cancer, it's important to know how your
body works normally. Your body is made up of tiny building blocks called cells. Normal
cells grow when your body needs them and die when your body doesn't need them any
longer.
Cancer is made up of abnormal cells that grow even though your body doesn't need them.
Genetic changes in cancer cells keeps them multiplying. They don't turn off without
treatment. In most cancers, the abnormal cells grow to form a lump or mass called
a tumor. If cancer cells are in the body long enough, they can grow into (invade)
nearby areas. They can even spread to other parts of the body (metastasis).
What is colorectal cancer?
Colorectal cancer is cancer that starts in either your colon or your rectum. These
make up the lower part of your digestive tract. In most cases, cancer doesn't start
in both places. But colon and rectal cancer have a lot in common. So they're often
called colorectal cancer.
Understanding the colon and rectum
The colon is a muscular tube about 5 feet long. It forms the last part of the digestive tract.
It absorbs water from the remaining food matter. The rectum is the last 6 inches of the digestive tract. It's the storage space for waste (feces
or stool) before it leaves the body through the anus.
Together, the colon and rectum make up the large intestine. This is sometimes called
the large bowel. The colon and rectum have an inner lining made of millions of cells.
Changes in these cells can lead to growths (polyps) that can become cancer.
What are the types of cancer in the colon and rectum?
These are the types of cancer that can start in the colon and rectum:
Other types of cancer that can start in the colon or rectum are much less common:
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Gastrointestinal stromal tumor. These tumors start in special cells in the wall of the digestive tract. They may
be found anywhere in the digestive tract. But they rarely start in the colon. They
may be benign, or not cancer, at first. But, over time, many do turn into cancer.
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Lymphoma. This cancer starts in a type of immune cell called a lymphocyte. Lymphomas often
start in bean-sized groups of lymphocytes, called lymph nodes. But they can also start
in the colon, rectum, or other organs.
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Carcinoid. This cancer starts in certain cells in the intestine that make hormones.
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Sarcoma. These tumors start in blood vessels, muscle, or connective tissue in the colon and
rectum wall.
How colorectal cancer starts and grows
Most colorectal cancers start as polyps. These are growths caused by changes in the
cells that line the inside of the colon or rectum. Over time, some types of polyps
can become cancer. Finding and removing polyps while they're small may stop cancer
from ever forming.
Polyps are fleshy clumps of tissue that form on the inner lining of the colon or rectum.
Small polyps are seldom cancer. But over time, the cells in a type of polyp called
an adenomatous polyp, or adenoma, can change and become cancer. The longer a polyp
is there and the bigger it gets, the more likely this is to happen.
Colorectal cancers most often start when cells in a polyp start growing abnormally. As a cancer tumor
grows, it can invade into the deeper layers of the colon or rectal wall. Over time,
the cancer can grow beyond the colon or rectum and into nearby organs. Or it can spread
to nearby lymph nodes. The cancer cells can also travel to other parts of the body,
where they can form new tumors. This is known as metastasis. If colorectal cancer
spreads, it most often goes to the liver first. But it can also spread to other organs,
like the lining of the belly (peritoneum) and the lungs.
Talk with your healthcare provider
If you have questions about colorectal cancer, talk with your healthcare provider.
Your healthcare provider can help you understand more about this cancer.