URMC / Labs / Anders Lab / Publications

Recent Publications

1. Anders MW
Exploiting endobiotic metabolic pathways to target xenobiotic antioxidants to mitochondria.; Mitochondrion; Vol 13(5). 2013 Sep.
1. Anders MW
Putting bioactivation reactions to work: Targeting antioxidants to mitochondria.; Chemico-biological interactions; Vol 192(1-2). 2011 Jun 30.
1. Board PG
2. Anders MW
Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice.; Drug metabolism reviews; Vol 43(2). 2011 May.
1. Roser KS
2. Brookes PS
3. Wojtovich AP
4. Olson LP
5. Shojaie J
6. Parton RL
7. Anders MW
Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: a prodrug strategy for targeting cytoprotective antioxidants to mitochondria.; Bioorganic & medicinal chemistry; Vol 18(4). 2010 Feb 15.
1. Xu L
2. Krenitsky DM
3. Seacat AM
4. Butenhoff JL
5. Tephly TR
6. Anders MW
N-glucuronidation of perfluorooctanesulfonamide by human, rat, dog, and monkey liver microsomes and by expressed rat and human UDP-glucuronosyltransferases.; Drug metabolism and disposition: the biological fate of chemicals; Vol 34(8). 2006 Aug.
1. Starr TB
2. Matanoski G
3. Anders MW
4. Andersen ME
Workshop overview: reassessment of the cancer risk of dichloromethane in humans.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 91(1). 2006 May.
1. Fang YY
2. Kashkarov U
3. Anders MW
4. Board PG
Polymorphisms in the human glutathione transferase zeta promoter.; Pharmacogenetics and genomics; Vol 16(5). 2006 May.
1. Blackburn AC
2. Matthaei KI
3. Lim C
4. Taylor MC
5. Cappello JY
6. Hayes JD
7. Anders MW
8. Board PG
Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.; Molecular pharmacology; Vol 69(2). 2006 Feb.
1. Sheu SS
2. Nauduri D
3. Anders MW
Targeting antioxidants to mitochondria: a new therapeutic direction.; Biochimica et biophysica acta; Vol 1762(2). 2006 Feb.
1. Anders MW
2. Robotham JL
3. Sheu SS
Mitochondria: new drug targets for oxidative stress-induced diseases.; Expert opinion on drug metabolism & toxicology; Vol 2(1). 2006 Feb.
1. Board PG
2. Anders MW
Human glutathione transferase zeta.; Methods in enzymology; Vol 401. 2005.
1. Anders MW
Formation and toxicity of anesthetic degradation products.; Annual review of pharmacology and toxicology; Vol 45. 2005.
1. Anders MW
Glutathione-dependent bioactivation of haloalkanes and haloalkenes.; Drug metabolism reviews; Vol 36(3-4). 2004 Oct.
1. Brookes PS
2. Yoon Y
3. Robotham JL
4. Anders MW
5. Sheu SS
Calcium, ATP, and ROS: a mitochondrial love-hate triangle.; American journal of physiology. Cell physiology; Vol 287(4). 2004 Oct.
1. Lim CE
2. Matthaei KI
3. Blackburn AC
4. Davis RP
5. Dahlstrom JE
6. Koina ME
7. Anders MW
8. Board PG
Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases.; The American journal of pathology; Vol 165(2). 2004 Aug.
1. Xu L
2. Krenitsky DM
3. Seacat AM
4. Butenhoff JL
5. Anders MW
Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450.; Chemical research in toxicology; Vol 17(6). 2004 Jun.
1. Anderson WB
2. Board PG
3. Anders MW
Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles.; Chemical research in toxicology; Vol 17(5). 2004 May.
1. Lantum HB
2. Iyer RA
3. Anders MW
Acivicin-induced alterations in renal and hepatic glutathione concentrations and in gamma-glutamyltransferase activities.; Biochemical pharmacology; Vol 67(7). 2004 Apr 1.
1. Board PG
2. Taylor MC
3. Coggan M
4. Parker MW
5. Lantum HB
6. Anders MW
Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique.; The Biochemical journal; Vol 374(Pt 3). 2003 Sep 15.
1. Lantum HB
2. Cornejo J
3. Pierce RH
4. Anders MW
Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 74(1). 2003 Jul.
1. Jolivette LJ
2. Anders MW
Computational and experimental studies on the distribution of addition and substitution products of the microsomal glutathione transferase 1-catalyzed conjugation of glutathione with fluoroalkenes.; Chemical research in toxicology; Vol 16(2). 2003 Feb.
1. Lantum HB
2. Baggs RB
3. Krenitsky DM
4. Anders MW
Nephrotoxicity of chlorofluoroacetic acid in rats.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 70(2). 2002 Dec.
1. Anderson WB
2. Liebler DC
3. Board PG
4. Anders MW
Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta.; Chemical research in toxicology; Vol 15(11). 2002 Nov.
1. Enomoto A
2. Wempe MF
3. Tsuchida H
4. Shin HJ
5. Cha SH
6. Anzai N
7. Goto A
8. Sakamoto A
9. Niwa T
10. Kanai Y
11. Anders MW
12. Endou H
Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.; The Journal of biological chemistry; Vol 277(39). 2002 Sep 27.
1. Cooper AJ
2. Bruschi SA
3. Anders MW
Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism.; Biochemical pharmacology; Vol 64(4). 2002 Aug 15.
1. Jolivette LJ
2. Anders MW
Structure-activity relationship for the biotransformation of haloalkenes by rat liver microsomal glutathione transferase 1.; Chemical research in toxicology; Vol 15(8). 2002 Aug.
1. Lantum HB
2. Board PG
3. Anders MW
Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).; Chemical research in toxicology; Vol 15(7). 2002 Jul.
1. Lantum HB
2. Baggs RB
3. Krenitsky DM
4. Board PG
5. Anders MW
Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues.; Drug metabolism and disposition: the biological fate of chemicals; Vol 30(6). 2002 Jun.
1. Tong Z
2. Anders MW
Reactive intermediate formation from the 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived cysteine S-conjugate S-[2-(Fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-L-cysteine in pyridoxal model systems.; Chemical research in toxicology; Vol 15(5). 2002 May.
1. Lantum HB
2. Liebler DC
3. Board PG
4. Anders MW
Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.; Chemical research in toxicology; Vol 15(5). 2002 May.
1. Bayer T
2. Amberg A
3. Bertermann R
4. Rusch GM
5. Anders MW
6. Dekant W
Biotransformation of 1,1,1,3,3-Pentafluoropropane (HFC-245fa).; Chemical research in toxicology; Vol 15(5). 2002 May.
1. Uchino H
2. Kanai Y
3. Kim DK
4. Wempe MF
5. Chairoungdua A
6. Morimoto E
7. Anders MW
8. Endou H
Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition.; Molecular pharmacology; Vol 61(4). 2002 Apr.
1. Pombrio JM
2. Giangreco A
3. Li L
4. Wempe MF
5. Anders MW
6. Sweet DH
7. Pritchard JB
8. Ballatori N
Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1.; Molecular pharmacology; Vol 60(5). 2001 Nov.
1. Blackburn AC
2. Coggan M
3. Tzeng HF
4. Lantum H
5. Polekhina G
6. Parker MW
7. Anders MW
8. Board PG
GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase.; Pharmacogenetics; Vol 11(8). 2001 Nov.
1. DeCory HH
2. Piech-Dumas KM
3. Sheu SS
4. Federoff HJ
5. Anders MW
Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons.; Drug metabolism and disposition: the biological fate of chemicals; Vol 29(10). 2001 Oct.
1. Board PG
2. Chelvanayagam G
3. Jermiin LS
4. Tetlow N
5. Tzeng HF
6. Anders MW
7. Blackburn AC
Identification of novel glutathione transferases and polymorphic variants by expressed sequence tag database analysis.; Drug metabolism and disposition: the biological fate of chemicals; Vol 29(4 Pt 2). 2001 Apr.
1. Chen Y
2. Cai J
3. Anders MW
4. Stevens JL
5. Jones DP
Role of mitochondrial dysfunction in S-(1,2-dichlorovinyl)-l-cysteine-induced apoptosis.; Toxicology and applied pharmacology; Vol 170(3). 2001 Feb 1.
1. Anders MW
Formation and fate of reactive intermediates of haloalkanes, haloalkenes, and alpha-haloacids.; Advances in experimental medicine and biology; Vol 500. 2001.
1. Lantum HB
2. Board PG
3. Anders MW
Inactivation of polymorphic variants of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.; Advances in experimental medicine and biology; Vol 500. 2001.
1. Luu NC
2. Iyer RA
3. Anders MW
4. Ridge DP
Bioactivation mechanisms of haloalkene cysteine S-conjugates modeled by gas-phase, ion-molecule reactions.; Chemical research in toxicology; Vol 13(7). 2000 Jul.
1. Uttamsingh V
2. Baggs RB
3. Krenitsky DM
4. Anders MW
Immunohistochemical localization of the acylases that catalyze the deacetylation of N-acetyl-L-cysteine and haloalkene-derived mercapturates.; Drug metabolism and disposition: the biological fate of chemicals; Vol 28(6). 2000 Jun.
1. Tzeng HF
2. Blackburn AC
3. Board PG
4. Anders MW
Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetate.; Chemical research in toxicology; Vol 13(4). 2000 Apr.
1. Kraus T
2. Uttamsingh V
3. Anders MW
4. Wolf S
Porcine kidney microsomal cysteine S-conjugate N-acetyltransferase-catalyzed N-acetylation of haloalkene-derived cysteine S-conjugates.; Drug metabolism and disposition: the biological fate of chemicals; Vol 28(4). 2000 Apr.
1. Morrow PE
2. Witschi H
3. Vore M
4. Hakkinen PE
5. MacGregor J
6. MacGregor J
7. Anders MW
8. Willhite C
Profiles in toxicology. Harold Carpenter Hodge (1904-1990).; Toxicological sciences : an official journal of the Society of Toxicology; Vol 53(2). 2000 Feb.
1. Blackburn AC
2. Tzeng HF
3. Anders MW
4. Board PG
Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.; Pharmacogenetics; Vol 10(1). 2000 Feb.
1. Anderson WB
2. Board PG
3. Gargano B
4. Anders MW
Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking alpha-haloalkanoic acids.; Chemical research in toxicology; Vol 12(12). 1999 Dec.
1. Uttamsingh V
2. Anders MW
Acylase-catalyzed deacetylation of haloalkene-derived mercapturates.; Chemical research in toxicology; Vol 12(10). 1999 Oct.
1. Wempe MF
2. Anderson WB
3. Tzeng HF
4. Board PG
5. Anders MW
Glutathione transferase zeta-catalyzed biotransformation of deuterated dihaloacetic acids.; Biochemical and biophysical research communications; Vol 261(3). 1999 Aug 11.
1. Tu Z
2. Anders MW
Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis.; The Biochemical journal; Vol 336 ( Pt 3). 1998 Dec 15.
1. Tong Z
2. Board PG
3. Anders MW
Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids.; Chemical research in toxicology; Vol 11(11). 1998 Nov.