URMC / Labs / Brookes Lab / Publications Recent Publications Cohen EDRoethlin KYee MWoeller CFBrookes PSPorter GAO'Reilly MA PPARγ drives mitochondrial stress signaling and the loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia.; Redox biology; Vol 76, pp. 103351. 2024 Sep 12. Faniyan TSZhang XMorgan DARobles JBathina SBrookes PSRahmouni KPerry RJChhabra KH A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria.; eLife; Vol 12. 2024 Jul 31. Jeon KIKumar ABrookes PSNehrke KHuxlin KR Manipulating mitochondrial pyruvate carrier function causes metabolic remodeling in corneal myofibroblasts that ameliorates fibrosis.; Redox biology; Vol 75, pp. 103235. 2024 Jun 08. Beutner GBurris JRCollins MPKulkarni CANadtochiy SMde Mesy Bentley KLCohen EDBrookes PSPorter GA Coordinated metabolic responses to cyclophilin D deletion in the developing heart.; iScience; Vol 27(3), pp. 109157. 2024 Feb 09. Tabata Fukushima CDancil ISClary HShah NNadtochiy SMBrookes PS Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions.; Redox biology; Vol 70, pp. 103047. 2024 Jan 27. Faniyan TSZhang XMorgan DARobles JBathina SBrookes PSRahmouni KPerry RJChhabra KH A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria.; bioRxiv : the preprint server for biology. 2023 Sep 05. Mia SSonkar RWilliams LLatimer MNRawnsley DRRana SHe JDierickx PKim TXie MHabegger KMKubo MZhou LThomsen MBPrabhu SDFrank SJBrookes PSLazar MADiwan AYoung ME Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology.; JACC. Basic to translational science; Vol 8(9), pp. 1141-1156. 2023 Jun 14. Sautchuk RYu CMcArthur MMassie CBrookes PSPorter GAAwad HEliseev RA ROLE OF THE MITOCHONDRIAL PERMEABILITY TRANSITION IN BONE METABOLISM AND AGING.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2023 Feb 13. Fukushima CTDancil ISClary HShah NNadtochiy SMBrookes PS Reactive Oxygen Species Generation by Reverse Electron Transfer at Mitochondrial Complex I Under Simulated Early Reperfusion Conditions.; bioRxiv : the preprint server for biology. 2023 Jan 21. Paine ABrookes PSBhattacharya SLi DGarcia-Hernandez MLTausk FRitchlin C Dysregulation of bile acids, lipids, and nucleotides in psoriatic arthritis revealed by unbiased profiling of serum metabolites.; Arthritis & rheumatology (Hoboken, N.J.). 2022 Jul 11. Milliken ASNadtochiy SMBrookes PS Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation.; Journal of the American Heart Association. 2022 Jun 29. Milliken ASCiesla JHNadtochiy SMBrookes PS Distinct effects of intracellular vs. extracellular acidic pH on the cardiac metabolome during ischemia and reperfusion.; Journal of molecular and cellular cardiology; Vol 174, pp. 101-114. 2022 Jan 05. Kotla SZhang AImanishi MKo KALin SHGi YJMoczygemba MIsgandarova SSchadler KLChung CMilgrom SABanchs JYusuf SWAmaya DNGuo HThomas TNShen YHDeswal AHerrmann JKleinerman ESEntman MLCooke JPSchifitto GMaggirwar SBMcBeath EGupte AAKrishnan SPatel ZSYoon YBurks JKFujiwara KBrookes PSLe NTHamilton DJAbe JI Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation.; Redox biology; Vol 47. 2021 Sep 20. Brookes PSJimenez AG Metabolomics of aging in primary fibroblasts from small and large breed dogs.; GeroScience. 2021 Jun 16. Cohen EDYee MPorter GARitzer EEMcDavid ANBrookes PSPryhuber GSO'Reilly MA Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.; JCI insight. 2021 Jan 28. Lim YBerry BViteri SMcCall MPark ECRongo CBrookes PSNehrke K FNDC-1-Mediated Mitophagy and ATFS-1 Coordinate to Protect Against Hypoxia-Reoxygenation.; Autophagy. 2021 Jan 08. Nadtochiy SMNgai MBrookes PS Modified Blue Native Gel Approach for Analysis of Respiratory Supercomplexes.; Methods in molecular biology (Clifton, N.J.); Vol 2276. 2021. Trippier PCHuwaimel BIBhakta MKulkarni CAMilliken ASWang FPeng ABrookes PS Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity.; ChemMedChem. 2020 Dec 16. Milliken ASKulkarni CABrookes PS Acid enhancement of ROS generation by complex-I reverse electron transport is balanced by acid inhibition of complex-II: Relevance for tissue reperfusion injury.; Redox biology; Vol 37. 2020 Sep 19. Kulkarni CANadtochiy SMKennedy LZhang JChhim SAlwaseem HMurphy EFu DBrookes PS ALKBH7 mediates necrosis via rewiring of glyoxal metabolism.; eLife; Vol 9. 2020 Aug 14. Milliken ASBrookes PS Amber Alert: Getting to the Heart of Succinate Efflux in Reperfusion Injury.; Cardiovascular research. 2020 Jul 14. Bennett JAMastrangelo MATure SKSmith COLoelius SGBerg RAShi XBurke RMSpinelli SLCameron SJCarey TEBrookes PSGerszten RESabater-Lleal Mde Vries PSHuffman JESmith NLMorrell CNLowenstein CJ The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function.; Nature communications; Vol 11(1). 2020 Jul 13. Zuurbier CJBertrand LBeauloye CRAndreadou IRuiz-Meana MJespersen NRKula-Alwar DPrag HAEric Botker HDambrova MMontessuit CKaambre TLiepinsh EBrookes PSKrieg T Cardiac metabolism as a driver and therapeutic target of myocardial infarction.; Journal of cellular and molecular medicine. 2020 May 08. Chapa-Dubocq XRRodríguez-Graciani KMGuzmán-Hernández RAJang SBrookes PSJavadov S Cardiac Function is not Susceptible to Moderate Disassembly of Mitochondrial Respiratory Supercomplexes.; International journal of molecular sciences; Vol 21(5). 2020 Feb 25. Dylag AMBrookes PSO'Reilly MA Swapping mitochondria: A key to understanding susceptibility to neonatal chronic lung disease.; American journal of physiology. Lung cellular and molecular physiology. 2019 Oct 09. Lim YRubio-Peña KSobraske PJMolina PABrookes PSGaly VNehrke K Fndc-1 contributes to paternal mitochondria elimination in C. elegans.; Developmental biology; Vol 454(1). 2019 Oct 01. Kulkarni CABrookes PS Cellular Compartmentation and the Redox/Nonredox Functions of NAD.; Antioxidants & redox signaling; Vol 31(9). 2019 Sep 20. Burke CGMyers JRBoule LAPost CMBrookes PSLawrence BP Early life exposures shape the CD4+ T cell transcriptome, influencing proliferation, differentiation, and mitochondrial dynamics later in life.; Scientific reports; Vol 9(1). 2019 Aug 07. Wang YTLim YMcCall MNHuang KTHaynes CMNehrke KBrookes PS Cardioprotection by the mitochondrial unfolded protein response requires ATF5.; American journal of physiology. Heart and circulatory physiology; Vol 317(2). 2019 Aug 01. Nadtochiy SMWang YTNehrke KMunger JBrookes PS Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.; Journal of molecular and cellular cardiology. 2018 Jun 26. Smith COWang YTNadtochiy SMMiller JHJonas EADirksen RTNehrke KBrookes PS Cardiac metabolic effects of KNa1.2 channel deletion and evidence for its mitochondrial localization.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018 Jun 04. Zhang JWang YTMiller JHDay MMMunger JCBrookes PS Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity.; Cell reports; Vol 23(9). 2018 May 29. Peoples JNRMaxmillian TLe QNadtochiy SMBrookes PSPorter GADavidson VLEbert SN Metabolomics reveals critical adrenergic regulatory checkpoints in glycolysis and pentose-phosphate pathways in embryonic heart.; The Journal of biological chemistry; Vol 293(18). 2018 May 04. Sahni PVZhang JSosunov SGalkin ANiatsetskaya ZStarkov ABrookes PSTen VS Krebs cycle metabolites and preferential succinate oxidation following neonatal hypoxic-ischemic brain injury in mice.; Pediatric research; Vol 83(2). 2018 Feb. Resseguie EABrookes PSO'Reilly MA SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia.; Experimental lung research. 2017 Jul 27. Wang HHuwaimel BVerma KMiller JGermain TMKinarivala NPappas DBrookes PSTrippier PC Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5.; ChemMedChem; Vol 12(13). 2017 Jul 06. Nadtochiy SMWang YTZhang JNehrke KSchafer XWelle KGhaemmaghami SMunger JBrookes PS Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.; The Biochemical journal. 2017 Jul 03. Smith CONehrke KBrookes PS The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.; The Biochemical journal; Vol 474(12). 2017 Jun 09. Brookes PSTaegtmeyer H Metabolism: A Direct Link Between Cardiac Structure and Function.; Circulation; Vol 136(22). 2017 Jan 28. Brand MDGoncalves RLOrr ALVargas LGerencser AABorch Jensen MWang YTMelov STurk CNMatzen JTDardov VJPetrassi HMMeeusen SLPerevoshchikova IVJasper HBrookes PSAinscow EK Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.; Cell metabolism; Vol 24(4). 2016 Oct 11. Nadtochiy SMSchafer XFu DNehrke KMunger JBrookes PS Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.; The Journal of biological chemistry; Vol 291(38). 2016 Sep 16. Wojtovich APSmith COUrciuoli WRWang YTXia XMBrookes PSNehrke K Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.; Anesthesiology; Vol 124(5). 2016 May. Pell VRChouchani ETMurphy MPBrookes PSKrieg T Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.; Circulation research; Vol 118(5). 2016 Mar 4. Shi XO'Neill MMMacDonnell SBrookes PSYan CBerk BC The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.; Journal of cardiovascular pharmacology and therapeutics; Vol 21(2). 2016 Mar. Peña SSherman TBrookes PSNehrke K The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans.; PloS one; Vol 11(7). 2016. Shum LCWhite NSNadtochiy SMBentley KLBrookes PSJonason JHEliseev RA Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone.; PloS one; Vol 11(5). 2016. 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