URMC / Labs / Chu Lab / Publications Recent Publications Van Wagoner CMRivera-Escalera FJaimes-Delgadillo NCChu CCZent CSElliott MR Antibody-mediated phagocytosis in cancer immunotherapy.; Immunological reviews. 2023 Aug 21. Brady MTLaniewski NStrawderman MChu CCKanagaiah PSangster MYTopham DJFriedberg JWZent CS Long-term results of vaccination with adjuvanted recombinant varicella zoster glycoprotein E during initial Bruton tyrosine kinase inhibitors therapy for chronic lymphocytic leukemia or lymphoplasmacytic lymphoma.; American journal of hematology. 2023 Jul 23. Moore JEBloom PCChu CCBruno JEHerne CABaran AMQuataert SAMosmann TRTaylor RPWallace DSElliott MRBarr PMZent CS Rituximab induced cytokine release with high serum IP-10 (CXCL10) concentrations is associated with infusion reactions.; Leukemia research; Vol 129, pp. 107072. 2023 Mar 29. Pinney JJBlick-Nitko SKBaran AMPeterson DRWhitehead HEIzumi RMunugalavadla VVan DerMeid KRBarr PMZent CSElliott MRChu CC The highly selective Bruton tyrosine kinase inhibitor acalabrutinib leaves macrophage phagocytosis intact.; Haematologica. 2022 Feb 17. Rajendran NKLiu WChu CCCahill PARedmond EM Moderate dose alcohol protects against serum amyloid protein A1-induced endothelial dysfunction via both notch-dependent and notch-independent pathways.; Alcoholism, clinical and experimental research. 2021 Sep 29. Zent CSPinney JJChu CCElliott MR Complement Activation in the Treatment of B-Cell Malignancies.; Antibodies (Basel, Switzerland); Vol 9(4). 2020 Dec 01. Zent CSBrady MTDelage CStrawderman MLaniewski NContant PNKanagaiah PSangster MYBarr PMChu CCTopham DJFriedberg JW Short term results of vaccination with adjuvanted recombinant varicella zoster glycoprotein E during initial BTK inhibitor therapy for CLL or lymphoplasmacytic lymphoma.; Leukemia. 2020 Oct 30. Pinney JJRivera-Escalera FChu CCWhitehead HEVanDerMeid KNelson AMBarbeau MCZent CSElliott MR Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance.; Blood. 2020 Jun 17. Chu CCPinney JJWhitehead HERivera-Escalera FVanDerMeid KRZent CSElliott MR High-resolution quantitation of discrete phagocytic events by live cell time-lapse high-content microscopy imaging.; Journal of cell science. 2020 Jan 31. Chu CCPinney JJWhitehead HERivera-Escalera FVanDerMeid KRZent CSElliott MR High-resolution quantitation of discrete phagocytic events by live cell time-lapse high-content microscopy imaging.; Journal of cell science. 2020 Jan 01. VanDerMeid KRElliott MRBaran AMBarr PMChu CCZent CS Cellular Cytotoxicity of Next Generation CD20 Monoclonal Antibodies.; Cancer immunology research. 2018 Aug 08. Baliakas PMattsson MHadzidimitriou AMinga EAgathangelidis ASutton LAScarfo LDavis ZYan XJPlevova KSandberg YVojdeman FJTzenou TChu CCVeronese SMansouri LSmedby KEGiudicelli VNguyen-Khac FPanagiotidis PJuliusson GAnagnostopoulos ALefranc MPTrentin LCatherwood MMontillo MNiemann CULangerak AWPospisilova SStavroyianni NChiorazzi NOscier DJelinek DFShanafelt TDarzentas NBelessi CDavi FGhia PRosenquist RStamatopoulos K No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy.; Haematologica. 2017 Dec 21. Xochelli ABaliakas PKavakiotis IAgathangelidis ASutton LAMinga ENtoufa STausch EYan XJShanafelt TPlevova KBoudjogra MRossi DDavis ZNavarro ASandberg YVojdeman FJScarfo LStavroyianni NSudarikov AVeronese STzenou TKaran-Djurasevic TCatherwood MKienle DChatzouli MFacco MBahlo JPott CPedersen LBMansouri LSmedby KEChu CCGiudicelli VLefranc MPPanagiotidis PJuliusson GAnagnostopoulos AVlahavas IAntic DTrentin LMontillo MNiemann CDöhner HLangerak AWPospisilova SHallek MCampo EChiorazzi NMaglaveras NOscier DGaidano GJelinek DFStilgenbauer SChouvarda IDarzentas NBelessi CDavi FHadzidimitriou ARosenquist RGhia PStamatopoulos K Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes.; Clinical cancer research : an official journal of the American Association for Cancer Research; Vol 23(17). 2017 Sep 01. Catera RLiu YGao CYan XJMagli AAllen SLKolitz JERai KRChu CCFeizi TStamatopoulos KChiorazzi N Binding of CLL subset 4 B-cell receptor immunoglobulins to viable human memory B lymphocytes requires a distinctive IGKV somatic mutation.; Molecular medicine (Cambridge, Mass.); Vol 23. 2017 Jan 12. Yuan CChu CCYan XJBagnara DChiorazzi NMacCarthy T The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.; PloS one; Vol 12(1). 2017. Hatzi KCatera RMoreno Atanasio CFischetti VAAllen SLKolitz JERai KRChu CCChiorazzi N Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-/poly-reactivity and IGHV mutation status.; Clinical immunology (Orlando, Fla.); Vol 172. 2016 Nov. Patten PEFerrer GChen SSSimone RMarsilio SYan XJGitto ZYuan CKolitz JEBarrientos JAllen SLRai KRMacCarthy TChu CCChiorazzi N Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6-deficient process.; JCI insight; Vol 1(4). 2016 Apr 07. Cui XZhang LMagli ARCatera RYan XJGriffin DORothstein TLBarrientos JKolitz JEAllen SLRai KRChiorazzi NChu CC Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability.; Leukemia; Vol 30(1). 2016 Jan. Mongini PKGupta RBoyle ENieto JLee HStein JBandovic JStankovic TBarrientos JKolitz JEAllen SLRai KChu CCChiorazzi N TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells.; Journal of immunology (Baltimore, Md. : 1950); Vol 195(3). 2015 Aug 01. Gounari MNtoufa SApollonio BPapakonstantinou NPonzoni MChu CCRossi DGaidano GChiorazzi NStamatopoulos KGhia P Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8.; Blood; Vol 125(23). 2015 Jun 04. Liu LYu HHuang XTan HLi SLuo YZhang LJiang SJia HXiong YZhang RHuang YChu CCTian W A novel engineered VEGF blocker with an excellent pharmacokinetic profile and robust anti-tumor activity.; BMC cancer; Vol 15. 2015 Mar 25. Baliakas PAgathangelidis AHadzidimitriou ASutton LAMinga ETsanousa AScarfò LDavis ZYan XJShanafelt TPlevova KSandberg YVojdeman FJBoudjogra MTzenou TChatzouli MChu CCVeronese SGardiner AMansouri LSmedby KEPedersen LBMoreno DVan Lom KGiudicelli VFrancova HSNguyen-Khac FPanagiotidis PJuliusson GAngelis LAnagnostopoulos ALefranc MPFacco MTrentin LCatherwood MMontillo MGeisler CHLangerak AWPospisilova SChiorazzi NOscier DJelinek DFDarzentas NBelessi CDavi FGhia PRosenquist RStamatopoulos K Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.; Blood; Vol 125(5). 2015 Jan 29. Baliakas PHadzidimitriou ASutton LAMinga EAgathangelidis ANichelatti MTsanousa AScarfò LDavis ZYan XJShanafelt TPlevova KSandberg YVojdeman FJBoudjogra MTzenou TChatzouli MChu CCVeronese SGardiner AMansouri LSmedby KEPedersen LBvan Lom KGiudicelli VFrancova HSNguyen-Khac FPanagiotidis PJuliusson GAngelis LAnagnostopoulos ALefranc MPFacco MTrentin LCatherwood MMontillo MGeisler CHLangerak AWPospisilova SChiorazzi NOscier DJelinek DFDarzentas NBelessi CDavi FRosenquist RGhia PStamatopoulos K Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study.; The Lancet. Haematology; Vol 1(2). 2014 Nov. Hwang KKTrama AMKozink DMChen XWiehe KCooper AJXia SMWang MMarshall DJWhitesides JAlam MTomaras GDAllen SLRai KRMcKeating JCatera RYan XJChu CCKelsoe GLiao HXChiorazzi NHaynes BF IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.; PloS one; Vol 9(3). 2014. Cesano APerbellini OEvensen EChu CCCioffi FPtacek JDamle RNChignola RCordeiro JYan XJHawtin RENichele IWare JRCavallini CLovato OZanotti RRai KRChiorazzi NPizzolo GScupoli MT Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies.; Haematologica; Vol 98(4). 2013 Apr. Patten PEChu CCAlbesiano EDamle RNYan XJKim DZhang LMagli ARBarrientos JKolitz JEAllen SLRai KRRoa SMongini PKMacCarthy TScharff MDChiorazzi N IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.; Blood; Vol 120(24). 2012 Dec 06. Agathangelidis ADarzentas NHadzidimitriou ABrochet XMurray FYan XJDavis Zvan Gastel-Mol EJTresoldi CChu CCCahill NGiudicelli VTichy BPedersen LBForoni LBonello LJanus ASmedby KAnagnostopoulos AMerle-Beral HLaoutaris NJuliusson Gdi Celle PFPospisilova SJurlander JGeisler CTsaftaris ALefranc MPLangerak AWOscier DGChiorazzi NBelessi CDavi FRosenquist RGhia PStamatopoulos K Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies.; Blood; Vol 119(19). 2012 May 10. Hwang KKChen XKozink DMGustilo MMarshall DJWhitesides JFLiao HXCatera RChu CCYan XJLuftig MAHaynes BFChiorazzi N Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells.; Blood; Vol 119(7). 2012 Feb 16. Ghiotto FMarcatili PTenca CCalevo MGYan XJAlbesiano EBagnara DColombo MCutrona GChu CCMorabito FBruno SFerrarini MTramontano AFais FChiorazzi N Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells.; Molecular medicine (Cambridge, Mass.); Vol 17(11-12). 2011. Chu CCZhang LDhayalan AAgagnina BMMagli ARFraher GDidier SJohnson LPKennedy WJDamle RNYan XJPatten PETeichberg SKoduru PKolitz JEAllen SLRai KRChiorazzi N Torque teno virus 10 isolated by genome amplification techniques from a patient with concomitant chronic lymphocytic leukemia and polycythemia vera.; Molecular medicine (Cambridge, Mass.); Vol 17(11-12). 2011. Chu CCCatera RZhang LDidier SAgagnina BMDamle RNKaufman MSKolitz JEAllen SLRai KRChiorazzi N Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin.; Blood; Vol 115(19). 2010 May 13. Seiler TWoelfle MYancopoulos SCatera RLi WHatzi KMoreno CTorres MPaul SDohner HStilgenbauer SKaufman MSKolitz JEAllen SLRai KRChu CCChiorazzi N Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells.; Blood; Vol 114(17). 2009 Oct 22. Chu CCCatera RHatzi KYan XJZhang LWang XBFales HMAllen SLKolitz JERai KRChiorazzi N Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA.; Blood; Vol 112(13). 2008 Dec 15. Catera RSilverman GJHatzi KSeiler TDidier SZhang LHervé MMeffre EOscier DGVlassara HScofield RHChen YAllen SLKolitz JRai KRChu CCChiorazzi N Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation.; Molecular medicine (Cambridge, Mass.); Vol 14(11-12). 2008 Nov. Benoff SChu CCMarmar JLSokol RZGoodwin LOHurley IR Voltage-dependent calcium channels in mammalian spermatozoa revisited.; Frontiers in bioscience : a journal and virtual library; Vol 12. 2007 Jan 01. Guzowski DChandrasekaran AGawel CPalma JKoenig JWang XPDosik MKaplan MChu CCChavan SFurie RAlbesiano EChiorazzi NGoodwin L Analysis of single nucleotide polymorphisms in the promoter region of interleukin-10 by denaturing high-performance liquid chromatography.; Journal of biomolecular techniques : JBT; Vol 16(2). 2005 Jun. Desai AVictor-Vega CGadangi SMontesinos MCChu CCCronstein BN Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1.; Molecular pharmacology; Vol 67(5). 2005 May. Mason JMNaidu MDBarcia MPorti DChavan SSChu CC IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization.; Journal of immunology (Baltimore, Md. : 1950); Vol 173(7). 2004 Oct 01. Miura YChu CCDines DMAsnis SEFurie RAChiorazzi N Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion.; Molecular medicine (Cambridge, Mass.); Vol 9(5-8). 2003 May. Tian WChua KStrober WChu CC ILG1 : a new integrase-like gene that is a marker of bacterial contamination by the laboratory Escherichia coli strain TOP10F'.; Molecular medicine (Cambridge, Mass.); Vol 8(7). 2002 Jul. Chavan SSTian WHsueh KJawaheer DGregersen PKChu CC Characterization of the human homolog of the IL-4 induced gene-1 (Fig1).; Biochimica et biophysica acta; Vol 1576(1-2). 2002 Jun 07. Hirose NWilliams RAlberts ARFurie RAChartash EKJain RISison CLahita RGMerrill JTCucurull EGharavi AESammaritano LRSalmon JEHashimoto SSawada TChu CCGregersen PKChiorazzi N A role for the polymorphism at position 247 of the beta2-glycoprotein I gene in the generation of anti-beta2-glycoprotein I antibodies in the antiphospholipid syndrome.; Arthritis and rheumatism; Vol 42(8). 1999 Aug. Chu CCPaul WE Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis.; Molecular immunology; Vol 35(8). 1998 Jun. Chu CCPaul WE Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis.; Proceedings of the National Academy of Sciences of the United States of America; Vol 94(6). 1997 Mar 18. Shimoda Kvan Deursen JSangster MYSarawar SRCarson RTTripp RAChu CQuelle FWNosaka TVignali DADoherty PCGrosveld GPaul WEIhle JN Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.; Nature; Vol 380(6575). 1996 Apr 18. Nakanishi KYoshimoto TChu CCMatsumoto HHase KNagai NTanaka TMiyasaka MPaul WEShinka S IL-2 inhibits IL-4-dependent IgE and IgG1 production in vitro and in vivo.; International immunology; Vol 7(2). 1995 Feb. Clark AJSatin LChu CC Transcription of the Escherichia coli recE gene from a promoter in Tn5 and IS50.; Journal of bacteriology; Vol 176(22). 1994 Nov. Clark AJSharma VBrenowitz SChu CCSandler SSatin LTemplin ABerger ICohen A Genetic and molecular analyses of the C-terminal region of the recE gene from the Rac prophage of Escherichia coli K-12 reveal the recT gene.; Journal of bacteriology; Vol 175(23). 1993 Dec. Mandler RChu CCPaul WEMax EESnapper CM Interleukin 5 induces S mu-S gamma 1 DNA rearrangement in B cells activated with dextran-anti-IgD antibodies and interleukin 4: a three component model for Ig class switching.; The Journal of experimental medicine; Vol 178(5). 1993 Nov 01. Chu CCMax EEPaul WE DNA rearrangement can account for in vitro switching to IgG1.; The Journal of experimental medicine; Vol 178(4). 1993 Oct 01. Chu CCPaul WEMax EE Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method.; Proceedings of the National Academy of Sciences of the United States of America; Vol 89(15). 1992 Aug 01. Tanaka TChu CCPaul WE An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion.; The Journal of experimental medicine; Vol 175(2). 1992 Feb 01. Scappino LAChu CGritzmacher CA Extended nucleotide sequence of the switch region of the murine gene encoding immunoglobulin E.; Gene; Vol 99(2). 1991 Mar 15. Mahajan SKChu CCWillis DKTemplin AClark AJ Physical analysis of spontaneous and mutagen-induced mutants of Escherichia coli K-12 expressing DNA exonuclease VIII activity.; Genetics; Vol 125(2). 1990 Jun. Chu CCClark AJ A 10- rather than 9-bp duplication associated with insertion of Tn5 in Escherichia coli K-12.; Plasmid; Vol 22(3). 1989 Nov. Chu CCTemplin AClark AJ Suppression of a frameshift mutation in the recE gene of Escherichia coli K-12 occurs by gene fusion.; Journal of bacteriology; Vol 171(4). 1989 Apr. Clark AJSandler SJWillis DKChu CCBlanar MALovett ST Genes of the RecE and RecF pathways of conjugational recombination in Escherichia coli.; Cold Spring Harbor symposia on quantitative biology; Vol 49. 1984.