Cole Lab

Research in the Cole lab focuses on investigating toxicities associated with Pancreatic cancer and Rheumatoid arthritis. In particular, we utilize novel, longitudinal imaging techniques such as bioluminescence imaging (BLI) and dual energy x-ray absorptiometry (DEXA), along with combined techniques such as CRISPR gene editing, transcriptomics, proteomics, tissue culture, and histology to investigate the molecular mechanisms of disease-related skeletal muscle wasting.

Calvin Cole, Ph.D.
Principal Investigator

Lab Members

Projects

IGFBP-3 and PDAC-induced Skeletal Muscle Wasting

Validation of Dual Energy X-ray Absorptiometry to Quantify Tumor Burden

IGFBP-3 and PDAC Tumor Progression

Rheumatoid Arthritis, Wheel Running, and Skeletal Muscle Wasting

View All Projects

Publications

View All Publications

1. Asantewaa G
2. Tuttle ET
3. Ward NP
4. Kang YP
5. Kim Y
6. Kavanagh ME
7. Girnius N
8. Chen Y
9. Rodriguez K
10. Hecht F
11. Zocchi M
12. Smorodintsev-Schiller L
13. Scales TQ
14. Taylor K
15. Alimohammadi F
16. Duncan RP
17. Sechrist ZR
18. Agostini-Vulaj D
19. Schafer XL
20. Chang H
21. Smith ZR
22. O'Connor TN
23. Whelan S
24. Selfors LM
25. Crowdis J
26. Gray GK
27. Bronson RT
28. Brenner D
29. Rufini A
30. Dirksen RT
31. Hezel AF
32. Huber AR
33. Munger J
34. Cravatt BF
35. Vasiliou V
36. Cole CL
37. DeNicola GM
38. Harris IS
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression.; Nature communications; Vol 15(1), pp. 6152. 2024 Jul 21.
1. Sechrist ZR
2. Lee G
3. Schwarz EM
4. Cole CL
Validation of dual energy X-ray absorptiometry for longitudinal quantification of tumor burden in a murine model of pancreatic ductal adenocarcinoma.; PloS one; Vol 19(1), pp. e0292196. 2024 Jan 02.
1. Asantewaa G
2. Tuttle ET
3. Ward NP
4. Kang YP
5. Kim Y
6. Kavanagh ME
7. Girnius N
8. Chen Y
9. Duncan R
10. Rodriguez K
11. Hecht F
12. Zocchi M
13. Smorodintsev-Schiller L
14. Scales TQ
15. Taylor K
16. Alimohammadi F
17. Sechrist ZR
18. Agostini-Vulaj D
19. Schafer XL
20. Chang H
21. Smith Z
22. O'Connor TN
23. Whelan S
24. Selfors LM
25. Crowdis J
26. Gray GK
27. Bronson RT
28. Brenner D
29. Rufini A
30. Dirksen RT
31. Hezel AF
32. Huber AR
33. Munger J
34. Cravatt BF
35. Vasiliou V
36. Cole CL
37. DeNicola GM
38. Harris IS
Glutathione supports lipid abundance in vivo.; bioRxiv : the preprint server for biology. 2023 Feb 11.
1. Kenney HM
2. Wood RW
3. Ramirez G
4. Bell RD
5. Chen KL
6. Schnur L
7. Rahimi H
8. Korman BD
9. Xing L
10. Ritchlin CT
11. Schwarz EM
12. Cole CL
Implementation of automated behavior metrics to evaluate voluntary wheel running effects on inflammatory-erosive arthritis and interstitial lung disease in TNF-Tg mice.; Arthritis research & therapy; Vol 25(1), pp. 17. 2023 Feb 02.

Contact Us

Cole Lab
601 Elmwood Ave
Room 1.7534
Rochester, NY 14642

calvin_cole@urmc.rochester.edu

(585) 273-2559