Enhanced Neurotoxicity of Metals in Combination With Other Pertinent Risk Factors

This project is focused on:

• The potential synergistic neurodevelopmental consequences of developmental lead exposure in conjunction with maternal and/or offspring stress
• Determination of whether enhanced toxicity of lead exposure and stress is seen with other neurotoxic metals, including methylmercury and arsenic, that likewise impact the HPA axis and brain mesocorticolimbic systems
• The potential for positive vs negative early behavioral experience to modify the trajectory of consequences of developmental lead and/or prenatal stress exposures

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