Recent Publications

• 1. Millar MW
  2. Najar RA
  3. Slavin SA
  4. Shadab M
  5. Tahir I
  6. Mahamed Z
  7. Lin X
  8. Abe JI
  9. Wright TW
  10. Dean DA
  11. Fazal F
  12. Rahman A
  MTOR maintains endothelial cell integrity to limit lung vascular injury.; The Journal of biological chemistry. 2024 Nov 05.
• 1. Lin X
  2. Bai H
  3. Barravecchia M
  4. Norman R
  5. Schiralli Lester GM
  6. Kottmann RM
  7. Leonard A
  8. Rahman A
  9. Young JL
  10. Dean DA
  Occludin Is Essential to Maintain Normal Alveolar Barrier Integrity and Its Protective Role During ARDS Progression.; International journal of molecular sciences; Vol 25(21). 2024 Oct 29.
• 1. Shadab M
  2. Slavin SA
  3. Mahamed Z
  4. Millar MW
  5. Najar RA
  6. Leonard A
  7. Pietropaoli A
  8. Dean DA
  9. Fazal F
  10. Rahman A
  Spleen Tyrosine Kinase phosphorylates VE-cadherin to cause endothelial barrier disruption in acute lung injury.; The Journal of biological chemistry; Vol 299(12), pp. 105408. 2023 Oct 28.
• 1. Liu J
  2. Schiralli-Lester GM
  3. Norman R
  4. Dean DA
  Upregulation of alveolar fluid clearance is not sufficient for Na+,K+-ATPase β subunit-mediated gene therapy of LPS-induced acute lung injury in mice.; Scientific reports; Vol 13(1), pp. 6792. 2023 Apr 26.
• 1. Gurunian A
  2. Dean DA
  Multiple conductance states of lipid pores during Voltage-Clamp electroporation.; Bioelectrochemistry (Amsterdam, Netherlands); Vol 151, pp. 108396. 2023 Feb 11.
• 1. Jagrosse ML
  2. Baliga UK
  3. Jones CW
  4. Russell JJ
  5. García CI
  6. Najar RA
  7. Rahman A
  8. Dean DA
  9. Nilsson BL
  Impact of Peptide Sequence on Functional siRNA Delivery and Gene Knockdown with Cyclic Amphipathic Peptide Delivery Agents.; Molecular pharmaceutics. 2023 Jan 14.
• 1. Gurunian A
  2. Dean DA
  Modeling and simulation of current-clamp electroporation.; Bioelectrochemistry (Amsterdam, Netherlands); Vol 147. 2022 May 19.
• 1. Liu J
  2. Dean DA
  Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function.; Scientific reports; Vol 11(1). 2021 Oct 21.
• 1. Bai H
  2. Zhou R
  3. Barravecchia M
  4. Norman R
  5. Friedman AE
  6. Yu D
  7. Lin X
  8. Young JL
  9. Dean DA
  MRCKα interacts with and mediates Na+, K+-ATPase-induced tight junction assembly in the lung epithelium.; JCI insight. 2021 Jan 28.
• 1. Eliseeva SI
  2. Knowlden ZA
  3. Lester GM
  4. Dean DA
  5. Georas SN
  6. Chapman TJ
  Changes in lung immune cell infiltrates after electric field treatment in mice.; Scientific reports; Vol 11(1). 2021 Jan 14.
• 1. Welch JJ
  2. Dean DA
  3. Nilsson BL
  Synthesis and Application of Peptide-siRNA Nanoparticles from Disulfide-Constrained Cyclic Amphipathic Peptides for the Functional Delivery of Therapeutic Oligonucleotides to the Lung.; Methods in molecular biology (Clifton, N.J.); Vol 2208. 2021.
• 1. Liu J
  2. Dean DA
  Gene Therapy for Acute Respiratory Distress Syndrome.; Frontiers in physiology; Vol 12. 2021.
• 1. Baliga UK
  2. Dean DA
  Pulmonary gene delivery-Realities and possibilities.; Experimental biology and medicine (Maywood, N.J.). 2020 Nov 12.
• 1. Ávila-Pérez G
  2. Nogales A
  3. Park JG
  4. Vasquez DM
  5. Dean DA
  6. Barravecchia M
  7. Perez DR
  8. Almazán F
  9. Martínez-Sobrido L
  In vivo rescue of recombinant Zika virus from an infectious cDNA clone and its implications in vaccine development.; Scientific reports; Vol 10(1). 2020 Jan 16.
• 1. Steiner LA
  2. Getman M
  3. Schiralli Lester GM
  4. Iqbal MA
  5. Katzman P
  6. Szafranski P
  7. Stankiewicz P
  8. Bhattacharya S
  9. Mariani T
  10. Pryhuber G
  11. Lin X
  12. Young JL
  13. Dean DA
  14. Scheible K
  Disruption of normal patterns of FOXF1 expression in a lethal disorder of lung development.; Journal of medical genetics. 2019 Oct 29.
• 1. Jagrosse ML
  2. Dean DA
  3. Rahman A
  4. Nilsson BL
  RNAi therapeutic strategies for acute respiratory distress syndrome.; Translational research : the journal of laboratory and clinical medicine. 2019 Jul 27.
• 1. Leonard A
  2. Millar MW
  3. Slavin SA
  4. Bijli KM
  5. Dionisio Santos DA
  6. Dean DA
  7. Fazal F
  8. Rahman A
  Critical role of autophagy regulator Beclin1 in endothelial cell inflammation and barrier disruption.; Cellular signalling. 2019 May 01.
• 1. Bai H
  2. Schiralli Lester GM
  3. Petishnok LC
  4. Dean DA
  Cytoplasmic transport and nuclear import of plasmid DNA.; Bioscience reports. 2017 Oct 20.
• 1. Barnett RC
  2. Lin X
  3. Barravecchia M
  4. Norman RA
  5. de Mesy Bentley KL
  6. Fazal F
  7. Young JL
  8. Dean DA
  Featured Article: Electroporation-mediated gene delivery of surfactant protein B (SP-B) restores expression and improves survival in mouse model of SP-B deficiency.; Experimental biology and medicine (Maywood, N.J.); Vol 242(13). 2017 Jul.
• 1. Rahmani K
  2. Dean DA
  Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1).; Biochemical and biophysical research communications; Vol 488(2). 2017 Jun 24.
• 1. Parikh P
  2. Bai H
  3. Swartz MF
  4. Alfieris GM
  5. Dean DA
  Identification of differentially regulated genes in human patent ductus arteriosus.; Experimental biology and medicine (Maywood, N.J.). 2016 Jul 27.
• 1. Gottfried L
  2. Lin X
  3. Barravecchia M
  4. Dean DA
  Identification of an alveolar type I epithelial cell-specific DNA nuclear import sequence for gene delivery.; Gene therapy. 2016 Jul 1.
• 1. Welch JJ
  2. Swanekamp RJ
  3. King C
  4. Dean DA
  5. Nilsson BL
  Functional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides.; ACS medicinal chemistry letters; Vol 7(6). 2016 Jun 09.
• 1. Lin X
  2. Barravecchia M
  3. Kothari P
  4. Young JL
  5. Dean DA
  β1-Na(+),K(+)-ATPase gene therapy upregulates tight junctions to rescue lipopolysaccharide-induced acute lung injury.; Gene therapy; Vol 23(6). 2016 Jun.
• 1. Emr BM
  2. Roy S
  3. Kollisch-Singule M
  4. Gatto LA
  5. Barravecchia M
  6. Lin X
  7. Young JL
  8. Wang G
  9. Liu J
  10. Satalin J
  11. Snyder K
  12. Nieman GF
  13. Dean DA
  Electroporation-mediated gene delivery of Na+,K+ -ATPase, and ENaC subunits to the lung attenuates acute respiratory distress syndrome in a two-hit porcine model.; Shock (Augusta, Ga.); Vol 43(1). 2015 Jan.
• 1. Young JL
  2. Dean DA
  Electroporation-mediated gene delivery.; Advances in genetics; Vol 89. 2015.
• 1. Huber AR
  2. Tan D
  3. Sun J
  4. Dean D
  5. Wu T
  6. Zhou Z
  High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7.; BMC gastroenterology; Vol 15. 2015.
• 1. Vernon MM
  2. Dean DA
  3. Dobson J
  DNA Targeting Sequence Improves Magnetic Nanoparticle-Based Plasmid DNA Transfection Efficiency in Model Neurons.; International journal of molecular sciences; Vol 16(8). 2015.
• 1. Young JL
  2. Barravecchia MS
  3. Dean DA
  Electroporation-mediated gene delivery to the lungs.; Methods in molecular biology (Clifton, N.J.); Vol 1121. 2014.
• 1. Emr B
  2. Gatto LA
  3. Roy S
  4. Satalin J
  5. Ghosh A
  6. Snyder K
  7. Andrews P
  8. Habashi N
  9. Marx W
  10. Ge L
  11. Wang G
  12. Dean DA
  13. Vodovotz Y
  14. Nieman G
  Airway pressure release ventilation prevents ventilator-induced lung injury in normal lungs.; JAMA surgery; Vol 148(11). 2013 Nov.
• 1. Dean DA
  Cell-specific targeting strategies for electroporation-mediated gene delivery in cells and animals.; The Journal of membrane biology; Vol 246(10). 2013 Oct.
• 1. Roy SK
  2. Emr B
  3. Sadowitz B
  4. Gatto LA
  5. Ghosh A
  6. Satalin JM
  7. Snyder KP
  8. Ge L
  9. Wang G
  10. Marx W
  11. Dean D
  12. Andrews P
  13. Singh A
  14. Scalea T
  15. Habashi N
  16. Nieman GF
  Preemptive application of airway pressure release ventilation prevents development of acute respiratory distress syndrome in a rat traumatic hemorrhagic shock model.; Shock (Augusta, Ga.); Vol 40(3). 2013 Sep.
• 1. Badding MA
  2. Dean DA
  Highly acetylated tubulin permits enhanced interactions with and trafficking of plasmids along microtubules.; Gene therapy; Vol 20(6). 2013 Jun.
• 1. Badding MA
  2. Lapek JD
  3. Friedman AE
  4. Dean DA
  Proteomic and functional analyses of protein-DNA complexes during gene transfer.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 21(4). 2013 Apr.
• 1. Roy S
  2. Habashi N
  3. Sadowitz B
  4. Andrews P
  5. Ge L
  6. Wang G
  7. Roy P
  8. Ghosh A
  9. Kuhn M
  10. Satalin J
  11. Gatto LA
  12. Lin X
  13. Dean DA
  14. Vodovotz Y
  15. Nieman G
  Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury.; Shock (Augusta, Ga.); Vol 39(1). 2013 Jan.
• 1. Cramer F
  2. Christensen CL
  3. Poulsen TT
  4. Badding MA
  5. Dean DA
  6. Poulsen HS
  Insertion of a nuclear factor kappa B DNA nuclear-targeting sequence potentiates suicide gene therapy efficacy in lung cancer cell lines.; Cancer gene therapy; Vol 19(10). 2012 Oct.
• 1. O'Reilly MA
  2. Yee M
  3. Buczynski BW
  4. Vitiello PF
  5. Keng PC
  6. Welle SL
  7. Finkelstein JN
  8. Dean DA
  9. Lawrence BP
  Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1.; The American journal of pathology; Vol 181(2). 2012 Aug.
• 1. Roy S
  2. Sadowitz B
  3. Andrews P
  4. Gatto LA
  5. Marx W
  6. Ge L
  7. Wang G
  8. Lin X
  9. Dean DA
  10. Kuhn M
  11. Ghosh A
  12. Satalin J
  13. Snyder K
  14. Vodovotz Y
  15. Nieman G
  16. Habashi N
  Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury.; The journal of trauma and acute care surgery; Vol 73(2). 2012 Aug.
• 1. Yao H
  2. Chung S
  3. Hwang JW
  4. Rajendrasozhan S
  5. Sundar IK
  6. Dean DA
  7. McBurney MW
  8. Guarente L
  9. Gu W
  10. Rönty M
  11. Kinnula VL
  12. Rahman I
  SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.; The Journal of clinical investigation; Vol 122(6). 2012 Jun.
• 1. Badding MA
  2. Vaughan EE
  3. Dean DA
  Transcription factor plasmid binding modulates microtubule interactions and intracellular trafficking during gene transfer.; Gene therapy; Vol 19(3). 2012 Mar.
• 1. Lin X
  2. Dean DA
  Gene therapy for ALI/ARDS.; Critical care clinics; Vol 27(3). 2011 Jul.
• 1. Eldib M
  2. Dean DA
  Cyclic stretch of alveolar epithelial cells alters cytoskeletal micromechanics.; Biotechnology and bioengineering; Vol 108(2). 2011 Feb.
• 1. Dean DA
  2. Barravecchia BD
  Use of Electroporation for Efficacious Gene Delivery to the Lungs; ECS Trans; Vol 35, pp. 167-177. 2011 Jan 01.
• 1. Kaufman CD
  2. Geiger RC
  3. Dean DA
  Electroporation- and mechanical ventilation-mediated gene transfer to the lung.; Gene therapy; Vol 17(9). 2010 Sep.
• 1. Staversky RJ
  2. Vitiello PF
  3. Yee M
  4. Callahan LM
  5. Dean DA
  6. O'Reilly MA
  Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development.; American journal of respiratory cell and molecular biology; Vol 43(3). 2010 Sep.
• 1. Degiulio JV
  2. Kaufman CD
  3. Dean DA
  The SP-C promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression.; Gene therapy; Vol 17(4). 2010 Apr.
• 1. Lam AP
  2. Dean DA
  Progress and prospects: nuclear import of nonviral vectors.; Gene therapy; Vol 17(4). 2010 Apr.
• 1. Wang Y
  2. Heilig KO
  3. Minto AW
  4. Chen S
  5. Xiang M
  6. Dean DA
  7. Geiger RC
  8. Chang A
  9. Pravtcheva DD
  10. Schlimme M
  11. Deb DK
  12. Wang Y
  13. Heilig CW
  Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF.; Laboratory investigation; a journal of technical methods and pathology; Vol 90(1). 2010 Jan.
• 1. Miller AM
  2. Munkonge FM
  3. Alton EW
  4. Dean DA
  Identification of protein cofactors necessary for sequence-specific plasmid DNA nuclear import.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 17(11). 2009 Nov.
• 1. Yee M
  2. Chess PR
  3. McGrath-Morrow SA
  4. Wang Z
  5. Gelein R
  6. Zhou R
  7. Dean DA
  8. Notter RH
  9. O'Reilly MA
  Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity.; American journal of physiology. Lung cellular and molecular physiology; Vol 297(4). 2009 Oct.