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Diekwisch Lab

URMC / Labs / Diekwisch Lab / Areas of Research / Orthodontics

Orthodontics

Orthodontists focus on moving teeth using appliances.  However, post-eruptive teeth also move within jaws without any direct mechanical force:  they either supererupt or drift.  When UIC Orthodontics Department Head Dr. Carla Evans established the Brodie Laboratory for Craniofacial Genetics in 2001, Dr. Bernie Schneider, one of UIC’s senior orthodontists, sought to build a bridge between our lab and his interest in the model system of the un-opposed molar that he pursued under the tutelage of Vienna’s distinguished anatomists Harry Sicher and Joseph-Peter Weinmann (Holiday et al. 2005, Luan and Diekwisch 2007).  Bernie’s quest turned into a continuous inspiration to revisit fundamental questions about the molecular mechanisms behind tooth supereruption (Luan et al. 2007, Pandya et al. 2022) and the drift of the dentition (Walker et al. 2010).

Contributions to Journals

  • Pandya, M., Gopinathan, G., Tillberg, C., Wang, J., Luan, X., and Diekwisch, T.G.H. (2022). The Hippo pathway effectors YAP/TAZ are essential for mineralized tissue homeostasis in the alveolar bone/periodontal complex.  Journal of Developmental Biology 10(1):14.  doi: 10.3390/jdb10010014.
  • Walker, C.G.*, Dangaria, S.*, Ito, Y., Luan, X., and Diekwisch, T.G.H. (2010). Osteopontin is Required for Unloading-Induced Osteoclast Recruitment and Modulation of RANKL Expression during Tooth Drift-associated Bone Remodeling, but Not for Super-Eruption. BONE 47, 1020-1029.
  • Walker, C., Ito, Y., Dangaria, S., Luan, X., and Diekwisch, T.G.H. (2008). RANKL, osteopontin and osteoclast homeostasis in a hyper-occlusion mouse model. Eur. J. Oral Sci. 116, 312-318.
  • Luan, X., and Diekwisch, T.G.H. (2007). Vienna - Chicago: the cultural transformation of the model system of the un-opposed molar. Bioessays 29, 819-830.
  • Luan, X., Ito, Y., Holliday, S., Walker, C., Daniel, J., Galang, T.M., Fukui, T., Yamane, A., Begole, E., Evans, C., and Diekwisch, T.G.H. (2007). Extracellular matrix-mediated tissue remodeling following axial movement of teeth. J. Histochem. Cytochem. 55, 127-140.
  • Holliday, S., Schneider, B., Galang, M.T., Fukui, T., Yamane, A., Luan, X., and Diekwisch, T.G.H. (2005). Bones, Teeth, and Genes: A Genomic Homage to Harry Sicher’s “Axial Movement of Teeth“. World J. Orthodontics 6, 61-70.