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Recent Publications

1. Du T
2. Raghunandan A
3. Mestre H
4. Plá V
5. Liu G
6. Ladrón-de-Guevara A
7. Newbold E
8. Tobin P
9. Gahn-Martinez D
10. Pattanayak S
11. Huang Q
12. Peng W
13. Nedergaard M
14. Kelley DH
Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage.; Nature aging. 2024 Aug 15.
1. Raicevic N
2. Forer JM
3. Ladrón-de-Guevara A
4. Du T
5. Nedergaard M
6. Kelley DH
7. Boster K
Sizes and shapes of perivascular spaces surrounding murine pial arteries.; Fluids and barriers of the CNS; Vol 20(1), pp. 56. 2023 Jul 17.
1. Boster KAS
2. Cai S
3. Ladrón-de-Guevara A
4. Sun J
5. Zheng X
6. Du T
7. Thomas JH
8. Nedergaard M
9. Karniadakis GE
10. Kelley DH
Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(14), pp. e2217744120. 2023 Mar 29.
1. Gomolka RS
2. Hablitz LM
3. Mestre H
4. Giannetto M
5. Du T
6. Hauglund NL
7. Xie L
8. Peng W
9. Martinez PM
10. Nedergaard M
11. Mori Y
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation.; eLife; Vol 12. 2023 Feb 09.
1. Wang X
2. Delle C
3. Peng W
4. Plá V
5. Giannetto M
6. Kusk P
7. Sigurdsson B
8. Sakurai S
9. Sweeney A
10. Sun Q
11. Du T
12. Libby RT
13. Nedergaard M
Age- and glaucoma-induced changes to the ocular glymphatic system.; Neurobiology of disease. 2023 Jan 11.
1. Liu G
2. Ladrón-de-Guevara A
3. Izhiman Y
4. Nedergaard M
5. Du T
Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies.; Fluids and barriers of the CNS; Vol 19(1), pp. 101. 2022 Jan 15.
1. Du T
2. Mestre H
3. Kress BT
4. Liu G
5. Sweeney AM
6. Samson AJ
7. Rasmussen MK
8. Mortensen KN
9. Bork PAR
10. Peng W
11. Olveda GE
12. Bashford L
13. Toro ER
14. Tithof J
15. Kelley DH
16. Thomas JH
17. Hjorth PG
18. Martens EA
19. Mehta RI
20. Hirase H
21. Mori Y
22. Nedergaard M
Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.; Brain : a journal of neurology. 2021 Sep 28.
1. Raghunandan A
2. Ladron-de-Guevara A
3. Tithof J
4. Mestre H
5. Du T
6. Nedergaard M
7. Thomas JH
8. Kelley DH
Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection.; eLife; Vol 10. 2021 Mar 09.
1. Liu G
2. Mestre H
3. Sweeney AM
4. Sun Q
5. Weikop P
6. Du T
7. Nedergaard M
Direct Measurement of Cerebrospinal Fluid Production in Mice.; Cell reports; Vol 33(12). 2020 Dec 22.
1. Min Rivas F
2. Liu J
3. Martell BC
4. Du T
5. Mestre H
6. Nedergaard M
7. Tithof J
8. Thomas JH
9. Kelley DH
Surface periarterial spaces of the mouse brain are open, not porous.; Journal of the Royal Society, Interface; Vol 17(172). 2020 Nov.
1. Mestre H
2. Du T
3. Sweeney AM
4. Liu G
5. Samson AJ
6. Peng W
7. Mortensen KN
8. Stæger FF
9. Bork PAR
10. Bashford L
11. Toro ER
12. Tithof J
13. Kelley DH
14. Thomas JH
15. Hjorth PG
16. Martens EA
17. Mehta RI
18. Solis O
19. Blinder P
20. Kleinfeld D
21. Hirase H
22. Mori Y
23. Nedergaard M
Cerebrospinal fluid influx drives acute ischemic tissue swelling.; Science (New York, N.Y.). 2020 Jan 30.
1. Sweeney AM
2. Plá V
3. Du T
4. Liu G
5. Sun Q
6. Peng S
7. Plog BA
8. Kress BT
9. Wang X
10. Mestre H
11. Nedergaard M
In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy.; Journal of visualized experiments : JoVE. 2019 Jul 29.
1. Lilius TO
2. Blomqvist K
3. Hauglund NL
4. Liu G
5. Stæger FF
6. Bærentzen S
7. Du T
8. Ahlström F
9. Backman JT
10. Kalso EA
11. Rauhala PV
12. Nedergaard M
Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.; Journal of controlled release : official journal of the Controlled Release Society; Vol 304. 2019 Jun 28.
1. Mestre H
2. Hablitz LM
3. Xavier AL
4. Feng W
5. Zou W
6. Pu T
7. Monai H
8. Murlidharan G
9. Castellanos Rivera RM
10. Simon MJ
11. Pike MM
12. Plá V
13. Du T
14. Kress BT
15. Wang X
16. Plog BA
17. Thrane AS
18. Lundgaard I
19. Abe Y
20. Yasui M
21. Thomas JH
22. Xiao M
23. Hirase H
24. Asokan A
25. Iliff JJ
26. Nedergaard M
Aquaporin-4-dependent glymphatic solute transport in the rodent brain.; eLife; Vol 7. 2018 Dec 18.
1. Mestre H
2. Tithof J
3. Du T
4. Song W
5. Peng W
6. Sweeney AM
7. Olveda G
8. Thomas JH
9. Nedergaard M
10. Kelley DH
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.; Nature communications; Vol 9(1). 2018 Nov 19.
1. Plog BA
2. Mestre H
3. Olveda GE
4. Sweeney AM
5. Kenney HM
6. Cove A
7. Dholakia KY
8. Tithof J
9. Nevins TD
10. Lundgaard I
11. Du T
12. Kelley DH
13. Nedergaard M
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.; JCI insight; Vol 3(20). 2018 Oct 18.
1. Du T
2. Rong Y
3. Feng R
4. Verkhratsky A
5. Peng L
Chronic Treatment with Anti-bipolar Drugs Down-Regulates Gene Expression of TRPC1 in Neurones.; Frontiers in cellular neuroscience; Vol 10. 2016.
1. Zhou J
2. Du T
3. Li B
4. Rong Y
5. Verkhratsky A
6. Peng L
Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion.; ASN neuro; Vol 7(5). 2015 Sep.
1. Wang F
2. Du T
3. Liang C
4. Verkhratsky A
5. Peng L
Ammonium increases Ca(2+) signalling and upregulates expression of Cav1.2 gene in astrocytes in primary cultures and in the in vivo brain.; Acta physiologica (Oxford, England); Vol 214(2). 2015 Jun.
1. Hertz L
2. Xu J
3. Song D
4. Du T
5. Li B
6. Yan E
7. Peng L
Astrocytic glycogenolysis: mechanisms and functions.; Metabolic brain disease; Vol 30(1). 2015 Feb.
1. Chen Y
2. Du T
3. Peng L
4. Gibbs ME
5. Hertz L
Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca(2+)]i Regulation, Glycogenolysis, Glutamate Synthesis, and K(+) Homeostasis are Similar but Not Identical in Learning and Mood Regulation.; Frontiers in integrative neuroscience; Vol 9. 2015.
1. Liang C
2. Du T
3. Zhou J
4. Verkhratsky A
5. Peng L
Ammonium increases Ca(2+) signalling and up-regulates expression of TRPC1 gene in astrocytes in primary cultures and in the in vivo brain.; Neurochemical research; Vol 39(11). 2014 Nov.
1. Hertz L
2. Xu J
3. Chen Y
4. Gibbs ME
5. Du T
6. Hertz L
7. Xu J
8. Chen Y
9. Gibbs ME
10. Du T
Antagonists of the Vasopressin V1 Receptor and of the β(1)-Adrenoceptor Inhibit Cytotoxic Brain Edema in Stroke by Effects on Astrocytes - but the Mechanisms Differ.; Current neuropharmacology; Vol 12(4). 2014 Jul.
1. Song D
2. Du T
Ammonium activates ouabain-activated signalling pathway in astrocytes: therapeutic potential of ouabain antagonist.; Current neuropharmacology; Vol 12(4). 2014 Jul.
1. Du T
2. Liang C
3. Li B
4. Hertz L
5. Peng L
Chronic fluoxetine administration increases expression of the L-channel gene Cav1.2 in astrocytes from the brain of treated mice and in culture and augments K(+)-induced increase in [Ca(2+)]i.; Cell calcium; Vol 55(3). 2014 Mar.
1. Song D
2. Xu J
3. Du T
4. Yan E
5. Hertz L
6. Walz W
7. Peng L
Inhibition of brain swelling after ischemia-reperfusion by β-adrenergic antagonists: correlation with increased K+ and decreased Ca2+ concentrations in extracellular fluid.; BioMed research international; Vol 2014. 2014.
1. Hertz L
2. Song D
3. Li B
4. Du T
5. Xu J
6. Gu L
7. Chen Y
8. Peng L
Signal Transduction in Astrocytes during Chronic or Acute Treatment with Drugs (SSRIs, Antibipolar Drugs, GABA-ergic Drugs, and Benzodiazepines) Ameliorating Mood Disorders.; Journal of signal transduction; Vol 2014. 2014.
1. Hertz L
2. Song D
3. Xu J
4. Du T
5. Gu L
6. Peng L
When can AQP4 assist transporter-mediated K⁺ uptake?; The Journal of general physiology; Vol 142(1). 2013 Jul.
1. Hertz L
2. Xu J
3. Song D
4. Du T
5. Yan E
6. Peng L
Brain glycogenolysis, adrenoceptors, pyruvate carboxylase, Na(+),K(+)-ATPase and Marie E. Gibbs' pioneering learning studies.; Frontiers in integrative neuroscience; Vol 7. 2013.
1. Desjardins P
2. Du T
3. Jiang W
4. Peng L
5. Butterworth RF
Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined.; Neurochemistry international; Vol 60(7). 2012 Jun.
1. Peng L
2. Li B
3. Du T
4. Wang F
5. Hertz L
Does conventional anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function?; Pharmacology, biochemistry, and behavior; Vol 100(4). 2012 Feb.
1. Cai L
2. Du T
3. Song D
4. Li B
5. Hertz L
6. Peng L
Astrocyte ERK phosphorylation precedes K(+)-induced swelling but follows hypotonicity-induced swelling.; Neuropathology : official journal of the Japanese Society of Neuropathology; Vol 31(3). 2011 Jun.
1. Peng L
2. Li B
3. Du T
4. Kong EK
5. Hu X
6. Zhang S
7. Shan X
8. Zhang M
Astrocytic transactivation by alpha2A-adrenergic and 5-HT2B serotonergic signaling.; Neurochemistry international; Vol 57(4). 2010 Nov.
1. Du T
2. Li B
3. Li H
4. Li M
5. Hertz L
6. Peng L
Signaling pathways of isoproterenol-induced ERK1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent.; Journal of neurochemistry; Vol 115(4). 2010 Nov.
1. Du T
2. Li B
3. Liu S
4. Zang P
5. Prevot V
6. Hertz L
7. Peng L
ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors.; Neurochemistry international; Vol 55(7). 2009 Dec.
1. Song D
2. Du T
3. Li B
4. Cai L
5. Gu L
6. Li H
7. Chen Y
8. Hertz L
9. Peng L
Astrocytic alkalinization by therapeutically relevant lithium concentrations: implications for myo-inositol depletion.; Psychopharmacology; Vol 200(2). 2008 Oct.
1. Du T
2. Song D
3. Li H
4. Li B
5. Cai L
6. Hertz L
7. Peng L
Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent.; European journal of pharmacology; Vol 587(1-3). 2008 Jun 10.
1. Li B
2. Du T
3. Li H
4. Gu L
5. Zhang H
6. Huang J
7. Hertz L
8. Peng L
Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons.; British journal of pharmacology; Vol 154(1). 2008 May.