Projects

Glymphatic function in chronic neuropathic pain

Chronic pain persists long after the initial injury is healed, impairing quality of life of approximately 30-60% of the US population.

Peptidergic regulation of glymphatic flow

The glymphatic system is a network of tunnel-like perivascular spaces that promotes cerebrospinal fluid movement into and interstitial fluid through the brain, ultimately draining into the traditional lymphatic system.

Circadian disruption of glymphatic function

The glymphatic system is a network of tunnel-like perivascular spaces that promotes cerebrospinal fluid movement into and interstitial fluid through the brain, ultimately draining into the traditional lymphatic system.

Circadian rhythms in stroke pathology and recovery

Stroke is a debilitating disease, affecting over 1.5 million Americans a year.  Interestingly, both stroke onset and severity fluctuate dramatically over the course of the day; the highest prevalence of stroke is observed in the morning hours, whereas stroke severity increases during sleep. 

Glymphatic/lymphatic homology

Throughout the body, lymphatic fluid movement supports critical functions including clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the lymphatic system in the brain.