URMC / Labs / Holt Lab / Publications

Recent Publications

1. Lee C
2. Shokrian M
3. Henry KS
4. Carney LH
5. Holt JC
6. Nam JH
Outer hair cells stir cochlear fluids.; bioRxiv : the preprint server for biology. 2024 Aug 09.
1. Heffer A
2. Lee C
3. Holt JC
4. Kiernan AE
Notch1 is required to maintain supporting cell identity and vestibular function during maturation of the mammalian balance organs.; bioRxiv : the preprint server for biology. 2024 Jun 21.
1. Poppi LA
2. Bigland MJ
3. Cresswell ET
4. Tabatabaee H
5. Lorincz D
6. Drury HR
7. Callister RJ
8. Holt JC
9. Lim R
10. Brichta AM
11. Smith DW
Molecular and functional changes to postsynaptic cholinergic signaling in the vestibular sensory organs of aging C57BL/6 mice.; The journals of gerontology. Series A, Biological sciences and medical sciences. 2023 Feb 25.
1. Schneider GT
2. Lee C
3. Sinha AK
4. Jordan PM
5. Holt JC
The mammalian efferent vestibular system utilizes cholinergic mechanisms to excite primary vestibular afferents.; Scientific reports; Vol 11(1). 2021 Jan 13.
1. Lee C
2. Sinha AK
3. Henry K
4. Walbaum AW
5. Crooks PA
6. Holt JC
Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear.; Frontiers in neuroscience; Vol 15. 2021.
1. Lorincz D
2. Poppi LA
3. Holt JC
4. Drury HR
5. Lim R
6. Brichta AM
The Long and Winding Road-Vestibular Efferent Anatomy in Mice.; Frontiers in neural circuits; Vol 15. 2021.
1. Jabeen T
2. Holt JC
3. Becker JR
4. Nam JH
Interactions between Passive and Active Vibrations in the Organ of Corti In Vitro.; Biophysical journal. 2020 Jun 17.
1. Poppi LA
2. Holt JC
3. Lim R
4. Brichta AM
A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications.; Journal of neurophysiology; Vol 123(2). 2020 Feb 01.
1. Jones SM
2. Vijayakumar S
3. Dow SA
4. Holt JC
5. Jordan PM
6. Luebke AE
Loss of α-Calcitonin Gene-Related Peptide (αCGRP) Reduces Otolith Activation Timing Dynamics and Impairs Balance.; Frontiers in molecular neuroscience; Vol 11. 2018.
1. Poppi LA
2. Tabatabaee H
3. Drury HR
4. Jobling P
5. Callister RJ
6. Migliaccio AA
7. Jordan PM
8. Holt JC
9. Rabbitt RD
10. Lim R
11. Brichta AM
ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.; Journal of neurophysiology. 2017 Oct 04.
1. Lee C
2. Holt JC
3. Jones TA
The effect of M-current modulation on mammalian vestibular responses to transient head motion.; Journal of neurophysiology. 2017 Aug 30.
1. Holt JC
2. Jordan PM
3. Lysakowski A
4. Shah A
5. Barsz K
6. Contini D
Muscarinic Acetylcholine Receptors and M-Currents Underlie Efferent-Mediated Slow Excitation in Calyx-Bearing Vestibular Afferents.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 37(7). 2017 Feb 15.
1. Parks XX
2. Contini D
3. Jordan PM
4. Holt JC
Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista.; Frontiers in cellular neuroscience; Vol 11. 2017.
1. Dickerson IM
2. Bussey-Gaborski R
3. Holt JC
4. Jordan PM
5. Luebke AE
Maturation of suprathreshold auditory nerve activity involves cochlear CGRP-receptor complex formation.; Physiological reports; Vol 4(14). 2016 Jul.
1. Jordan PM
2. Fettis M
3. Holt JC
Efferent innervation of turtle semicircular canal cristae: comparisons with bird and mouse.; The Journal of comparative neurology; Vol 523(8). 2015 Jun 1.
1. Holt JC
2. Kewin K
3. Jordan PM
4. Cameron P
5. Klapczynski M
6. McIntosh JM
7. Crooks PA
8. Dwoskin LP
9. Lysakowski A
Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(8). 2015 Feb 25.
1. Luebke AE
2. Holt JC
3. Jordan PM
4. Wong YS
5. Caldwell JS
6. Cullen KE
Loss of α-Calcitonin Gene-Related Peptide (αCGRP) Reduces the Efficacy of the Vestibulo-ocular Reflex (VOR).; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 34(31). 2014 Jul 30.
1. Jordan PM
2. Parks XX
3. Contini D
4. Holt JC
A review of synaptic mechanisms of vestibular efferent signaling in turtles: extrapolation to efferent actions in mammals.; Journal of vestibular research : equilibrium & orientation; Vol 23(3). 2013.
1. Holt JC
2. Chatlani S
3. Lysakowski A
4. Goldberg JM
Quantal and nonquantal transmission in calyx-bearing fibers of the turtle posterior crista.; Journal of neurophysiology; Vol 98(3). 2007 Sep.
1. Holt JC
2. Lysakowski A
3. Goldberg JM
Mechanisms of efferent-mediated responses in the turtle posterior crista.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 26(51). 2006 Dec 20.
1. Holt JC
2. Xue JT
3. Brichta AM
4. Goldberg JM
Transmission between type II hair cells and bouton afferents in the turtle posterior crista.; Journal of neurophysiology; Vol 95(1). 2006 Jan.
1. Holt JC
2. Lioudyno M
3. Guth PS
A pharmacologically distinct nicotinic ACh receptor is found in a subset of frog semicircular canal hair cells.; Journal of neurophysiology; Vol 90(3). 2003 Sep.
1. Lioudyno MI
2. Verbitsky M
3. Glowatzki E
4. Holt JC
5. Boulter J
6. Zadina JE
7. Elgoyhen AB
8. Guth PS
The alpha9/alpha10-containing nicotinic ACh receptor is directly modulated by opioid peptides, endomorphin-1, and dynorphin B, proposed efferent cotransmitters in the inner ear.; Molecular and cellular neurosciences; Vol 20(4). 2002 Aug.
1. Holt JC
2. Lioudyno M
3. Athas G
4. Garcia MM
5. Perin P
6. Guth PS
The effect of proteolytic enzymes on the alpha9-nicotinic receptor-mediated response in isolated frog vestibular hair cells.; Hearing research; Vol 152(1-2). 2001 Feb.
1. Lioudyno MI
2. Verbitsky M
3. Holt JC
4. Elgoyhen AB
5. Guth PS
Morphine inhibits an alpha9-acetylcholine nicotinic receptor-mediated response by a mechanism which does not involve opioid receptors.; Hearing research; Vol 149(1-2). 2000 Nov.
1. Holt JC
2. Pantoja AM
3. Athas GB
4. Guth PS
A role for chloride in the hyperpolarizing effect of acetylcholine in isolated frog vestibular hair cells.; Hearing research; Vol 146(1-2). 2000 Aug.
1. Guth PS
2. Holt JC
3. Perin P
4. Athas G
5. Garcia M
6. Puri A
7. Zucca G
8. Botta L
9. Valli P
The metabotropic glutamate receptors of the vestibular organs.; Hearing research; Vol 125(1-2). 1998 Nov.
1. Norris CH
2. Miller AJ
3. Perin P
4. Holt JC
5. Guth PS
Mechanisms and effects of transepithelial polarization in the isolated semicircular canal.; Hearing research; Vol 123(1-2). 1998 Sep.
1. Pantoja AM
2. Holt JC
3. Guth PS
A role for chloride in the suppressive effect of acetylcholine on afferent vestibular activity.; Hearing research; Vol 112(1-2). 1997 Oct.
1. Michel RE
2. Holt JC
3. Domer FR
Ketorolac causes the release of methionine-enkephalin in rats.; Research communications in molecular pathology and pharmacology; Vol 91(2). 1996 Feb.