Loiselle Lab - URMC & UR Research Laboratories - University of Rochester Medical Center

Musculoskeletal and Soft Tissue Fibrosis and Regeneration Lab

The overarching goals of our research program are to: i) identify novel strategies to promote regenerative tendon healing; ii) develop strategies to preserve tendon structure-function through the lifespan; and iii) understand the cellular and molecular drivers of soft tissue fibrosis, with a particular emphasis on the musculoskeletal system.

Loiselle Lab Team

Alayna E. Loiselle, Ph.D.
Principal Investigator

Projects

Tendon Regeneration

Maintain Tendon Structure-Function Through the Lifespan

Mechanisms of Soft Tissue Fibrosis

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Publications

Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function. Ackerman JE, Best KT, Muscat SN, Pritchett EM, Nichols AEC, Wu C, Loiselle AE. Cell Reports. 2022 Nov 22. 41(8).

Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis. Best KT, Korcari A, Mora KE, Nichols AE, Muscat SN, Knapp E, Buckley MR, Loiselle AE. Elife. 2021 Jan 22;10:e62203. doi: 10.7554/eLife.62203. PMID: 33480357.

NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival. Best KT, Nichols AEC, Knapp E, Hammert WC, Ketonis C, Jonason JH, Awad HA, Loiselle AE. Sci Signal. 2020 Nov 17;13(658):eabb7209. doi: 10.1126/scisignal.abb7209. PMID: 33203721.

Cell non-autonomous functions of S100a4 drive fibrotic tendon healing. Ackerman JE, Nichols AE, Studentsova V, Best KT, Knapp E, Loiselle AE. Elife. 2019 May 24;8:e45342. doi: 10.7554/eLife.45342. PMID: 31124787.

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