Luebke Lab
Auditory & Vestibular Efferent Systems
2nd generation adenovirus
The long-term goal of my laboratory is to understand the role of cochlear outer hair cells in hearing and hearing loss both at the molecular and at the systems level. Specifically, we are interested in agents that block or enhance the action of receptors on outer hair cells of the cochlea, which enhance hearing and decrease hearing loss. To design and discover agents that block or enhance receptor action on cochlear outer hair cells, we are cloning neurotransmitter receptors expressed in the hair cells, and modulating expression of these receptors by viral-mediated gene transfer into the cochlea.
Anne E. Luebke, Ph.D.
Principal Investigator
- Human RAMP1 overexpressing mice are resistant to migraine therapies for motion sensitivity.; PloS one; Vol 19(12), pp. e0313482. 2024 Dec 09.
- Loss of Calcitonin Gene Related Receptor component protein (RCP) in nervous system can bias "gepant" antagonism.; bioRxiv : the preprint server for biology. 2024 Oct 26.
- Musical training does not enhance neural sound encoding at early stages of the auditory system: A large-scale multisite investigation.; bioRxiv : the preprint server for biology. 2024 Sep 04.
- A vestibular challenge combined with calcitonin gene-related peptide (CGRP) promotes anxiety-like behaviors.; eNeuro. 2024 Jul 12.
- Loss of calcitonin gene-related peptide (αCGRP) and use of a vestibular challenge highlight balance deficiencies in aging mice.; PloS one; Vol 19(6), pp. e0303801. 2024 Jun 12.
- Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2-infected older mice with neurological signs.; Journal of virology. 2024 May 30.
News
Affiliations
August 27, 2021
Anne Luebke co-authors: Intermittent broadband sound may be key to slowing hearing loss
October 2, 2018
Professors Anne Luebke and Ross Maddox receive NSF award
August 10, 2018
Professor Luebke receives NIH R01
July 25, 2016
Luebke and Bennetto Explore Hearing Test That May Identify Autism Risk
Contact Us
Luebke Lab
MC 6-8547
601 Elmwood Ave
Rochester, NY 14642