MacLean Lab
Welcome to the MacLean Lab
We study how the structure of neurotransmitter-gated ion channels produces their unique biophysical and functional properties and also how these properties enable the receptors to fulfill specific roles in the brain. Our focus is on two families of ion channels: ionotropic Glutamate Receptors (iGluRs) and Acid Sensing Ion Channels (ASICs). To better understand these channels we combine patch clamp electrophysiology, kinetic and molecular modeling, fluorescence spectroscopy, unnatural amino acid incorporation and basic molecular biochemical techniques.
David M. MacLean, Ph.D.
Principal Investigator
Publications
View All Publications- Inositol 1,4,5-Trisphosphate Receptor Mutations Associated with Human Disease: Insights into Receptor Function and Dysfunction.; Annual review of physiology. 2024 Nov 26.
- Photomodulation of the ASIC1a acidic pocket destabilizes the open state.; Protein science : a publication of the Protein Society. 2023 Jan 08.
- Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.; Human molecular genetics. 2023 Jan 07.
- Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.; The Journal of general physiology; Vol 153(8). 2021 Aug 02.
News
Affiliations
- Pharmacology & Physiology
- Del Monte Institute for Neuroscience
- NIH T32 Training Grant in Cellular, Biochemical & Molecular Sciences
- Biophysics, Structural & Computational Biology Ph.D. Program
- Cellular and Molecular Pharmacology and Physiology Ph.D. Program
- Master’s Degree in Pharmacology
- Master’s Degree in Physiology
- Medical Pharmacology Master's Degree
- Neuroscience Ph.D. Program
February 25, 2021
Matthew Rook Wins Poster Award at 2021 Biophysical Society Meeting
June 1, 2020
Matthew Rook awarded a Joan Wright Goodman Dissertation Fellowship
August 9, 2017
Dr. MacLean Attends Yale Retreat
June 3, 2017
Lyndee joins the lab
Contact Us
MacLean Lab
601 Elmwood Ave
Rochester, NY 14642
(585) 275-6007