Projects

T cell engineering for cancer immunotherapy

Adoptive cell transfer utilizing genetically engineered cytotoxic T lymphocytes (CTLs) (e.g., chimeric antigen receptor (CAR)-T cells) is one of the most effective immunotherapies against hematological malignancies, but significant clinical success has not yet been achieved for solid tumors.

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Activated Protein C in Sepsis

Sepsis, also known as systemic inflammatory response syndrome (SIRS) by infection, is a serious medical condition caused by inflammatory response which leads to secretion of pro- and anti-inflammatory cytokines, activation and migration of leukocytes, activation of coagulation and inhibition of fibrinolysis, and increased apoptosis.

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Mac-1 (CD11b/CD18) in Neutrophil Migration

Neutrophils play key roles in the host defense network against pathogens by virtue of their abilities to phagocytose microorganisms and to produce oxygen free radicals and proteolytic enzymes. Extravasation of neutrophils from the blood stream proceeds through three coordinated steps: rolling and tethering, firm adhesion, and transmigration. The first step depends on the selectin molecules expressed on both neutrophils and endothelial cells (EC).

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Inflammatory Cues Regulating Effector T cell Recruitment

The maintenance of homeostatic immune surveillance and the development of effective immune responses require that leukocytes cross tissue barriers and move throughout the body, migrating in and out of the bone marrow, lymphoid and non-lymphoid tissues, under both normal and infected or inflamed conditions.

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T Lymphocyte Migration: Live-cell Imaging by a Novel Fluorescence-based Technique

A number of fundamental physiological processes are dependent on cell surface integrins including embryogenesis, development, inflammation, immune responsiveness, wound healing, and regulation of cell growth and differentiation. The role of integrins in the immune system is particularly complex as these molecules regulate many aspects of the immune response.

Learn more about T Lymphocyte Migration: Live-cell Imaging by a Novel Fluorescence-based Technique