Illustration of neurons

The Science of Neuro-Glia Interaction

Welcome to the Science of Neuro-Glia Interaction Lab

My research program focuses on neuroglia interactions. Specifically, my lab studies how neuromodulators mediate the unique interactions between neurons, astrocytes, and microglia in healthy brains and how disruptions in neuronal-glial crosstalk contribute to ADHD, epilepsy, and insulin resistance. My research program is supported by the NIH, NSF, and DOD.

Lab Members

Nathan A. Smith, M.S., Ph.D.
Principal Investigator

Projects

Astrocytes modulate synaptic plasticity via Norepinephrine

NCS-FR: Protecting the Aging Brain: Self-Organizing Networks and Multi-Scale Dynamics Under Energy Constraints

Role of astrocytes in Ca2+-dependent microglia modulation of synaptic plasticity

Identification of biomarkers for biochemical pathophysiological and neurological effects of high ammonia

View All Projects

Publications

1. Li B
2. Sun Q
3. Ding F
4. Xu Q
5. Kang N
6. Xue Y
7. Ladron-de-Guevara A
8. Hirase H
9. Weikop P
10. Gong S
11. Nathan S
12. Nedergaard M
Anti-seizure effects of norepinephrine-induced free fatty acid release.; Cell metabolism. 2024 Oct 29.
1. Neikirk K
2. Kabugi K
3. Mungai M
4. Kula B
5. Smith N
6. Hinton AO
Ethnicity-related differences in mitochondrial regulation by insulin stimulation in diabetes.; Journal of cellular physiology; Vol 239(8), pp. e31317. 2024 May 22.
1. Kula B
2. Antal B
3. Weistuch C
4. Gackière F
5. Barre A
6. Velado V
7. Hubbard JM
8. Kukley M
9. Mujica-Parodi LR
10. Smith NA
D-ꞵ-hydroxybutyrate stabilizes hippocampal CA3-CA1 circuit during acute insulin resistance.; PNAS nexus; Vol 3(5), pp. pgae196. 2024 May 16.
1. Kula B
2. Antal B
3. Weistuch C
4. Gackière F
5. Barre A
6. Velado V
7. Hubbard JM
8. Kukley M
9. Mujica-Parodi LR
10. Smith NA
D-β-hydroxybutyrate stabilizes hippocampal CA3-CA1 circuit during acute insulin resistance.; bioRxiv : the preprint server for biology. 2024 May 12.

View All Publications

Affiliations

Contact Us

Nathan Smith Lab
The Science of Neuro-Glia Interaction

Nathan_Smith@URMC.Rochester.edu