Projects

The Identity, Function, and Fate of Epitenon-Derived Progenitor Cells in Tendon Healing

The epitenon is a poorly described part of the tendon structure that contributes to both homeostasis and healing. Our work seeks to define the epitenon cellular niche and to understand the cues driving divergent epitenon cell fates post-injury. The ultimate goal is to leverage this knowledge to improve overall tendon healing.

Epitenon-Tenocyte Mechanotransduction in Tendon Homeostasis and Adaptation

Tendons are mechanosensitive tissues that respond to repeated mechanical load by altering their biomechanical properties; however, how this process is coordinated at the cellular level remains largely unknown. Using complex genetic mouse models combined with cutting-edge sequencing and imaging modalities, our goal is to understand how tendon cells located in different parts of the tendon communicate to affect tissue-level adaptation.

The Origins of Pain in Injured Tendons

The primary complaint of patients with tendon injuries is persistent pain. Despite this, little is known about the origins of tendon-related pain. The goal of our work is to understand the cellular drivers of persistent tendon-related pain and to identify therapeutic candidates for targeted pain relief.