URMC / Labs / Orlandi Lab / Publications

Publications

1. Kwon J
2. Kawase H
3. Mattonet K
4. Guenther S
5. Hahnefeld L
6. Shamsara J
7. Heering J
8. Kurz M
9. Kirchhofer S
10. Krasel C
11. Ulrich M
12. Persechino M
13. Murthy S
14. Orlandi C
15. Sadik CD
16. Geisslinger G
17. Bünemann M
18. Kolb P
19. Offermanns S
20. Wettschureck N
Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling.; Nature communications; Vol 16(1), pp. 1448. 2025 Feb 07.
1. Franchini L
2. Porter JJ
3. Lueck JD
4. Orlandi C
Gz Enhanced Signal Transduction assaY (G Z ESTY) for GPCR deorphanization.; bioRxiv : the preprint server for biology. 2024 Jul 26.
1. Franchini L
2. Orlandi C
Deorphanization of G Protein Coupled Receptors (GPCRs): a historical perspective.; Molecular pharmacology. 2024 Apr 15.
1. Alabdali R
2. Franchini L
3. Orlandi C
Gα protein signaling bias at 5-HT1A receptor.; Molecular pharmacology. 2023 Aug 11.
1. Franchini L
2. Orlandi C
Probing the orphan receptors: Tools and directions.; Progress in molecular biology and translational science; Vol 195, pp. 47-76. 2022 Jul 13.
1. Fu W
2. Franchini L
3. Orlandi C
Comprehensive Spatial Profile of the Orphan G Protein Coupled Receptor GPRC5B Expression in Mouse Brain.; Frontiers in neuroscience; Vol 16, pp. 891544. 2022 Jun 23.
1. Watkins LR
2. Orlandi C
In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity.; British journal of pharmacology. 2021 Mar 30.
1. Cao Y
2. Wang Y
3. Dunn HA
4. Orlandi C
5. Shultz N
6. Kamasawa N
7. Fitzpatrick D
8. Li W
9. Zeitz C
10. Hauswirth W
11. Martemyanov KA
Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors.; Proceedings of the National Academy of Sciences of the United States of America. 2020 Sep 02.
1. Watkins LR
2. Orlandi C
Orphan G Protein Coupled Receptors in Affective Disorders.; Genes; Vol 11(6). 2020 Jun 24.
1. Sutton LP
2. Muntean BS
3. Ostrovskaya O
4. Zucca S
5. Dao M
6. Orlandi C
7. Song C
8. Xie K
9. Martemyanov KA
NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control.; PLoS biology; Vol 17(10). 2019 Oct.
1. Wang D
2. Stoveken HM
3. Zucca S
4. Dao M
5. Orlandi C
6. Song C
7. Masuho I
8. Johnston C
9. Opperman KJ
10. Giles AC
11. Gill MS
12. Lundquist EA
13. Grill B
14. Martemyanov KA
Genetic behavioral screen identifies an orphan anti-opioid system.; Science (New York, N.Y.); Vol 365(6459). 2019 Sep 20.
1. Dunn HA
2. Zucca S
3. Dao M
4. Orlandi C
5. Martemyanov KA
ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior.; Molecular psychiatry. 2019 Sep 04.
1. Song C
2. Orlandi C
3. Sutton LP
4. Martemyanov KA
The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex.; The Journal of biological chemistry; Vol 294(35). 2019 Aug 30.
1. Orlandi C
2. Sutton LP
3. Muntean BS
4. Song C
5. Martemyanov KA
Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors.; Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology; Vol 44(3). 2019 Feb.
1. Dunn HA
2. Orlandi C
3. Martemyanov KA
Beyond the Ligand: Extracellular and Transcellular G Protein-Coupled Receptor Complexes in Physiology and Pharmacology.; Pharmacological reviews; Vol 71(4). 2019 Jan.
1. Dunn HA
2. Patil DN
3. Cao Y
4. Orlandi C
5. Martemyanov KA
Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans.; Proceedings of the National Academy of Sciences of the United States of America; Vol 115(19). 2018 May 08.
1. Sarria I
2. Cao Y
3. Wang Y
4. Ingram NT
5. Orlandi C
6. Kamasawa N
7. Kolesnikov AV
8. Pahlberg J
9. Kefalov VJ
10. Sampath AP
11. Martemyanov KA
LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors.; Cell reports; Vol 22(13). 2018 Mar 27.
1. Sutton LP
2. Orlandi C
3. Song C
4. Oh WC
5. Muntean BS
6. Xie K
7. Filippini A
8. Xie X
9. Satterfield R
10. Yaeger JDW
11. Renner KJ
12. Young SM
13. Xu B
14. Kwon H
15. Martemyanov KA
Orphan receptor GPR158 controls stress-induced depression.; eLife; Vol 7. 2018 Feb 08.
1. Ostrovskaya OI
2. Orlandi C
3. Fajardo-Serrano A
4. Young SM
5. Lujan R
6. Martemyanov KA
Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 38(46). 2018 Jan 14.
1. Condomitti G
2. Wierda KD
3. Schroeder A
4. Rubio SE
5. Vennekens KM
6. Orlandi C
7. Martemyanov KA
8. Gounko NV
9. Savas JN
10. de Wit J
An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses.; Neuron; Vol 100(1). 2018 Jan 10.
1. Orlandi C
2. Omori Y
3. Wang Y
4. Cao Y
5. Ueno A
6. Roux MJ
7. Condomitti G
8. de Wit J
9. Kanagawa M
10. Furukawa T
11. Martemyanov KA
Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.; Cell reports; Vol 25(1). 2018 Jan 02.
1. Sutton LP
2. Ostrovskaya O
3. Dao M
4. Xie K
5. Orlandi C
6. Smith R
7. Wee S
8. Martemyanov KA
Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum.; Biological psychiatry; Vol 80(3). 2016 Aug 01.
1. Tayou J
2. Wang Q
3. Jang GF
4. Pronin AN
5. Orlandi C
6. Martemyanov KA
7. Crabb JW
8. Slepak VZ
Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein.; The Journal of biological chemistry; Vol 291(17). 2016 Apr 22.
1. Sarria I
2. Orlandi C
3. McCall MA
4. Gregg RG
5. Martemyanov KA
Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 36(10). 2016 Mar 09.
1. Xu Y
2. Orlandi C
3. Cao Y
4. Yang S
5. Choi CI
6. Pagadala V
7. Birnbaumer L
8. Martemyanov KA
9. Vardi N
The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go.; Scientific reports; Vol 6. 2016 Feb 17.
1. Xie K
2. Colgan LA
3. Dao MT
4. Muntean BS
5. Sutton LP
6. Orlandi C
7. Boye SL
8. Boye SE
9. Shih CC
10. Li Y
11. Xu B
12. Smith RG
13. Yasuda R
14. Martemyanov KA
NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum.; Current biology : CB; Vol 26(22). 2016 Jan 21.
1. Aguado C
2. Orlandi C
3. Fajardo-Serrano A
4. Gil-Minguez M
5. Martemyanov KA
6. Luján R
Cellular and Subcellular Localization of the RGS7/Gβ5/R7BP Complex in the Cerebellar Cortex.; Frontiers in neuroanatomy; Vol 10. 2016.
1. Cao Y
2. Sarria I
3. Fehlhaber KE
4. Kamasawa N
5. Orlandi C
6. James KN
7. Hazen JL
8. Gardner MR
9. Farzan M
10. Lee A
11. Baker S
12. Baldwin K
13. Sampath AP
14. Martemyanov KA
Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision.; Neuron; Vol 87(6). 2015 Sep 23.
1. Orlandi C
2. Xie K
3. Masuho I
4. Fajardo-Serrano A
5. Lujan R
6. Martemyanov KA
Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain.; The Journal of biological chemistry; Vol 290(22). 2015 May 29.
1. Orlandi C
2. Cao Y
3. Martemyanov KA
Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons.; Investigative ophthalmology & visual science; Vol 54(10). 2013 Oct 29.
1. La Via L
2. Bonini D
3. Russo I
4. Orlandi C
5. Barlati S
6. Barbon A
Modulation of dendritic AMPA receptor mRNA trafficking by RNA splicing and editing.; Nucleic acids research; Vol 41(1). 2013 Jan 07.
1. Orlandi C
2. Posokhova E
3. Masuho I
4. Ray TA
5. Hasan N
6. Gregg RG
7. Martemyanov KA
GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes.; The Journal of cell biology; Vol 197(6). 2012 Jun 11.
1. Orlandi C
2. Barbon A
3. Barlati S
Activity regulation of adenosine deaminases acting on RNA (ADARs).; Molecular neurobiology; Vol 45(1). 2012 Feb.
1. Barbon A
2. Caracciolo L
3. Orlandi C
4. Musazzi L
5. Mallei A
6. La Via L
7. Bonini D
8. Mora C
9. Tardito D
10. Gennarelli M
11. Racagni G
12. Popoli M
13. Barlati S
Chronic antidepressant treatments induce a time-dependent up-regulation of AMPA receptor subunit protein levels.; Neurochemistry international; Vol 59(6). 2011 Nov.
1. Barbon A
2. Orlandi C
3. La Via L
4. Caracciolo L
5. Tardito D
6. Musazzi L
7. Mallei A
8. Gennarelli M
9. Racagni G
10. Popoli M
11. Barlati S
Antidepressant treatments change 5-HT2C receptor mRNA expression in rat prefrontal/frontal cortex and hippocampus.; Neuropsychobiology; Vol 63(3). 2011.
1. Orlandi C
2. La Via L
3. Bonini D
4. Mora C
5. Russo I
6. Barbon A
7. Barlati S
AMPA receptor regulation at the mRNA and protein level in rat primary cortical cultures.; PloS one; Vol 6(9). 2011.
1. Barbon A
2. Gervasoni A
3. LaVia L
4. Orlandi C
5. Jaskolski F
6. Perrais D
7. Barlati S
Human GluR6c, a functional splicing variants of GluR6, is mainly expressed in non-nervous cells.; Neuroscience letters; Vol 434(1). 2008 Mar 21.