News

Doug Portman named a fellow of the AAAS

Thursday, April 18, 2024

Douglas Portman, PhD, holds the Donald M. Foster, MD Professorship in Biomedical Genetics and is a professor of Neuroscience and Biology at the University of Rochester Medical Center, was named a Fellow of the American Association for the Advancement of Science (AAAS). AAAS is the world’s largest general scientific society and publisher of the journal Science.

Each year the AAAS Council elects members whose “efforts on behalf of the advancement of science, or its applications, are scientifically or socially distinguished.” Portman, a member of the University’s Del Monte Institute for Neuroscience, was elected a Fellow for his “distinguished contributions to the field of behavioral neuroscience, particularly for elucidating mechanisms of sexual dimorphism of behavior, and for outstanding mentoring of the next generation of neuroscientists.”

Turns out—male roundworms are picky when choosing a mate, new research finds

Monday, March 11, 2024

A piece of rotting fruit is likely covered in hundreds if not thousands of microscopic roundworms, including C. elegans—a popular experimental model system for studying neurogenetics. With a lifespan of only a few weeks, C. elegans must reproduce quickly and often. The species is made up of hermaphrodites and males. The hermaphrodites have female bodies, can self-fertilize, and can mate with males. Recent research from of the Portman Lab at the Del Monte Institute for Neuroscience at the University of Rochester, found the males do not mate indiscriminately—they are selective about things like age, mating history, and nutrition.

“We have been aware of many of the mating cues this species uses, but this is the first time we have been able to look at them together to learn more about what they tell a male about a potential mate,” Doug Portman, PhD, professor of Biomedical Genetics said. “Assessing a mate’s characteristics seems to be something that only the male does. Understanding sex differences in C. elegans gives us important insight into how genes influence the function of neurons and circuits to guide innate behaviors—like choosing a mate.”

C. elegans is an invaluable tool to neuroscience research. Scientists have identified all of the roundworm’s neurons—there are only a few hundred of them—and the connections between its neurons have also been mapped, providing a model for understanding how neuronal circuits work in humans. It is well understood that mating is a priority for male C. elegans. Previous research out of the Portman lab found male C. elegans will suppress the ability to locate food in order to find a mate.

In a study out today in Current Biology, the Portman lab conducted experiments to observe how roundworms in petri dishes choose between potential mates. They discovered that the male worms used diverse chemical (pheromones) and physical (touch) signals to determine the sex, age, nutritional health, and mating history of the hermaphrodites. Researchers found male worms can determine a hermaphrodite’s nutritional status—whether it is healthy or food-deprived—and whether it has previously mated. When given a choice, the males showed preference toward hermaphrodites that have not previously mated with another male and are nutritionally healthy. However, once a hermaphrodite is a few days old—approaching middle age for a worm—it puts out a powerful sex pheromone that attracts males over long distances. That is because it starts to run out of its own sperm, so finding a mate becomes a more important.