Comparative Toxicology of Electronic Cigarettes with Flavorings

Electronic cigarettes (E-cigs) with different flavors represent a significant and increasing proportion of tobacco consumption in the United States and globally in youth/adult population. We are studying the aerosol constituents and cellular toxicity of E-cigs with nicotine and flavorings. The identification of established and potential harmful chemicals/constituents, and development of measurable comparative toxicity data based on oxidative stress, DNA damage and inflammation that result from exposure to E-cigs vapor with different flavorings are studied. Comparative chemical constituents and toxicity will provide crucial information related to hazard ranking and adverse health outcomes associated with E-cigs with specific flavorings as well as relevant to FDA regulation of tobacco products.

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