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Impact of Radiation on Immunity
Preliminary data in our lab have shown a long-lasting impact of neonatal irradiation on the CD4 T cell response against influenza viruses. Although defective CD4 T cells response did not compromise immunity to influenza viruses, it is possible that CD4 T cell-mediated protection against other extracellular pulmonary pathogens can be compromised by exposure to radiation in neonatal life (Radiat Res 184(4): 352-366: 2015). Thus, we are currently focused to investigate the effect of neonatal irradiation in the control of clinically relevant pulmonary pathogens.
![Immunofluorescence of lymph node after exposure to neonatal irradiation. PNAd in red, Lyve 1 in green and B220 in white.](/MediaLibraries/URMCMedia/labs/rangel-moreno-lab/images/radiation-immunity-large.jpg)
Immunofluorescence of lymph node after exposure to neonatal irradiation. PNAd in red, Lyve 1 in green and B220 in white.