Use of Laser-capture Microdissection to Decipher RNA Signatures in Target Tissues

In a project supported by the AMP and NIH, we are dissecting the molecular signatures of infiltrating lymphocytes in the inflamed synovium of patients with rheumatoid arthritis by using immunofluorescence and laser capture microdissection. The purpose is to reveal molecules that can be used as markers of disease progression/severity and identify novel targets to increase the therapeutic armamentarium for rheumatoid arthritis.

Synovium with inflammatory cells (CD3 in red and CD20 in green)