Tertiary Lymphoid Organs in Cancer

In a recent collaboration with researchers from University of Washington in Saint Louis (Shabaana Abdul Khader), University of Southern California in los Angeles (Martin W. Kast) and colleagues from the National Institute of Medical Sciences and Nutrition in Mexico City (Norma Ofelia Uribe Uribe, Ricardo Espinosa-Gonzalez), we demonstrated the existence of a unique microenvironment that is associated with the spontaneous regression of prostate cancer. Picture from TLO in evanescent prostate carcinoma (Front Immunol 8: 563: 2017).

100x picture showing an ectopic lymphoid structure in prostate of individual with prostate intraepithelial neoplasia.