Takimoto Lab
Host-virus interaction of Influenza and Paramyxoviruses
The main focus of our research is to reveal molecular mechanism of parainfluenza and influenza virus infection, replication, and assembly and host-virus interactions. We analyze structures and functions of viral proteins as well as interactions between viral and cellular proteins to reveal the mechanism of virus growth and to identify the factors that restrict host range of the viruses. Our study will unveil the process of viral replication and assembly, which are essential for developing antiviral agents.
Toru Takimoto, D.V.M., Ph.D.
Principal Investigator
- Functional Analysis of GRSF1 in the Nuclear Export and Translation of Influenza A Virus mRNAs.; Viruses; Vol 16(7). 2024 Jul 16.
- Human coronavirus NL63 nsp1 induces degradation of RNA polymerase II to inhibit host protein synthesis.; PLoS pathogens; Vol 20(6), pp. e1012329. 2024 Jun 20.
- Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1.; Communications biology; Vol 5(1), pp. 1102. 2022 Jan 17.
- Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro.; Virology; Vol 566. 2021 Nov 27.
Contact Us
Takimoto Lab
MC 4-5705
601 Elmwood Ave
Rochester, NY 14642