The overall goal of this pilot project is to determine whether the use of a new specialized MRI sequence, double inversion recovery (DIR), and post-processing techniques enhance the detection of epileptogenic lesions in patients with medically intractable epilepsy. We hypothesize that these techniques will reveal previously unrecognized causative lesions and better define known lesions in patients with medically intractable epilepsy.

Figure 1: Cortical lesion in the mesial left temporal lobe identified only on DIR (right) MRI and not on standard CUBE T2 FLAIR (left).