URMC / Labs / Zhang Lab / Publications Recent Publications Ahamed SHRShakil SLyu HZhang XLuo J Doctors vs. Nurses: Understanding the Great Divide in Vaccine Hesitancy among Healthcare Workers.; Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data; Vol 2022, pp. 5865-5870. 2022 Dec. Wang HZhou XWang JZhang XZhu MWang H Fabrication of channeled scaffolds through polyelectrolyte complex (PEC) printed sacrificial templates for tissue formation.; Bioactive materials; Vol 17. 2022 Nov. Parimala Chelvi Ratnamani MZhang XWang H A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting.; Gels (Basel, Switzerland); Vol 8(4). 2022 Apr 13. Schilling KZhai YZhou ZZhou BBrown EZhang X High resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy.; eLife; Vol 11. 2022 Jan 03. Schilling KBrown EZhang X NAD(P)H autofluorescence lifetime imaging enables single cell analyses of cellular metabolism of osteoblasts in vitro and in vivo via two-photon microscopy.; Bone. 2021 Nov 12. Zhai YSchilling KWang TEl Khatib MVinogradov SBrown EBZhang X Spatiotemporal blood vessel specification at the osteogenesis and angiogenesis interface of biomimetic nanofiber-enabled bone tissue engineering.; Biomaterials; Vol 276. 2021 Jul 26. Lam LRWSchilling KRomas SMisra RZhou ZCaton JGZhang X Electrospun core-shell nanofibers with encapsulated enamel matrix derivative for guided periodontal tissue regeneration.; Dental materials journal. 2021 Jun 12. Zhuang ZJohn JVLiao HLuo JRubery PMesfin ABoda SKXie JZhang X Periosteum Mimetic Coating on Structural Bone Allografts via Electrospray Deposition Enhances Repair and Reconstruction of Segmental Defects.; ACS biomaterials science & engineering; Vol 6(11). 2020 Nov 09. Schilling KEl Khatib MPlunkett SXue JXia YVinogradov SABrown EZhang X Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair.; ACS applied materials & interfaces; Vol 11(37). 2019 Sep 18. Yukata KXie CLi TFBrown MLKanchiku TZhang XAwad HASchwarz EMBeck CAJonason JHO'Keefe RJ Teriparatide (human PTH1-34) compensates for impaired fracture healing in COX-2 deficient mice.; Bone. 2018 Feb 02. Wang TZhai YNuzzo MYang XYang YZhang X Layer-by-layer nanofiber-enabled engineering of biomimetic periosteum for bone repair and reconstruction.; Biomaterials; Vol 182. 2018 Jan. Zhang X Intravital Imaging to Understand Spatiotemporal Regulation of Osteogenesis and Angiogenesis in Cranial Defect Repair and Regeneration.; Methods in molecular biology (Clifton, N.J.); Vol 1842. 2018. Zhang LWang TChang MKaiser CKim JDWu TCao XZhang XSchwarz EM Teriparatide treatment improves bone defect healing via anabolic effects on new bone formation and non-anabolic effects on inhibition of mast cells in a murine cranial window model.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017 May 30. Wang TZhang XBikle DD Osteogenic Differentiation of Periosteal Cells During Fracture Healing.; Journal of cellular physiology; Vol 232(5). 2017 May. Antebi BZhang LSheyn DPelled GZhang XGazit ZSchwarz EMGazit D Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts.; Bioengineering; Vol 3(1). 2016 Mar. Antebi BZhang LSheyn DPelled GZhang XGazit ZSchwarz EMGazit D Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts.; Bioengineering (Basel, Switzerland); Vol 3(1). 2016 Jan 11. Huang CNess VPYang XChen HLuo JBrown EBZhang X Spatiotemporal Analyses of Osteogenesis and Angiogenesis via Intravital Imaging in Cranial Bone Defect Repair.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015 Jan 15. Yukata KXie CLi TFTakahata MHoak DKondabolu SZhang XAwad HASchwarz EMBeck CAJonason JHO'Keefe RJ Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.; Bone; Vol 62. 2014 May. Huang CTang MYehling EZhang X Overexpressing sonic hedgehog peptide restores periosteal bone formation in a murine bone allograft transplantation model.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 22(2). 2014 Feb. Huang CXue MChen HJiao JHerschman HRO'Keefe RJZhang X The spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of periosteum-derived mesenchymal progenitors in fracture repair.; PloS one; Vol 9(7). 2014. Hoffman MDXie CZhang XBenoit DS The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing.; Biomaterials; Vol 34(35). 2013 Nov. Lyu SHuang CYang HZhang X Electrospun fibers as a scaffolding platform for bone tissue repair.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 31(9). 2013 Sep. Yazici CTakahata MReynolds DGXie CSamulski RJSamulski JBeecham EJGertzman AASpilker MZhang XO'Keefe RJAwad HASchwarz EM Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 19(8). 2011 Aug. Wang QHuang CXue MZhang X Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healing.; Bone; Vol 48(3). 2011 Mar 01. Wang QHuang CZeng FXue MZhang X Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair.; The American journal of pathology; Vol 177(6). 2010 Dec. Liu YZhang XXia YYang H Magnetic-field-assisted electrospinning of aligned straight and wavy polymeric nanofibers.; Advanced materials (Deerfield Beach, Fla.); Vol 22(22). 2010 Jun 11. Tsutsumi RXie CWei XZhang XFlick LMSchwarz EMO'Keefe RJ PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis; J Bone Miner Res; Vol 24(10), pp. 1753-62. 2009 Jan 01. Tsutsumi RXie CWei XZhang MZhang XFlick LMSchwarz EMO'Keefe RJ PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; Vol 24(10). 2009 Oct. Xie CLiang BXue MLin ASLoiselle ASchwarz EMGuldberg REO'Keefe RJZhang X Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.; The American journal of pathology; Vol 175(2). 2009 Aug. Xie CLiang BXue MLin ALoiselle ASchwarz EMGuldberg REO'Keefe RJZhang X Rescue of Impaired Fracture Healing in Cox-2-/- mice via Activation of Prostaglandin E2 Receptor Subtype 4; The American Journal of Pathology; Vol 175(2), pp. 772-85. 2009 Jan 01. Wei XZhang XFlick LMDrissi HSchwarz EMO'Keefe RJ Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway.; American journal of physiology. Cell physiology; Vol 297(2). 2009 Aug. Clark CALi TFKim KODrissi HZuscik MJZhang XO'Keefe RJ Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation; J. Orthop. Res.; Vol 27(6), pp. 785-92. 2009 Jan 01. Clark CALi TFKim KODrissi HZuscik MJZhang XO'Keefe RJ Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 27(6). 2009 Jun. Xie CKingsley PZuscik MJSchwarz EMAwad HGuldberg RDrissi HPuzas EBoyce BZhang XO'Keefe RJ Reduced COX-2 expression in aged mice is associated with impaired fracture healing; Journal of Bone & Mineral Research; Vol 24(2), pp. 251-64. 2009 Jan 01. Naik AAXie CZuscik MJKingsley PSchwarz EMAwad HGuldberg RDrissi HPuzas JEBoyce BZhang XO'Keefe RJ Reduced COX-2 expression in aged mice is associated with impaired fracture healing.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; Vol 24(2). 2009 Feb. Xie CLiang BXue MLin ALoiselle ASEM GO'Keefe RJZhang X Rescue of impaired fracture healing in COX-2 mice via activation of prostaglandin E2 receptor subtype 4.; The American Journal of Pathology; Vol 175(2), pp. 772-85. 2009 Jan 01. Xie CMing XWang QSchwarz EMGuldberg REO'Keefe RJZhang X COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing.; Bone; Vol 43(6). 2008 Dec. Yazici CYanoso LXie CReynolds DGSamulski RJSamulski JYannariello-Brown JGertzman AAZhang XAwad HASchwarz EM The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings.; Biomaterials; Vol 29(28). 2008 Oct. Zhang XAwad HAO'Keefe RJGuldberg RESchwarz EM A perspective: engineering periosteum for structural bone graft healing.; Clinical orthopaedics and related research; Vol 466(8). 2008 Aug. Zuscik MJHilton MJZhang XChen DO'Keefe RJ Regulation of chondrogenesis and chondrocyte differentiation by stress.; The Journal of clinical investigation; Vol 118(2). 2008 Feb. Xie CXue MWang QSchwarz EMO'Keefe RJZhang X Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation.; The Journal of bone and joint surgery. American volume; Vol 90 Suppl 1. 2008 Feb. Zhang XAwad AHO'Keefe RJGuldberg RJSchwarz EM Periosteum is essential for the initiation of structural bone graft healing: implication for tissue engineering.; Clinical Orthopaedics and Related Research.. 2008 Jan 01. Zhang XAwad HAO'Keefe RJGuldberg RESchwarz EM Perspective: Engineering Periosteum for Structural Bone Graft Healing; Clinical Orthopaedics & Related Research; Vol 466(8), pp. 1777-87. 2008 Jan 01. Xie CXue MLin ASchwarz EGuldberg RO'Keefe RZhang X COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing; Bone; Vol 43(6), pp. 1075-83. 2008 Jan 01. Yazici CYanoso LXie CReynolds DGSamulski RJSamulski JYannariello-Brown JGertzmann AAZhang XAwad HASchwarz EM The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings; Biomaterials; Vol 29(28), pp. 3882-7. 2008 Jan 01. Zhang XSun B Organic crystal fibers aligned into oriented bundles with polarized emission.; The journal of physical chemistry. B; Vol 111(37). 2007 Sep 20. Awad HAZhang XReynolds DGGuldberg REO'Keefe RJSchwarz EM Recent advances in gene delivery for structural bone allografts.; Tissue engineering; Vol 13(8). 2007 Aug. Wang QWei XZhu TZhang MShen RXing LO'Keefe RJChen D Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2.; The Journal of biological chemistry; Vol 282(14). 2007 Apr 6. Xie CReynolds DAwad HRubery PTPelled GGazit DGuldberg RESchwarz EMO'Keefe RJZhang X Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering.; Tissue engineering; Vol 13(3). 2007 Mar. Reynolds DGHock CShaikh SJacobson JZhang XRubery PTBeck CAO'keefe RJLerner ALSchwarz EMAwad HA Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts.; Journal of biomechanics; Vol 40(14). 2007. Zhang XChen D Targeted Gene Delivery for Femoral Allografts: A Novel Acellular Tissue Engineering Approach; Genesis; Vol 45(1), pp. 44-50. 2007 Jan 01. Chen MLichtler ACSheu TJXie CZhang XO'Keefe RJChen D Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase.; Genesis (New York, N.Y. : 2000); Vol 45(1). 2007 Jan. Bärnighausen TLiu YZhang XSauerborn R Willingness to pay for social health insurance among informal sector workers in Wuhan, China: a contingent valuation study.; BMC health services research; Vol 7. 2007. Xie CXue MNaik ALin ASchwarz EGuldberg RR JZhang X Cox-2 deficient bone healing environment impairs initiation of periosteum dependent endochondral bone repair. (under review in JBMR); JBMR (under review). 2007 Jan 01. Reynolds DGHock CShaikh SJacobson JZhang XRubery PTBeck CO'Keefe RJLerner ASchwarz EM Radiographic Prediction of Biomechanical Strength in Structural Bone Grafts.; J. Biomech. 40(14):3178-86.. 2007 Jan 01. O'Keefe RJTiyapatanaputi PXie CLi TFClark CZuscik MJChen DDrissi HSchwarz EZhang X COX-2 has a critical role during incorporation of structural bone allografts.; Annals of the New York Academy of Sciences; Vol 1068. 2006 Apr. Zhang XSun BFriend RHGuo HNau DGiessen H Metallic photonic crystals based on solution-processible gold nanoparticles.; Nano letters; Vol 6(4). 2006 Apr. Murugan RRamakrishna S Nano-featured scaffolds for tissue engineering: a review of spinning methodologies.; Tissue engineering; Vol 12(3). 2006 Mar. Robertson GXie CChen DAwad HSchwarz EMO'Keefe RJZhang X Alteration of femoral bone morphology and density in cox-2-/- mice.; Bone Oct.. 2006 Jan 01. Zhang XXie CLin ASIto HAwad HLieberman JRRubery PTSchwarz EMO'Keefe RJGuldberg RE Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; Vol 20(12). 2005 Dec. Zhang XNaik AXie CReynolds DPalmer JLin AAwad HGuldberg RSchwarz EO'Keefe R Periosteal stem cells are essential for bone revitalization and repair.; Journal of musculoskeletal & neuronal interactions; Vol 5(4). 2005 Oct. Koefoed MIto HGromov KReynolds DGAwad HARubery PTUlrich-Vinther MSoballe KGuldberg RELin ASO'Keefe RJZhang XSchwarz EM Biological effects of rAAV-caAlk2 coating on structural allograft healing.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 12(2). 2005 Aug. Wei XZhang XZuscik MJDrissi MHSchwarz EMO'Keefe RJ Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; Vol 20(7). 2005 Jul. Carmouche JJPuzas JEZhang XTiyapatanaputi PCory-Slechta DAGelein RZuscik MRosier RNBoyce BFO'Keefe RJSchwarz EM Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency.; Environmental health perspectives; Vol 113(6). 2005 Jun. Clark CASchwarz EMZhang XZiran NMDrissi HO'Keefe RJZuscik MJ Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation.; Biochemical and biophysical research communications; Vol 328(3). 2005 Mar 18. Ito HKoefoed MTiyapatanaputi PGromov KGoater JJCarmouche JZhang XRubery PTRabinowitz JSamulski RJNakamura TSoballe KO'Keefe RJBoyce BFSchwarz EM Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.; Nature medicine; Vol 11(3). 2005 Mar. Gu XFeng YShi CLi MFu ZZhang X Antiapoptotic mechanism of insulin in reoxygenation-induced injury in cultured cardiomyocytes of neonatal rats.; Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban; Vol 25(6). 2005. Guldberg REOest MLin ASIto HChao XGromov KGoater JJKoefoed MSchwarz EMO'Keefe RJZhang X Functional integration of tissue-engineered bone constructs.; Journal of musculoskeletal & neuronal interactions; Vol 4(4). 2004 Dec. Tiyapatanaputi PRubery PTCarmouche JSchwarz EMO'keefe RJZhang X A novel murine segmental femoral graft model.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 22(6). 2004 Nov. Li TFZuscik MJIonescu AMZhang XRosier RNSchwarz EMDrissi HO'Keefe RJ PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling.; Experimental cell research; Vol 300(1). 2004 Oct 15. Zhang XZiran NGoater JJSchwarz EMPuzas JERosier RNZuscik MDrissi HO'Keefe RJ Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation.; Bone; Vol 34(5). 2004 May. Bukata SGelinas JWei XRosier RNPuzas JEZhang XSchwarz EMSong XRGriswold DEO'Keefe RJ PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a COX-2 dependent pathway. .; J. of Orthopaedic Research.. 2004 Jan 01. Tiyapatanaputi PRubery PTCarmouche JSchwarz EMO'Keefe RJZhang X A Novel Murine Segmental Femoral Graft Model. J. of Othopaedic Research.; J. of Othopaedic Research.. 2004 Jan 01. Bukata SVGelinas JWei XRosier RNPuzas JEZhang XSchwarz EMSong XYGriswold DEO'Keefe RJ PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 22(1). 2004 Jan. Li XIonescu AMSchwarz EMZhang XDrissi HPuzas JERosier RNZuscik MJO'Keefe RJ Smad6 is induced by BMP-2 and modulates chondrocyte differentiation.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 21(5). 2003 Sep. Flick LMWeaver JMUlrich-Vinther MAbuzzahab FZhang XDougall WCAnderson DO'Keefe RJSchwarz EM Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 21(4). 2003 Jul. Flick LMWeaver JMUlrich-Vinther MAbuzzahab FZhang XDougal WCAnderson DO'Keefe RJSchwarz EM Effects of receptor activator of NFkB (RANK) signaling blockade on fracture healing.; J. of Orthopaedic Research.. 2003 Jan 01. Zhang XSchwarz EMYoung DAPuzas JERosier RNO'Keefe RJ Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair.; The Journal of clinical investigation; Vol 109(11). 2002 Jun. Mungo DVZhang XO'Keefe RJRosier RNPuzas JESchwarz EM COX-1 and COX-2 expression in osteoid osteomas.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 20(1). 2002 Jan. Zhang XSchwarz EMYoung DAPuzas JERosier RNO'Keefe RJ COX-2 Regulates Mesenchymal Cell Differentiation into Osteoblast Lineage and is Critically Involved in Bone Repair. Journal of Clinical Investigation; . 2002 Jan 01. Zhang XMorham SGLangenback RYoung DAXing LBoyce BFPuzas JERosier RNO'Keefe RJSchwarz EM Evidence for a 4 Direct Role of COX-2 in Implant Wear Debris Induced Osteolysis; J. Bone. Min. Res.; Vol 16 (4), pp. 660-669. 2001 Jan 01. Zhang XZhang YSchwarz EO'Keefe RJ The role of COX-2 in bone repair.; Current opinion in Orthopaedics.. 2001 Jan 01. Zhang XMorham SGLangenbach RBaggs RBYoung DA Lack of cyclooxygenase-2 inhibits growth of teratocarcinomas in mice.; Experimental cell research; Vol 254(2). 2000 Feb 1. Zhang XMorham SGLangenbach RYoung DA Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts.; The Journal of experimental medicine; Vol 190(4). 1999 Aug 16.