Zhu Lab
Welcome to the Zhu Lab
Our lab works with retroviruses (HIV-1, MLV, etc.) and focuses on identifying new host antiviral factors and deciphering viral antagonism of host defense. We use a combination of molecular, genomic, and cellular techniques to study the interactions between retroviruses and host cells. Particularly, we are interested in:
- Epigenetic silencing and latency of HIV-1 DNA
- Translation and stability control of HIV-1 mRNA
Comprehensive understanding mechanisms of host-retrovirus interactions will provide unique insights into gene regulation and potential opportunities for new antiviral therapies.
Yiping Zhu, Ph.D.
Principal Investigator
- NP220 mediates silencing of unintegrated retroviral DNA.; Nature; Vol 564(7735). 2018 Jan.
- Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling.; Cell host & microbe; Vol 21(2). 2017 Feb 08.
- Translational repression precedes and is required for ZAP-mediated mRNA decay.; The EMBO journal; Vol 31(21). 2012 Nov 05.
Contact Us
Yiping Zhu Lab
KMRB 3-9812
601 Elmwood Ave
Rochester, NY 14642