2019 Publications

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2019, December

• Krammer F, Li L, Wilson PC
  Emerging from the Shadow of Hemagglutinin: Neuraminidase Is an Important Target for Influenza Vaccination.
  PMID: 31951584
• Nayak J, Hoy G, Gordon A
  Influenza in Children.
  PMID: 31871228
• Nogales A, Aydillo T, Ávila-Pérez G, Escalera A, Chiem K, Cadagan R, DeDiego ML, Li F, García-Sastre A, Martínez-Sobrido L​
  Functional Characterization and Direct Comparison of Influenza A, B, C, and D NS1 Proteins in vitro and in vivo.
  PMID: 31921042
• Shannon I, White CL, Nayak JL
  Understanding Immunity in Children Vaccinated With Live Attenuated Influenza Vaccine.
  PMID: 31848606
• Wan H, Gao J, Yang H, Yang S, Harvey R, Chen YQ, Zheng NY, Chang J, Carney PJ, Li X, Plant E, Jiang L, Couzens L, Wang C, Strohmeier S, Wu WW, Shen RF, Krammer F, Cipollo JF, Wilson PC, Stevens J, Wan XF, Eichelberger MC, Ye Z
  The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain.
  PMID: 31406333
• Topham DJ, DeDiego ML, Nogales A, Sangster MY, Sant A
  Immunity to Influenza Infection in Humans.
  PMID: 31871226
• Zost SJ, Lee J, Gumina ME, Parkhouse K, Henry C, Wu NC, Lee CD, Wilson IA, Wilson PC, Bloom JD, Hensley SE
  Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site following Vaccination of Humans.
  PMID: 31875553

2019, November

• Knowlden ZAG, Richards KA, Moritzky SA, Sant AJ​
  Peptide Epitope Hot Spots of CD4 T Cell Recognition Within Influenza Hemagglutinin During the Primary Response to Infection.
  PMID: 31694141
• Harding AT, Haas GD, Chambers BS, Heaton NS
  Influenza viruses that require 10 genomic segments as antiviral therapeutics.
  PMID: 31730644

2019, October

• Rodriguez L, Blanco-Lobo P, Reilly EC, Maehigashi T, Nogales A, Smith A, Topham DJ, Dewhurst S, Kim B, Martínez-Sobrido L
  Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines.
  PMID: 31658679
• Gouma S, Zost SJ, Parkhouse K, Branche A, Topham DJ, Cobey S, Hensley SE
  Comparison of human H3N2 antibody responses elicited by egg-based, cell-based, and recombinant protein-based influenza vaccines during the 2017-2018 season.
  PMID: 31598646

2019, September

• Sangster MY, Nguyen PQT, Topham DJ​
  Role of Memory B Cells in Hemagglutinin-Specific Antibody Production Following Human Influenza A Virus Infection.
  PMID: 31569328
• Zhang H, Miller BL
  Immunosensor-based label-free and multiplex detection of influenza viruses: State of the art.
  PMID: 31272058
• Fiege JK, Stone IA, Dumm RE, Waring BM, Fife BT, Agudo J, Brown BD, Heaton NS, Langlois RA
  Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance.
  PMID: 31557273
• Wasik BR, de Wit E, Munster V, Lloyd-Smith JO, Martinez-Sobrido L, Parrish CR
  Onward transmission of viruses: how do viruses emerge to cause epidemics after spillover?
  PMID: 31401954
• DiPiazza AT, Fan S, Rattan A, DeDiego ML, Chaves F, Neumann G, Kawaoka Y, Sant AJ
  A Novel Vaccine Strategy to Overcome Poor Immunogenicity of Avian Influenza Vaccines through Mobilization of Memory CD4 T Cells Established by Seasonal Influenza.
  PMID: 31399519
• Wasik BR, Voorhees IEH, Barnard KN, Alford-Lawrence BK, Weichert WS, Hood G, Nogales A, Martínez-Sobrido L, Holmes EC, Parrish CR
  Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation.
  PMID: 31511393

2019, August

• Dumm RE, Heaton NS
  The Development and Use of Reporter Influenza B Viruses.
  PMID: 31404985
• DeDiego ML, Nogales A, Martinez-Sobrido L, Topham DJ
  Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication.
  PMID: 31455651
• Lee JM, Eguia R, Zost SJ, Choudhary S, Wilson PC, Bedford T, Stevens-Ayers T, Boeckh M, Hurt AC, Lakdawala SS, Hensley SE, Bloom JD
  Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin.
  PMID: 31452511
• Wang H, Dou D, Östbye H, Revol R, Daniels R
  Structural restrictions for influenza neuraminidase activity promote adaptation and diversification.
  PMID: 31451775
• Richards KA, Shannon I, Treanor JJ, Yang H, Nayak JL, Sant AJ
  Evidence that blunted CD4 T cells responses underlie deficient protective antibody responses to influenza vaccines in repeatedly vaccinated human subjects.
  PMID: 31504534
• DeDiego ML, Martinez-Sobrido L, Topham DJ
  Novel functions of the interferon-induced protein 44-like (IFI44L) as a feedback regulator of host antiviral responses.
  PMID: 31434731
• Henry C, Palm AE, Utset HA, Huang M, Ho IY, Zheng NY, Fitzgerald T, Neu KE, Chen YQ, Krammer F, Treanor JJ, Sant AJ, Topham DJ, Wilson PC
  Monoclonal antibody responses after recombinant HA vaccine versus subunit inactivated influenza virus vaccine: a comparative study.
  PMID: 31434733
• Fiege JK, Stone IA, Fay EJ, Markman MW, Wijeyesinghe S, Macchietto MG, Shen S, Masopust D, Langlois RA
  The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection.
  PMID: 31235552
• Chiem K, Rangel-Moreno J, Nogales A, Martinez-Sobrido L
  A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection.
  PMID: 31475986
• Gouma S, Weirick M, Hensley SE
  Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine.
  PMID: 31400756
• Brewer MG, Anderson EA, Pandya RP, De Benedetto A, Yoshida T, Hilimire TA, Martinez-Sobrido L, Beck LA, Miller BL
  Peptides Derived from the Tight Junction Protein, Claudin-1, Disrupt Skin Barrier and Promote Responsiveness to an Epicutaneous Vaccine.
  PMID: 31381894

2019, July

• Khurana S, Hahn M, Coyle EM, King LR, Lin TL, Treanor J, Sant A, Golding H​
  Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans.
  PMID: 31350391
• Palm AE, Henry C
  Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination.
  PMID: 31417562
• Simon LM, Morandi E, Luganini A, Gribaudo G, Martinez-Sobrido L, Turner DH, Oliviero S, Incarnato D
  In vivo analysis of influenza A mRNA secondary structures identifies critical regulatory motifs.
  PMID: 31053845
• Rattan A, Richards KA, Knowlden ZAG, Sant AJ
  Protein vaccination directs the CD4+ T cell response towards shared protective epitopes that can be recalled after influenza infection.
  PMID: 31341045
• Karyolaimos A, Ampah-Korsah H, Hillenaar T, Mestre Borras A, Dolata KM, Sievers S, Riedel K, Daniels R, de Gier JW
  Enhancing Recombinant Protein Yields in the E. coli Periplasm by Combining Signal Peptide and Production Rate Screening.
  PMID: 31396164

2019, June

• Sagong HY, Bauman JD, Nogales A, Martínez-Sobrido L, Arnold E, LaVoie EJ
  Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease.
  PMID: 30983160
• Moreno-Pescador G, Florentsen CD, Østbye H, Sønder SL, Boye TL, Veje EL, Sonne AK, Semsey S, Nylandsted J, Daniels R, Bendix PM
  Curvature- and Phase-Induced Protein Sorting Quantified in Transfected Cell-Derived Giant Vesicles.
  PMID: 31199124

2019, May

• Li D, Wang J, Garigen J, Treanor JJ, Zand MS​
  Continuous Readout versus Titer-Based Assays of Influenza Vaccine Trials: Sensitivity, Specificity, and False Discovery Rates.
  PMID: 31205481
• Nelson SA, Sant AJ
  Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus.
  PMID: 31134060

2019, April

• Sant AJ
  The Way Forward: Potentiating Protective Immunity to Novel and Pandemic Influenza Through Engagement of Memory CD4 T Cells.
  PMID: 30715376
• Varga SM, Sant AJ
  Forward to: Orchestration of an Immune Response to Respiratory Pathogens.
  PMID: 31024541
• Christensen SR, Toulmin SA, Griesman T, Lamerato LE, Petrie JG, Martin ET, Monto AS, Hensley SE
  Assessing the Protective Potential of H1N1 Influenza Virus Hemagglutinin Head and Stalk.
  PMID: 30700610
• Ranjeva S, Subramanian R, Fang VJ, Leung GM, Ip DKM, Perera RAPM, Peiris JSM, Cowling BJ, Cobey S
  Age-specific differences in the dynamics of protective immunity to influenza.
  PMID: 30971703
• Zhang Y, Bandyopadhyay G, Topham DJ, Falsey AR, Qiu X
  Highly efficient hypothesis testing methods for regression-type tests with correlated observations and heterogeneous variance structure.
  PMID:  30987598

2019, March

• Nogales A, Ávila-Pérez G, Rangel-Moreno J, Chiem K, DeDiego ML, Martínez-Sobrido L
  A novel fluorescent and bioluminescent Bi-Reporter influenza A virus (BIRFLU) to evaluate viral infections.
  PMID: 30867298
• Piepenbrink MS, Nogales A, Basu M, Fucile CF, Liesveld JL, Keefer MC, Rosenberg AF, Martinez-Sobrido L, Kobie JJ
  Broad and Protective Influenza B Virus Neuraminidase Antibodies in Humans after Vaccination and their Clonal Persistence as Plasma Cells.
  PMID: 30862743
• Henry C, Zheng NY, Huang M, Cabanov A, Rojas KT, Kaur K, Andrews SF, Palm AE, Chen YQ, Li Y, Hoskova K, Utset HA, Vieira MC, Wrammert J, Ahmed R, Holden-Wiltse J, Topham DJ, Treanor JJ, Ertl HC, Schmader KE, Cobey S, Krammer F, Hensley SE, Greenberg H, He XS, Wilson PC
  Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.
  PMID: 30795982
• Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML
  Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain.
  PMID: 29511250

2019, February

• Blanco-Lobo P, Nogales A, Rodríguez L, Martínez-Sobrido L
  Novel Approaches for The Development of Live Attenuated Influenza Vaccines.
  PMID: 30813325
• Tesini BL, Kanagaiah P, Wang J, Hahn M, Halliley JL, Chaves FA, Nguyen PQT, Nogales A, DeDiego ML, Anderson CS, Ellebedy AH, Strohmeier S, Krammer F, Yang H, Bandyopadhyay S, Ahmed R, Treanor JJ, Martinez-Sobrido L, Golding H, Khurana S, Zand MS, Topham DJ, Sangster MY
  Broad hemagglutinin-specific memory B cell expansion by seasonal influenza virus infection reflects early-life imprinting and adaptation to the infecting virus.
  PMID: 30728266
• Chen YQ, Lan LY, Huang M, Henry C, Wilson PC
  Hemagglutinin Stalk-Reactive Antibodies Interfere with Influenza Virus Neuraminidase Activity by Steric Hindrance.
  PMID: 30518651

2019, January

• Shannon I, White CL, Murphy A, Qiu X, Treanor JJ, Nayak JL
  Differences in the influenza-specific CD4 T cell immunodominance hierarchy and functional potential between children and young adults.
  PMID: 30692574
• Neu KE, Guthmiller JJ, Huang M, La J, Vieira MC, Kim K, Zheng NY, Cortese M, Tepora ME, Hamel NJ, Rojas KT, Henry C, Shaw D, Dulberger CL, Pulendran B, Cobey S, Khan AA, Wilson PC
  Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination.
  PMID: 30457979
• Guthmiller JJ, Dugan HL, Neu KE, Lan LY, Wilson PC
  An Efficient Method to Generate Monoclonal Antibodies from Human B Cells.
  PMID: 30539468