From Menarche to Menopause: The Story of Progesterone

The hormone progesterone frequently is discussed with regard to menstruation, fertility, pregnancy, and contraception during reproductive years or in the context of hormone replacement therapy (HRT) with estrogen in menopause. Women, however, often have questions as to the nature of “natural” progesterone as compared with a progestin, which is a synthetic version, or why the route of administration may at times create different reactions, risks, and benefits.