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Marilyn R. Brown, M.D.

Marilyn R. Brown, M.D.

Contact

Appointment (585) 275-2647
Fax (585) 275-0707

About Me

Dr. Brown is a Professor of Pediatrics at the Golisano Children's Hospital at the University of Rochester Medical Center (URMC). She is the Director of Education for Medical Students and Residents within the Division of Pediatric GI/Nutrition and she is also a member of the Scholarship Oversight C...
Dr. Brown is a Professor of Pediatrics at the Golisano Children's Hospital at the University of Rochester Medical Center (URMC). She is the Director of Education for Medical Students and Residents within the Division of Pediatric GI/Nutrition and she is also a member of the Scholarship Oversight Committee which oversees scholarly activity throughout each Pediatric Fellow's training.

Dr. Brown teaches a Pediatric Gastroenterology Elective for Pediatric Residents and fourth year medical students as well as coordinates the Pediatric GI electives for medical students and residents.

Dr. Brown earned her medical degree from the University of Rochester School of Medicine in Rochester, New York. Subsequently, she completed her residency in Pediatrics at The Genesee Hospital, Rochester General Hospital and Strong Memorial Hospital. She also completed a Fellowship in Physiology at the University of Rochester in Rochester, New York.

Faculty Appointments

Professor Emerita - Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition (SMD)

Credentials

Post-doctoral Training & Residency

NIH Trainee in Medicine (Gastroenterology), University of Rochester, Rochester, NY 1967 - 1970

Associate Resident in Pediatrics, Rochester General Hospital and Strong Memorial Hospital, Rochester, NY 1964 - 1965

Assistant Resident in Pediatrics, The Genesee Hospital and
Strong Memorial Hospital, Rochester, NY 1963 - 1964

Mixed Medicine-Pediatrics Internship, The Genesee Hospital,
Rochester, NY 1962 - 1963

Physiology Fellowship, University of Rochester, Rochester, NY 1961 - 1962

Education

MD | University of Rochester School of Medicine and Dentistry. Medicine. 1962

A.B. | Cornell University. 1957

Awards

Albert Kaiser Medal of the Rochester Academy of Medicine. 2013

Cambridge Who's Who. 2010

Best Doctors in America. 2007 - 2013

Rochester Academy of Medicine Award of Merit. 2005

Ruth A Lawrence Faculty Service Award. 2004

Research

Dr. Brown's primary research interest is Parenteral Nutrition.

Prokinetic agents in the treatment of gastroesophageal reflux in premature infants with Abhay Bhatt MD, Robert Sinkin MD, and Ronnie Guillet MD, 1998.

Limited Access Protocol for the Use of Oral Cisapride in the Treatment o...
Dr. Brown's primary research interest is Parenteral Nutrition.

Prokinetic agents in the treatment of gastroesophageal reflux in premature infants with Abhay Bhatt MD, Robert Sinkin MD, and Ronnie Guillet MD, 1998.

Limited Access Protocol for the Use of Oral Cisapride in the Treatment of Pediatric Patients with Refractory Gastroesophageal Reflux Disease and other Gastrointestinal Motility Disorders with Thomas M Rossi MD, 1999-2009.

3rd Generation Low Profile Balloon Gastrostomy Tube Insertion, Removal and Performance Study with Ross Products Division of Abbott Laboratories. Marilyn R. Brown with TM Rossi, TL Miller and RE Quiros 2001-2.

An open label, randomized, multiple dose, parallel multicenter study of Axid (Nizatidine) in the treatment of gastroesophageal reflux symptoms in pediatric subjects age 5days –18 years. Reliant Pharmaceuticals. Tracie L. Miller, Marilyn R. Brown. 2001.

Phase 3 double-masked, placebo-controlled study of alicaforsen (ISIS 2302), an Antisense Inhibitor of ICAM-1, for the treatment of patients with active Crohn's disease. ISIS Pharmaceuticals. Tracie L. Miller, Marilyn R. Brown, 2002.

A Phase II, Multi-Center, Open-Label Long-Term Study of the Safety Tolerability and Effectiveness of Intravenous antergren (natalizumab) in Adolescent Crohn's Disease. ELAN Pharmaceuticals. Tracie L. Miller, Brown MR. Completed 2005.

Pathways of differentiation of blood mononuclear cells in children with inflammatory bowel disease with Christopher Ritchlin, Juan Villalona, Cary Qualia, Marilyn R. Brown,Thomas Rossi, Koorosh Kooros and Natalie Sikka. IRB approved 05, several patients studied.

Brown MR, Nicchitta, J. Healthy habit goals for elevated body mass index: A program for the PCP. Tested in three Pediatric offices. Review done, Summer 2006.

Duration of pancreatic enzyme elevation in acute pancreatitis. Cary Qualia, Thomas Rossi, Brown MR, Asad Ullah. IRB approval 3/07

Specificity of the polyclonal antibody test system for human elastase-1 in stool in Cystic Fibrosis. Villalona J, Qualia C, Brown MR, Ren CL, Rossi T,. Data collection completed 3/07. Dr. Villalona writing up.

Eosinophilic Esophagitis in children: A retrospective review. Villalona, J, Brown MR, Rossi, TR, Katzman,P, Mathur, J. Finished in spring 06, waiting for Juan Villalona to finish the manuscript.

Evaluation of esophageal mucosa for filaggrin expression in patients with eosinophilic esophagitis. Qualia, C, Brown MR, Lisa Beck, Rossi, TR. Letter to Journal of Allergy and Clinical Immunology by Dr. Beck.

Review of Bravo pH studies in the Golisano Children's Hospital @ Strong Pediatric GI practice. Wahaj Zaidi, Thomas Rossi, Marilyn R. Brown. Poster In progress.

A phase 3, multi-center, randomized study to evaluate the safety, efficacy and pharmacokinetics of the Human Anti-TNF Monoclonal antibody Adalimumab in pediatric subjects with moderate to severe Crohn's disease. Abbott Laboratories. Marilyn R. Brown. 2007-2009.

Hepatic portal eosinophilia in an adolescent girl taking tacrolimus after liver transplantation. Rene P. Myers, Anne B. Fender, Marilyn R. Brown, Charlotte K Ryan. Submitted to Pediatric Transplantation, August 2007, rejected

Choledochal cysts in children: Experience in New Delhi, India. Deepak Sobti, Devendra Gupta, Marilyn R. Brown. Poster presentation at Annual Poster Session of the Department of Pediatrics, October 2007.

Microarray analysis of peripheral blood and tissues of patients with immune mediated inflammatory diseases. Christopher Ritchlin, Edward Schwartz and others. IRB approval 6/07.

2007-present Co-Investigator, Autism Treatment Network: University of Rochester
ATN-INV-07-16. Principal investigator, Susan Hyman, MD. (Total direct costs: $150,000/yr x 3 yrs)

Koorosh Kooros, Heidi Connelly, Susan Hyman, Marilyn R. Brown. Sleep Studies with gastroesophageal reflux studies in children with autism spectrum disorder, 2010.

Publications

Journal Articles

A nine-year-old girl with liver enlargement.

Sood V, Mohanty P, Brown M

Pediatric annals.. 2012 June 41 (6):7-10. Epub 1900 01 01.

Parenteral fish oil-associated burr cell anemia.

Mallah HS, Brown MR, Rossi TM, Block RC

The Journal of pediatrics.. 2010 February 156 (2):324-6.e1. Epub 1900 01 01.

Jejunal Atresia and Cystic Fibrosis in a Newborn Male Infant: A Case Report.

Katzman P J, Villalona J, Rossi TM, Brown MR.

Internet Journal of Pediatrics and Neonatology. 2009; 9: 1-6.

Pediatric gastroenterology fellows, class of 2007: how well are they prepared for the future?

Qualia CM, Baldwin CD, Rossi TM, Wang H, Brown MR

Journal of pediatric gastroenterology and nutrition.. 2008 September 47 (3):327-33. Epub 1900 01 01.

Index of suspicion.

Qualia CM, Brown MR, Leung AK, Robson WL, Janner D, Zouros A, McClure C, Wycliffe N, Barron S

Pediatrics in review. 2007 May 28 (5):193-8. Epub 1900 01 01.

Index of suspicion.

Luck RP, Soltani MA, Villalona JF, Lehman RK, Brown MR, Kooros K, Kwon JM

Pediatrics in review. 2007 March 28 (3):111-7. Epub 1900 01 01.

Oral Mucosal Neuromas Leading to the Diagnosis of Multiple Endocrine Neoplasia Type 2B in a Child With Intestinal Pseudo-obstruction.

Qualia CM, Brown MR, Ryan CK, Rossi TM

Gastroenterology & hepatology.. 2007 March 3 (3):208-11. Epub 1900 01 01.

Index of Suspicion: Failure to Thrive: More than just nutritional and social causes, a case report

Villalona J, Brown MR, Lehman R, Kooros K, Rossi TR.

Pediatric Review. 2007; 28(3): 111-117.

Index of Suspicion:Colonic Polyposis a cause of rectal bleeding anemia and failure to thrive

Qualia CM, Brown MR.

Pediatric Review. 2007; 28(5): 193-195.

A report of two children with Helicobacter heilmannii gastritis and review of the literature.

Qualia CM, Katzman PJ, Brown MR, Kooros K

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.. 2007 10 (5):391-4. Epub 1900 01 01.

Eosinophilic esophagitis in adolescents.

Villalona J, Brown MR, Kooros K, Rossi, TR, Shah A, Katzman P.

Submitted for publication to American Journal of Gastroenterology. 2006; .

Esophageal Parakeratosis in a Pediatric Patient.

Villalona J, Brown MR, Katzman P.

Submitted to Gastroenterology for Image of the Month. 2006; .

Use of cholecystokinin-octapeptide for the prevention of parenteral nutrition-associated cholestasis.

Teitelbaum DH, Tracy TF, Aouthmany MM, Llanos A, Brown MB, Yu S, Brown MR, Shulman RJ, Hirschl RB, Derusso PA, Cox J, Dahlgren J, Groner JI, Strouse PJ

Pediatrics.. 2005 May 115 (5):1332-40. Epub 1900 01 01.

Jejunal Atresia and Cystic Fibrosis in a Newborn Male Infant

Katzman P, Villalona J, Rossi TR, Brown MR.

Submitted to Archives of Pathology and Laboratory Medicine. 2005; .

Parenteral nutrition-associated cholestasis in neonates: multivariate analysis of the potential protective effect of taurine

Spencer AU, Yu S, Tracy TF, Aouthmany MM, Llanos A, Brown MB, Brown M, Shulman RJ, Hirschl RB, Derusso PA, Cox J, Dahlgren J, Strouse PJ, Groner JI, Teitelbaum DH.

J Parenteral and Enteral Nutrition. 2005; 29(5): 337-344.

Liver function tests are not always tests of liver function.

Korones DN, Brown MR, Palis J.

American Journal of Hematology. 2001; 66(1): 46-8.

Multiple esophageal rings: an association with eosinophilic esophagitis: case report and review of the literature.

Siafakas CG, Ryan CK, Brown MR, Miller TL

The American journal of gastroenterology.. 2000 June 95 (6):1572-5. Epub 1900 01 01.

Neonatal pancreatitis associated with familial lipoprotein lipase deficiency.

Siafakas CG, Brown MR, Miller TL

Journal of pediatric gastroenterology and nutrition.. 1999 July 29 (1):95-8. Epub 1900 01 01.

Image of the month. Esophageal and rectosigmoid ulcers.

Siafakas CG, Miller TL, Brown MR

Gastroenterology.. 1998 December 115 (6):1316, 1616. Epub 1900 01 01.

Detection of group C rotavirus in infants with extrahepatic biliary atresia.

Riepenhoff-Talty M, Gouvea V, Evans MJ, Svensson L, Hoffenberg E, Sokol RJ, Uhnoo I, Greenberg SJ, Schäkel K, Zhaori G, Fitzgerald J, Chong S, el-Yousef M, Nemeth A, Brown M, Piccoli D, Hyams J, Ruffin D, Rossi T

The Journal of infectious diseases.. 1996 July 174 (1):8-15. Epub 1900 01 01.

Wilson's disease presenting as symptomatic urolithiasis: a case report and review of the literature.

Nakada SY, Brown MR, Rabinowitz R

The Journal of urology.. 1994 September 152 (3):978-9. Epub 1900 01 01.

Hyperammonemic encephalopathy secondary to diphtheroid urinary tract infection in a patient with prune belly syndrome.

Goldstein B, Brown MR, Hulbert WC, Rabinowitz R

Critical care medicine.. 1991 April 19 (4):578-86. Epub 1900 01 01.

Fibroinflammatory tumor of the liver causing biliary cirrhosis in an infant.

Alonso EM, Zdunek TM, Brown MR, Yousefzadeh DK, Whitington PF

Journal of pediatric gastroenterology and nutrition.. 1991 February 12 (2):283-7. Epub 1900 01 01.

Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant.

Brown MR, Thunberg BJ, Golub L, Maniscalco WM, Cox C, Shapiro DL

Journal of pediatric gastroenterology and nutrition.. 1989 July 9 (1):21-7. Epub 1900 01 01.

Hormonal response to overfeeding.

Forbes GB, Brown MR, Welle SL, Underwood LE

The American journal of clinical nutrition.. 1989 April 49 (4):608-11. Epub 1900 01 01.

Energy need for weight maintenance in human beings: effect of body size and composition.

Forbes GB, Brown MR

Journal of the American Dietetic Association.. 1989 April 89 (4):499-502. Epub 1900 01 01.

Fatal multisystem disease with immune enteropathy heralded by juvenile rheumatoid arthritis.

Pearson RD, Swenson I, Schenk EA, Klish WJ, Brown MR

Journal of pediatric gastroenterology and nutrition.. 1989 February 8 (2):259-65. Epub 1900 01 01.

Glutathione peroxidase and selenium deficiency in patients receiving home parenteral nutrition: time course for development of deficiency and repletion of enzyme activity in plasma and blood cells.

Cohen HJ, Brown MR, Hamilton D, Lyons-Patterson J, Avissar N, Liegey P

The American journal of clinical nutrition.. 1989 January 49 (1):132-9. Epub 1900 01 01.

Arm muscle plus bone area: anthropometry and CAT scan compared.

Forbes GB, Brown MR, Griffiths HJ

The American journal of clinical nutrition.. 1988 June 47 (6):929-31. Epub 1900 01 01.

Deliberate overfeeding in women and men: energy cost and composition of the weight gain.

Forbes GB, Brown MR, Welle SL, Lipinski BA

The British journal of nutrition.. 1986 July 56 (1):1-9. Epub 1900 01 01.

Proximal muscle weakness and selenium deficiency associated with long term parenteral nutrition.

Brown MR, Cohen HJ, Lyons JM, Curtis TW, Thunberg B, Cochran WJ, Klish WJ

The American journal of clinical nutrition.. 1986 April 43 (4):549-54. Epub 1900 01 01.

Chylous ascites in infants and children: a case report and literature review.

Cochran WJ, Klish WJ, Brown MR, Lyons JM, Curtis T

Journal of pediatric gastroenterology and nutrition.. 1985 August 4 (4):668-73. Epub 1900 01 01.

Effect of breast-feeding on morbidity in rotavirus gastroenteritis.

Weinberg RJ, Tipton G, Klish WJ, Brown MR

Pediatrics.. 1984 August 74 (2):250-3. Epub 1900 01 01.

Esophageal function after repair of esophageal atresia.

Putnam TC, Lawrence RA, Wood BP, Campbell MA, Emmens RW, Brown MR, Klish WJ

Surgery, gynecology & obstetrics.. 1984 April 158 (4):344-8. Epub 1900 01 01.

A high protein, low calorie liquid diet in the treatment of very obese adolescents: long-term effect on lean body mass.

Brown MR, Klish WJ, Hollander J, Campbell MA, Forbes GB

The American journal of clinical nutrition.. 1983 July 38 (1):20-31. Epub 1900 01 01.

Infantile colic

Brown MR.

Clinical Practice Update. 1983; 2(7): 25-26.

Weight control program for children and adolescents

Braunschweig A, Brown MR.

Nutrition News. 1983; 46(3): 11-12.

Body weight and its effect on immunoreactive parathyroid hormone levels.

Patton ML, Brown MR, Lewis A, Baran DT

Mineral and electrolyte metabolism.. 1983 9 (3):151-3. Epub 1900 01 01.

Hepatic abscess as a complication of Crohn's disease.

Weinberg RJ, Klish WJ, Brown MR, Smalley JR, Emmens RW

Journal of pediatric gastroenterology and nutrition.. 1983 2 (1):171-4. Epub 1900 01 01.

Acquired distal aganglionosis of the colon.

Weinberg RJ, Klish WJ, Smalley JR, Brown MR, Putnam TC

The Journal of pediatrics.. 1982 September 101 (3):406-9. Epub 1900 01 01.

Chronic diarrhea associated with campylobacter.

Smalley JR, Klish WJ, Brown MR, Campbell MA

Clinical pediatrics.. 1982 April 21 (4):220. Epub 1900 01 01.

Bowel dysfunction in children with meningomyelocoele: A survey of Spina Bifida centers in the United States and Canada

Liptak GS, Masiulis BS, Brown MR, Campbell MA.

Spina Bifida Therapy. 1982; 4(4): 195.

Use of psyllium in the management of chronic nonspecific diarrhea of childhood.

Smalley JR, Klish WJ, Campbell MA, Brown MR

Journal of pediatric gastroenterology and nutrition.. 1982 1 (3):361-3. Epub 1900 01 01.

Milk meal in children; gastrin response.

Brown MR, Gordon A, Campbell MA, Chey WY

New York state journal of medicine.. 1980 October 80 (11):1681-3. Epub 1900 01 01.

Viral serology (hepatitis B virus, cytomegalovirus, Epstein-Barr virus) and abnormal liver function tests in transfused patients with hereditary hemorrhagic diseases.

Enck RE, Betts RF, Brown MR, Miller G

Transfusion.. 1979 19 (1):32-8. Epub 1900 01 01.

Cholestasis associated with central intravenous nutrition in infants.

Brown MR, Putnam TC

New York state journal of medicine.. 1978 January 78 (1):27-30. Epub 1900 01 01.

Failure of specific immunotherapy in fulminant type B hepatitis.

Annals of internal medicine.. 1977 March 86 (3):272-7. Epub 1900 01 01.

Liver tests, HB-Ag and HB-Ab in asymptomatic drug addicts.

Mangla JC, Kim YM, Brown MR, Schwob D, Hanson SE

The American journal of gastroenterology.. 1976 February 65 (2):121-6. Epub 1900 01 01.

When to think of celiac disease: the classical features of gluten sensitive enteropathy are absent.

Brown MR, Lillibridge CB

Clinical pediatrics.. 1975 January 14 (1):76-82. Epub 1900 01 01.

The electron microscopic appearance of presecreted gastric mucus in cystic fibrosis.

Lillibridge CB, Brown MR, Hall JG

Pediatrics.. 1974 June 53 (6):913-9. Epub 1900 01 01.

Acalculous biliary pain in children; cholecystokinin (CCK)-cholescintigraphy in the evaluation of chronic recurrent abdominal pain (submitted but not published).

Siafakas CG, Brown MR, Ryan CK, Miller TL.

Eosinophilic esophagitis in adolescents

Villalona J, Brown MR, Kooros K, Rossi, TR, Shah A, Katzman P.

Submitted for publication to American Journal of Gastroenterology (May 2006). .

Failure to Thrive: More than just nutritional and social causes, a case report

Villalona J, Brown MR, Lehman R, Kooros K, Rossi TR.

Submitted to Pediatrics in Review (May 2006). .

Esophageal Parakeratosis in a Pediatric Patient

Villalona J, Brown MR, Katzman P.

Submitted to Gastroenterology for Image of the Month, May 2006. .

Books

Merck Manual (1994)

Chapter: Obesity in Adolescence

Principles and Practice of Pediatrics (1994)

Chapter: Gastrointestinal Bleeding (Revised 1997, 2003, 2005 for new editions)

Textbook of Adolescent Medicine (1992)

Chapter: Constipation in the Adolescent

Merck Manual (1990)

Chapter: Obesity in Adolescence

Essential and Toxic Trace Elements in Human Health and Disease (1988)

Chapter: Clinical physiological and biochemical consequences of human selenium deficiency

A Family Guide for Helping the Child with Spina Bifida (1981)

Chapter: Bowel care for the child with Spina Bifida