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Russell Hilf, Ph.D.

Russell Hilf, Ph.D.

About Me

Faculty Appointments

Professor Emeritus - Department of Biochemistry and Biophysics (SMD)

Credentials

Education

PhD | Rutgers State University. Biochemistry. 1955

MS | Rutgers State University. Biochemistry. 1953

BS | Cuny City College. Chemistry. 1952

Research

Hormone action is mediated by specific cell receptors, resulting in a variety of metabolic responses and/or growth. A number of hormones are implicated in the etiology and growth of mammary cancer. Our studies are directed towards elucidation of the roles of estrogens and antiestrogens, insulin and ...
Hormone action is mediated by specific cell receptors, resulting in a variety of metabolic responses and/or growth. A number of hormones are implicated in the etiology and growth of mammary cancer. Our studies are directed towards elucidation of the roles of estrogens and antiestrogens, insulin and insulin-like growth factors (IGFS) as regulators of neoplastic growth. By utilizing well characterized rodent models, in vivo and in vitro, experiments are designed to gain understanding of these regulatory actions.

Mechanism of action of estrogens and antiestrogens is being studied by defining the nucleotide requirements for binding of estrogen and antiestrogen activated estrogen receptor with their DNA regulatory element (ERE) and by transfection assays. Estrogen response depends on the expression level of one or both estrogen receptor (ER) isoforms, alpha and beta, and the concentration and type of ER-ligands. Our goal is to understand how these factors contribute to the level of induction characteristic of a particular gene. We have now established that insulin affects tumor growth and regulation, both directly and in a permissive role. We have examined insulin and estrogen receptors, how they are regulated by hormones and how such regulation relates to changes in tumor growth behavior.

A second active area of study is to define the mechanisms whereby tumor cytotoxicity ensues photoradiation therapy, a treatment approach that employs hematoporphyrin photosensitizers followed by exposure of tumors to visible light. The singlet oxygen produced is cytotoxic. We reported that important cellular targets are several mitochondrial respiratory enzymes, leading to reduced ATP production. Current aims are to elucidate these actions and to evolve methods to optimize therapeutic efficacy. The role of estrogenic and antiestrogenic agents in altering production of protoporphyrin IX from 5-aminolevulinic acid and the actions of new synthetic porphyrin derivatives are ongoing projects aimed at improving PDT outcome.

Publications

Journal Articles

Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17 beta-estradiol-estrogen receptor beta is uncoupled from the induction of phenotypic changes in cell models.

Li X, Nott SL, Huang Y, Hilf R, Bambara RA, Qiu X, Yakovlev A, Welle S, Muyan M

Journal of molecular endocrinology.. 2008 May 40 (5):211-29. Epub 1900 01 01.

Mitochondria are targets of photodynamic therapy.

Hilf R

Journal of bioenergetics and biomembranes.. 2007 February 39 (1):85-9. Epub 1900 01 01.

A tale of two estrogen receptors (ERs): how differential ER-estrogen responsive element interactions contribute to subtype-specific transcriptional responses.

Huang J, Li X, Qiao T, Bambara RA, Hilf R, Muyan M

Nuclear receptor signaling. 2006 4 :e015. Epub 07/07/2006.

Molecular basis of therapeutic strategies for breast cancer.

Huang J, Li X, Hilf R, Bambara RA, Muyan M

Current drug targets. Immune, endocrine and metabolic disorders. 2005 December 5 (4):379-96. Epub 1900 01 01.

Binding of estrogen receptor beta to estrogen response element in situ is independent of estradiol and impaired by its amino terminus.

Huang J, Li X, Maguire CA, Hilf R, Bambara RA, Muyan M

Molecular endocrinology.. 2005 November 19 (11):2696-712. Epub 06/23/2005.

Core-modified porphyrins. Part 4: Steric effects on photophysical and biological properties in vitro.

You Y, Gibson SL, Hilf R, Ohulchanskyy TY, Detty MR

Bioorganic & medicinal chemistry.. 2005 March 1513 (6):2235-51. Epub 1900 01 01.

Analogues of tetramethylrosamine as transport molecules for and inhibitors of P-glycoprotein-mediated multidrug resistance.

Gibson SL, Hilf R, Donnelly DJ, Detty MR

Bioorganic & medicinal chemistry.. 2004 September 112 (17):4625-31. Epub 1900 01 01.

Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways.

Li X, Huang J, Yi P, Bambara RA, Hilf R, Muyan M

Molecular and cellular biology.. 2004 September 24 (17):7681-94. Epub 1900 01 01.

Synthesis, properties, and photodynamic properties in vitro of heavy-chalcogen analogues of tetramethylrosamine.

Detty MR, Prasad PN, Donnelly DJ, Ohulchanskyy T, Gibson SL, Hilf R

Bioorganic & medicinal chemistry.. 2004 May 1512 (10):2537-44. Epub 1900 01 01.

Comparison of the dark and light-induced toxicity of thio and seleno analogues of the thiopyrylium dye AA1.

Detty MR, Gibson SL, Hilf R

Bioorganic & medicinal chemistry.. 2004 May 1512 (10):2589-96. Epub 1900 01 01.

Targeting estrogen responsive elements (EREs): design of potent transactivators for ERE-containing genes.

Huang J, Li X, Yi P, Hilf R, Bambara RA, Muyan M

Molecular and cellular endocrinology.. 2004 April 15218 (1-2):65-78. Epub 1900 01 01.

Water soluble, core-modified porphyrins. 3. Synthesis, photophysical properties, and in vitro studies of photosensitization, uptake, and localization with carboxylic acid-substituted derivatives.

You Y, Gibson SL, Hilf R, Davies SR, Oseroff AR, Roy I, Ohulchanskyy TY, Bergey EJ, Detty MR

Journal of medicinal chemistry.. 2003 August 1446 (17):3734-47. Epub 1900 01 01.

In vitro photodynamic properties of chalcogenopyrylium analogues of the thiopyrylium antitumor agent AA1.

Brennan NK, Hall JP, Davies SR, Gollnick SO, Oseroff AR, Gibson SL, Hilf R, Detty MR

Journal of medicinal chemistry.. 2002 November 745 (23):5123-35. Epub 1900 01 01.

Differences in the abilities of estrogen receptors to integrate activation functions are critical for subtype-specific transcriptional responses.

Yi P, Bhagat S, Hilf R, Bambara RA, Muyan M

Molecular endocrinology.. 2002 August 16 (8):1810-27. Epub 1900 01 01.

Structural regions of ERalpha critical for synergistic transcriptional responses contain co-factor interacting surfaces.

Sathya G, Yi P, Bhagat S, Bambara RA, Hilf R, Muyan M

Molecular and cellular endocrinology.. 2002 June 28192 (1-2):171-85. Epub 1900 01 01.

The effects of estrogen-responsive element- and ligand-induced structural changes on the recruitment of cofactors and transcriptional responses by ER alpha and ER beta.

Yi P, Driscoll MD, Huang J, Bhagat S, Hilf R, Bambara RA, Muyan M

Molecular endocrinology.. 2002 April 16 (4):674-93. Epub 1900 01 01.

Water-soluble, core-modified porphyrins as novel, longer-wavelength-absorbing sensitizers for photodynamic therapy. II. Effects of core heteroatoms and meso-substituents on biological activity.

Hilmey DG, Abe M, Nelen MI, Stilts CE, Baker GA, Baker SN, Bright FV, Davies SR, Gollnick SO, Oseroff AR, Gibson SL, Hilf R, Detty MR

Journal of medicinal chemistry.. 2002 January 1745 (2):449-61. Epub 1900 01 01.

Fusion estrogen receptor proteins: toward the development of receptor-based agonists and antagonists.

Muyan M, Yi P, Sathya G, Willmert LJ, Driscoll MD, Hilf R, Bambara RA

Molecular and cellular endocrinology.. 2001 September 182 (2):249-63. Epub 1900 01 01.

Is delta-aminolevulinic acid dehydratase rate limiting in heme biosynthesis following exposure of cells to delta-aminolevulinic acid?

Gibson SL, Havens JJ, Metz L, Hilf R

Photochemistry and photobiology.. 2001 March 73 (3):312-7. Epub 1900 01 01.

A selenopyrylium photosensitizer for photodynamic therapy related in structure to the antitumor agent AA1 with potent in vivo activity and no long-term skin photosensitization.

Leonard KA, Hall JP, Nelen MI, Davies SR, Gollnick SO, Camacho S, Oseroff AR, Gibson SL, Hilf R, Detty MR

Journal of medicinal chemistry.. 2000 November 1643 (23):4488-98. Epub 1900 01 01.

Water-soluble, core-modified porphyrins as novel, longer-wavelength-absorbing sensitizers for photodynamic therapy.

Stilts CE, Nelen MI, Hilmey DG, Davies SR, Gollnick SO, Oseroff AR, Gibson SL, Hilf R, Detty MR

Journal of medicinal chemistry.. 2000 June 1543 (12):2403-10. Epub 1900 01 01.

Effect of estrogenic perturbations on delta-aminolevulinic acid-induced porphobilinogen deaminase and protoporphyrin IX levels in rat Harderian glands, liver, and R3230AC tumors.

Gibson SL, Anderson LT, Havens JJ, Hilf R

Biochemical pharmacology.. 1999 December 158 (11):1821-9. Epub 1900 01 01.

Relationship of delta-aminolevulinic acid-induced protoporphyrin IX levels to mitochondrial content in neoplastic cells in vitro.

Gibson SL, Nguyen ML, Havens JJ, Barbarin A, Hilf R

Biochemical and biophysical research communications.. 1999 November 19265 (2):315-21. Epub 1900 01 01.

2,4,6-triarylchalcogenopyrylium dyes related in structure to the antitumor agent AA1 as in vitro sensitizers for the photodynamic therapy of cancer.

Leonard KA, Nelen MI, Anderson LT, Gibson SL, Hilf R, Detty MR

Journal of medicinal chemistry.. 1999 September 2342 (19):3942-52. Epub 1900 01 01.

Synthesis and evaluation of chalcogenopyrylium dyes as potential sensitizers for the photodynamic therapy of cancer.

Leonard KA, Nelen MI, Simard TP, Davies SR, Gollnick SO, Oseroff AR, Gibson SL, Hilf R, Chen LB, Detty MR

Journal of medicinal chemistry.. 1999 September 2342 (19):3953-64. Epub 1900 01 01.

Effect of delta-aminolevulinic acid on protoporphyrin IX accumulation in tumor cells transfected with plasmids containing porphobilinogen deaminase DNA.

Hilf R, Havens JJ, Gibson SL

Photochemistry and photobiology.. 1999 September 70 (3):334-40. Epub 1900 01 01.

Delta-aminolaevulinic acid-induced photodynamic therapy inhibits protoporphyrin IX biosynthesis and reduces subsequent treatment efficacy in vitro.

Gibson SL, Havens JJ, Nguyen ML, Hilf R

British journal of cancer.. 1999 June 80 (7):998-1004. Epub 1900 01 01.

An explanation for observed estrogen receptor binding to single-stranded estrogen-responsive element DNA.

Driscoll MD, Sathya G, Saidi LF, DeMott MS, Hilf R, Bambara RA

Molecular endocrinology.. 1999 June 13 (6):958-68. Epub 1900 01 01.

Sequence requirements for estrogen receptor binding to estrogen response elements.

Driscoll MD, Sathya G, Muyan M, Klinge CM, Hilf R, Bambara RA

The Journal of biological chemistry.. 1998 November 6273 (45):29321-30. Epub 1900 01 01.

Comparison of tamoxifen ligands on estrogen receptor interaction with estrogen response elements.

Klinge CM, Studinski-Jones AL, Kulakosky PC, Bambara RA, Hilf R

Molecular and cellular endocrinology.. 1998 August 25143 (1-2):79-90. Epub 1900 01 01.

A regulatory role for porphobilinogen deaminase (PBGD) in delta-aminolaevulinic acid (delta-ALA)-induced photosensitization?

Gibson SL, Cupriks DJ, Havens JJ, Nguyen ML, Hilf R

British journal of cancer.. 1998 77 (2):235-42. Epub 1900 01 01.

Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression.

Klinge CM, Silver BF, Driscoll MD, Sathya G, Bambara RA, Hilf R

The Journal of biological chemistry.. 1997 December 12272 (50):31465-74. Epub 1900 01 01.

Effects of multiple estrogen responsive elements, their spacing, and location on estrogen response of reporter genes.

Sathya G, Li W, Klinge CM, Anolik JH, Hilf R, Bambara RA

Molecular endocrinology.. 1997 December 11 (13):1994-2003. Epub 1900 01 01.

Time-dependent intracellular accumulation of delta-aminolevulinic acid, induction of porphyrin synthesis and subsequent phototoxicity.

Gibson SL, Havens JJ, Foster TH, Hilf R

Photochemistry and photobiology.. 1997 March 65 (3):416-21. Epub 1900 01 01.

hsp70 is not required for high affinity binding of purified calf uterine estrogen receptor to estrogen response element DNA in vitro.

Klinge CM, Brolly CL, Bambara RA, Hilf R

The Journal of steroid biochemistry and molecular biology.. 1997 63 (4-6):283-301. Epub 1900 01 01.

Stability of the ligand-estrogen receptor interaction depends on estrogen response element flanking sequences and cellular factors.

Anolik JH, Klinge CM, Brolly CL, Bambara RA, Hilf R

The Journal of steroid biochemistry and molecular biology.. 1996 December 59 (5-6):413-29. Epub 1900 01 01.

Site-directed estrogen receptor antibodies stabilize 4-hydroxytamoxifen ligand, but not estradiol, and indicate ligand-specific differences in the recognition of estrogen response element DNA in vitro.

Klinge CM, Traish AM, Driscoll MD, Hilf R, Bambara RA

Steroids.. 1996 May 61 (5):278-89. Epub 1900 01 01.

Footprint analysis of estrogen receptor binding to adjacent estrogen response elements.

Driscoll MD, Klinge CM, Hilf R, Bambara RA

The Journal of steroid biochemistry and molecular biology.. 1996 April 58 (1):45-61. Epub 1900 01 01.

Dissociation of 4-hydroxytamoxifen, but not estradiol or tamoxifen aziridine, from the estrogen receptor as the receptor binds estrogen response element DNA.

Klinge CM, Traish AM, Bambara RA, Hilf R

The Journal of steroid biochemistry and molecular biology.. 1996 January 57 (1-2):51-66. Epub 1900 01 01.

Effects of estradiol on the expression and production of IGFBP-2 by R3230AC mammary tumor cells.

Korc-Grodzicki B, Ren N, Hilf R

Oncology research.. 1996 8 (12):473-83. Epub 1900 01 01.

Effectiveness of delta-aminolevulinic acid-induced protoporphyrin as a photosensitizer for photodynamic therapy in vivo.

Hua Z, Gibson SL, Foster TH, Hilf R

Cancer research.. 1995 April 1555 (8):1723-31. Epub 1900 01 01.

Inhibition of the ATPase activity of P-glycoprotein by porphyrin photosensitization of multidrug-resistant cells in vitro.

Gibson SL, al-Shawi MK, Senior AE, Hile R

Photochemistry and photobiology.. 1995 April 61 (4):390-6. Epub 1900 01 01.

Cooperative binding of estrogen receptor to DNA depends on spacing of binding sites, flanking sequence, and ligand.

Anolik JH, Klinge CM, Hilf R, Bambara RA

Biochemistry.. 1995 February 2834 (8):2511-20. Epub 1900 01 01.

Efficacy of photodynamic therapy on original and recurrent rat mammary tumors.

Gibson SL, Nguyen ML, Foster TH, White G, Hilf R

Photochemistry and photobiology.. 1995 February 61 (2):196-9. Epub 1900 01 01.

Photosensitization and tissue distribution studies of the picket fence porphyrin, 3,1-TPro, a candidate for photodynamic therapy.

Lawrence DS, Gibson SL, Nguyen ML, Whittemore KR, Whitten DG, Hilf R

Photochemistry and photobiology.. 1995 January 61 (1):90-8. Epub 1900 01 01.

Quantitative MRI of Gd-DTPA uptake in tumors: response to photodynamic therapy.

Kennedy SD, Szczepaniak LS, Gibson SL, Hilf R, Foster TH, Bryant RG

Magnetic resonance in medicine.. 1994 March 31 (3):292-301. Epub 1900 01 01.

Effects of photodynamic therapy on xenografts of human mesothelioma and rat mammary carcinoma in nude mice.

Gibson SL, Foster TH, Feins RH, Raubertas RF, Fallon MA, Hilf R

British journal of cancer.. 1994 March 69 (3):473-81. Epub 1900 01 01.

Differential impact of flanking sequences on estradiol- vs 4-hydroxytamoxifen-liganded estrogen receptor binding to estrogen responsive element DNA.

Anolik JH, Klinge CM, Bambara RA, Hilf R

The Journal of steroid biochemistry and molecular biology.. 1993 December 46 (6):713-30. Epub 1900 01 01.

Insulin-like growth factor-binding proteins in R3230AC mammary tumors of intact and diabetic rats.

Korc-Grodzicki B, Ren N, Hilf R

Endocrinology.. 1993 November 133 (5):2362-70. Epub 1900 01 01.

Fluence rate effects in photodynamic therapy of multicell tumor spheroids.

Foster TH, Hartley DF, Nichols MG, Hilf R

Cancer research.. 1993 March 1553 (6):1249-54. Epub 1900 01 01.

Effects of diabetes and insulin on phosphoinositide metabolism in R3230AC mammary tumors.

Narayanan U, Hilf R

Cancer biochemistry biophysics. 1992 November 13 (2):93-101. Epub 1900 01 01.

Antiestrogen-liganded estrogen receptor interaction with estrogen responsive element DNA in vitro.

Klinge CM, Bambara RA, Hilf R

The Journal of steroid biochemistry and molecular biology.. 1992 October 43 (4):249-62. Epub 1900 01 01.

Cooperative estrogen receptor interaction with consensus or variant estrogen responsive elements in vitro.

Klinge CM, Peale FV, Hilf R, Bambara RA, Zain S

Cancer research.. 1992 March 152 (5):1073-81. Epub 1900 01 01.

Chalcogenapyrylium dyes as dual-action sensitizers for photodynamic therapy.

Detty MR, Merkel PB, Gibson SL, Hilf R

Oncology research.. 1992 4 (8-9):367-73. Epub 1900 01 01.

Characterization of insulin-like growth factor receptors in the insulin-responsive R3230AC mammary adenocarcinoma.

Korc-Grodzicki B, Furlanetto RW, Hilf R

Oncology research.. 1992 4 (3):109-19. Epub 1900 01 01.

Dietary fat and breast cancer: a search for mechanisms.

Dao TL, Hilf R

Advances in experimental medicine and biology.. 1992 322 :223-37. Epub 1900 01 01.

What differentiates antiestrogen-liganded vs estradiol-liganded estrogen receptor action?

Klinge CM, Bambara RA, Hilf R

Oncology research.. 1992 4 (4-5):137-44. Epub 1900 01 01.

EGF receptors in R3230AC rat mammary carcinomas: characteristics and regulation in vitro and in vivo.

Ryan PD, Hilf R

Oncology research.. 1992 4 (4-5):181-92. Epub 1900 01 01.

Photosensitized release of von Willebrand factor from cultured human endothelial cells.

Foster TH, Primavera MC, Marder VJ, Hilf R, Sporn LA

Cancer research.. 1991 June 1551 (12):3261-6. Epub 1900 01 01.

Hetergeneous tumour response to photodynamic therapy assessed by in vivo localised 31P NMR spectroscopy.

Ceckler TL, Gibson SL, Kennedy SD, Hill R, Bryant RG

British journal of cancer.. 1991 June 63 (6):916-22. Epub 1900 01 01.

Oxygen consumption and diffusion effects in photodynamic therapy.

Foster TH, Murant RS, Bryant RG, Knox RS, Gibson SL, Hilf R

Radiation research.. 1991 June 126 (3):296-303. Epub 1900 01 01.

Estrogen receptor alters the topology of plasmid DNA containing estrogen responsive elements.

Ishibe Y, Klinge CM, Hilf R, Bambara RA

Biochemical and biophysical research communications.. 1991 April 15176 (1):486-91. Epub 1900 01 01.

Photosensitizing activities of picket fence porphyrins in vitro and in vivo.

Barber DC, VanDerMeid KR, Gibson SL, Hilf R, Whitten DG

Cancer research.. 1991 April 151 (7):1836-45. Epub 1900 01 01.

Gross and microscopic changes in the viscera induced by photodynamic therapy applied to the lower abdomen of intact rats.

Chazen MD, Baggs RB, Gibson SL, Albert MS, Hilf R

Lasers in surgery and medicine.. 1991 11 (1):43-50. Epub 1900 01 01.

Effects of various photoradiation regimens on the antitumor efficacy of photodynamic therapy for R3230AC mammary carcinomas.

Gibson SL, VanDerMeid KR, Murant RS, Raubertas RF, Hilf R

Cancer research.. 1990 November 1550 (22):7236-41. Epub 1900 01 01.

Photodynamic therapy for human malignant mesothelioma in the nude mouse.

Feins RH, Hilf R, Ross H, Gibson SL

The Journal of surgical research.. 1990 October 49 (4):311-4. Epub 1900 01 01.

A microtiter well assay for quantitative measurement of estrogen receptor binding to estrogen-responsive elements.

Ludwig LB, Klinge CM, Peale FV, Bambara RA, Zain S, Hilf R

Molecular endocrinology.. 1990 July 4 (7):1027-33. Epub 1900 01 01.

Nuclease sensitivity of estradiol-charged estrogen receptor binding sites in nuclei isolated from normal and neoplastic rat mammary tissues.

Klinge CM, Bambara RA, Zain S, Hilf R

Journal of steroid biochemistry.. 1990 June 36 (1-2):7-14. Epub 1900 01 01.

Increased efficacy of photodynamic therapy of R3230AC mammary adenocarcinoma by intratumoral injection of Photofrin II.

Gibson SL, van der Meid KR, Murant RS, Hilf R

British journal of cancer.. 1990 April 61 (4):553-7. Epub 1900 01 01.

Chalcogenapyrylium dyes as photochemotherapeutic agents. 2. Tumor uptake, mitochondrial targeting, and singlet-oxygen-induced inhibition of cytochrome c oxidase.

Detty MR, Merkel PB, Hilf R, Gibson SL, Powers SK

Journal of medicinal chemistry.. 1990 April 33 (4):1108-16. Epub 1900 01 01.

In situ assessment of tumor vascularity using fluorine NMR imaging.

Ceckler TL, Gibson SL, Hilf R, Bryant RG

Magnetic resonance in medicine.. 1990 March 13 (3):416-33. Epub 1900 01 01.

Rapid purification of the estrogen receptor by sequence-specific DNA affinity chromatography.

Peale FV, Ishibe Y, Klinge CM, Zain S, Hilf R, Bambara RA

Biochemistry.. 1989 October 3128 (22):8671-5. Epub 1900 01 01.

Effects of laser photodynamic therapy on tumor phosphate levels and pH assessed by 31P-NMR spectroscopy.

Gibson SL, Ceckler TL, Bryant TG, Hilf R

Cancer biochemistry biophysics. 1989 October 10 (4):319-28. Epub 1900 01 01.

Antiestrogen(4-hydroxytamoxifen)-charged estrogen receptor binding to nuclei from normal and neoplastic rat mammary tissues is not affected by host hormonal status.

Klinge CM, Knox DT, Bambara RA, Zain S, Hilf R

Journal of steroid biochemistry.. 1989 September 33 (3):335-40. Epub 1900 01 01.

Picosecond fluorescence of R3230AC mammary carcinoma mitochondria after treatment with hematoporphyrin derivative and Photofrin II in vivo.

Hanzlik CA, Knox RS, Gibson SL, Hilf R

Photochemistry and photobiology.. 1989 July 50 (1):45-53. Epub 1900 01 01.

Effects of host hormonal status on binding of activated estrogen receptor to nuclei from R3230AC and 7,12-dimethylbenz[a]anthracene-induced mammary tumors.

Klinge CM, Bambara RA, Zain S, Hilf R

Cancer research.. 1989 March 149 (5):1165-70. Epub 1900 01 01.

In vitro photosensitization of tumour cell enzymes by photofrin II administered in vivo.

Gibson SL, Murant RS, Chazen MD, Kelly ME, Hilf R

British journal of cancer.. 1989 January 59 (1):47-53. Epub 1900 01 01.

Membrane-associated phosphatidylinositol kinase of R3230AC mammary tumors and normal mammary glands and effects of insulin on tumor enzyme activity.

Narayanan U, Keuker C, Hilf R

Cancer research.. 1988 December 148 (23):6727-32. Epub 1900 01 01.

Synthetic porphyrins at interfaces; photosensitization and related reactions of atropisomers of o-substituted tetraphenylporphine derivatives in films, reversed micelles and membranes.

Collins-Gold LC, Barber DC, Hagan WJ, Gibson SL, Hilf R, Whitten DG

Photochemistry and photobiology.. 1988 August 48 (2):165-75. Epub 1900 01 01.

Effects of diabetes and sex steroid hormones on insulin receptor tyrosine kinase activity in R3230AC mammary adenocarcinomas.

Hilf R, Livingston JN, Crofton DH

Cancer research.. 1988 July 148 (13):3742-50. Epub 1900 01 01.

Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomas.

Gibson SL, Murant RS, Hilf R

Cancer research.. 1988 June 1548 (12):3360-6. Epub 1900 01 01.

Picket-fence porphyrins as potential phototherapeutic agents.

Hagan WJ, Barber DC, Whitten DG, Kelly M, Albrecht F, Gibson SL, Hilf R

Cancer research.. 1988 March 148 (5):1148-52. Epub 1900 01 01.

Properties of a high-affinity DNA binding site for estrogen receptor.

Peale FV, Ludwig LB, Zain S, Hilf R, Bambara RA

Proceedings of the National Academy of Sciences of the United States of America.. 1988 February 85 (4):1038-42. Epub 1900 01 01.

Early biochemical responses to photodynamic therapy monitored by NMR spectroscopy.

Hilf R, Gibson SL, Penney DP, Ceckler TL, Bryant RG

Photochemistry and photobiology.. 1987 November 46 (5):809-17. Epub 1900 01 01.

Characterization of a cytosolic inhibitor of calf estrogen receptor binding to nuclei.

Lerea CC, Klinge CM, Bambara RA, Zain S, Hilf R

Endocrinology.. 1987 September 121 (3):1146-54. Epub 1900 01 01.

Photosensitizing effects of Photofrin II on the site-selected mitochondrial enzymes adenylate kinase and monoamine oxidase.

Murant RS, Gibson SL, Hilf R

Cancer research.. 1987 August 1547 (16):4323-8. Epub 1900 01 01.

Estrogen receptor binding to nuclei from normal and neoplastic rat mammary tissues in vitro.

Klinge CM, Bambara RA, Zain S, Hilf R

Cancer research.. 1987 June 147 (11):2852-9. Epub 1900 01 01.

Effects of estradiol and tamoxifen on creatine kinase in rodent mammary carcinomas.

Roghmann MC, Skinner KA, Hilf R

Cancer research.. 1987 March 147 (5):1348-53. Epub 1900 01 01.

Photosensitizing effects of hematoporphyrin derivative immobilized on sepharose.

Gibson SL, Murant RS, Hilf R

Photochemistry and photobiology.. 1987 January 45 (1):93-104. Epub 1900 01 01.

31P-NMR spectroscopy demonstrates decreased ATP levels in vivo as an early response to photodynamic therapy.

Ceckler TL, Bryant RG, Penney DP, Gibson SL, Hilf R

Biochemical and biophysical research communications.. 1986 October 15140 (1):273-9. Epub 1900 01 01.

Inhibition of mammalian DNA polymerases by hematoporphyrin derivative and photoradiation.

Crute JJ, Wahl AF, Bambara RA, Murant RS, Gibson SL, Hilf R

Cancer research.. 1986 January 46 (1):153-9. Epub 1900 01 01.

Relationship of mitochondrial function and cellular adenosine triphosphate levels to hematoporphyrin derivative-induced photosensitization in R3230AC mammary tumors.

Hilf R, Murant RS, Narayanan U, Gibson SL

Cancer research.. 1986 January 46 (1):211-7. Epub 1900 01 01.

Interdependence of fluence, drug dose and oxygen on hematoporphyrin derivative induced photosensitization of tumor mitochondria.

Gibson SL, Hilf R

Photochemistry and photobiology.. 1985 October 42 (4):367-73. Epub 1900 01 01.

Effects of streptozotocin-induced diabetes and insulin on phospholipid content of R3230AC mammary tumor cells.

Narayanan U, Ribes JA, Hilf R

Cancer research.. 1985 October 45 (10):4833-7. Epub 1900 01 01.

Failure of indomethacin to inhibit growth of the R3230AC mammary tumor in rats.

Feldman JM, Hilf R

Journal of the National Cancer Institute.. 1985 October 75 (4):751-6. Epub 1900 01 01.

Interactions of estrogen-receptor and antiestrogen-receptor complexes with nuclei in vitro.

Cushing CL, Bambara RA, Hilf R

Endocrinology.. 1985 June 116 (6):2419-29. Epub 1900 01 01.

Effect of estradiol-17 beta on glucose and proline uptake in plasma membrane vesicles from the R3230AC rat mammary carcinoma.

Feldman JM, Hilf R

Biochimica et biophysica acta.. 1985 May 30845 (2):265-71. Epub 1900 01 01.

A role of estrogens and insulin binding in the dietary lipid alteration of R3230AC mammary carcinoma growth in rats.

Feldman JM, Hilf R

Cancer research.. 1985 May 45 (5):1964-72. Epub 1900 01 01.

Effects of diabetes on the dietary lipid alteration of R3230AC mammary carcinoma growth in rats.

Feldman JM, Hilf R

Proceedings of the Society for Experimental Biology and Medicine.. 1985 May 179 (1):105-12. Epub 1900 01 01.

An analysis of the decrease in the assayed level of charged bovine estrogen receptor observed at physiological ionic strength.

Peale FV, Bond J, Hilf R, Bambara R

Journal of steroid biochemistry.. 1985 February 22 (2):161-7. Epub 1900 01 01.

Effects of photosensitization by hematoporphyrin derivative on mitochondrial adenosine triphosphatase-mediated proton transport and membrane integrity of R3230AC mammary adenocarcinoma.

Perlin DS, Murant RS, Gibson SL, Hilf R

Cancer research.. 1985 February 45 (2):653-8. Epub 1900 01 01.

Effects of estradiol on insulin receptor distribution in primary cultures of R3230AC mammary adenocarcinoma of the rat.

Hilf R, Crofton DH

Endocrinology.. 1985 January 116 (1):154-63. Epub 1900 01 01.

Evidence against the production of superoxide by photoirradiation of hematoporphyrin derivative.

Gibson SL, Cohen HJ, Hilf R

Photochemistry and photobiology.. 1984 October 40 (4):441-8. Epub 1900 01 01.

Analysis of the mechanism of ATP stimulation of calf thymus DNA alpha-polymerase.

Lawton KG, Wierowski JV, Schechter S, Hilf R, Bambara RA

Biochemistry.. 1984 September 1123 (19):4294-300. Epub 1900 01 01.

Photodynamic inactivation of selected intracellular enzymes by hematoporphyrin derivative and their relationship to tumor cell viability in vitro.

Hilf R, Warne NW, Smail DB, Gibson SL

Cancer letters.. 1984 September 24 (2):165-72. Epub 1900 01 01.

Bovine estrogen receptor binds chromatin at pre-existing nuclease hypersensitive sites.

Pratt K, Wierowski JV, Hilf R, Bambara RA

Molecular and cellular endocrinology.. 1984 May 35 (2-3):205-14. Epub 1900 01 01.

Hematoporphyrin derivative-induced photosensitivity of mitochondrial succinate dehydrogenase and selected cytosolic enzymes of R3230AC mammary adenocarcinomas of rats.

Hilf R, Smail DB, Murant RS, Leakey PB, Gibson SL

Cancer research.. 1984 April 44 (4):1483-8. Epub 1900 01 01.

Photosensitization of mitochondrial cytochrome c oxidase by hematoporphyrin derivative (HpD) in-vitro and in-vivo.

Gibson SL, Leakey PB, Crute JJ, Hilf R

Progress in clinical and biological research.. 1984 170 :323-34. Epub 1900 01 01.

Picosecond fluorescence of hematoporphyrin derivative, its components and related porphyrins.

Hanzlik CA, Knox WH, Nordlund TM, Hilf R, Gibson SL

Progress in clinical and biological research.. 1984 170 :201-10. Epub 1900 01 01.

Photosensitization of mitochondrial cytochrome c oxidase by hematoporphyrin derivative and related porphyrins in vitro and in vivo.

Gibson SL, Hilf R

Cancer research.. 1983 September 43 (9):4191-7. Epub 1900 01 01.

Photodynamic inactivation of R3230AC mammary carcinoma in vitro with hematoporphyrin derivative: effects of dose, time, and serum on uptake and phototoxicity.

Hilf R, Leakey PB, Sollott SJ, Gibson SL

Photochemistry and photobiology.. 1983 June 37 (6):633-42. Epub 1900 01 01.

Effect of environmental hydrogen ion concentration on regulation of insulin receptors in cultured R3230AC mammary carcinoma cells.

Sorge LK, Hilf R

Endocrinology.. 1983 June 112 (6):1964-72. Epub 1900 01 01.

A logistic model based on enzyme activities for the prediction of response of breast cancer patients to chemotherapy.

Hilf R, Feldstein ML, Gibson SL, Savlov ED

Cancer.. 1982 November 150 (9):1734-8. Epub 1900 01 01.

Down-regulation of insulin receptors in primary cultures of R3230 AC rat mammary adenocarcinoma cells.

Sorge LK, Hilf R

Endocrinology.. 1982 April 110 (4):1155-63. Epub 1900 01 01.

Effects of trypsin on binding of insulin and concanavalin A and on glucose and proline transport in the R3230AC mammary adenocarcinoma.

Hilf R, Helton DL

Biochimica et biophysica acta.. 1982 February 10720 (1):42-52. Epub 1900 01 01.

Reduction of proline transport in R3230AC mammary carcinomas by estrogens in vitro.

Hilf R, Helton DL

Biochemical pharmacology.. 1982 January 131 (1):37-41. Epub 1900 01 01.

The hormonal regulation and interaction of concanavalin A and insulin binding in R3230AC mammary adenocarcinoma cells.

Sorge LK, Hilf R

Biochimica et biophysica acta.. 1981 August 17676 (2):187-98. Epub 1900 01 01.

Low tissue enzyme activity seen in breast cancers of patients who fail adjuvant chemotherapy.

Savlov ED, Hilf R, Gibson SL, Feldstein M

Cancer.. 1981 May 147 (9):2214-7. Epub 1900 01 01.

Effect of estrogen on metabolism and enzyme activities of mammary adenocarcinoma R3230AC in Fischer rats.

Abraham S, Hillyard LA, Hansen FN, Lin CY, Hilf R

Cancer research.. 1981 April 41 (4):1435-40. Epub 1900 01 01.

Insulin receptor levels and magnitude of insulin-induced responses in 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats.

Shafie SM, Hilf R

Cancer research.. 1981 March 41 (3):826-9. Epub 1900 01 01.

Insulin binding and glucose transport.

Hilf R, Sorge LK, Gay RJ

International review of cytology.. 1981 72 :147-202. Epub 1900 01 01.

The lack of relationship between estrogen receptor status and response to chemotherapy.

Hilf R, Feldstein ML, Savlov ED, Gibson SL, Seneca B

Cancer.. 1980 December 1546 (12 Suppl):2797-800. Epub 1900 01 01.

Influence of proliferative rates and A system substrate availability on proline transport in primary cell cultures of the R3230AC mammary tumor.

Gay RJ, Hilf R

Journal of cellular physiology.. 1980 November 105 (2):287-300. Epub 1900 01 01.

Correlation of serum, tumor, and liver serum glycoprotein: N-acetylneuraminic acid transferase activity with growth of the R3230AC mammary tumor in rats and relationship of the serum activity to tumor burden.

Evans IM, Hilf R, Murphy M, Bosmann HB

Cancer research.. 1980 September 40 (9):3103-11. Epub 1900 01 01.

Influence of estrogen on glutathione levels and glutathione-metabolizing enzymes in uteri and R3230AC mammary tumors of rats.

Suojanen JN, Gay RJ, Hilf R

Biochimica et biophysica acta.. 1980 July 15630 (4):485-96. Epub 1900 01 01.

Regulation of estrogen-binding capacity by insulin in 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats.

Gibson SL, Hilf R

Cancer research.. 1980 July 40 (7):2343-8. Epub 1900 01 01.

Medium chain fatty acid synthesis in rodent mammary adenocarcinomas in vitro.

Libertini LJ, Lin CY, Abraham S, Hilf R, Smith S

Biochimica et biophysica acta.. 1980 May 28618 (2):185-91. Epub 1900 01 01.

The relative importance of estrogen receptor analysis as a prognostic factor for recurrence or response to chemotherapy in women with breast cancer.

Hilf R, Feldstein ML, Gibson SL, Savlov ED

Cancer.. 1980 April 1545 (8):1993-2000. Epub 1900 01 01.

Paradoxical effects of 17 beta-estradiol on glucose transport in primary cell cultures of a rat mammary tumor.

Gay RJ, Hilf R

Biochemical and biophysical research communications.. 1980 February 2792 (4):1180-8. Epub 1900 01 01.

Density-dependent and adaptive regulation of glucose transport in primary cell cultures of the R3230AC rat mammary adenocarcinoma.

Gay RJ, Hilf R

Journal of cellular physiology.. 1980 February 102 (2):155-74. Epub 1900 01 01.

Effects of estrogen to alter amino acid transport in R3230AC mammary carcinomas and its relationship to insulin action.

Hissin PJ, Hilf R

Cancer research.. 1979 September 39 (9):3381-7. Epub 1900 01 01.

Effect of pH and buffers on insulin binding to normal and neoplastic mammary cells, fat cells and membrane preparations.

Shafie SM, Cech JM, Livingston JN, Hilf R

Cancer biochemistry biophysics. 1979 4 (2):51-7. Epub 1900 01 01.

Prolactin binding to dissociated cells from rat mammary tumors and mammary gland.

Smith RD, Hilf R, Senior AE

Cancer biochemistry biophysics. 1979 3 (3):117-21. Epub 1900 01 01.

Regulatory interrelationships for insulin and estrogen action in mammary tumors.

Hilf R, Hissin PJ, Shafie SM

Cancer research.. 1978 November 38 (11 Pt 2):4076-85. Epub 1900 01 01.

Effects of insulin in vivo and in vitro on amino acid transport into cells from the R3230AC mammary adenocarcinoma and their relationship to tumor growth.

Hissin PJ, Hilf R

Cancer research.. 1978 November 38 (11 Pt 1):3646-55. Epub 1900 01 01.

alpha-aminoisobutyrate transport into cells from R3230AC mammary adenocarcinoma. Evidence for sodium ion-dependent and -independent carrier-mediated entry and effects of diabetes.

Hissin PJ, Hilf R

The Biochemical journal.. 1978 October 15176 (1):205-15. Epub 1900 01 01.

The effect of altered thyroid state on prolactin binding to liver and 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats.

Smith RD, Hilf R, Senior AE

Proceedings of the Society for Experimental Biology and Medicine.. 1978 September 158 (4):517-20. Epub 1900 01 01.

A statistical model for predicting response of breast cancer patients to cytotoxic chemotherapy.

Feldstein ML, Savlov ED, Hilf R

Cancer research.. 1978 August 38 (8):2544-8. Epub 1900 01 01.

Characteristics of proline transport into R3230AC mammary tumor cells.

Hissin PJ, Hilf R

Biochimica et biophysica acta.. 1978 April 4508 (2):401-12. Epub 1900 01 01.

Relationship between insulin and estrogen binding to growth response in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.

Shafie SM, Hilf R

Cancer research.. 1978 March 38 (3):759-64. Epub 1900 01 01.

Relationship Between the Multiple Molecular Forms of Glucose 6-Phosphate Dehydrogenase and Glutathione in Normal, Preneoplastic and Neoplastic Mammary Tissues

Hilf, R.; Ickowicz, R.; Bartley, J.; Abraham, S.;.

Cancer Biochem. Biophys. 1978; 2(3): 191-197.

Effect of insulin and estrogen on hormone binding in the R3230AC mammary adenocarcinoma.

Shafie SM, Gibson SL, Hilf R

Cancer research.. 1977 December 37 (12):4641-9. Epub 1900 01 01.

Prolactin binding to 7,12-dimethylbenz(a)anthracene-induced mammary tumors and liver in diabetic rats.

Smith RD, Hilf R, Senior AE

Cancer research.. 1977 November 37 (11):4070-4. Epub 1900 01 01.

RNA: DNA ratios in human tumors.

Hilf R

Journal of the National Cancer Institute.. 1977 October 59 (4):1053-4. Epub 1900 01 01.

Prolactin binding to R3230AC mammary carcinoma and liver in hormone-treated and diabetic rats.

Smith RD, Hilf R, Senior AE

Cancer research.. 1977 February 37 (2):595-8. Epub 1900 01 01.

Further studies of biochemical predictive tests in breast cancer.

Savlov ED, Wittliff JL, Hilf R

Cancer.. 1977 February 39 (2):539-41. Epub 1900 01 01.

Enzyme activities in human endometrium, myometrium and leiomyomas of the uterus.

Maggiulli MJ, Gustafson JC, Rector WD, Hilf R

Enzyme.. 1977 22 (1):13-8. Epub 1900 01 01.

Identification and characterization of the insulin receptor in the R3230AC mammary adenocarcinoma of the rat.

Harmon JT, Hilf R

Cancer research.. 1976 November 36 (11 Pt 1):3993-4000. Epub 1900 01 01.

Effect of insulin on glucose transport in DMBA-induced mammary tumors.

Harmon JT, Hilf R

European journal of cancer.. 1976 November 12 (11):933-4. Epub 1900 01 01.

Influence of hormonal alteration of host on estrogen-binding capacity in 7,12-dimethylbenz(a)anthracene-induced mammary tumors.

Gibson SL, Hilf R

Cancer research.. 1976 October 36 (10):3736-41. Epub 1900 01 01.

Prolactin binding to mammary gland, 7,12-dimethylbenz(a)-anthracene-induced mammary tumors, and liver in rats.

Smith RD, Hilf R, Senior AE

Cancer research.. 1976 October 36 (10):3726-31. Epub 1900 01 01.

Effect of insulin to decrease glucose transport in dissociated cells from the R3230AC mammary adenocarcinoma of diabetic rats.

Harmon JT, Hilf R

Biochimica et biophysica acta.. 1976 August 4443 (1):114-25. Epub 1900 01 01.

Relationship of glycolytic enzyme activities and response of breast cancer patients to chemotherapy: A preliminary report.

Hilf R, Savlov ED, Rector WD, Wittliff JL

Cancer.. 1976 August 38 (2):695-700. Epub 1900 01 01.

A fluorometric method for determination of oxidized and reduced glutathione in tissues.

Hissin PJ, Hilf R

Analytical biochemistry.. 1976 July 74 (1):214-26. Epub 1900 01 01.

Multiple molecular forms of lactate dehydrogenase and glucose 6-phosphate dehydrogenase in normal and abnormal human breast tissues.

Hilf R, Rector WD, Orlando RA

Cancer.. 1976 April 37 (4):1825-30. Epub 1900 01 01.

Relationship of adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate to growth of dimethylbenz(a)anthracene-induced mammary tumors in rats.

Matusik RJ, Hilf R

Journal of the National Cancer Institute.. 1976 March 56 (3):659-61. Epub 1900 01 01.

Insulin binding and glucose transport in the R3230AC mammary adenocarcinoma.

Harmon JT, Hilf R

Journal of supramolecular structure.. 1976 4 (2):233-40. Epub 1900 01 01.

Effect of estrogen on synthesis of glucose-6-phosphate dehydrogenase in R3230AC mammary tumors and uteri.

Ringler MB, Hilf R

Biochimica et biophysica acta.. 1975 November 10411 (1):50-62. Epub 1900 01 01.

A comparative study of inner membrane enzymes and transport systems in mitochondria from R3230AC mammary tumor and normal rat mammary gland.

Senior AE, McGowan SE, Hilf R

Cancer research.. 1975 August 35 (8):2061-7. Epub 1900 01 01.

Multiple molecular forms of glucose-6-phosphate dehydrogenase in normal, preneoplastic, and neoplastic mammary tissues of mice.

Hilf R, Ickowicz R, Bartley JC, Abraham S

Cancer research.. 1975 August 35 (8):2109-16. Epub 1900 01 01.

Influence of insulin on estrogen-induced responses in the r3230ac mammary carcinoma.

Cohen ND, Hilf R

Cancer research.. 1975 March 35 (3):560-7. Epub 1900 01 01.

Effect of estrogen treatment on DMBA-induced mammary tumor growth and biochemistry in intact and diabetic rats (38535).

Cohen ND, Hilf R

Proceedings of the Society for Experimental Biology and Medicine.. 1975 February 148 (2):339-43. Epub 1900 01 01.

Enzymatic Activities in Normal, Preneoplastic and Neoplastic Mammary Tissues in BALB/c Mice

Hilf, R. Ickowicz,; R.; Bartley, J.C.; Abraham, S.;.

Cancer Biochem. Biophys. 1975; 1(3): 143-149.

Influence of insulin on growth and metabolism of 7,12-dimethylbenz(alpha)anthracene-induced mammary tumors.

Cohen ND, Hilf R

Cancer research.. 1974 December 34 (12):3245-52. Epub 1900 01 01.

Elevations in serum glycoprotein-N-acetylneuraminic acid transferases in rats bearing mammary tumors.

Bosmann HB, Hilf R

FEBS letters.. 1974 August 3044 (3):313-6. Epub 1900 01 01.

Elevations in serum glycoprotein:N-acetylneuraminic acid transferases in rats bearing mammary tumors.

Bosmann HB, Hilf R

FEBS letters.. 1974 August 3044 (3):313-316. Epub 1900 01 01.

Proceedings: Correlations between certain biochemical properties of breast cancer and response to therapy: a preliminary report.

Savlov ED, Wittliff JL, Hilf R, Hall TC

Cancer.. 1974 February 33 (2):303-9. Epub 1900 01 01.

The Effect of the Anti-Estrogen, MER-25, on the Estrogen-induced Responses in Growth and Enzyme Activities in the R3230AC Mammary Carcinoma of Fischer Rats

Hilf, R.;.

Enzyme. 1974; 14(3): 318-324.

Kinetics of glucose-6-phosphate dehydrogenase from normal and neoplastic mammary tissue.

Ringler MI, Hilf R

Enzyme.. 1974 18 (5):257-61. Epub 1900 01 01.

Effect of androgen on glucose-6-phosphate dehydrogenase isoenzymes in rat ventral prostate and seminal vesicles.

Ozols RF, Hilf R

Proceedings of the Society for Experimental Biology and Medicine.. 1973 October 1144 (1):73-7. Epub 1900 01 01.

Response of endometrial and myometrial glucose-6-phosphate dehydrogenase isoenzymes to estrogen.

Sartini J, Meadows D, Rector WD, Hilf R

Endocrinology.. 1973 October 93 (4):990-3. Epub 1900 01 01.

Studies on certain cytoplasmic enzymes and specific estrogen receptors in human breast cancer and in nonmalignant diseases of the breast.

Hilf R, Wittliff JL, Rector WD, Savlov ED, Hall TC, Orlando RA

Cancer research.. 1973 September 33 (9):2054-62. Epub 1900 01 01.

A glucose-6-phosphate dehydrogenase isoenzyme characteristic of preneoplastic and neoplastic mouse mammary tissue.

Hilf R, Rector W, Abraham S

Journal of the National Cancer Institute.. 1973 May 50 (5):1395-8. Epub 1900 01 01.

Effect of dietary carbohydrate on fatty acids in the R3230AC mammary adenocarcinoma.

Zalenski D, Hilf R

Proceedings of the Society for Experimental Biology and Medicine.. 1973 April 142 (4):1137-40. Epub 1900 01 01.

Specific estrogen-binding capacity of the cytoplasmic receptor in normal and neoplastic breast tissues of humans.

Wittliff JL, Hilf R, Brooks WF, Savlov ED, Hall TC, Orlando RA

Cancer research.. 1972 September 32 (9):1983-92. Epub 1900 01 01.

Preliminary enzymatic studies of human benign prostate hypertrophy and prostatic cancer.

Miller HC, Rector W, Hilf R

Investigative urology.. 1972 July 10 (1):1-4. Epub 1900 01 01.

Response of uterine glucose-6-phosphate dehydrogenase isoenzymes to estrogen.

Hilf R, McDonald E, Sartini J, Rector WD, Richards AH

Endocrinology.. 1972 July 91 (1):280-6. Epub 1900 01 01.

Influence of pregnancy, lactation and involution on glucose-6-phosphate dehydrogenase and lactate dehydrogenase in the rat mammary gland.

Richards AH, Hilf R

Endocrinology.. 1972 July 91 (1):287-95. Epub 1900 01 01.

Effect of estrogen administration on glucose 6-phosphate dehydrogenase and lactate dehydrogenase isoenzymes in rodent mammary tumors and normal mammary glands.

Richards AH, Hilf R

Cancer research.. 1972 March 32 (3):611-6. Epub 1900 01 01.

Will the best model of breast cancer please come forward?

Hilf R

National Cancer Institute monograph.. 1971 December 34 :43-54. Epub 1900 01 01.

Some biochemical changes preceding regression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors following oophorectomy.

Hilf R, Battaglini JW, Delmez JA, Cohen N, Rector WD

Cancer research.. 1971 September 31 (9):1195-200. Epub 1900 01 01.

Effect of fluphenazine HCl on R3230AC mammary carcinoma and mammary glands of the rat.

Hilf R, Bell C, Goldenberg H, Michel I

Cancer research.. 1971 August 31 (8):1111-7. Epub 1900 01 01.

Glucose-6-phosphate dehydrogenase and lactate dehydrogenase isoenzynes in rodent mammary carcinomas and the effect of oophorectomy.

Richards AH, Hilf R

Biochimica et biophysica acta.. 1971 April 8232 (4):753-6. Epub 1900 01 01.

Biochemicaevents associated with regression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas after ovariectoy.

Hilf R, Goldenberg H, Michel I, Gruenstein M, Meranze DR, Shimkin MB

Cancer research.. 1971 January 31 (1):52-8. Epub 1900 01 01.

Cholesterol synthesis inhibitor showing reduction of lipids and hormone antagonism.

Lerner LJ, Harris DN, Yiacas E, Hilf R, Michel I

The American journal of clinical nutrition.. 1970 September 23 (9):1241-50. Epub 1900 01 01.

Enzymes, nucleic acids, and lipids in human breast cancer and normal breast tissue.

Hilf R, Goldenberg H, Michel I, Orlando RA, Archer FL

Cancer research.. 1970 June 30 (6):1874-82. Epub 1900 01 01.

Lack of correlation between morphological and biochemical parameters in mammary adenocarcinomas of rats induced with 7, 12-dimethylbenz(a)anthracene.

Hilf R, Goldenberg H, Gruenstein M, Meranze DR, Shimkin MB

Cancer research.. 1970 May 30 (5):1223-30. Epub 1900 01 01.

Enzymatic characteristics of the monkey endometrium during ovulatory and anovulatory cycles and under hormonal contraception treatment.

Wan LS, Hilf R, Shah M, Lerner LJ, Balin H

The Journal of reproductive medicine.. 1970 April 4 (4):43-52. Epub 1900 01 01.

Some biochemical characteristics of rodent and human mammary carcinomas.

Hilf R, Goldenberg H, Bell C, Michel I, Orlando RA, Archer FL

Enzymologia biologica et clinica. 1970 11 (1):162-76. Epub 1900 01 01.

Biochemical characteristics of mammary glands and mammary tumors of rats induced by 3-methylcholanthrene and 7,12-dimethylbenz(a)anthracene.

Hilf R, Goldenberg H, Michel I, Carrington MJ, Bell C, Gruenstein M, Meranze DR, Shimkin MB

Cancer research.. 1969 May 29 (5):977-88. Epub 1900 01 01.

Some Biochemical Characteristics of Human Breast Cancer and Non-Malignant Breast Lesions

Hilf, R.; Goldenberg, H.; Orlando, R.A.; Archer, F.L.;.

Proc. Soc. Exptl. Biol. Med. 1969; 132(3): 613-617.

Biochemical studies of hormone-responsive mammary tumors.

Hilf R

Cancer research.. 1968 September 28 (9):1888-90. Epub 1900 01 01.

Influence of hormonal treatment of Fischer rats on the biochemistry of a transplantable dimethylbenz(a)anthracene-induced mammary carcinoma and its sublines.

Hilf R, Segaloff A, Lerner LJ

Cancer research.. 1968 August 28 (8):1550-8. Epub 1900 01 01.

Hormonal dependence of DNA synthesis in mammary carcinoma cells in vitro.

Turkington RW, Hilf R

Science.. 1968 June 28160 (3835):1457-9. Epub 1900 01 01.

The effects of progesterone and ethamoxytriphetol on estradiol-induced changes in the immature rat uterus.

Harris DN, Lerner LJ, Hilf R

Transactions of the New York Academy of Sciences. 1968 April 30 (6):774-82. Epub 1900 01 01.

The effect of Actidione and actinomycin D on androgen-induced biochemical changes in the R3230AC mammary carcinoma and uterus of the rat.

Hilf R, Lerner LJ, Harris DN

Transactions of the New York Academy of Sciences. 1968 April 30 (6):794-803. Epub 1900 01 01.

The Effect of Antagonists on Androgen Estrogen-Induced Changes in the Male Accessory Sex Organs of the Rats

Lerner, L.J.; Hilf, R.; Harris, D.N.;.

Trans. NY Acad Sci. 1968; 30(3): 783-793.

Effect of actidione (cycloheximide) on estrogen-induced biochemical changes in R3230AC mammary tumors, uteri, and mammary glands.

Hilf R, Goldenberg H, Bell C

Cancer research.. 1967 August 27 (8):1485-93. Epub 1900 01 01.

Influence of the mammotropic tumor MtTF4 on the growth and biochemistry of the R3230AC mammary carcinoma and mammary glands.

Hilf R, Bell C, Michel I

Cancer research.. 1967 March 27 (3):482-9. Epub 1900 01 01.

Milk-like fluid in a mammary adenocarcinoma: biochemical characterization.

Hilf R

Science.. 1967 February 17155 (3764):826-7. Epub 1900 01 01.

Biochemical and morphological responses of normal and neoplastic mammary tissue to hormonal treatment.

Hilf R, Michel I, Bell C

Recent progress in hormone research.. 1967 23 :229-95. Epub 1900 01 01.

Effect of hydroxyurea and related compounds on HMC mammary tumor growth and nucleic acids in Fischer rats.

Hilf R, Bell C, Michel I, Freeman JJ, Borman A

Cancer research.. 1966 November 26 (11):2286-91. Epub 1900 01 01.

Influence of endocrine organ ablation on the growth and biochemical responses of the R3230AC mammary tumor to hormonal treatment.

Hilf R, Michel I, Bell C, Carrington MJ

Cancer research.. 1966 July 26 (7):1365-70. Epub 1900 01 01.

NADP-linked enzymes and lipids in normal and neoplastic mammary tissue: effects of estrogen and dietary glucose.

Hilf R, Michel I, Gibbs CC, Bell C

Biochimica et biophysica acta.. 1966 June 1116 (3):589-92. Epub 1900 01 01.

Dose responses of R3230AC mammary tumor and mammary tissue to estrogen: enzymes, nucleic acids, and lipids.

Hilf R, Michel I, Bell C

Cancer research.. 1966 May 26 (5):865-70. Epub 1900 01 01.

Effects of hormone antagonists on morphological and biochemical changes induced by hormonal steroids in the immature rat uterus.

Lerner LJ, Hilf R, Turkheimer AR, Michel I, Engel SL

Endocrinology.. 1966 January 78 (1):111-24. Epub 1900 01 01.

Responses of the Rat Uterus and Oviduct to Sex Steroids as Influenced by Time and Antagonists

Lerner, L.J.; Harris, D.N.; Hilf, R.; Bianchi, A.; Raskin, B.K.;.

Proc. Second International Congress on Hormonal Steroids, Excerpta medica, International Congress Series, No. 132. 1966; : pp. 629-636.

Effect of actinomycin D on estrogen-induced changes in enzymes and nucleic acids of R3230AC mammary tumors, uteri, and mammary glands.

Hilf R, Michel I, Silverstein G, Bell G

Cancer research.. 1965 December 25 (11):1854-9. Epub 1900 01 01.

Effect of small doses of actinomycin D on oestrogen-induced uterine changes in the immature rat.

Lerner LJ, Hilf R, Turkheimer AR, Michel I

The Journal of endocrinology.. 1965 November 33 (3):531-2. Epub 1900 01 01.

The mechanism of action of ACTH.

Hilf R

The New England journal of medicine.. 1965 October 7273 (15):798-811. Epub 1900 01 01.

BIOCHEMICAL AND MORPHOLOGIC PROPERTIES OF A NEW LACTATING MAMMARY TUMOR LINE IN THE RAT.

HILF R, MICHEL I, BELL C, FREEMAN JJ, BORMAN A

Cancer research.. 1965 April 25 :286-99. Epub 1900 01 01.

CHARACTERIZATION OF A TRANSPLANTABLE LACTATING MAMMARY TUMOR: ENDOCRINOLOGICAL, MORPHOLOGICAL, AND BIOCHEMICAL ASPECTS.

HILF R, FREEMAN JJ, MICHEL I, BORMAN A

Cancer research.. 1964 June 24 :812-23. Epub 1900 01 01.

EFFECTS OF STEROIDS UPON THE WEIGHT, PROTEIN AND NUCLEIC ACID CONCENTRATION OF THE PREPUTIAL GLANDS OF THE FEMALE RAT.

FREEMAN JJ, HILF R, IOVINO AJ, MICHEL I

Endocrinology.. 1964 June 74 :990-3. Epub 1900 01 01.

TRIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED ENZYMES IN THE REGENERATING RAT ADRENAL GLAND: EFFECT OF ADRENOCORTICOTROPHIN.

HILF R, BURNETT FF

Archives of biochemistry and biophysics.. 1964 January 104 :106-10. Epub 1900 01 01.

Effects of Steroids upon the Weight, Protein and Nucleic Acid Concentration of the Preputial Glands of the Female Rat

Freeman, J.J.; Hilf, R.; Iovino, A.J.; Michel, I.;.

Endocrinol. 1964; 74(3): 990-993.

COMPARATIVE BIOCHEMISTRY OF THREE TRANSPLANTABLE MAMMARY TUMORS AS INFLUENCED BY STEROID THERAPY.

HILF R, JOHNSON MM, BREUER C, FREEMAN JJ, BORMAN A

Journal of the National Cancer Institute.. 1963 September 31 :541-55. Epub 1900 01 01.

EFFECT OF STEROIDS ON THREE TRANSPLANTABLE MAMMARY TUMORS IN THE FISCHER RAT.

HILF R, FREEMAN JJ, JOHNSON MM, STAGG R, BORMAN A

Cancer chemotherapy reports. Part 1.. 1963 July 30 :1-8. Epub 1900 01 01.

A simplified method for determination of urinary lead.

HILF R, CASTANO FF

Clinical chemistry.. 1963 April 9 :163-7. Epub 1900 01 01.

The effect of progressive sarcoma 180 growth upon the uterotrophic response to estrogen in mice.

HILF R, LERNER LJ, LANG E, BORMAN A

Cancer research.. 1963 February 23 :304-9. Epub 1900 01 01.

Effects of Steroids on Three Transplantable Mammary Tumors in the Fischer Rat

Hilf, R.; Freeman, J.J.; Johnson, M.M.; Stagg, R.; Borman, A.;.

Cancer Chemother. Rpts. 1963; 30(3): 1-8.

The effect of ACTH upon adrenal glucose-6-phosphate metabolizing enzymes.

HILF R, BURNETT FF, BORMAN A

Biochemical and biophysical research communications.. 1962 July 38 :191-4. Epub 1900 01 01.

Adrenal glucose-6-phosphatase: alterations in intracellular distribution induced by treatment with adrenocorticotrophic hormone.

HILF R, BREUER C, BORMAN A

Nature.. 1962 June 2194 :867-8. Epub 1900 01 01.

The effect of sarcoma 180 and other stressing agents upon adrenal nucleic acids.

HILF R, COWETT VW, JOHNSON ML, BORMAN A

Cancer research.. 1962 May 22 :449-55. Epub 1900 01 01.

Effects of chronic food restriction in swine.

CALLOWAY DH, HILF R, MUNSON AH

The Journal of nutrition.. 1962 April 76 (4):365-74. Epub 1900 01 01.

The Effect of ACTH upon Adrenal Glucose-6-Phosphate Metabolizing Enzymes

Hilf, R.; Burnett, F.F.; Borman, A.;.

Biochem. & Biophys. Res. Comm. 1962; 8(3): 191-194.

The effect of sarcoma 180 and other stressing agents upon adrenal adenine nucleotide-metabolizing enzymes.

HILF R, BREUER C, BORMAN A

Cancer research.. 1961 November 21 :1439-44. Epub 1900 01 01.

Adrenal adenine nucleotide-metabolizing enzymes: alterations induced by ACTH treatment.

HILF R, BREUER C, BORMAN A

Archives of biochemistry and biophysics.. 1961 August 94 :319-27. Epub 1900 01 01.

Effect of dietary supplementation with broccoli on x-irradiation-induced enzyme changes in the guinea pig.

HILF R, ADACHI R, ECKFELDT G

Radiation research.. 1961 July 15 :86-93. Epub 1900 01 01.

The effect of sarcoma 180 and other stressing agents upon adrenal and plasma corticosterone in mice.

HILF R, BURNETT FF, BORMAN A

Cancer research.. 1960 October 20 :1389-93. Epub 1900 01 01.

Identification of alkaloids and related compounds by paper chromatography and ultraviolet spectrophotometry.

HILF R, CASTANO FF, LIGHTBOURN GA

The Journal of laboratory and clinical medicine.. 1959 October 54 :634-9. Epub 1900 01 01.

Fluid and electrolyte balance following in juries to the head.

WISE BL, HILF R, PILEGGI VJ

American journal of surgery.. 1959 February 97 (2):205-10. Epub 1900 01 01.

Identification of Barbiturates by Paper Chromatography

Hilf, R.; Lightbourn, G.A.; Castano, F.F.;.

J. Lab. & Clin. Med. 1959; 54(3): 320-324.

Effect of pneumoencephalography on fluid and electrolyte metabolism.

WISE BL, HILF R, PILEGGI VJ

A.M.A. archives of surgery.. 1958 July 77 (1):113-6. Epub 1900 01 01.

Effect of reuse and temperature upon Rana pipiens as a pregnancy test animal.

HILF R, ROSEN I

The Journal of laboratory and clinical medicine.. 1958 July 52 (1):153-7. Epub 1900 01 01.

Toxicology at the Army Area Laboratory.

HILF R

United States Armed Forces medical journal.. 1958 June 9 (6):843-50. Epub 1900 01 01.

Quantitative Determination of Reducing Sugars and a Sugar Acid by Hydroxamic Acid Formation

Hilf, R.; Castano, F.F.;.

Anal. Chem. 1958; 30(3): 1538-1540.

The effect of season on Rana pipiens as an animal for pregnancy tests.

HILF R, ROSEN I

American journal of clinical pathology.. 1957 December 28 (6):698-700. Epub 1900 01 01.

The effect of season on Rana pipiens as an animal for pregnancy tests.

HILF R, ROSEN I

Technical bulletin of the Registry of Medical Technologists.. 1957 November 27 (11):256-8. Epub 1900 01 01.

Effect of re-use of Rana pipiens upon the accuracy of the pregnancy test.

HILF R, ROSEN I

The Journal of clinical endocrinology and metabolism.. 1957 September 17 (9):1088-93. Epub 1900 01 01.

Effect of Re-Use of Rana pipiens upon the Accuracy of the Pregnancy Test

Hilf, R.; Rosen, I.;.

J. Clin. Endocrinol. & Metabol. 1957; 17(3): 1088-1093.

Some effects of sulfur amino acids upon tumor-host relationship in the rat.

HILF R

Cancer research.. 1956 September 16 (8):753-5. Epub 1900 01 01.

The effect of methionine supplementation upon the tumor-host relationship in the rat.

ALLISON JB, WANNEMACHER RW, HILF R, HETZEL CA

The Journal of nutrition.. 1956 May 1059 (1):27-38. Epub 1900 01 01.

Diet and TEPA therapy in sarcoma-bearing rats.

ALLISON JB, WANNEMACHER RW, HILF R, CROSSLEY ML

Proceedings of the Society for Experimental Biology and Medicine.. 1955 December 90 (3):728-30. Epub 1900 01 01.

Diet and TEPA Therapy in Sarcoma-Bearing Rats

Allison, J.B.; Wannemacher, R.W.; Hilf , R.; Crossley, M.L.;.

Proc. Soc. Exptl. Biol. and Med. 1955; 90(3): 728-730.

Dietary protein and tumor-host relationship in the rat.

ALLISON JB, WANNEMACHER RW, HILF R, MIGLIARESE JF, CROSSLEY ML

The Journal of nutrition.. 1954 December 1054 (4):593-600. Epub 1900 01 01.