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Jacob N. Finkelstein, Ph.D.

Jacob N. Finkelstein, Ph.D.

Contact

Office (585) 275-5220

About Me

Faculty Appointments

Professor Emeritus - Department of Pediatrics, Neonatology (SMD)

Credentials

Post-doctoral Training & Residency

NIH Postdoctoral Fellowship, Department of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 1977 - 1978

NSF Postdoctoral Fellowship, Department of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 1976 - 1977

Education

PhD | Northwestern University. Biochemistry. 1976

BS | Carnegie-Mellon University. Chemistry. 1971

Awards

March of Dimes Health Leadership Award 2006

Elected member, Perinatal Research Society 1986

Sigma Xi Graduate Research Symposium Award 1974

Research

Dr. Finkelstein's laboratory research emphasizes the role of the alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli. This includes studies of oxidant induced signaling in the pulmonary epithelium and macrophages and epithelial production of cyt...
Dr. Finkelstein's laboratory research emphasizes the role of the alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli. This includes studies of oxidant induced signaling in the pulmonary epithelium and macrophages and epithelial production of cytokines and chemokines in the regulation of the inflammatory functions of alveolar macrophages. His previous research effort focused on the pulmonary alveolar type II cell as the site of pulmonary surfactant synthesis and secretion, and studies on the basic cell and molecular biology of these processes are still an important facet of his work. In addition, the type II cell also plays an important role as the stem cell for renewal of the alveolar epithelium both in the normal lung development and during epithelial repair and renewal following lung injury. The most recent data suggest that type II cells may also be involved in regulating the inflammatory functions of alveolar macrophages, as well as the actions of interstitial fibroblasts during lung growth or pulmonary fibrosis.
The overall goal of the current research is to identify some of the key control mechanisms involved in epithelial cell and fibroblast proliferation, and in related extracellular matrix synthesis, processing and assembly. This work seeks to define such mechanisms not only during normal lung growth and normal development, but also during the repair of epithelial damage, and may have important implications for pediatric and adult lung disease, including bronchopulmonary dysplasia (BPD) in premature infants. This work is funded by grants from NIH, EPA and DoD.

The overall goal of some of their additional current research is to identify some of the key control mechanisms involved in epithelial cell and fibroblast proliferation, and in related extracellular matrix synthesis, processing and assembly. This work seeks to define such mechanisms not only during normal lung growth and normal development, but also during the repair of epithelial damage, and may have important implications for pediatric and adult lung disease, including bronchopulmonary dysplasia (BPD) in premature infants.

Publications

Journal Articles

Baseline Characteristics and Barriers to Recruitment in Cardiac and Pulmonary Rehabilitation NIH-Funded Trials.

Grimshaw C, Keteyian SJ, Benzo R, Finkelstein J, Forman DE, Gaalema DE, Peterson PN, Einhorn PT, Punturieri A, Shero S, Fleg JL

Journal of cardiopulmonary rehabilitation and prevention.. 2023 November 143 (6):407-411. Epub 08/29/2023.

Influence of the irradiated pulmonary microenvironment on macrophage and T cell dynamics.

Groves AM, Misra R, Clair G, Hernady E, Olson H, Orton D, Finkelstein J, Marples B, Johnston CJ

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2023 June 183 :109543. Epub 02/20/2023.

Epithelial Responses in Radiation-Induced Lung Injury (RILI) Allow Chronic Inflammation and Fibrogenesis.

Beach TA, Finkelstein JN, Chang PY

Radiation research.. 2023 May 1199 (5):439-451. Epub 1900 01 01.

Epithelial Responses in Radiation-Induced Lung Injury (RILI) Allow Chronic Inflammation and Fibrogenesis.

Beach TA, Finkelstein JN, Chang PY

Radiation research.. 2023 March 15 Epub 03/15/2023.

Update on RFA Increasing Use of Cardiac and Pulmonary Rehabilitation in Traditional and Community Settings NIH-Funded Trials: ADDRESSING CLINICAL TRIAL CHALLENGES PRESENTED BY THE COVID-19 PANDEMIC.

Shero ST, Benzo R, Cooper LS, Finkelstein J, Forman DE, Gaalema DE, Joseph L, Keteyian SJ, Peterson PN, Punturieri A, Zieman S, Fleg JL

Journal of cardiopulmonary rehabilitation and prevention.. 2022 January 142 (1):10-14. Epub 1900 01 01.

Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative.

Bennett TD, Moffitt RA, Hajagos JG, Amor B, Anand A, Bissell MM, Bradwell KR, Bremer C, Byrd JB, Denham A, DeWitt PE, Gabriel D, Garibaldi BT, Girvin AT, Guinney J, Hill EL, Hong SS, Jimenez H, Kavuluru R, Kostka K, Lehmann HP, Levitt E, Mallipattu SK, Manna A, McMurry JA, Morris M, Muschelli J, Neumann AJ, Palchuk MB, Pfaff ER, Qian Z, Qureshi N, Russell S, Spratt H, Walden A, Williams AE, Wooldridge JT, Yoo YJ, Zhang XT, Zhu RL, Austin CP, Saltz JH, Gersing KR, Haendel MA, Chute CG,

JAMA network open.. 2021 July 14 (7):e2116901. Epub 07/01/2021.

Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.

Wang J, Kim SY, House E, Olson HM, Johnston CJ, Chalupa D, Hernady E, Mariani TJ, Clair G, Ansong C, Qian WJ, Finkelstein JN, McGraw MD

Archives of toxicology.. 2021 July 95 (7):2469-2483. Epub 05/24/2021.

Increasing Use of Cardiac and Pulmonary Rehabilitation in Traditional and Community Settings: OPPORTUNITIES TO REDUCE HEALTH CARE DISPARITIES.

Fleg JL, Keteyian SJ, Peterson PN, Benzo R, Finkelstein J, Forman DE, Gaalema DE, Cooper LS, Punturieri A, Joseph L, Shero S, Zieman S

Journal of cardiopulmonary rehabilitation and prevention.. 2020 November 40 (6):350-355. Epub 1900 01 01.

Airway basal cell injury after acute diacetyl (2,3-butanedione) vapor exposure.

McGraw MD, Kim SY, Reed C, Hernady E, Rahman I, Mariani TJ, Finkelstein JN

Toxicology letters.. 2020 June 1325 :25-33. Epub 02/26/2020.

Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation.

Beach TA, Groves AM, Williams JP, Finkelstein JN

International journal of radiation biology.. 2020 January 96 (1):129-144. Epub 10/25/2018.

Apoptosis Resistance in Fibroblasts Precedes Progressive Scarring in Pulmonary Fibrosis and Is Partially Mediated by Toll-Like Receptor 4 Activation.

Hanson KM, Hernady E, Reed CK, Johnston CJ, Groves AM, Finkelstein JN

Toxicological sciences : an official journal of the Society of Toxicology.. 2019 August 1170 (2):489-498. Epub 1900 01 01.

An accessible and high-throughput strategy of continuously monitoring apoptosis by fluorescent detection of caspase activation.

Hanson KM, Finkelstein JN

Analytical biochemistry.. 2019 January 1564-565 :96-101. Epub 10/24/2018.

Recurrent DNA damage is associated with persistent injury in progressive radiation-induced pulmonary fibrosis.

Beach TA, Groves AM, Johnston CJ, Williams JP, Finkelstein JN

International journal of radiation biology.. 2018 December 94 (12):1104-1115. Epub 09/21/2018.

A Potential Biomarker for Predicting the Risk of Radiation-Induced Fibrosis in the Lung.

Groves AM, Williams JP, Hernady E, Reed C, Fenton B, Love T, Finkelstein JN, Johnston CJ

Radiation research.. 2018 November 190 (5):513-525. Epub 08/17/2018.

Role of Infiltrating Monocytes in the Development of Radiation-Induced Pulmonary Fibrosis.

Groves AM, Johnston CJ, Williams JP, Finkelstein JN

Radiation research.. 2018 March 189 (3):300-311. Epub 01/13/2018.

Radiation induced pulmonary fibrosis as a model of progressive fibrosis: Contributions of DNA damage, inflammatory response and cellular senescence genes.

Beach TA, Johnston CJ, Groves AM, Williams JP, Finkelstein JN

Experimental lung research.. 2017 April 43 (3):134-149. Epub 05/23/2017.

Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation.

Groves AM, Johnston CJ, Misra RS, Williams JP, Finkelstein JN

International journal of radiation biology.. 2016 December 92 (12):754-765. Epub 09/15/2016.

Thoracic Radiation Differentially Affects T Cells in Mediastinal Lymph Nodes of Fibrosis Sensitive and Resistant Mice.

Williams JP, Johnston C, Misra R, Finkelstein JN, Groves A

International journal of radiation oncology, biology, physics.. 2016 October 196 (2S):S66-S67. Epub 1900 01 01.

Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury.

Williams JP, Calvi L, Chakkalakal JV, Finkelstein JN, O'Banion MK, Puzas E

Radiation research.. 2016 July 186 (1):1-16. Epub 06/22/2016.

Whole-Lung Irradiation Results in Pulmonary Macrophage Alterations that are Subpopulation and Strain Specific.

Groves AM, Johnston CJ, Misra RS, Williams JP, Finkelstein JN

Radiation research.. 2015 December 184 (6):639-49. Epub 12/03/2015.

Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function.

Rangel-Moreno J, de la Luz Garcia-Hernandez M, Ramos-Payan R, Biear J, Hernady E, Sangster MY, Randall TD, Johnston CJ, Finkelstein JN, Williams JP

Radiation research.. 2015 October 184 (4):352-66. Epub 09/23/2015.

Examining the Effects of External or Internal Radiation Exposure of Juvenile Mice on Late Morbidity after Infection with Influenza A.

Misra RS, Johnston CJ, Groves A, DeDiego ML, St Martin J, Reed C, Hernady E, Miller JN, Love T, Finkelstein JN, Williams JP

Radiation research.. 2015 July 184 (1):3-13. Epub 06/26/2015.

Developmental exposure to concentrated ambient ultrafine particulate matter air pollution in mice results in persistent and sex-dependent behavioral neurotoxicity and glial activation.

Allen JL, Liu X, Weston D, Prince L, Oberdörster G, Finkelstein JN, Johnston CJ, Cory-Slechta DA

Toxicological sciences : an official journal of the Society of Toxicology.. 2014 July 140 (1):160-78. Epub 04/01/2014.

Cationic nanoparticles disrupt cellular signaling in a cholesterol dependent manner.

Thach CT, Finkelstein JN

Toxicology in vitro : an international journal published in association with BIBRA.. 2013 June 27 (4):1277-86. Epub 12/26/2012.

Exacerbation of lung radiation injury by viral infection: the role of Clara cells and Clara cell secretory protein.

Manning CM, Johnston CJ, Hernady E, Miller JN, Reed CK, Lawrence BP, Williams JP, Finkelstein JN

Radiation research.. 2013 June 179 (6):617-29. Epub 04/26/2013.

Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure.

Manning CM, Johnston CJ, Reed CK, Lawrence BP, Williams JP, Finkelstein JN

International journal of radiation oncology, biology, physics.. 2013 May 186 (1):128-35. Epub 11/27/2012.

Neonatal irradiation sensitizes mice to delayed pulmonary challenge.

Johnston CJ, Manning CM, Rangel-Moreno J, Randall TD, Hernady E, Finkelstein JN, Williams JP

Radiation research.. 2013 April 179 (4):475-84. Epub 03/15/2012.

Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration.

Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar KN, Finkelstein JN, Watterson DM, Rahman A

PloS one.. 2013 8 (3):e59965. Epub 03/21/2013.

Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1.

O'Reilly MA, Yee M, Buczynski BW, Vitiello PF, Keng PC, Welle SL, Finkelstein N, Dean DA, Lawrence BP

The American journal of pathology.. 2012 August 181 (2):441-51. Epub 06/05/2012.

Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data.

Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdörster G

Toxicology.. 2012 July 16297 (1-3):1-9. Epub 04/02/2012.

Validation of an LDH assay for assessing nanoparticle toxicity.

Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdörster G

Toxicology.. 2011 September 5287 (1-3):99-104. Epub 06/23/2011.

Micronutrient levels in children exposed to secondhand tobacco smoke.

Wilson KM, Finkelstein JN, Blumkin AK, Best D, Klein JD

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.. 2011 September 13 (9):800-8. Epub 05/09/2011.

Effect of total body irradiation on late lung effects: hidden dangers.

Johnston CJ, Manning C, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP

International journal of radiation biology.. 2011 August 87 (8):902-13. Epub 05/17/2011.

Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?

Williams JP, Johnston CJ, Finkelstein JN

Current drug targets.. 2010 November 11 (11):1386-94. Epub 1900 01 01.

Early alterations in cytokine expression in adult compared to developing lung in mice after radiation exposure.

Johnston CJ, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP

Radiation research.. 2010 April 173 (4):522-35. Epub 1900 01 01.

Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics.

Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdorster G

Journal of toxicology and environmental health. Part A.. 2010 73 (5):445-61. Epub 1900 01 01.

Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells.

Fazal F, Bijli KM, Minhajuddin M, Rein T, Finkelstein JN, Rahman A

The Journal of biological chemistry.. 2009 July 31284 (31):21047-56. Epub 05/29/2009.

IL-1beta augments TNF-alpha-mediated inflammatory responses from lung epithelial cells.

Saperstein S, Chen L, Oakes D, Pryhuber G, Finkelstein J

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.. 2009 May 29 (5):273-84. Epub 1900 01 01.

The influence of protein adsorption on nanoparticle association with cultured endothelial cells.

Ehrenberg MS, Friedman AE, Finkelstein JN, Oberdörster G, McGrath JL

Biomaterials.. 2009 February 30 (4):603-10. Epub 11/13/2008.

Nanoparticle (NP) uptake by type I alveolar epithelial cells and their oxidant stress response.

Vanwinkle BA, de Mesy Bentley KL, Malecki JM, Gunter KK, Evans IM, Elder A, Finkelstein JN, Oberdörster G, Gunter TE

Nanotoxicology.. 2009 January 13 (4):307-318. Epub 1900 01 01.

Inflammatory Cells vs Parachyma in Normal Tissue Response to Radiation Induced Lung Fibrosis.

Johnston CJ, Williams JP, Hernady E, Reed C, Finkelstein JN.

Radiation Research, In Review,. 2009; .

Developmental Effects of PM During Postnatal Lung Development.

Johnston CJ, Gelein R, Oberdoerster G, Finkelstein JN.

In preparation,. 2009; .

The effects of interleukin-1beta in tumor necrosis factor-alpha-induced acute pulmonary inflammation in mice.

Saperstein S, Huyck H, Kimball E, Johnston C, Finkelstein J, Pryhuber G

Mediators of inflammation.. 2009 2009 :958658. Epub 11/04/2009.

Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia.

Pryhuber GS, Huyck HL, Bhagwat S, O'Reilly MA, Finkelstein JN, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2008 July 15181 (2):1409-19. Epub 1900 01 01.

In vitro dosing of cells with poorly soluble particles.

Oberdörster G, Finkelstein JN

Toxicological sciences : an official journal of the Society of Toxicology.. 2006 December 94 (2):439; author reply 440. Epub 09/04/2006.

Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development.

Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2006 November 291 (5):L1101-11. Epub 07/21/2006.

Postnatal lung development: immediate-early gene responses post ozone and LPS exposure.

Johnston CJ, Holm BA, Gelein R, Finkelstein JN

Inhalation toxicology.. 2006 October 18 (11):875-83. Epub 1900 01 01.

Translocation of inhaled ultrafine manganese oxide particles to the central nervous system.

Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G

Environmental health perspectives.. 2006 August 114 (8):1172-8. Epub 1900 01 01.

Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells.

Bruckner L, Gigliotti F, Wright T, Harmsen A, Notter RH, Chess P, Wang Z, Finkelstein J

American journal of physiology. Lung cellular and molecular physiology.. 2006 June 290 (6):L1087-96. Epub 01/06/2006.

p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth.

Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA

The American journal of pathology.. 2006 June 168 (6):1838-47. Epub 1900 01 01.

A comparative dose-related response of several key pro- and anti-inflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black.

Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G.

J Occup Environ Med. 2006; 48(12): 1265-78.

Toxicological Profiles of Nanomaterials.

Rushton E, Finkelstein J, Oberdörster G.

Proc. Mat. Res. Soc. 2006; .

Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology.

Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G

Toxicological sciences : an official journal of the Society of Toxicology.. 2005 December 88 (2):614-29. Epub 09/21/2005.

Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells.

Chess PR, O'Reilly MA, Sachs F, Finkelstein JN

Journal of applied physiology.. 2005 September 99 (3):1226-32. Epub 05/12/2005.

Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli.

Singal M, Finkelstein JN

Inhalation toxicology.. 2005 August 17 (9):415-25. Epub 1900 01 01.

Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors.

Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J

International journal of radiation oncology, biology, physics.. 2005 May 162 (1):273-8. Epub 1900 01 01.

Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells.

Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW

Infection and immunity.. 2005 May 73 (5):2766-77. Epub 1900 01 01.

Sequential exposures to ozone and lipopolysaccharide in postnatal lung enhance or inhibit cytokine responses.

Johnston CJ, Holm BA, Finkelstein JN

Experimental lung research.. 2005 May 31 (4):431-47. Epub 1900 01 01.

Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate.

Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G

Experimental lung research.. 2005 31 (6):527-46. Epub 1900 01 01.

Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells.

Singal M, Finkelstein JN

Experimental lung research.. 2005 31 (6):581-97. Epub 1900 01 01.

Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains.

Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G

Inhalation toxicology.. 2004 June 16 (6-7):461-71. Epub 1900 01 01.

Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model.

Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN

Radiation research.. 2004 May 161 (5):560-7. Epub 1900 01 01.

Enhanced sensitivity of the postnatal lung to environmental insults and oxidant stress.

Finkelstein JN, Johnston CJ

Pediatrics.. 2004 April 113 (4 Suppl):1092-6. Epub 1900 01 01.

Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate.

Elder AC, Gelein R, Oberdörster G, Finkelstein J, Notter R, Wang Z

Experimental lung research.. 2004 March 30 (2):105-20. Epub 1900 01 01.

Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage.

D'Angio CT, LoMonaco MB, Johnston CJ, Reed CK, Finkelstein JN

American journal of physiology. Lung cellular and molecular physiology.. 2004 January 286 (1):L30-6. Epub 08/08/2003.

On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats.

Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G

Inhalation toxicology.. 2004 16 Suppl 1 :41-53. Epub 1900 01 01.

Inflammatory cell recruitment following thoracic irradiation.

Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN

Experimental lung research.. 2004 30 (5):369-82. Epub 1900 01 01.

Differential proinflammatory cytokine responses of the lung to ozone and lipopolysaccharide exposure during postnatal development.

Carl J, Bruce H, Jacob F

Experimental lung research.. 2004 30 (7):599-614. Epub 1900 01 01.

Identification and isolation of mouse type II cells on the basis of intrinsic expression of enhanced green fluorescent protein.

Roper JM, Staversky RJ, Finkelstein JN, Keng PC, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2003 September 285 (3):L691-700. Epub 05/09/2003.

Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth.

Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I

American journal of clinical oncology.. 2003 August 26 (4):S103-9. Epub 1900 01 01.

The biological basis of a comprehensive grading system for the adverse effects of cancer treatment.

Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P

Seminars in radiation oncology.. 2003 July 13 (3):182-8. Epub 1900 01 01.

Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release.

Hjort MR, Brenyo AJ, Finkelstein JN, Frampton MW, LoMonaco MB, Stewart JC, Johnston CJ, D'Angio CT

Inflammation.. 2003 June 27 (3):137-45. Epub 1900 01 01.

Induction of chemokines by low-dose intratracheal silica is reduced in TNFR I (p55) null mice.

Pryhuber GS, Huyck HL, Baggs R, Oberdörster G, Finkelstein JN

Toxicological sciences : an official journal of the Society of Toxicology.. 2003 March 72 (1):150-7. Epub 1900 01 01.

Activation of the G2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxia.

O'Reilly MA, Staversky RJ, Finkelstein JN, Keng PC

American journal of physiology. Lung cellular and molecular physiology.. 2003 February 284 (2):L368-75. Epub 10/11/2002.

Williams JP, Hernady E, Levitt M, Johnston C, Reed C, Okunieff P, Finkelstein JN.

Role of the recruited bone marrow-derived alveolar macrophage and the chemokine receptor, CCR2, in the development of pulmonary late radiation effects in a mouse

Endotoxin potentiates ozone-induced pulmonary chemokine and inflammatory responses.

Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN

Experimental lung research.. 2002 September 28 (6):419-33. Epub 1900 01 01.

Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families.

Johnston CJ, Williams JP, Okunieff P, Finkelstein JN

Radiation research.. 2002 March 157 (3):256-65. Epub 1900 01 01.

Radiation pneumonitis and early circulatory cytokine markers.

Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff P

Seminars in radiation oncology.. 2002 January 12 (1 Suppl 1):26-33. Epub 1900 01 01.

Transforming growth factor alpha (TGF(alpha)) is increased during hyperoxia and fibrosis.

Waheed S, D'Angio CT, Wagner CL, Madtes DK, Finkelstein JN, Paxhia A, Ryan RM

Experimental lung research.. 2002 28 (5):361-72. Epub 1900 01 01.

Comparison of tracheal aspirate and bronchoalveolar lavage specimens from premature infants.

D'Angio CT, Basavegowda K, Avissar NE, Finkelstein JN, Sinkin RA

Biology of the neonate.. 2002 82 (3):145-9. Epub 1900 01 01.

Recovery from oxidant-mediated lung injury: response of metallothionein, MIP-2, and MCP-1 to nitrogen dioxide, oxygen, and ozone exposures.

Johnston CJ, Oberdörster G, Finkelstein JN

Inhalation toxicology.. 2001 August 13 (8):689-702. Epub 1900 01 01.

The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress.

O'Reilly MA, Staversky RJ, Watkins RH, Reed CK, de Mesy Jensen KL, Finkelstein JN, Keng PC

American journal of respiratory cell and molecular biology.. 2001 June 24 (6):703-10. Epub 1900 01 01.

Pulmonary effects induced by ultrafine PTFE particles.

Johnston CJ, Finkelstein JN, Mercer P, Corson N, Gelein R, Oberdörster G

Toxicology and applied pharmacology.. 2000 November 1168 (3):208-15. Epub 1900 01 01.

Ozone, but not nitrogen dioxide, exposure decreases glutathione peroxidases in epithelial lining fluid of human lung.

Avissar NE, Reed CK, Cox C, Frampton MW, Finkelstein JN

American journal of respiratory and critical care medicine.. 2000 October 162 (4 Pt 1):1342-7. Epub 1900 01 01.

Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica.

Johnston CJ, Driscoll KE, Finkelstein JN, Baggs R, O'Reilly MA, Carter J, Gelein R, Oberdörster G

Toxicological sciences : an official journal of the Society of Toxicology.. 2000 August 56 (2):405-13. Epub 1900 01 01.

Acute pulmonary effects of ultrafine particles in rats and mice.

Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC

Research report. 2000 August (96):5-74; disc. 75-86. Epub 1900 01 01.

Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cells.

Chess PR, Toia L, Finkelstein JN

American journal of physiology. Lung cellular and molecular physiology.. 2000 July 279 (1):L43-51. Epub 1900 01 01.

Antioxidant and inflammatory response after acute nitrogen dioxide and ozone exposures in C57Bl/6 mice.

Johnston CJ, Reed CK, Avissar NE, Gelein R, Finkelstein JN

Inhalation toxicology.. 2000 March 12 (3):187-203. Epub 1900 01 01.

Newborn mice differ from adult mice in chemokine and cytokine expression to ozone, but not to endotoxin.

Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN

Inhalation toxicology.. 2000 March 12 (3):205-24. Epub 1900 01 01.

Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice.

Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G

Inhalation toxicology.. 2000 March 12 (3):225-43. Epub 1900 01 01.

Tumor necrosis factor-alpha-induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2.

Pryhuber GS, Huyck HL, Staversky RJ, Finkelstein JN, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2000 February 22 (2):150-6. Epub 1900 01 01.

Endotoxin priming affects the lung response to ultrafine particles and ozone in young and old rats

Elder ACP, Gelein R, Finkelstein JN, Cox C, Oberdorster G.

Inhal Tox. 2000; 12((Suppl 1)): 85-98.

Oxygen regulation of gene expression: a study in opposites.

D'Angio CT, Finkelstein JN

Molecular genetics and metabolism.. 2000 71 (1-2):371-80. Epub 1900 01 01.

Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin.

Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdörster G

Inhalation toxicology.. 2000 12 Suppl 4 :227-46. Epub 1900 01 01.

Silica binds serum proteins resulting in a shift of the dose-response for silica-induced chemokine expression in an alveolar type II cell line.

Barrett EG, Johnston C, Oberdörster G, Finkelstein JN

Toxicology and applied pharmacology.. 1999 December 1161 (2):111-22. Epub 1900 01 01.

Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia.

Wright TW, Gigliotti F, Finkelstein JN, McBride JT, An CL, Harmsen AG

The Journal of clinical investigation.. 1999 November 104 (9):1307-17. Epub 1900 01 01.

Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure.

Barrett EG, Johnston C, Oberdörster G, Finkelstein JN

Toxicology and applied pharmacology.. 1999 August 1158 (3):211-20. Epub 1900 01 01.

Chemokine gene expression during Pneumocystis carinii-driven pulmonary inflammation.

Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN

Infection and immunity.. 1999 July 67 (7):3452-60. Epub 1900 01 01.

Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha-induced oxidant stress.

Barrett EG, Johnston C, Oberdörster G, Finkelstein JN

The American journal of physiology.. 1999 June 276 (6):L979-88. Epub 1900 01 01.

Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung.

Charafeddine L, D'Angio CT, Richards JL, Stripp BR, Finkelstein JN, Orlowski CC, LoMonaco MB, Paxhia A, Ryan RM

American journal of physiology. Lung cellular and molecular physiology.. 1999 January 1276 (1):L105-L113. Epub 1900 01 01.

Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung.

Charafeddine L, D'Angio CT, Richards JL, Stripp BR, Finkelstein JN, Orlowski CC, LoMonaco MB, Paxhia A, Ryan RM

The American journal of physiology.. 1999 January 276 (1):L105-13. Epub 1900 01 01.

Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin.

Johnston CJ, Finkelstein JN, Oberdörster G, Reynolds SD, Stripp BR

Experimental lung research.. 1999 25 (1):7-21. Epub 1900 01 01.

Inflammatory and antioxidant gene expression in C57BL/6J mice after lethal and sublethal ozone exposures.

Johnston CJ, Stripp BR, Reynolds SD, Avissar NE, Reed CK, Finkelstein JN

Experimental lung research.. 1999 25 (1):81-97. Epub 1900 01 01.

Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-?.

Barrett EG, Johnston C, Oberdörster G, Finkelstein JN

American journal of physiology. Lung cellular and molecular physiology.. 1998 December 1275 (6):L1110-L1119. Epub 1900 01 01.

Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis.

Adawi A, Zhang Y, Baggs R, Rubin P, Williams J, Finkelstein J, Phipps RP

Clinical immunology and immunopathology.. 1998 December 89 (3):222-30. Epub 1900 01 01.

Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha.

Barrett EG, Johnston C, Oberdörster G, Finkelstein JN

The American journal of physiology.. 1998 December 275 (6):L1110-9. Epub 1900 01 01.

Pulmonary cytokine and chemokine mRNA levels after inhalation of lipopolysaccharide in C57BL/6 mice.

Johnston CJ, Finkelstein JN, Gelein R, Oberdörster G

Toxicological sciences : an official journal of the Society of Toxicology.. 1998 December 46 (2):300-7. Epub 1900 01 01.

Radiation-induced changes in bone perfusion and angiogenesis.

Okunieff P, Wang X, Rubin P, Finkelstein JN, Constine LS, Ding I

International journal of radiation oncology, biology, physics.. 1998 November 142 (4):885-9. Epub 1900 01 01.

Clara cell secretory protein deficiency increases oxidant stress response in conducting airways.

Mango GW, Johnston CJ, Reynolds SD, Finkelstein JN, Plopper CG, Stripp BR

American journal of physiology. Lung cellular and molecular physiology.. 1998 August 1275 (2):L348-L356. Epub 1900 01 01.

Clara cell secretory protein deficiency increases oxidant stress response in conducting airways.

Mango GW, Johnston CJ, Reynolds SD, Finkelstein JN, Plopper CG, Stripp BR

The American journal of physiology.. 1998 August 275 (2):L348-56. Epub 1900 01 01.

Cell-specific gene expression reveals changes in epithelial cell populations after bleomycin treatment.

Daly HE, Baecher-Allan CM, Paxhia AT, Ryan RM, Barth RK, Finkelstein JN

Laboratory investigation; a journal of technical methods and pathology.. 1998 April 78 (4):393-400. Epub 1900 01 01.

Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome.

Adawi A, Zhang Y, Baggs R, Finkelstein J, Phipps RP

The American journal of pathology.. 1998 March 152 (3):651-7. Epub 1900 01 01.

Exposure to hyperoxia induces p53 expression in mouse lung epithelium.

O'Reilly MA, Staversky RJ, Stripp BR, Finkelstein JN

American journal of respiratory cell and molecular biology.. 1998 January 18 (1):43-50. Epub 1900 01 01.

Ambient ultrafine particle: inducers of acute lung injury

Oberdoerster G, Gelein R, Johnston C, Mercer P, Corson N, Finkelstein JN.

Exp Tox Pathol. 1998; .

Pulmonary inflammatory responses and cytokine and antioxidant mRNA levels in the lungs of young and old C57BL/6 mice after exposure to teflon fumes.

Johnston CJ, Finkelstein JN, Gelein R, Oberdoerster G.

Inh Tox 10. 1998; 10((10)): 931-953.

H441 pulmonary epithelial cell mitogenic effects and signaling pathways in response to HGF and TGF-alpha.

Chess PR, Ryan RM, Finkelstein JN

Experimental lung research.. 1998 24 (1):27-39. Epub 1900 01 01.

Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury.

Johnston CJ, Stripp BR, Piedbeouf B, Wright TW, Mango GW, Reed CK, Finkelstein JN

Experimental lung research.. 1998 24 (2):189-202. Epub 1900 01 01.

Alterations in the expression of chemokine mRNA levels in fibrosis-resistant and -sensitive mice after thoracic irradiation.

Johnston CJ, Wright TW, Rubin P, Finkelstein JN

Experimental lung research.. 1998 24 (3):321-37. Epub 1900 01 01.

Chemokine mRNA alterations in newborn and adult mouse lung during acute hyperoxia.

D'Angio CT, Johnston CJ, Wright TW, Reed CK, Finkelstein JN

Experimental lung research.. 1998 24 (5):685-702. Epub 1900 01 01.

Analysis of cytokine mRNA profiles in the lungs of Pneumocystis carinii-infected mice.

Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN

American journal of respiratory cell and molecular biology.. 1997 October 17 (4):491-500. Epub 1900 01 01.

Particulate-cell interactions and pulmonary cytokine expression.

Finkelstein JN, Johnston C, Barrett T, Oberdörster G

Environmental health perspectives.. 1997 September 105 Suppl 5 (Suppl 5):1179-82. Epub 1900 01 01.

Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice.

Johnston CJ, Mango GW, Finkelstein JN, Stripp BR

American journal of respiratory cell and molecular biology.. 1997 August 17 (2):147-55. Epub 1900 01 01.

Changes in surfactant protein gene expression in a neonatal rabbit model of hyperoxia-induced fibrosis.

D'Angio CT, Finkelstein JN, Lomonaco MB, Paxhia A, Wright SA, Baggs RB, Notter RH, Ryan RM

The American journal of physiology.. 1997 April 272 (4 Pt 1):L720-30. Epub 1900 01 01.

Bleomycin induces strain-dependent alterations in the pattern of epithelial cell-specific marker expression in mouse lung.

Daly HE, Baecher-Allan CM, Barth RK, D'Angio CT, Finkelstein JN

Toxicology and applied pharmacology.. 1997 February 142 (2):303-10. Epub 1900 01 01.

Temporal changes in expression of TGF-beta isoforms in mouse lung exposed to oxygen.

O'Reilly MA, Staversky RJ, Flanders KC, Johnston CJ, Finkelstein JN

The American journal of physiology.. 1997 January 272 (1 Pt 1):L60-7. Epub 1900 01 01.

A flow cytometric assay of Fc receptor-mediated phagocytosis

Schurmann WHT, Frampton MW, Schurmann G, Roberts NJ, Nicols JE, Finkelstein JN, Oberdoerster G, Utell MJ.

J Aerosol Med. 1997; 10((1)): 1-11.

Comparison of adult and newborn pulmonary cytokine mRNA expression after hyperoxia.

Johnston CJ, Wright TW, Reed CK, Finkelstein JN

Experimental lung research.. 1997 23 (6):537-52. Epub 1900 01 01.

Characterization of the early pulmonary inflammatory response associated with PTFE fume exposure.

Johnston CJ, Finkelstein JN, Gelein R, Baggs R, Oberdörster G

Toxicology and applied pharmacology.. 1996 September 140 (1):154-63. Epub 1900 01 01.

Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation.

Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R, Finkelstein JN

Radiation research.. 1996 June 145 (6):762-7. Epub 1900 01 01.

Ultrafine particles as a potential environmental health hazard. Studies with model particles.

Oberdörster G, Finkelstein J, Ferin J, Godleski J, Chang LY, Gelein R, Johnston C, Crapo JD

Chest.. 1996 March 109 (3 Suppl):68S-69S. Epub 1900 01 01.

Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells.

Avissar N, Finkelstein JN, Horowitz S, Willey JC, Coy E, Frampton MW, Watkins RH, Khullar P, Xu YL, Cohen HJ

The American journal of physiology.. 1996 February 270 (2 Pt 1):L173-82. Epub 1900 01 01.

Relationship of lead-induced proteins to stress response proteins in astroglial cells.

Opanashuk LA, Finkelstein JN

Journal of neuroscience research.. 1995 December 42 (5):623-32. Epub 1900 01 01.

Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury.

Maniscalco WM, Watkins RH, Finkelstein JN, Campbell MH

American journal of respiratory cell and molecular biology.. 1995 October 13 (4):377-86. Epub 1900 01 01.

A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis.

Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN

International journal of radiation oncology, biology, physics.. 1995 August 3033 (1):99-109. Epub 1900 01 01.

Secretion of transforming growth factor-alpha (TGF alpha) by postnatal rabbit alveolar macrophages.

Wagner CL, Ryan RM, Forsythe DE, Keenan A, Finkelstein JN

Pediatric research.. 1995 July 38 (1):49-54. Epub 1900 01 01.

Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis.

Johnston CJ, Piedboeuf B, Baggs R, Rubin P, Finkelstein JN

Radiation research.. 1995 May 142 (2):197-203. Epub 1900 01 01.

Interleukin-8 and monocyte chemoattractant protein-1 mRNAs in oxygen-injured rabbit lung.

D'Angio CT, Sinkin RA, LoMonaco MB, Finkelstein JN

The American journal of physiology.. 1995 May 268 (5 Pt 1):L826-31. Epub 1900 01 01.

Induction of newly synthesized proteins in astroglial cells exposed to lead.

Opanashuk LA, Finkelstein JN

Toxicology and applied pharmacology.. 1995 March 131 (1):21-30. Epub 1900 01 01.

Cell-specific expression of fibronectin in adult and developing rabbit lung.

Sinkin RA, Sanders RS, Horowitz S, Finkelstein JN, Lomonaco MB

Pediatric research.. 1995 February 37 (2):189-95. Epub 1900 01 01.

Tyrosine kinase activity is necessary for growth factor-stimulated rabbit type II pneumocyte proliferation.

Chess PR, Ryan RM, Finkelstein JN

Pediatric research.. 1994 October 36 (4):481-6. Epub 1900 01 01.

Early alterations in extracellular matrix and transforming growth factor beta gene expression in mouse lung indicative of late radiation fibrosis.

Finkelstein JN, Johnston CJ, Baggs R, Rubin P

International journal of radiation oncology, biology, physics.. 1994 February 128 (3):621-31. Epub 1900 01 01.

Growth factors alter neonatal type II alveolar epithelial cell proliferation.

Ryan RM, Mineo-Kuhn MM, Kramer CM, Finkelstein JN

The American journal of physiology.. 1994 January 266 (1 Pt 1):L17-22. Epub 1900 01 01.

Time course of postnatal lead-induced changes in dopamine receptors and their relationship to changes in dopamine sensitivity.

Widzowski DV, Finkelstein JN, Pokora MJ, Cory-Slechta DA

Neurotoxicology.. 1994 15 (4):853-65. Epub 1900 01 01.

Pulmonary changes induced by combined mouse beta-interferon (rMuIFN-beta) and irradiation in normal mice--toxic versus protective effects.

McDonald S, Rubin P, Chang AY, Penney DP, Finkelstein JN, Grossberg S, Feins R, Gregory PK

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 1993 March 26 (3):212-8. Epub 1900 01 01.

Role of pulmonary blood flow in postpneumonectomy lung growth.

McBride JT, Kirchner KK, Russ G, Finkelstein J

Journal of applied physiology.. 1992 December 73 (6):2448-51. Epub 1900 01 01.

Increased fibronectin mRNA in alveolar macrophages following in vivo hyperoxia.

Sinkin RA, LoMonaco MB, Finkelstein JN, Watkins RH, Cox C, Horowitz S

American journal of respiratory cell and molecular biology.. 1992 November 7 (5):548-55. Epub 1900 01 01.

Cellular and molecular responses to lung injury in relation to induction of tissue repair and fibrosis.

Finkelstein JN, Horowitz S, Sinkin RA, Ryan RM

Clinics in perinatology.. 1992 September 19 (3):603-20. Epub 1900 01 01.

Role of the alveolar macrophage in lung injury: studies with ultrafine particles.

Oberdörster G, Ferin J, Gelein R, Soderholm SC, Finkelstein J

Environmental health perspectives.. 1992 July 97 :193-9. Epub 1900 01 01.

Alteration of Type II Pneumocyte Proliferation by Alveolar Macrophage-Derived Growth Factors

Brandes ME, Finkelstein JN.

Exp Cell Res (Suppl). 1992; 198: 321-327.

Alveolar Macrophage Production of Type II Cell Growth Modulators Following In Vivo Hyperoxia

Brandes ME, Finkelstein JN, Shapiro DL.

Exp Lung Res (Suppl). 1992; 18: 173-180.

Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: interrelationship between the alveolar macrophage and the septal fibroblast.

Rubin P, Finkelstein J, Shapiro D

International journal of radiation oncology, biology, physics.. 1992 24 (1):93-101. Epub 1900 01 01.

Thermal degradation events as health hazards: particle vs gas phase effects, mechanistic studies with particles.

Oberdörster G, Ferin J, Finkelstein J, Soderholm S

Acta astronautica.. 1992 27 :251-6. Epub 1900 01 01.

Temporal sequence of early alterations in rat lung following thoracic X-irradiation.

Lehnert BE, Dethloff LA, Finkelstein JN, van der Kogel AJ

International journal of radiation biology.. 1991 October 60 (4):657-75. Epub 1900 01 01.

Mechanisms of nitrogen dioxide toxicity in humans.

Utell MJ, Frampton MW, Roberts NJ, Finkelstein JN, Cox C, Morrow PE

Research report. 1991 August (43):1-33. Epub 1900 01 01.

The production of alveolar macrophage-derived growth-regulating proteins in response to lung injury.

Brandes ME, Finkelstein JN

Toxicology letters.. 1990 November 54 (1):3-22; discussion 1-2. Epub 1900 01 01.

Changes in gene expression in hyperoxia-induced neonatal lung injury.

Horowitz S, Shapiro DL, Finkelstein JN, Notter RH, Johnston CJ, Quible DJ

The American journal of physiology.. 1990 February 258 (2 Pt 1):L107-11. Epub 1900 01 01.

Increased pulmonary toxicity of ultrafine particles? II. Lung lavage studies

Oberdörster G, Ferin J, Finkelstein J, Wade P, Carson N.

J Aerosol Sci. 1990; 21: 384-391.

Physiologic and toxicologic responses of alveolar type II cells.

Finkelstein JN

Toxicology.. 1990 60 (1-2):41-52. Epub 1900 01 01.

Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans.

Frampton MW, Finkelstein JN, Roberts NJ, Smeglin AM, Morrow PE, Utell MJ

American journal of respiratory cell and molecular biology.. 1989 December 1 (6):499-505. Epub 1900 01 01.

Isolation of alveolar epithelial cells from lung tissue obtained at autopsy.

Shapiro DL, Finkelstein JN, Van Diver T

In vitro cellular & developmental biology : journal of the Tissue Culture Association.. 1989 November 25 (11):1051-4. Epub 1900 01 01.

Serum markers for prediction of pulmonary radiation syndromes. Part I: Surfactant apoprotein.

Rubin P, McDonald S, Maasilta P, Finkelstein JN, Shapiro DL, Penney D, Gregory PK

International journal of radiation oncology, biology, physics.. 1989 September 17 (3):553-8. Epub 1900 01 01.

Stimulated rabbit alveolar macrophages secrete a growth factor for type II pneumocytes.

Brandes ME, Finkelstein JN

American journal of respiratory cell and molecular biology.. 1989 August 1 (2):101-9. Epub 1900 01 01.

Effects of exogenous fatty acids and inhibition of de novo fatty acid synthesis on disaturated phosphatidylcholine production by fetal lung cells and adult type II cells.

Maniscalco WM, Finkelstein JN, Parkhurst AB

Experimental lung research.. 1989 May 15 (3):473-89. Epub 1900 01 01.

Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro.

Frampton MW, Smeglin AM, Roberts NJ, Finkelstein JN, Morrow PE, Utell MJ

Environmental research.. 1989 April 48 (2):179-92. Epub 1900 01 01.

Radiolabeling microsomes in vitro with Tritiated Alpha-Tocopherol

Robey-Bond SM, Mavis RD, Finkelstein JN.

Ann NY Acad Sci. 1989; 570: 511-513.

Membrane phospholipid methylation is associated with surfactant secretion in rabbit type II alveolar epithelial cells.

Hendricks-Muñoz KD, Finkelstein JN, Shapiro DL

Experimental lung research.. 1989 15 (1):63-76. Epub 1900 01 01.

Induction of the stress response by isolation of rabbit type II pneumocytes.

Brandes ME, Finkelstein JN

Experimental lung research.. 1989 15 (1):93-111. Epub 1900 01 01.

Type II pneumocyte changes during hyperoxic lung injury and recovery.

Holm BA, Matalon S, Finkelstein JN, Notter RH

Journal of applied physiology.. 1988 December 65 (6):2672-8. Epub 1900 01 01.

Increased axonal transport in the rat optic system after systemic exposure to methylmercury: differential effects in local vs systemic exposure conditions.

Aschner M, Rodier PM, Finkelstein JN

Brain research.. 1987 January 13401 (1):132-41. Epub 1900 01 01.

Inhibition of reaggregation of isolated cerebellar neurons by methylmercury and the kinetics of reversal by exogenous serum albumin

Jacobs AJ, Berg GG, Finkelstein JN.

In Vitro Toxicol. 1987; 1: 219-231.

Effects of methylmercuric chloride, cycloheximide, and colchicine on the reaggregation of dissociated mouse cerebellar cells.

Jacobs AJ, Maniscalco WM, Finkelstein JN

Toxicology and applied pharmacology.. 1986 December 86 (3):362-71. Epub 1900 01 01.

Reduction of axonal transport in the rat optic system after direct application of methylmercury.

Aschner M, Rodier PM, Finkelstein JN

Brain research.. 1986 September 3381 (2):244-50. Epub 1900 01 01.

A quantitative study of the development of type II pneumocytes in fetal lung.

Leary JF, Finkelstein JN, Notter RH, Shapiro DL

Cytometry.. 1986 September 7 (5):431-8. Epub 1900 01 01.

Predictive biochemical assays for late radiation effects.

Rubin P, Finkelstein JN, Siemann DW, Shapiro DL, Van Houtte P, Penney DP

International journal of radiation oncology, biology, physics.. 1986 April 12 (4):469-76. Epub 1900 01 01.

An examination of the oxidation of mercury vapor by rat brain homogenate.

Sichak SP, Mavis RD, Finkelstein JN, Clarkson TW

Journal of biochemical toxicology.. 1986 March 1 (1):53-68. Epub 1900 01 01.

Insulin receptors and insulin effects on type II alveolar epithelial cells.

Shapiro DL, Livingston JN, Maniscalco WM, Finkelstein JN

Biochimica et biophysica acta.. 1986 February 21885 (2):216-20. Epub 1900 01 01.

Adsorption of natural lung surfactant and phospholipid extracts related to tubular myelin formation.

Notter RH, Penney DP, Finkelstein JN, Shapiro DL

Pediatric research.. 1986 January 20 (1):97-101. Epub 1900 01 01.

In vivo and in vitro demonstration of reduced myelin synthesis following early postnatal exposure to ionizing radiation in the rat.

Jacobs AJ, Maniscalco WM, Parkhurst AB, Finkelstein JN

Radiation research.. 1986 January 105 (1):97-104. Epub 1900 01 01.

Dexamethasone increases de novo fatty acid synthesis in fetal rabbit lung explants.

Maniscalco WM, Finkelstein JN, Parkhurst AB

Pediatric research.. 1985 December 19 (12):1272-7. Epub 1900 01 01.

Surface property changes from interactions of albumin with natural lung surfactant and extracted lung lipids.

Holm BA, Notter RH, Finkelstein JN

Chemistry and physics of lipids.. 1985 September 38 (3):287-98. Epub 1900 01 01.

The effect of lateral mobility on the binding and reaction rate at membrane sites.

Finkelstein JN, Ghosh S

Physiological chemistry and physics and medical NMR. 1985 17 (1):77-9. Epub 1900 01 01.

Pulmonary surfactant: an interdisciplinary approach.

Notter RH, Finkelstein JN

Journal of applied physiology: respiratory, environmental and exercise physiology.. 1984 December 57 (6):1613-24. Epub 1900 01 01.

Lysophosphatidylcholine cell depolarization: increased membrane permeability for use in the determination of cell membrane potentials.

Gallo RL, Wersto RP, Notter RH, Finkelstein JN

Archives of biochemistry and biophysics.. 1984 December 235 (2):544-54. Epub 1900 01 01.

Monoclonal antibodies to surface antigens of rabbit type II pneumocytes.

Fraser CM, Venter JC, Finkelstein JN, Shapiro DL

The American review of respiratory disease.. 1984 September 130 (3):505-7. Epub 1900 01 01.

Characterization of the plasma and mitochondrial membrane potentials of alveolar type II cells by the use of ionic probes.

Gallo RL, Finkelstein JN, Notter RH

Biochimica et biophysica acta.. 1984 April 11771 (2):217-27. Epub 1900 01 01.

Arterial influx, efflux and tissue content of albumin in rabbits in vivo.

Brasch SP, Finkelstein JN, Makhani G, Ghosh S

Cardiovascular research.. 1984 April 18 (4):244-8. Epub 1900 01 01.

Radiation induced secretion of surfactant from cell cultures of type II pneumocytes: an in vitro model of radiation toxicity.

Shapiro DL, Finkelstein JN, Rubin P, Penney DP, Siemann DW

International journal of radiation oncology, biology, physics.. 1984 March 10 (3):375-8. Epub 1900 01 01.

Surfactant release as an early measure of radiation pneumonitis.

Rubin P, Siemann DW, Shapiro DL, Finkelstein JN, Penney DP

International journal of radiation oncology, biology, physics.. 1983 November 9 (11):1669-73. Epub 1900 01 01.

Comparative adsorption of natural lung surfactant, extracted phospholipids, and artificial phospholipid mixtures to the air-water interface.

Notter RH, Finkelstein JN, Taubold RD

Chemistry and physics of lipids.. 1983 July 33 (1):67-80. Epub 1900 01 01.

Properties of freshly isolated type II alveolar epithelial cells.

Finkelstein JN, Maniscalco WM, Shapiro DL

Biochimica et biophysica acta.. 1983 June 2762 (3):398-404. Epub 1900 01 01.

De novo fatty acid synthesis by freshly isolated alveolar type II epithelial cells.

Maniscalco WM, Finkelstein JN, Parkhurst AB

Biochimica et biophysica acta.. 1983 May 16751 (3):462-9. Epub 1900 01 01.

Changes in phospholipid biosynthetic enzymes in type II cells and alveolar macrophages isolated from rat lungs after NO2 exposure.

Wright ES, Vang MJ, Finkelstein JN, Mavis RD

Toxicology and applied pharmacology.. 1982 November 66 (2):305-11. Epub 1900 01 01.

Path dependence of adsorption behavior of mixtures containing dipalmitoyl phosphatidylcholine.

Notter RH, Smith S, Taubold RD, Finkelstein JN

Pediatric research.. 1982 July 16 (7):515-9. Epub 1900 01 01.

Sequential effects of irradiation on the pulmonary surfactant system.

Shapiro DL, Finkelstein JN, Penney DP, Siemann DW, Rubin P

International journal of radiation oncology, biology, physics.. 1982 May 8 (5):879-82. Epub 1900 01 01.

De novo fatty acid synthesis in developing rat lung.

Maniscalco WM, Finkelstein JN, Parkhurst AB

Biochimica et biophysica acta.. 1982 April 15711 (1):49-58. Epub 1900 01 01.

Isolation of type II pneumocytes by laser flow cytometry.

Leary JF, Finkelstein JN, Notter RH, Shapiro DL

The American review of respiratory disease.. 1982 March 125 (3):326-30. Epub 1900 01 01.

Isolation of type II alveolar epithelial cells using low protease concentrations.

Finkelstein JN, Shapiro DL

Lung.. 1982 160 (2):85-98. Epub 1900 01 01.

Newborn tracheal aspirate cytology: classification during respiratory distress syndrome and bronchopulmonary dysplasia.

Merritt TA, Stuard ID, Puccia J, Wood B, Edwards DK, Finkelstein J, Shapiro DL

The Journal of pediatrics.. 1981 June 98 (6):949-56. Epub 1900 01 01.

Effects of radiation on the mouse lung and potential induction of radiation pneumonitis

Penney DP, Shapiro DL, Rubin P, Finkelstein JN, Siemann DW.

Virchows Archiv of Cell Pathol. 1981; 37: 327-336.

The early release of surfactant following lung irradiation of alveolar type II cells.

Rubin P, Shapiro DL, Finklestein JN, Penney DP

International journal of radiation oncology, biology, physics.. 1980 January 6 (1):75-7. Epub 1900 01 01.

Biochemical evidence for internal proteolytic damage during isolation of type II alveolar epithelial cells.

Finkelstein JN, Mavis RD

Lung.. 1979 156 (4):243-54. Epub 1900 01 01.

Pulmonary surfactant synthesis. A highly active microsomal phosphatidate phosphohydrolase in the lung.

Mavis RD, Finkelstein JN, Hall BP

Journal of lipid research.. 1978 May 19 (4):467-77. Epub 1900 01 01.

Treatment of an unusual adolescent bed-wetting behavior by covert sensitization. A case study.

Finkelstein JN, Carlin AS

Journal of the American Academy of Child Psychiatry.. 1977 16 (1):159-64. Epub 1900 01 01.

Kinetic analysis of in vivo lipoprotein flux in the normal rabbit aorta

Finkelstein JN, Ghosh S, Schweppe JS.

Artery. 1976; 2: 161-173.

Evaluation of the permeability parameters (influx, efflux and volume of distribution) of arterial wall for LDL and other proteins.

Ghosh S, Finkelstein JN, Moss DB, Schweppe JS

Advances in experimental medicine and biology.. 1976 67 (00):191-204. Epub 1900 01 01.

Studies on the binding of 1-anilino-8-naphthalene sulfonate to very low density and high density himan serum lipoproteins.

Basu MK, Finkelstein JN, Ghosh S, Schweppe JS

Biochimica et biophysica acta.. 1975 September 19398 (3):385-93. Epub 1900 01 01.

Books

Lung Injury: Mechanisms, Pathophysiology, and Therapy (2005)

Chapter: Cell and animal models of lung injury

Authors: Finkelstein JN, O'Reilly M, Holm BA, Chess PR, Notter RH

Publisher: Taylor & Francis Group, Boca Raton, FL 2005

Lung Injury: Mechanisms, Pathophysiology, and Therapy (2005)

Chapter: Surfactant replacement therapy in lung injury.

Authors: Chess PR, Finkelstein JN, Holm BA, Notter RH

Publisher: Taylor & Francis Group, Boca Raton, FL 2005

Lung Injury: Mechanisms, Pathophysiology, and Therapy (2005)

Chapter: Combined-modality therapies for lung Injury

Authors: Pryhuber GS, D'Angio CT, Finkelstein JN, Notter RH

Publisher: Taylor & Francis Group, Boca Raton, FL 2005

Particle-Lung Interactions (2000)

Chapter: Alterations in gene expression in pulmonary cells following particle interactions

Authors: Finkelstein JN, Barrett EG

Publisher: Marcel Dekker, Inc., New York, NY 2000

Current Radiation Oncology (1998)

Chapter: Radiation pathophysiology of late effects in normal tissues: molecular vs. Classic concepts

Authors: Rubin P, Finkelstein JN, Williams JP

Publisher: Arnold, London, UK 1998

Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract (1994)

Chapter: Cell-cell Interactions and the role of epithelial cells in the pulmonary response to particulate injury

Authors: Finkelstein JN

Publisher: ILSI Press, Washington, DC 1994

Vitro Biological Systems (1993)

Chapter: Isolation and Culture of Type II Alveolar Epithelial Cells

Authors: Finkelstein JN

Publisher: Academic Press 1993

Signal Transduction in Lung Cells (1993)

Chapter: Growth Factors and Pulmonary Epithelia

Authors: Ryan RM, Finkelstein JN

Publisher: Marcel Dekker, New York, NY 1993

Aerosols, Science, Industry, Health and Environment (1990)

Chapter: Mechanistic studies on particle-induced acute and chronic lung injury

Authors: Oberdörster G, Ferin J, Finkelstein J, Soderholm S, Gelein R

Publisher: BPCC Wheatons Ltd, Exeter, UK 1990