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Robert H. Notter, M.D., Ph.D.

Robert H. Notter, M.D., Ph.D.

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About Me

Robert H. Notter, M.D. (1980, with distinction in research, University of Rochester)
Ph.D. (1969, Chemical Engineering, University of Washington)
M.S. (1965, Chemical Engineering, Stanford University)
B.S. (1964, Chemical Engineering, Stanford University)

Professor of Pediatrics and...
Robert H. Notter, M.D. (1980, with distinction in research, University of Rochester)
Ph.D. (1969, Chemical Engineering, University of Washington)
M.S. (1965, Chemical Engineering, Stanford University)
B.S. (1964, Chemical Engineering, Stanford University)

Professor of Pediatrics and Environmental Medicine, University of Rochester (1989-present)

Past positions:
Professor of Chemical Engineering, University of Rochester (1983-2003)
Professor of Biomedical Engineering, University of Rochester (2001-2004)
Director of Research, Division of Neonatology, University of Rochester (1990-2000) Director of University-wide Program in Biomedical Engineering, University of Rochester (1984-1995)

Research awards:
*Health Leadership Award in Research, March of Dimes (2005)
*Two time principal investigator and program director for National Institutes of Health (NIH) Special Center of Research (SCOR) in Lung Biology and Disease in Infants and Children at Rochester (1989-1997)
*Research Career Development Award, National Heart, Lung, Blood Institute (NHLBI) of NIH (1981-1986)
*Principal investigator of multiple individual NIH RO1 research grants on lung surfactant activity, inhibition and replacement (1980-present)
*NIH young investigator award, NHLBI (1975-1976)
*NIH Postdoctoral Fellowship award in Bioengineering (1969-1971)
*American Society for Testing Materials (ASTM) research award, Stanford University (1964)
*NSF undergraduate research award, Stanford University (1962)

Teaching awards: Outstanding Teacher in the College of Engineering, Penn State University (1976)

Other activities:
*Associate Editor, American Journal of Physiology: Lung Cellular and Molecular Biology (1997)
*Member of NIH Working Group on Lung Development (1992)
*Elected to Perinatal Research Society, Society for Pediatric Research, Sigma Xi, Tau Beta Pi
*Author of over 250 scientific papers and abstracts, plus the book Lung Surfactants: Basic Science and Clinical Applications (Marcel Dekker, 2000)
*Senior editor of Lung Injury: Mechanisms, Pathophysiology, and Therapy (Taylor Francis, 2005)
*Co-editor of Surfactant Replacement Therapy (Wiley Interscience, 1989)

Research interests:
Pulmonary surfactant; bioengineering; lung injury
Molecular Biophysics of Phospholipids and Proteins
Biomedical Engineering

Faculty Appointments

Professor Emeritus - Department of Pediatrics, Neonatology (SMD)

Professor Emeritus - Department of Environmental Medicine (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Bioengineering Postdoctoral Fellowship, NIH (NHLBI), University of Washington, Seattle, WA 1969 - 1971

Education

MD | University of Rochester School of Medicine and Dentistry. Medicine. 1980

PhD | University of Washington. Chemical Engineering. 1969

MS | Stanford University. Chemical Engineering. 1965

BS | Stanford University. Chemical Engineering. 1964

Awards

Health Leadership Award in Research. 2005

Two time NIH Pulmonary SCOR Director (NHLBI). 1989 - 1997

Elected to Perinatal Research Society. 1985

Research Career Development Award, National Lung Institute. 1981 - 1986

Above the 95th percentile for total NIH research funding over the 25 year period 1980 - 2005.. 1980 - 2005

Distinction in MD Research, University of Rochester School of Medicine. 1980

Outstanding Teacher in College of Engineering, Penn State University, PA. 1975 - 1976

NIH Young Investigator (National Lung Institute). 1975 - 1977

Outstanding Senior Chemical Engineer, Stanford University. 1964

American Society for Testing Materials Award, Stanford University. 1964

NSF Undergraduate Research Award, Stanford University. 1962 - 1963

Research

Research in the Notter laboratory focuses on lung surfactant, a complex mixture of lipids and proteins that is essential for normal respiratory function. Lung surfactant deficiency in premature infants leads to the neonatal respiratory distress syndrome (NRDS), and surfactant dysfunction (inhibition...
Research in the Notter laboratory focuses on lung surfactant, a complex mixture of lipids and proteins that is essential for normal respiratory function. Lung surfactant deficiency in premature infants leads to the neonatal respiratory distress syndrome (NRDS), and surfactant dysfunction (inhibition, inactivation) is important in the pathology of clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) that occur in patients of all ages. The prevalent and lethal syndromes of ALI/ARDS can result from direct pulmonary insults like viral or bacterial pneumonia, gastric or meconium aspiration, lung contusion, hyperoxia, lung transplant, or radiation pneumonitis or from indirect extra-pulmonary causes like sepsis, shock, burn injury, long bone fracture, pancreatitis, or bone marrow transplant. A major focus of our on-going NIH-funded multi-university collaborative research is on developing new highly-active synthetic exogenous surfactants for treating NRDS and direct pulmonary forms of ALI/ARDS. This includes basic and translational NIH Bioengineering Research Partnership (BRP) studies on the molecular design and biophysics of novel amphipathic peptides having structural homology to active surfactant proteins (SP) like SP-B, and the surface and pulmonary activity of synthetic surfactants containing these peptides combined with novel phospholipase-resistant lipids or synthetic biologic lipids. Also studied is the use of exogenous surfactants not just to reverse surfactant dysfunction in ALI/ARDS, but also to deliver added pharmacologic agents or exogenous DNA to concurrently target other aspects of the complex pathology of ALI/ARDS (edema, vascular dysfunction, inflammation). Our research at Rochester over the past three decades helped to develop clinically-significant first-generation surfactant therapy for premature infants with animal-derived drugs, and this is now being extended using sophisticated bioengineering principles to define new fully-synthetic lung surfactants for treating NRDS and direct pulmonary forms of ALI/ARDS.

Patents

Synthetic Lung Surfactants and Use Thereof

Issue date: October 22, 2013

Patent #: 8,563,683

Country: United States

Inventors: Jason A Davy, Larry M Gordon, Robert H Notter, Adrian Schwan, Frans J Walther, Zhengdong Wang, Zhongyi Wang, Alan J Waring

Synthetic Lung Surfactants and Use Thereof

Issue date: February 13, 2018

Patent #: 2,658,478

Country: Canada

Inventors: Robert H Notter, Adrian Schwan, Zhengdong Wang, Zhongyi Wang

Synthetic Lung Surfactants and Use Thereof

Issue date: September 20, 2016

Patent #: 9,447,127

Country: United States

Inventors: Jason A Davy, Larry M Gordon, Robert H Notter, Adrian Schwan, Frans J Walther, Zhengdong Wang, Zhongyi Wang, Alan J Waring

Novel SP-B and SP-C Peptides, Synthetic Lung Surfactants, and Use Thereof

Issue date: December 05, 2018

Patent #: 2812018

Country: Europe

Inventors: Larry M Gordon, Robert H Notter, Frans J Walther, Zhengdong Wang, Alan J Waring

SP-B and SP-C Peptiedes, Synthetic Lung Surfactants, and Use Thereof

Issue date: November 14, 2017

Patent #: 9,815,869

Country: United States

Inventors: Larry M Gordon, Robert H Notter, Frans J Walther, Zhengdong Wang, Alan J Waring

Novel SP-B and SP-C Peptides, Synthetic Lung Surfactants, and Use Thereof

Issue date: December 05, 2018

Patent #: FR2812018

Country: France

Inventors: Larry M Gordon, Robert H Notter, Frans J Walther, Zhengdong Wang, Alan J Waring

Novel SP-B and SP-C Peptides, Synthetic Lung Surfactants, and Use Thereof

Issue date: December 05, 2018

Patent #: 602013047786.8

Country: Germany

Inventors: Larry M Gordon, Robert H Notter, Frans J Walther, Zhengdong Wang, Alan J Waring

Novel SP-B and SP-C Peptides, Synthetic Lung Surfactants, and Use Thereof

Issue date: December 05, 2018

Patent #: GB2812018

Country: United Kingdom

Inventors: Larry M Gordon, Robert H Notter, Frans J Walther, Zhengdong Wang, Alan J Waring

Novel SP-B and SP-C Peptides, Synthetic Lung Surfactants, and Use Thereof

Issue date: July 23, 2019

Patent #: 10,358,465

Country: United States

Inventors: Larry M Gordon, Robert H Notter, Frans J Walther, Alan J Waring

Publications

Journal Articles

Exogenous surfactant in the pediatric patient.

Willson, D; Egan, EA; Notter, RH.

Pediatric and Neonatal Mechanical Ventilation, Rimensberger PC (Ed.): Springer-Verlag. 2011; .

Surfactant therapy of ALI/ARDS.

Raghavendran, KR; Willson, D; Notter, RH.

Crit Care Clin. 2011; .

New Horizons. The future of exogenous surfactant therapy.

Willson,D; Notter, RH.

J Respir Care. 2011; .

Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs.

Walther FJ, Waring AJ, Hernandez-Juviel JM, Gordon LM, Wang Z, Jung CL, Ruchala P, Clark AP, Smith WM, Sharma S, Notter RH

PloS one.. 2010 January 135 (1):e8672. Epub 01/13/2010.

Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity.

Yee M, Chess PR, McGrath-Morrow SA, Wang Z, Gelein R, Zhou R, Dean DA, Notter RH, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2009 October 297 (4):L641-9. Epub 07/17/2009.

Lung contusion: inflammatory mechanisms and interaction with other injuries.

Raghavendran K, Notter RH, Davidson BA, Helinski JD, Kunkel SL, Knight PR

Shock.. 2009 August 32 (2):122-30. Epub 1900 01 01.

Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion.

Raghavendran K, Davidson BA, Huebschmann JC, Helinski JD, Hutson AD, Dayton MT, Notter RH, Knight PR

The Journal of surgical research.. 2009 August 155 (2):273-82. Epub 09/16/2008.

Transcriptional responses of Mycobacterium tuberculosis to lung surfactant.

Schwab U, Rohde KH, Wang Z, Chess PR, Notter RH, Russell DG

Microbial pathogenesis.. 2009 April 46 (4):185-93. Epub 01/14/2009.

Predictive modeling and inflammatory biomarkers in rats with lung contusion and gastric aspiration.

Raghavendran K; Davidson BA, Hutson AD; Helinski JD; Nodzo SR; Notter RH; Knight PR.

J Trauma.2009; Dec;67(6):1182-90. 2009; .

Surfactant dysfunction in lung contusion with and without superimposed gastric aspiration in a rat model.

Raghavendran K, Davidson BA, Knight PR, Wang Z, Helinski J, Chess PR, Notter RH

Shock.. 2008 November 30 (5):508-17. Epub 1900 01 01.

Peripheral cell wall lipids of Mycobacterium tuberculosis are inhibitory to surfactant function.

Wang Z, Schwab U, Rhoades E, Chess PR, Russell DG, Notter RH

Tuberculosis.. 2008 May 88 (3):178-86. Epub 12/21/2007.

Surfactant for pediatric acute lung injury.

Willson, DF.; Chess, PR,; Notter, RH.

Pediatr Clin N Am. 2008; : Jun;55:545-575.

Pharmacotherapy of acute lung injury and acute respiratory distress syndrome.

Raghavendran K, Pryhuber GS, Chess PR, Davidson BA, Knight PR, Notter RH

Current medicinal chemistry.. 2008 15 (19):1911-24. Epub 1900 01 01.

Activity and inhibition resistance of a phospholipase-resistant synthetic surfactant in rat lungs.

Wang Z, Chang Y, Schwan AL, Notter RH

American journal of respiratory cell and molecular biology.. 2007 October 37 (4):387-94. Epub 06/07/2007.

Capsule and O-antigen from an extraintestinal isolate of Escherichia coli modulate cytokine levels in rat macrophages in vitro and in a rat model of pneumonia.

Russo TA, Davidson BA, Beanan JM, Olson R, Holm BA, Notter RH, Knight PR

Experimental lung research.. 2007 September 33 (7):337-56. Epub 1900 01 01.

Novel phospholipase-resistant lipid/peptide synthetic lung surfactants.

Notter RH, Schwan AL, Wang Z, Waring AJ

Mini reviews in medicinal chemistry.. 2007 September 7 (9):932-44. Epub 1900 01 01.

Surfactant dysfunction and lung injury due to the E. coli virulence factor hemolysin in a rat pneumonia model.

Russo TA, Wang Z, Davidson BA, Genagon SA, Beanan JM, Olson R, Holm BA, Knight PR, Chess PR, Notter RH

American journal of physiology. Lung cellular and molecular physiology.. 2007 March 292 (3):L632-43. Epub 1900 01 01.

Synthesis and surface activity of diether-linked phosphoglycerols: potential applications for exogenous lung surfactants.

Notter RH, Wang Z, Wang Z, Davy JA, Schwan AL

Bioorganic & medicinal chemistry letters.. 2007 January 117 (1):113-7. Epub 09/30/2006.

Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection.

Hickman-Davis JM, Wang Z, Fierro-Perez GA, Chess PR, Page GP, Matalon S, Notter RH

American journal of respiratory cell and molecular biology.. 2007 January 36 (1):103-13. Epub 08/17/2006.

Surfactant dysfunction and lung injury due to the E. colil virulence factor hemolysin in a rat pneumonia model.

Russo, T.; Wang, Z.; Davidson, B.; Genagon, S.; Beanan, J.; Olsen, R.; Holm, B.; Knight, P.; Chess, P.; Notter, R.

Am J Physiol. 2007; 292: L632-L643.

Synthesis of sulfur-containing glycerophospholipids.

Davy, J.; Wang, Z.; Notter, RH.; Schwan, AL.

J Sulfur Chem. 2007; 28: 45-72.

Dynamic surface activity of a fully-synthetic phospholipase-resistant lipid/peptide lung surfactant.

Walther, F.; Waring, A.; Hernandez-Juviel, J.; Gordon, L.; Schwan, A.; Chang, Y.; Wang, Z.; Notter, R.

Dynamic surface activity of a fully-synthetic phospholipase-resistant lipid/peptide lung surfactant. 2007; 2(10): 1-10: e1039. doi:10.1371.

Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells.

Bruckner L, Gigliotti F, Wright T, Harmsen A, Notter RH, Chess P, Wang Z, Finkelstein J

American journal of physiology. Lung cellular and molecular physiology.. 2006 June 290 (6):L1087-96. Epub 01/06/2006.

Statistical prediction of the type of gastric aspiration lung injury based on early cytokine/chemokine profiles.

Hutson AD, Davidson BA, Raghavendran K, Chess PR, Tait AR, Holm BA, Notter RH, Knight PR

Anesthesiology.. 2006 January 104 (1):73-9. Epub 1900 01 01.

A rat model for isolated bilateral lung contusion from blunt chest trauma.

Raghavendran K, Davidson BA, Helinski JD, Marschke CJ, Manderscheid P, Woytash JA, Notter RH, Knight PR

Anesthesia and analgesia.. 2005 November 101 (5):1482-1489. Epub 1900 01 01.

Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins.

Chang Y, Wang Z, Schwan AL, Wang Z, Holm BA, Baatz JE, Notter RH

Chemistry and physics of lipids.. 2005 October 137 (1-2):77-93. Epub 1900 01 01.

The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses.

Raghavendran K, Davidson BA, Woytash JA, Helinski JD, Marschke CJ, Manderscheid PA, Notter RH, Knight PR

Shock.. 2005 August 24 (2):132-8. Epub 1900 01 01.

Acid and particulate-induced aspiration lung injury in mice: importance of MCP-1.

Raghavendran K, Davidson BA, Mullan BA, Hutson AD, Russo TA, Manderscheid PA, Woytash JA, Holm BA, Notter RH, Knight PR

American journal of physiology. Lung cellular and molecular physiology.. 2005 July 289 (1):L134-43. Epub 03/18/2005.

Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitro.

Wang Z, Foye A, Chang Y, Chess PR, Wright TW, Bhagwat S, Gigliotti F, Notter RH

American journal of physiology. Lung cellular and molecular physiology.. 2005 June 288 (6):L1124-31. Epub 1900 01 01.

Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates.

Davidson BA, Knight PR, Wang Z, Chess PR, Holm BA, Russo TA, Hutson A, Notter RH

American journal of physiology. Lung cellular and molecular physiology.. 2005 April 288 (4):L699-708. Epub 1900 01 01.

Discrimination of resident and infiltrated alveolar macrophages by flow cytometry in influenza A virus-infected mice.

Davidson BA, Stewart CC, Russo TA, Chess PR, Knight PR

Experimental lung research.. 2005 April 31 (3):323-39. Epub 1900 01 01.

Structure and properties of phospholipid-peptide monolayers containing monomeric SP-B(1-25) I. Phases and morphology by epifluorescence microscopy.

Biswas N, Shanmukh S, Waring AJ, Walther F, Wang Z, Chang Y, Notter RH, Dluhy RA

Biophysical chemistry.. 2005 March 1113 (3):223-32. Epub 1900 01 01.

Structure and properties of phospholipid-peptide monolayers containing monomeric SP-B(1-25) II. Peptide conformation by infrared spectroscopy.

Shanmukh S, Biswas N, Waring AJ, Walther FJ, Wang Z, Chang Y, Notter RH, Dluhy RA

Biophysical chemistry.. 2005 March 1113 (3):233-44. Epub 1900 01 01.

Host-bacterial interactions in the lungs in the perioperative period

Raghavendran K, Manderscheid PA, Notter RH, Knight PR.

Res Signpost: Recent Res Develop Microbiol. 2005; 9: 159-181.

Acute inflammatory gastric aspiration-related lung injury

Raghavendran K, Davidson BA, Chess PR, Nader N, Notter RH, Knight PR.

Current Respir Med Rev. 2005; 1: 279-290.

Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate.

Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G

Experimental lung research.. 2005 31 (6):527-46. Epub 1900 01 01.

Synthesis and interfacial behavior of sulfur-containing analogs of lung surfactant dipalmitoyl phosphatidylcholine.

Chang Y, Wang Z, Notter RH, Wang Z, Qu L, Schwan AL

Bioorganic & medicinal chemistry letters.. 2004 December 2014 (24):5983-6. Epub 1900 01 01.

TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia.

Wright TW, Pryhuber GS, Chess PR, Wang Z, Notter RH, Gigliotti F

The Journal of immunology : official journal of the American Association of Immunologists.. 2004 February 15172 (4):2511-21. Epub 1900 01 01.

Basic science research on clinical exogenous surfactants: composition, activity, viscosity, and utility in lung injury

Notter RH, Holm BA.

Neonatal Intensive Care. 2004; 17((Suppl)): S3-S7.

Efficient depletion of alveolar macrophages using intratracheally-inhaled aerosols of liposome-encapsulated clodronate

Elder ACP, Gelein R, Finkelstein J, Wang Z, Notter RH, Oberdoerster G.

Experimental Lung Res. 2004; 30((2)): 105-120.

Alternative Strategies for Dispensing Exogenous Surfactant: Drug Cost Implications and In Vitro Feasibility Studies

Stevens TP, Sinkin RA, Notter RH, Wang Z, Consenstein L, Maniscalco WM.

Hospital Pharmacy. 2004; 39: 338-345.

Progressive, severe lung injury secondary to the interaction of insults in gastric aspiration.

Knight PR, Davidson BA, Nader ND, Helinski JD, Marschke CJ, Russo TA, Hutson AD, Notter RH, Holm BA

Experimental lung research.. 2004 30 (7):535-57. Epub 1900 01 01.

Surface activity of a synthetic lung surfactant containing a phospholipase-resistant phosphonolipid analog of dipalmitoyl phosphatidylcholine.

Wang Z, Schwan AL, Lairson LL, O'Donnell JS, Byrne GF, Foye A, Holm BA, Notter RH

American journal of physiology. Lung cellular and molecular physiology.. 2003 September 285 (3):L550-9. Epub 1900 01 01.

Effect of hydrophobic surfactant proteins SP-B and SP-C on binary phospholipid monolayers: II. Infrared external reflectance-absorption spectroscopy.

Brockman JM, Wang Z, Notter RH, Dluhy RA

Biophysical journal.. 2003 January 84 (1):326-40. Epub 1900 01 01.

Content-dependent activity of lung surfactant protein B in mixtures with lipids.

Wang Z, Baatz JE, Holm BA, Notter RH

American journal of physiology. Lung cellular and molecular physiology.. 2002 November 283 (5):L897-906. Epub 1900 01 01.

Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia.

Russo TA, Bartholomew LA, Davidson BA, Helinski JD, Carlino UB, Knight PR, Beers MF, Atochina EN, Notter RH, Holm BA

American journal of physiology. Lung cellular and molecular physiology.. 2002 September 283 (3):L655-63. Epub 1900 01 01.

Bulk shear viscosities of endogenous and exogenous lung surfactants.

King DM, Wang Z, Palmer HJ, Holm BA, Notter RH

American journal of physiology. Lung cellular and molecular physiology.. 2002 February 282 (2):L277-84. Epub 1900 01 01.

Component-specific surface and physiological activity in bovine-derived lung surfactants.

Notter RH, Wang Z, Egan EA, Holm BA

Chemistry and physics of lipids.. 2002 January 114 (1):21-34. Epub 1900 01 01.

High-yield purification of lung surfactant proteins sp-b and sp-c and the effects on surface activity.

Baatz JE, Zou Y, Cox JT, Wang Z, Notter RH

Protein expression and purification.. 2001 October 23 (1):180-90. Epub 1900 01 01.

Concentration-dependent, temperature-dependent non-Newtonian viscosity of lung surfactant dispersions.

King DM, Wang Z, Kendig JW, Palmer HJ, Holm BA, Notter RH

Chemistry and physics of lipids.. 2001 July 112 (1):11-9. Epub 1900 01 01.

Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia.

Wright TW, Notter RH, Wang Z, Harmsen AG, Gigliotti F

Infection and immunity.. 2001 February 69 (2):758-64. Epub 1900 01 01.

Combined-modality therapy with inhaled nitric oxide and exogenous surfactant in term infants with acute respiratory failure.

Uy IP, Pryhuber GS, Chess PR, Notter RH

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2000 October 1 (2):107-10. Epub 1900 01 01.

Acid aspiration increases sensitivity to increased ambient oxygen concentrations.

Knight PR, Kurek C, Davidson BA, Nader ND, Patel A, Sokolowski J, Notter RH, Holm BA

American journal of physiology. Lung cellular and molecular physiology.. 2000 June 278 (6):L1240-7. Epub 1900 01 01.

Surfactant therapy and its potential use with other agents in term neonates, children, and adults with acute lung injury

Notter RH, Apostolakos M, Holm BA, Willson D, Wang Z, Finkelstein JN, Hyde RW.

Perspectives Neonatol. 2000; 1((4)): 4-20.

Function and dysfunction of endogenous and exogenous lung surfactants

Notter RH, Wang Z, Holm BA.

Res Advances Lipids. 2000; 1: 73-105.

The reaction of thiolates with 2,3-dibromo-1-propanol revisited: application to the synthesis of bis(fattyalkylthio)propanols.

Gernon MD, Turcotte JG, Notter RH, Mu M, Lear Y, Snelgrove JL, Schwan AL

Chemistry and physics of lipids.. 1999 September 101 (2):215-22. Epub 1900 01 01.

Effect of hydrophobic surfactant peptides SP-B and SP-C on binary phospholipid monolayers. I. Fluorescence and dark-field microscopy.

Krüger P, Schalke M, Wang Z, Notter RH, Dluhy RA, Lösche M

Biophysical journal.. 1999 August 77 (2):903-14. Epub 1900 01 01.

Multiple mechanisms of lung surfactant inhibition.

Holm BA, Wang Z, Notter RH

Pediatric research.. 1999 July 46 (1):85-93. Epub 1900 01 01.

Additivity of protein and nonprotein inhibitors of lung surfactant activity.

Wang Z, Notter RH

American journal of respiratory and critical care medicine.. 1998 July 158 (1):28-35. Epub 1900 01 01.

Comparison of two strategies for surfactant prophylaxis in very premature infants: a multicenter randomized trial.

Kendig JW, Ryan RM, Sinkin RA, Maniscalco WM, Notter RH, Guillet R, Cox C, Dweck HS, Horgan MJ, Reubens LJ, Risemberg H, Phelps DL

Pediatrics.. 1998 June 101 (6):1006-12. Epub 1900 01 01.

Primary importance of zwitterionic over anionic phospholipids in the surface-active function of calf lung surfactant extract.

Wang Z, Gurel O, Weinbach S, Notter RH

American journal of respiratory and critical care medicine.. 1997 October 156 (4 Pt 1):1049-57. Epub 1900 01 01.

Changes in surfactant protein gene expression in a neonatal rabbit model of hyperoxia-induced fibrosis.

D'Angio CT, Finkelstein JN, Lomonaco MB, Paxhia A, Wright SA, Baggs RB, Notter RH, Ryan RM

The American journal of physiology.. 1997 April 272 (4 Pt 1):L720-30. Epub 1900 01 01.

Pulmonary surfactant: Physical chemistry, physiology, and replacement

Notter RH, Wang Z.

Rev Chem Engin. 1997; 13: 1-118.

Acylation of pulmonary surfactant protein-C is required for its optimal surface active interactions with phospholipids.

Wang Z, Gurel O, Baatz JE, Notter RH

The Journal of biological chemistry.. 1996 August 9271 (32):19104-9. Epub 1900 01 01.

Differential activity and lack of synergy of lung surfactant proteins SP-B and SP-C in interactions with phospholipids.

Wang Z, Gurel O, Baatz JE, Notter RH

Journal of lipid research.. 1996 August 37 (8):1749-60. Epub 1900 01 01.

Content of dipalmitoyl phosphatidylcholine in lung surfactant: ramifications for surface activity.

Holm BA, Wang Z, Egan EA, Notter RH

Pediatric research.. 1996 May 39 (5):805-11. Epub 1900 01 01.

Roles of different hydrophobic constituents in the adsorption of pulmonary surfactant.

Wang Z, Hall SB, Notter RH

Journal of lipid research.. 1996 April 37 (4):790-8. Epub 1900 01 01.

Dynamic surface activity of films of lung surfactant phospholipids, hydrophobic proteins, and neutral lipids.

Wang Z, Hall SB, Notter RH

Journal of lipid research.. 1995 June 36 (6):1283-93. Epub 1900 01 01.

Bilayer characteristics of a diether phosphonolipid analog of the major lung surfactant glycerophospholipid dipalmitoyl phosphatidylcholine.

Skita V, Chester DW, Oliver CJ, Turcotte JG, Notter RH

Journal of lipid research.. 1995 May 36 (5):1116-27. Epub 1900 01 01.

Thermotropic behavior of structurally-related phospholipids and phosphonolipid analogs of lung surfactant glycerophospholipids

Liu H, Turcotte JG, Notter RH.

Langmuir. 1995; 11: 101-107.

FTIR studies of calcium-dependent molecular order in lung surfactant and surfactant extract dispersions

Ge Z, Brown CW, Turcotte JG, Wang Z, Notter RH.

J Colloid Interface Sci. 1995; 173: 471-477.

In vivo function of surfactants containing phosphatidylcholine analogs.

Dizon-Co L, Ikegami M, Ueda T, Jobe AH, Lin WH, Turcotte JG, Notter RH, Rider ED

American journal of respiratory and critical care medicine.. 1994 October 150 (4):918-23. Epub 1900 01 01.

Separation of subfractions of the hydrophobic components of calf lung surfactant.

Hall SB, Wang Z, Notter RH

Journal of lipid research.. 1994 August 35 (8):1386-94. Epub 1900 01 01.

Changes in subphase aggregates in rabbits injured by free fatty acid.

Hall SB, Hyde RW, Notter RH

American journal of respiratory and critical care medicine.. 1994 May 149 (5):1099-106. Epub 1900 01 01.

Dynamic interfacial properties of surface-excess films of phospholipid and phosphonolipid analogs: I. Effects of pH

Liu H, Lu Z, Turcotte JG, Notter RH.

J Colloid Interface Sci. 1994; 167: 378-390.

Dynamic interfacial properties of surface-excess films of phospholipid and phosphonolipid analogs: II. Effects of chain linkage and headgroup structure

Liu H, Turcotte JG, Notter RH.

J Colloid Interface Sci. 1994; 167: 391-400.

Approximations in the measurement of surface tension on the oscillating bubble surfactometer.

Hall SB, Bermel MS, Ko YT, Palmer HJ, Enhorning G, Notter RH

Journal of applied physiology.. 1993 July 75 (1):468-77. Epub 1900 01 01.

High-frequency jet ventilation and surfactant treatment of newborns with severe respiratory failure.

Davis JM, Richter SE, Kendig JW, Notter RH

Pediatric pulmonology.. 1992 June 13 (2):108-12. Epub 1900 01 01.

Inhibition of pulmonary surfactant by oleic acid: mechanisms and characteristics.

Hall SB, Lu RZ, Venkitaraman AR, Hyde RW, Notter RH

Journal of applied physiology.. 1992 May 72 (5):1708-16. Epub 1900 01 01.

Importance of hydrophobic apoproteins as constituents of clinical exogenous surfactants.

Hall SB, Venkitaraman AR, Whitsett JA, Holm BA, Notter RH

The American review of respiratory disease.. 1992 January 145 (1):24-30. Epub 1900 01 01.

Differential scanning calorimetry studies of phosphonolipid analogs of lung surfactant phospholipids

Lu RZ, Turcotte JG, Lin WH, Steim JM, Notter RH.

J Colloid Interface Sci. 1992; : 24-34.

Chemical synthesis and surface activity of lung surfactant phospholipid analogs. II. Racemic N-substituted diether phosphonolipids.

Turcotte JG, Lin WH, Pivarnik PE, Sacco AM, Shirali SS, Bermel MM, Lu Z, Notter RH

Biochimica et biophysica acta.. 1991 June 191084 (1):1-12. Epub 1900 01 01.

A comparison of surfactant as immediate prophylaxis and as rescue therapy in newborns of less than 30 weeks' gestation.

Kendig JW, Notter RH, Cox C, Reubens LJ, Davis JM, Maniscalco WM, Sinkin RA, Bartoletti A, Dweck HS, Horgan MJ

The New England journal of medicine.. 1991 March 28324 (13):865-71. Epub 1900 01 01.

Surfactant treatment of full-term newborns with respiratory failure.

Auten RL, Notter RH, Kendig JW, Davis JM, Shapiro DL

Pediatrics.. 1991 January 87 (1):101-7. Epub 1900 01 01.

Chemical synthesis and surface activity of lung surfactant phospholipid analogs. III. Chiral N-substituted ether-amide phosphonolipids.

Turcotte JG, Lin WH, Motola NC, Pivarnik PE, Bhongle NN, Heyman HR, Shirali SS, Lu Z, Notter RH

Chemistry and physics of lipids.. 1991 58 (1-2):81-95. Epub 1900 01 01.

Biophysical inhibition of synthetic phospholipid-lung surfactant apoprotein admixtures by plasma proteins.

Venkitaraman AR, Baatz JE, Whitsett JA, Hall SB, Notter RH

Chemistry and physics of lipids.. 1991 57 (1):49-57. Epub 1900 01 01.

Enhancement of biophysical activity of lung surfactant extracts and phospholipid-apoprotein mixtures by surfactant protein A.

Venkitaraman AR, Hall SB, Whitsett JA, Notter RH

Chemistry and physics of lipids.. 1990 December 56 (2-3):185-94. Epub 1900 01 01.

Altered function of pulmonary surfactant in fatty acid lung injury.

Hall SB, Notter RH, Smith RJ, Hyde RW

Journal of applied physiology.. 1990 September 69 (3):1143-9. Epub 1900 01 01.

Relationships among surfactant fraction lipids, proteins and biophysical properties in the developing rat lung.

Farrell PM, Bourbon JR, Notter RH, Marin L, Nogee LM, Whitsett JA

Biochimica et biophysica acta.. 1990 May 11044 (1):84-90. Epub 1900 01 01.

Early pulmonary changes associated with high-frequency jet ventilation in newborn piglets.

Davis JM, Metlay LA, Dickerson B, Penney DP, Notter RH

Pediatric research.. 1990 May 27 (5):460-5. Epub 1900 01 01.

Hydrophobic homopolymeric peptides enhance the biophysical activity of synthetic lung phospholipids.

Venkitaraman AR, Hall SB, Notter RH

Chemistry and physics of lipids.. 1990 March 53 (2-3):157-64. Epub 1900 01 01.

Changes in gene expression in hyperoxia-induced neonatal lung injury.

Horowitz S, Shapiro DL, Finkelstein JN, Notter RH, Johnston CJ, Quible DJ

The American journal of physiology.. 1990 February 258 (2 Pt 1):L107-11. Epub 1900 01 01.

Biophysical inhibition of synthetic lung surfactants.

Holm BA, Venkitaraman AR, Enhorning G, Notter RH

Chemistry and physics of lipids.. 1990 February 52 (3-4):243-50. Epub 1900 01 01.

Lung injury in the neonatal piglet caused by hyperoxia and mechanical ventilation.

Davis JM, Penney DP, Notter RH, Metlay L, Dickerson B, Shapiro DL

Journal of applied physiology.. 1989 September 67 (3):1007-12. Epub 1900 01 01.

Hyperoxic exposure alters gene expression in the lung. Induction of the tissue inhibitor of metalloproteinases mRNA and other mRNAs.

Horowitz S, Dafni N, Shapiro DL, Holm BA, Notter RH, Quible DJ

The Journal of biological chemistry.. 1989 May 5264 (13):7092-5. Epub 1900 01 01.

Alveolar hyperoxic injury in rabbits receiving exogenous surfactant.

Loewen GM, Holm BA, Milanowski L, Wild LM, Notter RH, Matalon S

Journal of applied physiology.. 1989 March 66 (3):1087-92. Epub 1900 01 01.

Controversies regarding surfactant replacement therapy.

Shapiro DL, Notter RH

Clinics in perinatology.. 1988 December 15 (4):891-902. Epub 1900 01 01.

Fetal cerebral responses to ventilation and oxygenation in utero.

Gleason CA, Jones MD, Traystman RJ, Notter RH

The American journal of physiology.. 1988 December 255 (6 Pt 2):R1049-54. Epub 1900 01 01.

Type II pneumocyte changes during hyperoxic lung injury and recovery.

Holm BA, Matalon S, Finkelstein JN, Notter RH

Journal of applied physiology.. 1988 December 65 (6):2672-8. Epub 1900 01 01.

Surfactant replacement therapy at birth: final analysis of a clinical trial and comparisons with similar trials.

Kendig JW, Notter RH, Cox C, Aschner JL, Benn S, Bernstein RM, Hendricks-Munoz K, Maniscalco WM, Metlay LA, Phelps DL

Pediatrics.. 1988 November 82 (5):756-62. Epub 1900 01 01.

A biophysical mechanism by which plasma proteins inhibit lung surfactant activity.

Holm BA, Enhorning G, Notter RH

Chemistry and physics of lipids.. 1988 November 49 (1-2):49-55. Epub 1900 01 01.

Changes in pulmonary mechanics after the administration of surfactant to infants with respiratory distress syndrome.

Davis JM, Veness-Meehan K, Notter RH, Bhutani VK, Kendig JW, Shapiro DL

The New England journal of medicine.. 1988 August 25319 (8):476-9. Epub 1900 01 01.

Biophysical behavior of lung surfactant: implications for respiratory physiology and pathophysiology.

Notter RH

Seminars in perinatology.. 1988 July 12 (3):180-212. Epub 1900 01 01.

Sublethal hyperoxic injury to the alveolar epithelium and the pulmonary surfactant system.

Matalon S, Holm BA, Loewen GM, Baker RR, Notter RH

Experimental lung research.. 1988 14 Suppl :1021-33. Epub 1900 01 01.

Exogenous lung surfactant: effect on radiographic appearance in premature infants.

Wood BP, Sinkin RA, Kendig JW, Notter RH, Shapiro DL

Radiology.. 1987 October 165 (1):11-3. Epub 1900 01 01.

Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity.

Holm BA, Notter RH

Journal of applied physiology.. 1987 October 63 (4):1434-42. Epub 1900 01 01.

Lung surfactants for replacement therapy: biochemical, biophysical, and clinical aspects.

Notter RH, Shapiro DL

Clinics in perinatology.. 1987 September 14 (3):433-79. Epub 1900 01 01.

Biophysical activity of synthetic phospholipids combined with purified lung surfactant 6000 dalton apoprotein.

Notter RH, Shapiro DL, Ohning B, Whitsett JA

Chemistry and physics of lipids.. 1987 June 44 (1):1-17. Epub 1900 01 01.

Alveolar epithelial changes in rabbits after a 21-day exposure to 60% O2.

Holm BA, Notter RH, Leary JF, Matalon S

Journal of applied physiology.. 1987 June 62 (6):2230-6. Epub 1900 01 01.

Mitigation of pulmonary hyperoxic injury by administration of exogenous surfactant.

Matalon S, Holm BA, Notter RH

Journal of applied physiology.. 1987 February 62 (2):756-61. Epub 1900 01 01.

Interfacial properties of arabinofuranosylcytosine diphosphate diacylglycerol, a synthetic liponucleotide

Bermel MS, Turcotte JG, Steim J, Notter RH.

J Colloid Interface Sci. 1987; 115: 167-175.

Expedient and high-yield synthesis of alkylphosphonyl dichlorides under mild, neutral conditions: reaction of bis (trimethylsilyl) alkyl phosphonates with oxalyl chloride/dimethylformamide

Bhongle NN, Notter RH, Turcotte JG.

Synthetic Comm. 1987; 17: 1071-1076.

The effect of lipid emulsions on neonatal and adult blood viscosity

Deluga KD, Cokelet GR, Notter RH, Shapiro DL.

J Clin Hemorheol. 1987; 7: 793-802.

Phospholipid binding and biophysical activity of pulmonary surfactant-associated protein (SAP)-35 and its non-collagenous COOH-terminal domains.

Ross GF, Notter RH, Meuth J, Whitsett JA

The Journal of biological chemistry.. 1986 October 25261 (30):14283-91. Epub 1900 01 01.

A quantitative study of the development of type II pneumocytes in fetal lung.

Leary JF, Finkelstein JN, Notter RH, Shapiro DL

Cytometry.. 1986 September 7 (5):431-8. Epub 1900 01 01.

Hydrophobic surfactant-associated protein in whole lung surfactant and its importance for biophysical activity in lung surfactant extracts used for replacement therapy.

Whitsett JA, Ohning BL, Ross G, Meuth J, Weaver T, Holm BA, Shapiro DL, Notter RH

Pediatric research.. 1986 May 20 (5):460-7. Epub 1900 01 01.

Adsorption of natural lung surfactant and phospholipid extracts related to tubular myelin formation.

Notter RH, Penney DP, Finkelstein JN, Shapiro DL

Pediatric research.. 1986 January 20 (1):97-101. Epub 1900 01 01.

Pulmonary physiological and surfactant changes during injury and recovery from hyperoxia.

Holm BA, Notter RH, Siegle J, Matalon S

Journal of applied physiology.. 1985 November 59 (5):1402-9. Epub 1900 01 01.

Double-blind clinical trial of calf lung surfactant extract for the prevention of hyaline membrane disease in extremely premature infants.

Kwong MS, Egan EA, Notter RH, Shapiro DL

Pediatrics.. 1985 October 76 (4):585-92. Epub 1900 01 01.

Double-blind, randomized trial of a calf lung surfactant extract administered at birth to very premature infants for prevention of respiratory distress syndrome.

Shapiro DL, Notter RH, Morin FC, Deluga KS, Golub LM, Sinkin RA, Weiss KI, Cox C

Pediatrics.. 1985 October 76 (4):593-9. Epub 1900 01 01.

Surface property changes from interactions of albumin with natural lung surfactant and extracted lung lipids.

Holm BA, Notter RH, Finkelstein JN

Chemistry and physics of lipids.. 1985 September 38 (3):287-98. Epub 1900 01 01.

Lung surfactant replacement in premature lambs with extracted lipids from bovine lung lavage: effects of dose, dispersion technique, and gestational age.

Notter RH, Egan EA, Kwong MS, Holm BA, Shapiro DL

Pediatric research.. 1985 June 19 (6):569-77. Epub 1900 01 01.

Size stability of phosphatidylcholine-phosphatidylglycerol aerosols and a dynamic film compression state from their interfacial impaction

Wojciak JF, Oberdoerster G, Notter RH.

J Colloid Interface Sci. 1985; 106: 547-557.

Pulmonary surfactant: an interdisciplinary approach.

Notter RH, Finkelstein JN

Journal of applied physiology: respiratory, environmental and exercise physiology.. 1984 December 57 (6):1613-24. Epub 1900 01 01.

Lysophosphatidylcholine cell depolarization: increased membrane permeability for use in the determination of cell membrane potentials.

Gallo RL, Wersto RP, Notter RH, Finkelstein JN

Archives of biochemistry and biophysics.. 1984 December 235 (2):544-54. Epub 1900 01 01.

Characterization of the plasma and mitochondrial membrane potentials of alveolar type II cells by the use of ionic probes.

Gallo RL, Finkelstein JN, Notter RH

Biochimica et biophysica acta.. 1984 April 11771 (2):217-27. Epub 1900 01 01.

Lavaged excised rat lungs as a model of surfactant deficiency.

Bermel MS, McBride JT, Notter RH

Lung.. 1984 162 (2):99-113. Epub 1900 01 01.

Natural and artificial lung surfactant replacement therapy in premature lambs.

Egan EA, Notter RH, Kwong MS, Shapiro DL

Journal of applied physiology: respiratory, environmental and exercise physiology.. 1983 September 55 (3):875-83. Epub 1900 01 01.

Ultrasonic and jet aerosolization of phospholipids and the effects on surface activity.

Marks LB, Notter RH, Oberdorster G, McBride JT

Pediatric research.. 1983 September 17 (9):742-7. Epub 1900 01 01.

Comparative adsorption of natural lung surfactant, extracted phospholipids, and artificial phospholipid mixtures to the air-water interface.

Notter RH, Finkelstein JN, Taubold RD

Chemistry and physics of lipids.. 1983 July 33 (1):67-80. Epub 1900 01 01.

Generation and characterization of aerosols of dispersed surface-active phospholipids by ultrasonic and jet nebulization

Marks LB, Oberdoerster G, Notter RH.

J Aerosol Sci. 1983; 14: 783-794.

Path dependence of adsorption behavior of mixtures containing dipalmitoyl phosphatidylcholine.

Notter RH, Smith S, Taubold RD, Finkelstein JN

Pediatric research.. 1982 July 16 (7):515-9. Epub 1900 01 01.

Hysteresis in saturated phospholipid films and its potential relevance for lung surfactant function in vivo.

Notter RH, Taubold R, Mavis RD

Experimental lung research.. 1982 May 3 (2):109-27. Epub 1900 01 01.

Isolation of type II pneumocytes by laser flow cytometry.

Leary JF, Finkelstein JN, Notter RH, Shapiro DL

The American review of respiratory disease.. 1982 March 125 (3):326-30. Epub 1900 01 01.

Bilirubin interactions with phospholipid components of lung surfactant.

Notter RH, Shapiro DL, Taubold R, Chen J

Pediatric research.. 1982 February 16 (2):130-6. Epub 1900 01 01.

Lung surfactant in an era of replacement therapy.

Notter RH, Shapiro DL

Pediatrics.. 1981 December 68 (6):781-9. Epub 1900 01 01.

Surface properties of binary mixtures of some pulmonary surfactant components.

Notter RH, Tabak SA, Mavis RD

Journal of lipid research.. 1980 January 21 (1):10-22. Epub 1900 01 01.

Post-collapse dynamic surface pressure relaxation in binary surface films containing dipalmitoyl phosphatidylcholine

Notter RH, Tabak SA, Holcomb S, Mavis R.

J Colloid Interface Sci. 1980; 74: 370-377.

Dynamic surface properties of phosphatidylglycerol-dipalmitoyl phosphatidylcholine mixed films

Notter RH, Holcomb S, Mavis RD.

Chem Phys Lipids. 1980; 27: 305-319.

Surfactant composition in hyaline-membrane disease.

Notter RH

The New England journal of medicine.. 1979 September 13301 (11):612-3. Epub 1900 01 01.

Steady non-ionic countergradient transport through membranes by coupled diffusion

Notter RH, Tam YM, Min S.

A.I.Ch.E. Journal. 1979; 25: 469-478.

Chemical synthesis and surface properties of an analog of the pulmonary surfactant dipalmitoyl phosphatidylcholine.

Turcotte JG, Sacco AM, Steim JM, Tabak SA, Notter RH

Biochimica et biophysica acta.. 1977 August 24488 (2):235-48. Epub 1900 01 01.

Effect of plasma proteins on the dynamic pi-A characteristics of saturated phospholipid films

Tabak SA, Notter RH.

J Colloid Interface Sci. 1977; : 293-300.

Relaxation effects in the surface pressure behavior of dipalmitoyl lecithin

Tabak SA, Notter RH, Ultman JS, Dinh S.

J Colloid Interface Sci. 1977; 60: 117-125.

A modified technique for dynamic surface pressure and relaxation measurements at the air-water interface

Tabak SA, Notter RH.

Rev Sci Instruments. 1977; 48: 1196-1201.

An interferometric technique for the study of steady-state membrane transport

Min S, Duda JL, Notter RH, Vrentas JS.

AIChE Journal. 1976; : 175-182.

Pulmonary surfactant: a surface chemistry viewpoint.

Notter RH, Morrow PE

Annals of biomedical engineering.. 1975 June 3 (2):119-59. Epub 1900 01 01.

Diffusivity ratios in fully developed turbulent flow

Notter RH, Sleicher CA.

AIChE Journal. 1975; 21: 169-170.

Analysis of two-dimensional diffusion controlled moving boundary problems

Duda JL, Malone M, Notter RH, Vrentas JS.

1975; 18: 901-910.

Temperature and eddy diffusivity profiles in NaK

Sleicher CA, Awad AS, Notter RH.

Int J Heat Mass Trans. 1973; 16: 1565-1575.

Transport resistance of dipalmitoyl and rat lung lecithin films

Notter RH, Berg JC.

J Colloid Interface Sci. 1973; : 421-424.

A solution to the turbulent Graetz problem by matched asymptotic expansions - III. Fully developed and entry region heat transfer rates

Notter RH, Sleicher CA.

Chem Engr Sci. 1972; 27: 2073-2093.

The eddy diffusivity in the turbulent boundary layer near a wall

Notter RH, Sleicher CA.

Chem Engr Sci. 1971; 26: 161-171.

A solution to the turbulent Graetz problem by matched asymptotic expansions - II. The case of uniform wall heat flux

Notter RH, Sleicher CA.

Chem Engr Sci. 1971; 26: 559-565.

Normal momentum transfer on ideal crystalline surfaces

Notter RH, Sather NF.

AIAA Journal. 1971; 9: 965-966.

A solution to the turbulent Graetz problem by matched asymptotic expansions - I. The case of uniform wall temperature.

Sleicher, C.A.; Notter, R.H.; Crippen, M.

Chem Engr Sci. 1970; 25:: 845-857.

A molecular model for tangential momentum accommodation

Notter RH, Kaku YJ, Sather NF.

AIAA Journal. 1970; 8: 2064-2066.

The limiting form of the eddy diffusivity close to a wall.

Notter, R.H.; Sleicher, C.A.

AIChE Journal. 1969; : 936-939.

Books

Encyclopedia of Biomaterials and Biomedical Engineering, Vol. 3, 2nd Edition (2008)

Chapter: Informa Healthcare, pp. 1683-1694

Authors: Notter RH, Wang Z

Publisher: Wnek GE, Bowlin GL (Eds) 2008

Pediatric Critical Care Medicine: Basic Science and Clinical Evidence (2007)

Chapter: Pulmonary surfactant: Biology and therapy

Authors: Willson DF, Chess PR, Wang Z, Notter RH

Publisher: Springer-Verlag, London, England 2007

Encyclopedia of Respiratory Medicine (2006)

Chapter: Lung surfactant: An overview

Authors: Notter RH, Wang Z, Chess PR

Publisher: Elsevier Publishers, Oxford, England 2006

Lung Injury: Mechanisms, Pathophysiology, and Therapy (2005)

Authors: Notter RH, Finkelstein JN, Holm BA (editors)

Publisher: Taylor & Francis Group, Boca Raton, FL 2005

Lung Injury: Mechanisms, Pathophysiology, and Therapy (2005)

Chapter: Surfactant activity and dysfunction in lung injury

Authors: Wang Z, Holm BA, Matalon S, Notter RH

Publisher: Taylor & Francis Group, Boca Raton, FL 2005

Lung Injury: Mechanisms, Pathophysiology, and Therapy (2005)

Chapter: Cell and animal models of lung injury

Authors: Finkelstein JN, O'Reilly M, Holm BA, Chess PR, Notter RH

Publisher: Taylor & Francis Group, Boca Raton, FL 2005

Lung Injury: Mechanisms, Pathophysiology, and Therapy (2005)

Chapter: Surfactant replacement therapy in lung injury

Authors: Chess PR, Finkelstein JN, Holm BA, Notter RH

Publisher: Taylor & Francis Group, Boca Raton, FL 2005

Lung Injury: Mechanisms, Pathophysiology, and Therapy (2005)

Chapter: Combined-modality therapies for lung injury

Authors: Pryhuber GS, D'Angio CT, Finkelstein JN, Notter RH

Publisher: Taylor & Francis Group, Boca Raton, FL 2005

Encyclopedia of Biomaterials and Biomedical Engineering (2004)

Chapter: Lung surfactants

Authors: Notter RH, Wang Z

Publisher: Marcel Dekker, Inc., New York, NY 2004

Enhorning Roundtable in Lung Research: (2002)

Chapter: Current Issues in Surfactant Replacement Therapy

Authors: Notter RH, Holm BA (editors)

Publisher: Dannemiller Memorial Educational Foundation and MedPro Communications 2002

Enhorning Roundtable in Lung Research: Current Issues in Surfactant Replacement (2002)

Chapter: Inhibition of lung surfactants and the importance of SP-B in inhibition resistance

Authors: Holm BA, Wang Z, Notter RH

Publisher: Dannemiller Memorial Educational Foundation and MedPro Communications 2002

Lung surfactants: Basic science and clinical applications (2000)

Authors: Notter RH

Publisher: Marcel Dekker, New York, NY 2000

Lung surfactants: Basic science and clinical applications (2000)

Authors: Notter RH

Publisher: Marcel Dekker, New York, NY 2000

New therapies for neonatal respiratory failure: A physiologic approach (1994)

Chapter: Lung surfactant replacement for neonatal pathology other than primary respiratory distress syndrome

Authors: Davis JM, Notter RH

Publisher: Cambridge University Press, New York, NY 1994

Surfactant replacement therapy (1989)

Authors: Shapiro DL, Notter RH (editors)

Publisher: AR Liss, Inc., New York, NY 1989

Surfactant and the respiratory tract (1989)

Chapter: The inhibition of surfactant function by plasma-derived protein

Authors: Holm BA, Enhorning G, Notter RH

Publisher: Elsevier, The Netherlands 1989

Surfactant replacement therapy (1989)

Chapter: The physical chemistry and physiological activity of pulmonary surfactants

Authors: Notter RH

Publisher: AR Liss, Inc., New York, NY 1989

Surfactant replacement therapy (1989)

Chapter: Clinical experience with calf lung surfactant extract

Authors: Kendig JW, Notter RH, Maniscalco WM, Davis JM, Shapiro DL

Publisher: AR Liss, Inc., New York, NY 1989

Surfactant replacement therapy (1989)

Chapter: Surfactant therapy in ARDS and lung injury

Authors: Holm BA, Notter RH

Publisher: AR Liss, Inc., New York, NY 1989

Surfactant treatment of lung diseases (1988)

Chapter: Animal models for testing surfactants

Authors: Holm BA, Notter RH

Publisher: Ross Laboratories Press, Columbus, OH 1988

Surfactant replacement therapy in neonatal and adult respiratory distress syndro (1988)

Chapter: Multicenter randomized trial of surfactant replacement with calf lung surfactant extract (CLSE): Effects of pre- and post-ventilatory instillation and of multiple doses

Authors: Kendig JW, Notter RH, Davis J, Bartoletti A, Dweck HS, Risenberg HM, Cox C, Shapiro DL

Publisher: Springer-Verlag, Berlin, Germany 1988

Surfactant replacement therapy in neonatal and adult respiratory distress syndro (1988)

Chapter: Pulmonary surfactant effects and replacement in oxygen toxicity and other ARDS-type lung injuries

Authors: Holm BA, Notter RH

Publisher: Springer-Verlag, Berlin, Germany 1988

Physiology of the fetal and neonatal lung (1987)

Chapter: Adsorption of fetal lung liquid and exogenous surfactant in premature lambs

Authors: Egan EA, Kwong MS, Notter RH

Publisher: MTP Press, Ltd., Lancaster, England 1987

Oxygen radicals (1986)

Chapter: Pulmonary surfactant effects in sublethal hyperoxic lung injury

Authors: Holm BA, Notter RH

Publisher: APS Press, Bethesda, MD 1986

CHEMI Modules (1986)

Chapter: Biomedical examples of transport phenomena: Coupled diffusion effects

Authors: Notter RH

Publisher: A.I.Ch.E. Press, New York, NY 1986

CHEMI Modules (1986)

Chapter: Biomedical examples of transport phenomena: facilitated diffusion

Authors: Notter RH

Publisher: A.I.Ch.E. Press, New York, NY 1986

Aerosols: science, technology, and industrial applications of airborne particles (1984)

Chapter: Dynamic surface tension lowering by impaction of ultrasonically produced phospholipid aerosols at the air-water interface

Authors: Wojciak JJ, Notter RH, Oberdoerster G

Publisher: Elsevier, The Netherlands 1984

Pulmonary surfactant (1984)

Chapter: Surface chemistry of pulmonary surfactant: Role of individual components

Authors: Notter RH

Publisher: Elsevier, The Netherlands 1984

are included in the Publications Section (1984)

Authors: Scientific peer-reviewed book chapters

Publisher: - present 1984