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Shirley Joseph, Ph.D.

Shirley Joseph, Ph.D.

About Me

Faculty Appointments

Professor Emeritus - Department of Neurosurgery (SMD)

Credentials

Education

PhD | Univ Rochester Sch Med/Dent. Neuroanatomy. 1967

BA | Edgecliff College. Pre-Medical. 1961

Publications

Journal Articles

Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures.

Joseph SA, Lynd-Balta E, O'Banion MK, Rappold PM, Daschner J, Allen A, Padowski J

Neuroscience.. 2006 July 7140 (3):1051-65. Epub 05/04/2006.

P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain.

Rappold PM, Lynd-Balta E, Joseph SA

Brain research.. 2006 May 171089 (1):171-8. Epub 04/25/2006.

CA3 axonal sprouting in kainate-induced chronic epilepsy.

Siddiqui AH, Joseph SA

Brain research.. 2005 December 201066 (1-2):129-46. Epub 1900 01 01.

AMPA receptor alterations precede mossy fiber sprouting in young children with temporal lobe epilepsy.

Lynd-Balta E, Pilcher WH, Joseph SA

Neuroscience.. 2004 126 (1):105-14. Epub 1900 01 01.

Reciprocal circuits involved in nitroglycerin-induced neuronal activation of autonomic regions and pain pathways: a double immunolabeling and tract-tracing study.

Tassorelli C, Joseph SA, Nappi G

Brain research.. 1999 September 25842 (2):294-310. Epub 1900 01 01.

Localization of corticotropin-releasing factor in primary and secondary lymphoid organs of the rat.

Brouxhon,S. M.; Prasad,A. V.; Joseph,S. A.; Felten,D. L.; Bellinger,D. L.;.

Brain, Behavior, & Immunity. 1998; 12(2): 107-122.

Systemic administration of ephedrine induces Fos protein expression in caudate putamen and subthalamic nucleus of rats.

Blandini F, Joseph SA, Tassorelli C

Functional neurology.. 1997 12 (5):293-6. Epub 1900 01 01.

Adrenocorticotropic hormone immunoreactivity in the hippocampal formation of temporal lobe epilepsy patients.

Lynd-Balta E, Pilcher WH, Joseph SA

Epilepsia.. 1996 November 37 (11):1081-7. Epub 1900 01 01.

Distribution of AMPA receptor subunits in the hippocampal formation of temporal lobe epilepsy patients.

Lynd-Balta E, Pilcher WH, Joseph SA

Neuroscience.. 1996 May 72 (1):15-29. Epub 1900 01 01.

Systemic nitroglycerin activates peptidergic and catecholaminergic pathways in rat brain.

Tassorelli C, Joseph SA

Peptides.. 1996 17 (3):443-9. Epub 1900 01 01.

NF-kappa B transcription factor subunits in rat brain: colocalization of p65 and alpha-MSH.

Joseph SA, Tassorelli C, Prasad AV, Lynd-Balta E

Peptides.. 1996 17 (4):655-64. Epub 1900 01 01.

NADPH-diaphorase activity and Fos expression in brain nuclei following nitroglycerin administration.

Tassorelli C, Joseph SA

Brain research.. 1995 October 9695 (1):37-44. Epub 1900 01 01.

Systemic nitroglycerin induces Fos immunoreactivity in brainstem and forebrain structures of the rat.

Tassorelli C, Joseph SA

Brain research.. 1995 June 5682 (1-2):167-81. Epub 1900 01 01.

Nuclear factor-kappa B in rat brain: enhanced DNA-binding activity following convulsant-induced seizures.

Prasad AV, Pilcher WH, Joseph SA

Neuroscience letters.. 1994 March 28170 (1):145-8. Epub 1900 01 01.

Efferents of the opiocortin-containing region of the commissural nucleus tractus solitarius.

Sim LJ, Joseph SA

Peptides.. 1994 January 15 (1):169-74. Epub 1900 01 01.

Dorsal raphe nucleus efferents: termination in peptidergic fields.

Sim LJ, Joseph SA

Peptides.. 1993 14 (1):75-83. Epub 1900 01 01.

ACTH1-39 inputs to mesocorticolimbic dopaminergic neurons: light and electron microscopic examination.

Liang CL, Kozlowski GP, Joseph SA, German DC

Neuroscience letters.. 1992 October 26146 (1):79-83. Epub 1900 01 01.

Efferent projections of the nucleus raphe magnus.

Sim LJ, Joseph SA

Brain research bulletin.. 1992 May 28 (5):679-82. Epub 1900 01 01.

Serotonin and substance P afferents to parafascicular and central medial nuclei.

Sim LJ, Joseph SA

Peptides.. 1992 13 (1):171-6. Epub 1900 01 01.

Arcuate nucleus projections to brainstem regions which modulate nociception.

Sim LJ, Joseph SA

Journal of chemical neuroanatomy.. 1991 4 (2):97-109. Epub 1900 01 01.

Arginine vasopressin-anti-idiotypic immunostaining of human brain cells.

Joseph, S.A.; Pilcher, W.H.; Knigge, K.M.; Abood, L.G.; Michael, G.J.

Journal of Neuroendocrinology. 1990; 2: 659-665.

Immunocytochemistry of receptors using anti-idiotypic antibodies.

Knigge KM, Piekut DT, Abood LG, Joseph SA, Michael GJ, Xin L, Berlove DJ

Methods in enzymology.. 1989 178 :212-21. Epub 1900 01 01.

Opiocortin and catecholamine projections to raphe nuclei.

Sim LJ, Joseph SA

Peptides.. 1989 10 (5):1019-25. Epub 1900 01 01.

Immunocytochemical localization of pro-opiomelanocortin neurons in human brain areas subserving stimulation analgesia.

Pilcher WH, Joseph SA, McDonald JV

Journal of neurosurgery.. 1988 April 68 (4):621-9. Epub 1900 01 01.

Efferent ACTH-IR opiocortin projections from nucleus tractus solitarius: a hypothalamic deafferentation study.

Joseph SA, Michael GJ

Peptides.. 1988 9 (1):193-201. Epub 1900 01 01.

Effect of contrast media on beta-endorphin secretion. An in vitro study.

Harnish PP, Zuniga J, Northington FK, Melrose PA, Joseph SA, Kido DK, Knigge KM

Acta radiologica.. 1988 29 (6):741-3. Epub 1900 01 01.

Nitrous oxide analgesia: partial antagonism by naloxone and total reversal after periaqueductal gray lesions in the rat.

Zuniga J, Joseph S, Knigge K

European journal of pharmacology.. 1987 October 6142 (1):51-60. Epub 1900 01 01.

The effects of nitrous oxide on the secretory activity of pro-opiomelanocortin peptides from basal hypothalamic cells attached to cytodex beads in a superfusion in vitro system.

Zuniga JR, Joseph SA, Knigge KM

Brain research.. 1987 September 8420 (1):66-72. Epub 1900 01 01.

The effects of nitrous oxide on the central endogenous pro-opiomelanocortin system in the rat.

Zuniga JR, Joseph SA, Knigge KM

Brain research.. 1987 September 8420 (1):57-65. Epub 1900 01 01.

Central beta-endorphin release and recovery after exposure to nitrous oxide in rats.

Zuniga,J. R.; Knigge,K. K.; Joseph,S. A.;.

Journal of Oral & Maxillofacial Surgery. 1986; 44(9): 714-718.

Dual immunostaining procedure demonstrating neurotransmitter and neuropeptide codistribution in the same brain section.

Joseph SA, Piekut DT

The American journal of anatomy.. 1986 175 (2-3):331-42, 356-61. Epub 1900 01 01.

Differential sensitivity of hypothalamic and medullary opiocortin and tyrosine hydroxylase neurons to the neurotoxic effects of monosodium glutamate (MSG).

Pilcher WH, Joseph SA

Peptides.. 1986 7 (5):783-9. Epub 1900 01 01.

Immunocytochemical localization of somatostatin in human brain.

Bennett-Clarke CA, Joseph SA

Peptides.. 1986 7 (5):877-84. Epub 1900 01 01.

Co-existence of CRF and vasopressin immunoreactivity in parvocellular paraventricular neurons of rat hypothalamus.

Piekut DT, Joseph SA

Peptides.. 1986 7 (5):891-8. Epub 1900 01 01.

Pulmonary platelet trapping induced by beta-endorphin injection in the cerebrospinal fluid in dogs.

Almqvist PM, Knigge KM, Kuenzig M, Joseph SA, Pilcher WH, Schwartz SI

Surgery.. 1985 August 98 (2):344-9. Epub 1900 01 01.

Anatomy of the corticotropin-releasing factor and opiomelanocortin systems of the brain.

Joseph SA, Pilcher WH, Knigge KM

Federation proceedings.. 1985 January 44 (1 Pt 1):100-7. Epub 1900 01 01.

Relationship of CRF-immunostained cells and magnocellular neurons in the paraventricular nucleus of rat hypothalamus.

Piekut DT, Joseph SA

Peptides.. 1985 6 (5):873-82. Epub 1900 01 01.

The alpha MSH-specific and arcuate pro-opiomelanocortin neuronal systems of the hypothalamus: observations on their connectivity and response to colchicine treatment.

Knigge KM, Piekut DT, Joseph SA

Psychopharmacology bulletin.. 1985 21 (3):472-5. Epub 1900 01 01.

Co-localization of CRF-ir perikarya and ACTH-ir fibers in rat brain.

Pilcher WH, Joseph SA

Brain research.. 1984 May 7299 (1):91-102. Epub 1900 01 01.

Anatomy of the opioid-systems of the brain.

Knigge KM, Joseph SA

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.. 1984 February 11 (1):14-23. Epub 1900 01 01.

Immunocytochemical localization of ACTH1-39 in the brainstem of the rat.

Romagnano MA, Joseph SA

Brain research.. 1983 October 3276 (1):1-16. Epub 1900 01 01.

Immunocytochemical localization of ACTH perikarya in nucleus tractus solitarius: evidence for a second opiocortin neuronal system.

Joseph SA, Pilcher WH, Bennett-Clarke C

Neuroscience letters.. 1983 August 838 (3):221-5. Epub 1900 01 01.

Corticotropin releasing factor: immunocytochemical localization in rat brain.

Joseph SA, Knigge KM

Neuroscience letters.. 1983 February 2135 (2):135-41. Epub 1900 01 01.

Relationship of the central ACTH-immunoreactive opiocortin system to the supraoptic and paraventricular nuclei of the hypothalamus of the rat.

Knigge KM, Joseph SA

Brain research.. 1982 May 13239 (2):655-8. Epub 1900 01 01.

The distribution of enkephalin in the mediobasal hypothalamus of the mouse brain: effects of neonatal administration of MSG.

Romagnano MA, Chafel TL, Pilcher WH, Joseph SA

Brain research.. 1982 March 25236 (2):497-504. Epub 1900 01 01.

Distribution of somatostatin in the mouse brain: effects of neonatal MSG treatment.

Romagnano MA, Pilcher WH, Bennett-Clarke C, Chafel TL, Joseph SA

Brain research.. 1982 February 25234 (2):387-98. Epub 1900 01 01.

The distribution and cells of origin of ACTH(1-39)-stained varicosities in the paraventricular and supraoptic nuclei.

Sawchenko PE, Swanson LW, Joseph SA

Brain research.. 1982 January 28232 (2):365-74. Epub 1900 01 01.

Immunocytochemical distribution of LHRH neurons and processes in the rat: hypothalamic and extrahypothalamic locations.

Bennett-Clarke,C.; Joseph,S. A.;.

Cell & Tissue Research. 1982; 221(3): 493-504.

Topography of the ACTH-immunoreactive neurons in the basal hypothalamus of the rat brain.

Knigge KM, Joseph SA, Nocton J

Brain research.. 1981 July 20216 (2):333-41. Epub 1900 01 01.

Immunocytochemical localization of luteinizing hormone-releasing hormone (LHRH) in Vibratome-sectioned brain.

Joseph,S. A.; Piekut,D. T.; Knigge,K. M.;.

Journal of Histochemistry & Cytochemistry. 1981; 29(2): 247-254.

Relationship of the central ACTH-immunoreactive opiocortin system to the median eminence and the pituitary gland of the rat.

Knigge,K. M.; Joseph,S. A.;.

Cell & Tissue Research. 1981; 215(2): 333-340.

Immunoreactive adrenocorticotropin in rat brain: a neuroanatomical study using antiserum generated against synthetic ACTH.

Joseph SA

The American journal of anatomy.. 1980 August 158 (4):533-48. Epub 1900 01 01.

Distribution of somatostatin in the rat brain: telencephalon and diencephalon.

Bennett-Clarke C, Romagnano MA, Joseph SA

Brain research.. 1980 April 28188 (2):473-86. Epub 1900 01 01.

LHRH and anti-LHRH activity in ventricular cerebrospinal fluid of children with hydrocephalus

Knigge, K.M.; Joseph S.A.

Physiologist. 1980; 23: 145.

ACTH-like immunoreactivity in hypothalamic and extra-hypothalamic regions of the rat brain

Joseph, S.A.; Vullo, C.; Dembs, N.

Anatomical Record. 1980; .

The unlabeled antibody method. Contrasting color staining of beta-lipotropin and ACTH-associated hypothalamic peptides without antibody removal.

Joseph,S. A.; Sternberger,L. A.;.

Journal of Histochemistry & Cytochemistry. 1979; 27(11): 1430-1437.

The unlabeled antibody method. Contrasting color staining of paired pituitary hormones without antibody removal.

Sternberger,L. A.; Joseph,S. A.;.

Journal of Histochemistry & Cytochemistry. 1979; 27(11): 1424-1429.

Specificity of the immunocytochemical luteinizing hormone-releasing hormone receptor reaction.

Sternberger LA, Petrali JP, Joseph SA, Meyer HG, Mills KR

Endocrinology.. 1978 January 102 (1):63-73. Epub 1900 01 01.

The endocrine hypothalamus: recent anatomical studies.

Joseph,S. A.; Knigge,K. M.;.

Research Publications - Association for Research in Nervous & Mental Disease. 1978; 56: 15-47.

Organization of LRF-and SRIF-neurons in the endocrine hypothalamus.

Knigge,K. M.; Joseph,S. A.; Hoffman,G. E.;.

Research Publications - Association for Research in Nervous & Mental Disease. 1978; 56: 49-67.

Role of Cerebrospinal Fluid in Neuroendocrine Processes

Knigge, K.M.; Joseph, S.A.; Hoffman, G.; Morris, M.; Donofrio, R.

Excerpta Medica. 1976; 1: 111-116.

Biosynthesis of thyrotropin-releasing hormone in organ cultures of the guinea pig median eminence.

McKelvy JF, Sheridan M, Joseph S, Phelps CH, Perrie S

Endocrinology.. 1975 October 97 (4):908-18. Epub 1900 01 01.

Thyrotrophin releasing factor (TRF) in cerebrospinal fluid of the 3rd ventricle of rat.

Knigge KM, Joseph SA

Acta endocrinologica.. 1974 June 76 (2):209-13. Epub 1900 01 01.

Localization and content of TSH in median eminence of the hypothalamus.

Joseph SA, Knigge KM

The American journal of physiology.. 1974 March 226 (3):630-3. Epub 1900 01 01.

Pituitary thyrotroph function in hypothyroid rats.

Ching M, Evans AB, Evans ES, Joseph S, Sorrentino S

Acta endocrinologica.. 1974 February 75 (2):221-32. Epub 1900 01 01.

Role of the ventricular system in neuroendocrine processes: synthesis and distribution of thyrotropin releasing factor (TRF) in the hypothalamus and third ventricle.

Knigge KM, Schock SA, Silverman AJ, Ching MC, Scott DE, Zeman D, Krobish-Dudley G

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.. 1974 February 1 (1):74-84. Epub 1900 01 01.

Localization and content of thyrotrophin releasing factor (TRE) in median eminence of the hypothalamus.

Joseph SA, Scott DE, Vaala SS, Knigge KM, Krobisch-Dudley G

Acta endocrinologica.. 1973 October 74 (2):215-25. Epub 1900 01 01.

Further observations on the structure and function of median eminence, with reference to the organization of RF-producing elements in the endocrine hypothalamus.

Knigge KM, Joseph SA, Silverman AJ, Vaala S

Progress in brain research.. 1973 39 :7-20. Epub 1900 01 01.

Neural regulation of TSH secretion: thyroxine feedback in the newborn.

Joseph SA, Knigge KM

Neuroendocrinology.. 1972 10 (4):197-206. Epub 1900 01 01.

Neural regulation of TSH secretion: sites of thyroxine feedback.

Knigge KM, Joseph SA

Neuroendocrinology.. 1971 8 (5):273-88. Epub 1900 01 01.

Effects of isolation of the hypothalamo-pituitary unit in newborn guinea pigs.

Joseph SA, Knigge KM, Voloschin L

Neuroendocrinology.. 1969 4 (1):42-50. Epub 1900 01 01.

Effects of lesions in the ventro-medial nucleus of the hypothalamus in newborn and adult guinea pigs

Joseph, S.A. and Knigge, K.M.

Neuroendocrinology. 1968; 3: 309-331.

Endocrine function in male rats following complete and partial isolations of the hypothalamo-pituitary unit.

Voloschin L, Joseph SA, Knigge KM

Neuroendocrinology.. 1968 3 (6):387-97. Epub 1900 01 01.

Books

Headache Pathogenesis: Monamines, Neuropeptides Purines and Nitric Oxide (1997)

Chapter: Systemic nitroglycerine activates catecholamenergic, neuropeptidergic, and nitric oxide pathways in the rat brain

Advances in child health psychology (1991)

Chapter: Stress-induced analgesia as a model for investigating procedure-related distress in pediatric population

Antibodies, antigens, and molecular mimicry (1989)

Chapter: Use of anti-idiotype antibodies in receptor immunocytochemistry

Neuronal Control of Bodily Function-Basic and Clinical Aspects (1986)

Chapter: Neuropeptides and their possible role as auxiliary messengers

Frontiers of Hormone Research: Cerebrospinal Fluid (CSF) and Peptide Hormones (1982)

Chapter: Neuropeptides in ventricular cerebrospinal fluid of children with hydrocephalus

Handbook of the Hypothalamus (1980)

Chapter: Recent advances in structure and function of the endocrine hypotalamus

The Endocrine Functions of the Brain (1980)

Chapter: Systems to the ventricles of the brain

Current Studies of Hypothalamic Function (1978)

Chapter: Changes in hypothalamic content of LRF in animals immunized against melatonin

Brain-endocrine interaction II : The Ventricular System in Neuroendocrine Mecha (1975)

Chapter: Releasing Hormones LRF and TRF in the cerebrospinal fluid

Fluid environment of the brain (1975)

Chapter: Distribution of Hormones by Cerebrospinal Fluid

The Neuroendocrinology of Human Reproduction (1971)

Chapter: Observations on the architecture of the arcuatemedian eminence region after deafferntation with reference to the organization of the hypothalamic RF-producing elements.

A stereotaxic atlas of the brain of the golden hamster, Mesocricetus auratus (1963)