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John A. Olschowka, Ph.D.

John A. Olschowka, Ph.D.

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About Me

Faculty Appointments

Professor (Part-Time) - Department of Neuroscience (SMD)

Credentials

Post-doctoral Training & Residency

John Hopkins University School of Medicine:
Research Associate, Department of Neurology.

Johns Hopkins University School of Medicine:
Postdoctoral Fellow,
Department of Cell Biology and Anatomy. 1978 - 1980

Education

PhD | Univ of Cal Davis. Anatomy. 1978

MS | Univ of Cal Davis. Anatomy. 1974

BS | Univ of Cal Davis. Zoology. 1973

Awards

Commendation for Excellence in Medical Education. 2015

Commendation for Excellence in Medical Education. 2013

Commendation for Excellence in Medical Education. 2012

Commendation for excellence in medical education. 2004

Commendation for excellence in medical education. 2003

Commendation for excellence in medical education. 2001

Commendation for excellence in medical education. 2000

Commendation for excellence in medical education. 1996

Student (undergraduate) Advisor of the Year. 1995

Alumni Award for Excellence in Graduate Education. 1994

George W. Merck Dean's Teaching Scholar Award. 1992

Outstanding Teaching Award, Graduate Division. 1978

Sigma Xi Honor Society. 1974

Research

RECENT RESEARCH:

Models of CNS inflammation.

The inflammatory processes that follow injury (trauma, stroke, seizure, infection, radiation, etc.) to the central nervous system (CNS) dramatically amplify the damage. For example, reduction of the inflammatory process following stroke has...
RECENT RESEARCH:

Models of CNS inflammation.

The inflammatory processes that follow injury (trauma, stroke, seizure, infection, radiation, etc.) to the central nervous system (CNS) dramatically amplify the damage. For example, reduction of the inflammatory process following stroke has been shown to limit the volume of damaged tissue by 2/3's. Our laboratory is currently working to better understand the mechanisms of inflammation within the CNS. Currently we are examining several clinically relevant areas of CNS inflammation, most in collaboration with Dr. Kerry O'Banion. First, we are using a model of damage to the CNS caused by gamma-irradiation. Treatment of brain tumors with radiation leads to long-term damage of the normal brain tissue, damage caused by a massive inflammatory response. This model will be expanded beginning in the fall of 2008 by a NIAID funded pilot project as we examine the effects of combined injuries, radiation and a peripheral injury, on the functioning of both brain and lung. In a related model, we are examining the effect of cosmic radiation (similar to the exposure received in space) on the CNS. Third, using several transgenic mouse models of Alzheimer's disease coupled with a model of chronic inflammation, we are exploring the possible beneficial effects of inflammation in the clearing of Aß plaque pathology. Fourth, in a project begun this year, we are examining the potential brain injuring effects of underwater sound exposure. This project funded by the Office of Naval Research is interested in the use of sound exposure as a non-lethal weapon. Our final and newest area of research examines late appearing cytokines following brain injury. While suppression of acute pro-inflammatory cytokines has worked well in animal models, they have not proven useful clinically. We are now examining the late appearing cytokine HMGB-1 and its receptors (RAGE, TLR4 and TLR2) in a model of traumatic brain injury. With a better understanding, we hope to limit the inflammatory response and thus improve the effectiveness of therapy. Using techniques such as light microscopic immunocytochemistry, in situ hybridization, computerized image analysis, quantitative real time RT-PCR, and the immunohistochemical methods for detection of apoptosis, we have begun to unravel the cell types, cytokines, chemokines, apoptotic genes, and adhesion molecules involved in CNS inflammation.
With the aid of a pilot grant from the Schmitt Foundation, we are now beginning to examine to role of CNS inflammation in the development of seizure activity. Following a variety of inflammation models (radiation-induced, Alzheimer's transgenic mice, peripheral inflammation, etc), we have begun to record EEG's from mice to determine alterations in susceptibility to seizure activity.

PUBLICATIONS:
Cherry JD; Williams JP; O'Banion MK; Olschowka JA "Thermal injury lowers the threshold for radiation-induced neuroinflammation and cognitive dysfunction." Radiation research. 2013; 180(4):398-406.
Ghosh S; Wu MD; Shaftel SS; Kyrkanides S; Laferla FM; Olschowka JA; O'Banion MK "Sustained interleukin-1ß overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013; 33(11):5053-64.
Cherry JD; Liu B; Frost JL; Lemere CA; Williams JP; Olschowka JA; O'Banion MK "Galactic cosmic radiation leads to cognitive impairment and increased aß plaque accumulation in a mouse model of Alzheimer's disease." PloS one. 2012; 7(12):e53275. .
Hein AM, Stasko, MR, Matousek SB, Scott-McKean JJ, Maier SF, Olschowka JA, Costa AC, O'Banion MK. Sustained hippocampal IL-1ß overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav. Immun. 2009, PMCID: PMC2818290

Publications

Journal Articles

Pharmacologic Manipulation of Complement Receptor 3 Prevents Dendritic Spine Loss and Cognitive Impairment After Acute Cranial Radiation.

Hinkle JJ, Olschowka JA, Williams JP, O'Banion MK

International journal of radiation oncology, biology, physics.. 2024 July 1119 (3):912-923. Epub 12/23/2023.

Correction: Gas6 induces infammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease.

Owlett LD, Karaahmet B, Le L, Belcher EK, Dionisio-Santos D, Olschowka JA, Elliott MR, O'Banion MK

Journal of neuroinflammation.. 2023 November 620 (1):254. Epub 11/06/2023.

Inconsistent Effects of Glatiramer Acetate Treatment in the 5xFAD Mouse Model of Alzheimer's Disease.

Karaahmet B, Olschowka JA, O'Banion MK

Pharmaceutics.. 2023 June 2415 (7)Epub 06/24/2023.

Radiation and CNS effects: summary of evidence from a recent symposium of the Radiation Research Society.

Zablotska LB, Zupunski L, Leuraud K, Lopes J, Hinkle J, Pugeda T, Delgado T, Olschowka J, Williams J, O'Banion MK, Boice JD, Cohen SS, Mumma MT, Dauer LT, Britten RA, Stephenson S

International journal of radiation biology.. 2023 99 (9):1332-1342. Epub 11/11/2022.

Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease.

Owlett LD, Karaahmet B, Le L, Belcher EK, Dionisio-Santos D, Olschowka JA, Elliott MR, O'Banion MK

Journal of neuroinflammation.. 2022 February 719 (1):38. Epub 02/07/2022.

Effects of concentrated ambient ultrafine particulate matter on hallmarks of Alzheimer's disease in the 3xTgAD mouse model.

Herr D, Jew K, Wong C, Kennell A, Gelein R, Chalupa D, Raab A, Oberdörster G, Olschowka J, O'Banion MK, Elder A

Neurotoxicology.. 2021 May 84 :172-183. Epub 03/29/2021.

Evaluating Effects of Glatiramer Acetate Treatment on Amyloid Deposition and Tau Phosphorylation in the 3xTg Mouse Model of Alzheimer's Disease.

Dionisio-Santos DA, Karaahmet B, Belcher EK, Owlett LD, Trojanczyk LA, Olschowka JA, O'Banion MK

Frontiers in neuroscience.. 2021 15 :758677. Epub 10/22/2021.

Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease.

Owlett L, Belcher EK, Dionisio-Santos DA, Williams JP, Olschowka JA, O'Banion MK

Life sciences in space research.. 2020 November 27 :89-98. Epub 08/03/2020.

Cranial irradiation acutely and persistently impairs injury-induced microglial proliferation.

Belcher EK, Sweet TB, Karaahmet B, Dionisio-Santos DA, Owlett LD, Leffler KA, Janelsins MC, Williams JP, Olschowka JA, O'Banion MK

Brain, behavior, & immunity - health.. 2020 April 4 :100057. Epub 03/06/2020.

Evaluating the Effect of Interleukin-4 in the 3xTg Mouse Model of Alzheimer's Disease.

Dionisio-Santos DA, Behrouzi A, Olschowka JA, O'Banion MK

Frontiers in neuroscience.. 2020 14 :441. Epub 05/14/2020.

Cranial irradiation mediated spine loss is sex-specific and complement receptor-3 dependent in male mice.

Hinkle JJ, Olschowka JA, Love TM, Williams JP, O'Banion MK

Scientific reports.. 2019 December 119 (1):18899. Epub 12/11/2019.

IL-1?-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia.

Rivera-Escalera F, Pinney JJ, Owlett L, Ahmed H, Thakar J, Olschowka JA, Elliott MR, O'Banion MK

Journal of neuroinflammation.. 2019 December 1016 (1):261. Epub 12/10/2019.

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease.

Dionisio-Santos DA, Olschowka JA, O'Banion MK

Journal of neuroinflammation.. 2019 April 516 (1):74. Epub 04/05/2019.

Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion.

Begolly S, Olschowka JA, Love T, Williams JP, O'Banion MK

Glia.. 2018 April 66 (4):846-861. Epub 12/30/2017.

Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation.

Sweet TB, Hurley SD, Wu MD, Olschowka JA, Williams JP, O'Banion MK

Radiation research.. 2016 December 186 (6):614-623. Epub 12/01/2016.

Fractionation Spares Mice From Radiation-Induced Reductions in Weight Gain But Does Not Prevent Late Oligodendrocyte Lineage Side Effects.

Begolly S, Shrager PG, Olschowka JA, Williams JP, O'Banion MK

International journal of radiation oncology, biology, physics.. 2016 October 196 (2):449-457. Epub 05/12/2016.

Aryl hydrocarbon receptor deletion in cerebellar granule neuron precursors impairs neurogenesis.

Dever DP, Adham ZO, Thompson B, Genestine M, Cherry J, Olschowka JA, DiCicco-Bloom E, Opanashuk LA

Developmental neurobiology.. 2016 May 76 (5):533-50. Epub 08/17/2015.

Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling.

Moravan MJ, Olschowka JA, Williams JP, O'Banion MK

Journal of neuroinflammation.. 2016 February 313 :30. Epub 02/03/2016.

Arginase 1+ microglia reduce A? plaque deposition during IL-1?-dependent neuroinflammation.

Cherry JD, Olschowka JA, O'Banion MK

Journal of neuroinflammation.. 2015 November 412 :203. Epub 11/04/2015.

Characterization of binge-dosed methamphetamine-induced neurotoxicity and neuroinflammation.

McConnell SE, O'Banion MK, Cory-Slechta DA, Olschowka JA, Opanashuk LA

Neurotoxicology.. 2015 September 50 :131-41. Epub 08/15/2015.

Interleukin-1? mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease.

Rivera-Escalera F, Matousek SB, Ghosh S, Olschowka JA, Kerry O'Banion M

Neurobiology of disease.. 2014 September 69 :124-33. Epub 05/27/2014.

Central nervous system effects of whole-body proton irradiation.

Sweet TB, Panda N, Hein AM, Das SL, Hurley SD, Olschowka JA, Williams JP, O'Banion MK

Radiation research.. 2014 July 182 (1):18-34. Epub 06/17/2014.

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

Cherry JD, Olschowka JA, O Banion MK

Journal of neuroinflammation.. 2014 June 311 :98. Epub 06/03/2014.

Are "resting" microglia more "m2"?

Cherry JD, Olschowka JA, O'Banion MK

Frontiers in immunology.. 2014 5 :594. Epub 11/18/2014.

Thermal injury lowers the threshold for radiation-induced neuroinflammation and cognitive dysfunction.

Cherry JD, Williams JP, O'Banion MK, Olschowka JA

Radiation research.. 2013 October 180 (4):398-406. Epub 09/23/2013.

Sustained IL-1? expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+ neural precursor cells.

Wu MD, Montgomery SL, Rivera-Escalera F, Olschowka JA, Kerry O'Banion M

Brain, behavior, and immunity.. 2013 August 32 :9-18. Epub 03/16/2013.

Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies.

Montgomery SL, Narrow WC, Mastrangelo MA, Olschowka JA, O'Banion MK, Bowers WJ

The American journal of pathology.. 2013 June 182 (6):2285-97. Epub 04/06/2013.

Sustained interleukin-1? overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.

Ghosh S, Wu MD, Shaftel SS, Kyrkanides S, Laferla FM, Olschowka JA, O'Banion MK

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 March 1333 (11):5053-64. Epub 1900 01 01.

X-ray microbeam irradiation of the contusion-injured rat spinal cord temporarily improves hind-limb function.

Dilmanian FA, Jenkins AL, Olschowka J, Zhong Z, Park JY, Desnoyers NR, Sobotka S, Fois GR, Messina CR, Morales M, Hurley SD, Trojanczyk L, Ahmad S, Shahrab N, Coyle PK, Meek AG, O'Banion MK

Radiation research.. 2013 January 179 (1):76-88. Epub 12/05/2012.

Interleaved carbon minibeams: an experimental radiosurgery method with clinical potential.

Dilmanian FA, Rusek A, Fois GR, Olschowka J, Desnoyers NR, Park JY, Dioszegi I, Dane B, Wang R, Tomasi D, Lee H, Hurley SD, Coyle PK, Meek AG, O'Banion MK

International journal of radiation oncology, biology, physics.. 2012 October 184 (2):514-9. Epub 02/17/2012.

Conditional expression of human ?-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation.

Kyrkanides S, Brouxhon SM, Tallents RH, Miller JN, Olschowka JA, O'Banion MK

Journal of neuroinflammation.. 2012 August 49 :186. Epub 08/04/2012.

Behavioral, structural and molecular changes following long-term hippocampal IL-1? overexpression in transgenic mice.

Hein AM, Zarcone TJ, Parfitt DB, Matousek SB, Carbonari DM, Olschowka JA, O'Banion MK

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2012 March 7 (1):145-55. Epub 07/12/2011.

Chronic IL-1?-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration.

Matousek SB, Ghosh S, Shaftel SS, Kyrkanides S, Olschowka JA, O'Banion MK

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2012 March 7 (1):156-64. Epub 12/16/2011.

Adult murine hippocampal neurogenesis is inhibited by sustained IL-1? and not rescued by voluntary running.

Wu MD, Hein AM, Moravan MJ, Shaftel SS, Olschowka JA, O'Banion MK

Brain, behavior, and immunity.. 2012 February 26 (2):292-300. Epub 09/29/2011.

Galactic cosmic radiation leads to cognitive impairment and increased a? plaque accumulation in a mouse model of Alzheimer's disease.

Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O'Banion MK

PloS one.. 2012 7 (12):e53275. Epub 12/31/2012.

Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain.

Moravan MJ, Olschowka JA, Williams JP, O'Banion MK

Radiation research.. 2011 October 176 (4):459-73. Epub 07/25/2011.

Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice.

Kyrkanides S, Tallents RH, Miller JN, Olschowka ME, Johnson R, Yang M, Olschowka JA, Brouxhon SM, O'Banion MK

Journal of neuroinflammation.. 2011 September 78 :112. Epub 09/07/2011.

Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression.

Matousek SB, Hein AM, Shaftel SS, Olschowka JA, Kyrkanides S, O'Banion MK

Journal of neurochemistry.. 2010 July 114 (1):247-58. Epub 04/19/2010.

Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice.

Hein AM, Stasko MR, Matousek SB, Scott-McKean JJ, Maier SF, Olschowka JA, Costa AC, O'Banion MK

Brain, behavior, and immunity.. 2010 February 24 (2):243-53. Epub 10/13/2009.

The trigeminal retrograde transfer pathway in the treatment of neurodegeneration.

Kyrkanides S, Yang M, Tallents RH, Miller JN, Brouxhon SM, Olschowka JA

Journal of neuroimmunology.. 2009 April 30209 (1-2):139-42. Epub 03/10/2009.

Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration.

Kyrkanides S, Miller AW, Miller JN, Tallents RH, Brouxhon SM, Olschowka ME, O'Banion MK, Olschowka JA

Journal of neuroimmunology.. 2008 October 15203 (1):50-7. Epub 1900 01 01.

Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration.

Kyrakanides S, Miller AW, Miller JN, Tallents RH, Brouxhon SM, Olschowka ME, O'Banion MK, Olschowka JA.

J Neuroimmunol. 2008; 203(1): 50-57.

Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration.

Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O'Banion MK

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 August 2927 (35):9301-9. Epub 1900 01 01.

Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype.

Kyrkanides S, Miller JN, Tallents RH, Brouxhon SM, Centola GM, Olschowka JA

Journal of neuroimmunology.. 2007 August 188 (1-2):39-47. Epub 06/18/2007.

Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology.

Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, O'Banion MK

The Journal of clinical investigation.. 2007 June 117 (6):1595-604. Epub 1900 01 01.

Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain.

Lai YC, Shaftel SS, Miller JN, Tallents RH, Chang Y, Pinkert CA, Olschowka JA, Dickerson IM, Puzas JE, O'Banion MK, Kyrkanides S

Arthritis and rheumatism.. 2006 April 54 (4):1184-97. Epub 1900 01 01.

Acute morphine exposure potentiates the development of HSV-1-induced encephalitis.

Lioy DT, Sheridan PA, Hurley SD, Walton JR, Martin AM, Olschowka JA, Moynihan JA

Journal of neuroimmunology.. 2006 March 172 (1-2):9-17. Epub 12/02/2005.

Interleukin 1beta (IL1B) signaling is a critical component of radiation-induced skin fibrosis.

Liu W, Ding I, Chen K, Olschowka J, Xu J, Hu D, Morrow GR, Okunieff P

Radiation research.. 2006 February 165 (2):181-91. Epub 1900 01 01.

Acute morphine exposure potentiates the development of HSV-1-induced encephalitis.

Lioy, D.T.; Sheridan, P.A.; Hurley, S.D.; Walton, J.R.; Martin, A.M.; Olschowka, J.A.; Moynihan, J.A.

J. Neuroimmunology. 2006; 172((1-2)): 9-17.

Regulation of prostaglandin E2 synthesis after brain irradiation.

Moore AH, Olschowka JA, Williams JP, Okunieff P, O'Banion MK

International journal of radiation oncology, biology, physics.. 2005 May 162 (1):267-72. Epub 1900 01 01.

beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration.

Kyrkanides S, Miller JH, Brouxhon SM, Olschowka JA, Federoff HJ

Brain research. Molecular brain research.. 2005 February 18133 (2):286-98. Epub 1900 01 01.

ß-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration.

Kyrkanides, S.K.; Miller, J.H.; Brouxhon, S.M.; Olschowka, J.A.; Federoff, H.J.

Molecular Brain Res. 2005; 133(2): 286-298.

Regulation of prostaglandin E2 synthesis after brain irradiation.

Moore, A.H.; Olschowka, J.A.; Williams, J.P.; Okunieff, P.; OBanion, M.K.

Int. J. Radiation Oncology Biol. Phys. 2005; 62(1): 267-272.

Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain.

Moore AH, Olschowka JA, O'Banion MK

Journal of neuroimmunology.. 2004 March 148 (1-2):32-40. Epub 1900 01 01.

Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain.

Moore AH, Olschowka JA, Williams JP, Paige SL, O'Banion MK

Radiation research.. 2004 February 161 (2):153-60. Epub 1900 01 01.

Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys.

Hurley SD, O'Banion MK, Song DD, Arana FS, Olschowka JA, Haber SN

Experimental neurology.. 2003 December 184 (2):659-68. Epub 1900 01 01.

COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells.

Shaftel SS, Olschowka JA, Hurley SD, Moore AH, O'Banion MK

Brain research. Molecular brain research.. 2003 November 26119 (2):213-5. Epub 1900 01 01.

Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy.

Bowers WJ, Olschowka JA, Federoff HJ

Gene therapy.. 2003 June 10 (11):941-5. Epub 1900 01 01.

Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS.

Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ

Molecular therapy : the journal of the American Society of Gene Therapy.. 2003 February 7 (2):218-27. Epub 1900 01 01.

COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells.

Shaftel, S.S.; Olschowka, J.A.; Hurley, S.D.; Moore, A.H.; O'Banion, M.K.

Molecular Brain Res. 2003; 119: 213-215.

Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury.

Kyrkanides S, Moore AH, Olschowka JA, Daeschner JC, Williams JP, Hansen JT, Kerry O'Banion M

Brain research. Molecular brain research.. 2002 August 15104 (2):159-69. Epub 1900 01 01.

Expression of tumor necrosis factor alpha and its mRNA in the spinal cord following a weight-drop injury.

Wang CX, Reece C, Wrathall JR, Shuaib A, Olschowka JA, Hao C

Neuroreport.. 2002 August 713 (11):1391-3. Epub 1900 01 01.

Cyclooxygenase inhibition as a strategy to ameliorate brain injury.

Hurley SD, Olschowka JA, O'Banion MK

Journal of neurotrauma.. 2002 January 19 (1):1-15. Epub 1900 01 01.

Temporomandibular joint nociception: effects of capsaicin on substance P-like immunoreactivity in the rabbit brain stem.

Kyrkanides S, Tallents RH, Macher DJ, Olschowka JA, Stevens SY

Journal of orofacial pain.. 2002 16 (3):229-36. Epub 1900 01 01.

Selective inhibition of cyclooxygenase-2 attenuates expression of inflammation-related genes in CNS injury.

O'Banion MK, Kyrkanides S, Olschowka JA

Advances in experimental medicine and biology.. 2002 507 :155-60. Epub 1900 01 01.

Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury.

Kyrkanides S, O'Banion MK, Whiteley PE, Daeschner JC, Olschowka JA

Journal of neuroimmunology.. 2001 October 1119 (2):269-77. Epub 1900 01 01.

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K

The American journal of pathology.. 2001 April 158 (4):1345-54. Epub 1900 01 01.

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

Matsuoka Y; Picciano M; Malester B; LaFrancois J; Zehr C; Daeschner JM; Olschowka JA; Fonseca MI; O'Banion MK; Tenner AJ; Lemere CA; Duff K.

Amer. J. Pathology. 2001; 158(4): 1345-54.

TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury.

Kyrkanides S, Olschowka JA, Williams JP, Hansen JT, O'Banion MK

Journal of neuroimmunology.. 1999 March 195 (1-2):95-106. Epub 1900 01 01.

Expression of multiple Na+/H+ exchanger isoforms in rat parotid acinar and ductal cells.

Park K, Olschowka JA, Richardson LA, Bookstein C, Chang EB, Melvin JE

The American journal of physiology.. 1999 February 276 (2):G470-8. Epub 1900 01 01.

Expression of multiple Na+/H+ Exchanger Isoforms in Rat Parotid Acinar and Ductal Cells.

Park, K.; Olschowka, J.A.; Richardson, L.A.; Chang, E.B.; Melvin, J.E.

J. General Physiology. 1999; 276: G470-478.

Localization and distribution of cyclooxygenase-2 in brain tissue by immunohistochemistry.

O'Banion MK, Olschowka JA

Methods in molecular biology.. 1999 120 :55-66. Epub 1900 01 01.

Role of paraventricular nucleus parvicellular neurons in the compensatory responses to graded hemorrhage.

Blair ML, Want A, Olschowka JA, Piekut D

The American journal of physiology.. 1998 July 275 (1):R278-85. Epub 1900 01 01.

Role of paraventricular nucleus parvicellular neurons in the compensatory responses to graded hemorrhage.

Blair, M.L.; Want, A.; Olschowka, J.A.. Piekut, D.

Amer. J. Physiol.-Regulatory, Integrative, and Comparative Physiol. 1998; 44: R278- R285.

ICAM-1 induction in the mouse CNS following irradiation.

Olschowka JA, Kyrkanides S, Harvey BK, O'Banion MK, Williams JP, Rubin P, Hansen JT

Brain, behavior, and immunity.. 1997 December 11 (4):273-85. Epub 1900 01 01.

Cyclooxygenase-1 behaves as a delayed response gene in PC12 cells differentiated by nerve growth factor.

Kaplan MD, Olschowka JA, O'Banion MK

The Journal of biological chemistry.. 1997 July 25272 (30):18534-7. Epub 1900 01 01.

Increase of interleukin-1beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat.

Wang CX, Olschowka JA, Wrathall JR

Brain research.. 1997 June 13759 (2):190-6. Epub 1900 01 01.

ICAM-1 induction in the mouse CNS following irradiation.

Olschowka, J.A.; Kyrkanides, S.; Harvey, B.K.; OBanion, M.K.; Williams, J.P.; Rubin, P.; Hansen, J.T.

Brain Behavior and Immunity. 1997; 11: 273-285.

Cyclooxygenase-1 behaves as a delayed response gene in PC12 cells differentiated by nerve growth factor.

Kaplan, M.D.; Olschowka, J.A.; OBanion, M.K.

J. Biological Chemistry. 1997; 272(30): 18534-18537.

Role of the hypothalamic paraventricular nucleus in cardiovascular regulation.

Blair ML, Piekut D, Want A, Olschowka JA

Clinical and experimental pharmacology & physiology.. 1996 February 23 (2):161-5. Epub 1900 01 01.

Expression of ICAM-1, VCAM-1, L-selectin, and leukosialin in the mouse central nervous system during the induction and remission stages of experimental allergic encephalomyelitis.

Dopp JM, Breneman SM, Olschowka JA

Journal of neuroimmunology.. 1994 October 54 (1-2):129-44. Epub 1900 01 01.

Noradrenergic and peptidergic innervation of lymphoid organs in the beluga, Delphinapterus leucas: an anatomical link between the nervous and immune systems.

Romano TA, Felten SY, Olschowka JA, Felten DL

Journal of morphology.. 1994 September 221 (3):243-59. Epub 1900 01 01.

Dehydration induces Fos, but not increased vasopressin mRNA in the supraoptic nucleus of aged rats.

Sladek CD, Olschowka JA

Brain research.. 1994 August 1652 (2):207-15. Epub 1900 01 01.

Light induces expression of fos-related proteins within gastrin-releasing peptide neurons in the rat suprachiasmatic nucleus.

Earnest DJ, DiGiorgio S, Olschowka JA

Brain research.. 1993 November 12627 (2):205-9. Epub 1900 01 01.

A microscopic investigation of the lymphoid organs of the beluga, Delphinapterus leucas.

Romano TA, Felten SY, Olschowka JA, Felten DL

Journal of morphology.. 1993 March 215 (3):261-87. Epub 1900 01 01.

Circadian regulation of immediate-early gene expression in the SCN pacemaker by light.

Earnest, D.J.; Olschowka, J.A.

J. Biological Rhythms. 1993; 8: S65-S71.

Circadian regulation of c-fos expression in the suprachiasmatic pacemaker by light.

Earnest DJ, Olschowka JA

Journal of biological rhythms.. 1993 8 Suppl :S65-71. Epub 1900 01 01.

Selective effects on CRF neurons and catecholamine terminals in two stress-responsive regions of adult rat brain after prenatal exposure to diazepam.

Inglefield JR, Bitran D, Olschowka JA, Kellogg CK

Brain research bulletin.. 1993 31 (3-4):353-9. Epub 1900 01 01.

Rhythmic expression of Fos-related proteins within the rat suprachiasmatic nucleus during constant retinal illumination.

Earnest DJ, Ouyang S, Olschowka JA

Neuroscience letters.. 1992 June 8140 (1):19-24. Epub 1900 01 01.

Interaction of opioid peptide-containing terminals with dopaminergic perikarya in the rat hypothalamus.

Fitzsimmons MD, Olschowka JA, Wiegand SJ, Hoffman GE

Brain research.. 1992 May 22581 (1):10-8. Epub 1900 01 01.

Noradrenergic and peptidergic innervation of lymphoid organs.

Felten SY, Felten DL, Bellinger DL, Olschowka JA

Chemical immunology.. 1992 52 :25-48. Epub 1900 01 01.

Neuropeptide-Y innervation of the rat spleen: another potential immunomodulatory neuropeptide.

Romano TA, Felten SY, Felten DL, Olschowka JA

Brain, behavior, and immunity.. 1991 March 5 (1):116-31. Epub 1900 01 01.

Induction of interleukin-1 beta mRNA in adult rat brain.

Higgins GA, Olschowka JA

Brain research. Molecular brain research.. 1991 January 9 (1-2):143-8. Epub 1900 01 01.

IFN-g/LPS induction of IL-1beta gene expression in adult rat brain.

Higgins, G.A.; Olschowka, J.A.

Molecular Brain Research. 1991; 4: 143-148.

Photic regulation of c-fos expression in neural components governing the entrainment of circadian rhythms.

Earnest DJ, Iadarola M, Yeh HH, Olschowka JA

Experimental neurology.. 1990 September 109 (3):353-61. Epub 1900 01 01.

Limited recovery of striatal dopaminergic fibers by adrenal medullary grafts in MPTP-treated aging mice.

Date I, Felten SY, Olschowka JA, Felten DL

Experimental neurology.. 1990 March 107 (3):197-207. Epub 1900 01 01.

Neuropeptide innervation of lymphoid organs.

Bellinger DL, Lorton D, Romano TD, Olschowka JA, Felten SY, Felten DL

Annals of the New York Academy of Sciences.. 1990 594 :17-33. Epub 1900 01 01.

A simple embedding method for optimizing the thin sectioning of pre-embedded immunocytochemically stained tissue.

Olschowka, J.A.

J. Electron Microscopy Tech. 1989; 10: 373-374.

Limited recovery of striatal dopaminergic fibers by adrenal meduallary grafts in MPTP-treated aging mice.

Date, I.; Felten, S.Y.; Olschowka, J.A.; Felten, D.L.

Experimental Neurology. 1989; 107: 197-207.

A system of corticotropin releasing factor-containing amacrine cells in the rat retina.

Yeh HH, Olschowka JA

Neuroscience.. 1989 33 (1):229-40. Epub 1900 01 01.

A simple embedding method for optimizing the thin sectioning of pre-embedded immunocytochemically stained tissue.

Olschowka JA

Journal of electron microscopy technique. 1988 December 10 (4):373-4. Epub 1900 01 01.

Noradrenergic sympathetic neural interactions with the immune system: structure and function.

Felten, D.L.; Felten, S.Y.; Bellinger, D.L.; Carlson, S.L.; Ackerman, K.D.; Madden, K.S.; Olschowka, J.A.; Livnat, S.

Immunological Rev. 1988; 100: 225-260.

Regulation of vasopressin and oxytocin release in vitro.

Sladek CD, Olschowka JA

Advances in experimental medicine and biology.. 1988 245 :157-65. Epub 1900 01 01.

Noradrenergic sympathetic innervation of lymphoid organs.

Felten SY, Felten DL, Bellinger DL, Carlson SL, Ackerman KD, Madden KS, Olschowka JA, Livnat S

Progress in allergy. 1988 43 :14-36. Epub 1900 01 01.

Reinnervation of transplanted hypothalamic neurons by host aminergic fibers in rats.

Silverman WF, Aravich PF, Collier TJ, Olschowka JA, Sladek JR

Brain research.. 1987 June 2412 (2):375-80. Epub 1900 01 01.

Noradrenergic sympathetic innervation of the spleen: II. Tyrosine hydroxylase (TH)-positive nerve terminals form synapticlike contacts on lymphocytes in the splenic white pulp.

Felten SY, Olschowka J

Journal of neuroscience research.. 1987 18 (1):37-48. Epub 1900 01 01.

Noradrenergic and peptidergic innervation of lymphoid tissue.

Felten DL, Felten SY, Carlson SL, Olschowka JA, Livnat S

The Journal of immunology : official journal of the American Association of Immunologists.. 1985 August 135 (2 Suppl):755s-765s. Epub 1900 01 01.

Noradrenergic and peptidergic innervation of lymphoid tissue.

Felten, D.L.; Felten, S.Y.; Carlson, S.L.; Olschowka, J.A.; Livnat, S.

J. Immunology. 1985; 135: 755s-765s.

Behavioral investigation of the coexistence of substance P, corticotropin releasing factor, and acetylcholinesterase in lateral dorsal tegmental neurons projecting to the medial frontal cortex of the rat.

Crawley JN, Olschowka JA, Diz DI, Jacobowitz DM

Peptides.. 1985 6 (5):891-901. Epub 1900 01 01.

The subnuclear distribution of substance P, cholecystokinin, vasoactive intestinal peptide, somatostatin, leu-enkephalin, dopamine-beta-hydroxylase, and serotonin in the rat interpeduncular nucleus.

Hamill GS, Olschowka JA, Lenn NJ, Jacobowitz DM

The Journal of comparative neurology.. 1984 July 10226 (4):580-96. Epub 1900 01 01.

The development of peptide-containing neurons within neocortical transplants in adult mice.

Ebner FF, Olschowka JA, Jacobowitz DM

Peptides.. 1984 5 (1):103-13. Epub 1900 01 01.

Histochemical localization of FMRFamide-like immunoreactivity in the rat brain.

Chronwall BM, Olschowka JA, O'Donohue TL

Peptides.. 1984 5 (3):569-84. Epub 1900 01 01.

Vasoactive intestinal peptide inhibitory innervation in bovine mesenteric lymphatics. A histochemical and pharmacological study.

Ohhashi T, Olschowka JA, Jacobowitz DM

Circulation research.. 1983 October 53 (4):535-8. Epub 1900 01 01.

Bovine pancreatic polypeptide-like immunoreactive nerves in the rat major cerebral arteries.

Kobayashi S, Olschowka JA, Jacobowitz DM

Brain research bulletin.. 1983 March 10 (3):373-6. Epub 1900 01 01.

The coexistence and release of bovine pancreatic polypeptide-like immunoreactivity from noradrenergic superior cervical ganglia neurons.

Olschowka, J.A.; O'Donohue, T.L.; Jacobowitz, D.M.

Peptides. 1983; 4: 23l-238.

The coexistence and release of bovine pancreatic polypeptide-like immunoreactivity from noradrenergic superior cervical ganglia neurons.

Olschowka JA, Jacobowitz DM

Peptides.. 1983 4 (2):231-8. Epub 1900 01 01.

Vasoactive intestinal polypeptide immunoreactive and cholinergic nerves in the whole mount preparation of the major cerebral arteries of the rat.

Kobayashi S, Kyoshima K, Olschowka JA, Jacobowitz DM

Histochemistry.. 1983 79 (3):377-81. Epub 1900 01 01.

Hypothalamic and extrahypothalamic distribution of CRF-like immunoreactive neurons in the rat brain.

Olschowka JA, O'Donohue TL, Mueller GP, Jacobowitz DM

Neuroendocrinology.. 1982 October 35 (4):305-8. Epub 1900 01 01.

Coexistence of bovine pancreatic polypeptide-like immunoreactivity and catecholamine in neurons of the ventral aminergic pathway of the rat brain.

Jacobowitz, D.M.; Olschowka, J.A.

Brain Res. Bull. 1982; 9: 39l-406.

Coexistence of bovine pancreatic polypeptide-like immunoreactivity and catecholamine in neurons of the ventral aminergic pathway of the rat brain.

Jacobowitz DM, Olschowka JA

Brain research bulletin.. 1982 9 (1-6):391-406. Epub 1900 01 01.

Bovine pancreatic polypeptide-like immunoreactivity in brain and peripheral nervous system: coexistence with catecholaminergic nerves.

Jacobowitz DM, Olschowka JA

Peptides.. 1982 3 (3):569-90. Epub 1900 01 01.

The distribution of corticotropin releasing factor-like immunoreactive neurons in rat brain.

Olschowka JA, O'Donohue TL, Mueller GP, Jacobowitz DM

Peptides.. 1982 3 (6):995-1015. Epub 1900 01 01.

Ultrastructural demonstration of noradrenergic synapses in the rat central nervous system by dopamine-beta-hydroxylase immunocytochemistry.

Olschowka JA, Molliver ME, Grzanna R, Rice FL, Coyle JT

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.. 1981 February 29 (2):271-80. Epub 1900 01 01.

The ultrastructural demonstration of noradrenergic synapses in the rat central nervous by dopamine-beta-hydroxylase immunocytochemistry.

Olschowka, J.A.;Molliver, M.E.; Grzanna, R.; Rice, F.L.; Coyle, J.T.

J. Histochem. Cytochem. 1981; 29: 27l-280.

The distribution of bovine pancreatic polypeptide-like immunoreactive neurons in rat brain.

Olschowka JA, O'Donohue TL, Jacobowitz DM

Peptides.. 1981 2 (3):309-31. Epub 1900 01 01.

Postnatal development of cholinergic neurotransmitter enzymes in the mouse cerebellum. Biochemical, light microscopic and electron microscopic cytochemical investigations.

Olschowka JA, Vijayan VK

The Journal of comparative neurology.. 1980 May 1191 (1):77-101. Epub 1900 01 01.

Brain acetycholinesterase activity and multiplicity in the bonnet monkey (Macaca radiata) and the rhesus monkey (Macaca mulatta).

Vijayan, V.K.; Olschowka, J.A.

J. Neurochem. 1977; 28: ll4l-ll43.

Books

Molecular and Cell Biology of Marine Mammals (2002)

Chapter: Immune response, stress, and environment: implications for cetaceans.

Authors: Romano, T.A.; D.L. Felten; S.Y. Stevens; J.A. Olschowka; V. Quanranta; S. H. Ridgway

Publisher: Krieger Pub. Co. 2002

Neurobiology of Cytokines Part A; A volume of Methods in Neurosciences. (1993)

Chapter: Immunocytochemical methods for the localization of cytokines in brain.

Authors: Olschowka, J.A.

Publisher: Academic Press 1993

Peripheral Signaling of the Brain: Neural-Immune and Cognitive Function. (1991)

Chapter: Interleukin-1beta Expression in the Rat Brain

Authors: Olschowka, J.A.; Dopp, J.; Higgins, G.A.

Publisher: Hogrefe & Huber Publishers, Toronto 1991

Stockholm Symposium on Retinal Degeneration (1991)

Chapter: Development of rod and cone photoreceptor cells in intraretinal grafts.

Authors: del Cerro, M.; Kordower, J.; Lazar, E.; Olschowka, J.A.; Grover, D.; del Cerro, C.

Publisher: CRC Press 1991

Neuropeptides and immunopeptides: Messengers in a neuroimmune axis,. (1990)

Chapter: Neuropeptide innervation of lymphoid organs.

Authors: Bellinger, D.L.; Lorton, D.; Romano, T.; Olschowka, J.A.; Felten, S.Y.; Felten, D.L.

Publisher: Ann. N. Y. Acad. Sci. 1990

Inherited and Environmentally Induced Retinal Degenerations. (1989)

Chapter: Retinal tranplants for cell replacement in phototoxic retinal degeneration.

Authors: del Cerro, M.; Notter, M.F.; Grover,D.A.; Olschowka, J.A.; Qi Jiang, L.; Wiegand, S.J.; Lazar, E.; del Cerro, C.

Publisher: Alan R. Liss, New York 1989

Mechanisms of Physical and Emotional Stress (1988)

Chapter: Regulation of vasopressin and oxytocin release in vitro.

Authors: Sladek, C.D.; Olschowka, J.A.

Publisher: Plenum, New York 1988

Progress in Catecholamine Research, Part A. Basic Aspects and Peripheral Mechani (1988)

Chapter: Catecholaminergic innervation of the spleen: Are lymphocytes targets of noradrenergic nerves.

Authors: Felten, S.Y.; Olschowka, J.A.; Ackerman, K.D.; Felten, D.L.

Publisher: Alan R. Liss, Inc., New York 1988

Coexistence of Neuroactive Substances in Neurons. (1984)

Chapter: Co-existence of bovine pancreatic polypeptide and norepinephrine in the central and peripheral nervous system.

Authors: Jacobowitz, D.M.; Olschowka, J.A.

Publisher: J. Wiley and Sons, New York 1984

Cytochemical Methods in Neuroanatomy (1982)

Chapter: Monoamine systems in the cerebral cortex.

Authors: Molliver, M.E.; Grzanna, R.; Lidov, H.G.W.; Morrison, J.H.; Olschowka, J.A.

Publisher: Alan R. Liss, Inc., New York 1982