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Arnold W. Tank, Ph.D.

Arnold W. Tank, Ph.D.

About Me

Faculty Appointments

Professor Emeritus - Department of Pharmacology and Physiology (SMD)

Credentials

Post-doctoral Training & Residency

Instructor, University of Colorado Health Sciences Center, Dept. of Pharmacology. 1980 - 1982

Post-doctoral Research Fellow, Dept. of Pharmacology, University of Colorado Health Sciences Center. Advisor: Dr. Norman Weiner. 1976 - 1980

Education

PhD | Purdue University. Biochemistry. 1976

BS | Lehigh University. Chemistry. 1972

Awards

Lewis Pratt Ross Professor and Chair. 2011

Dean's Senior Teaching Scholar Award. 2000 - 2003

Paul Stark Professor of Pharmacology (endowed chair).. 2000

Special commendation for Excellence in Teaching Second Year Medical Students; University of Rochester Medical School. 1996

Herbert W. Mapstone Award for Excellence in Teaching Second Year Medical Students; University of Rochester Medical School. 1995

NRSA Post-doctoral Fellowship 5 F32 NS 05567. 1976 - 1979

Arnold K. Balls Award, Purdue University (for outstanding research as a graduate student).

David Ross Fellowship, Purdue University.

Publications

Journal Articles

Differential expression of polycytosine-binding protein isoforms in adrenal gland, locus coeruleus and midbrain.

Boschi NM, Takeuchi K, Sterling C, Tank AW

Neuroscience.. 2015 February 12286 :1-12. Epub 11/26/2014.

Posttranscriptional regulation of adrenal TH gene expression contributes to the maladaptive responses triggered by insulin-induced recurrent hypoglycemia.

Kudrick N, Chan O, La Gamma EF, Kim JL, Tank AW, Sterling C, Nankova BB

Physiological reports.. 2015 February 13 (2)Epub 02/22/2015.

Peripheral and central effects of circulating catecholamines.

Tank AW, Lee Wong D

Comprehensive Physiology.. 2015 January 5 (1):1-15. Epub 1900 01 01.

cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3'-untranslated region and poly(C)-binding protein 2.

Xu L, Sterling CR, Tank AW

Molecular pharmacology.. 2009 October 76 (4):872-83. Epub 07/20/2009.

Induction of tyrosine hydroxylase mRNA by nicotine in rat midbrain is inhibited by mifepristone.

Radcliffe PM, Sterling CR, Tank AW

Journal of neurochemistry.. 2009 June 109 (5):1272-84. Epub 03/23/2009.

Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain.

Tank AW, Xu L, Chen X, Radcliffe P, Sterling CR

Annals of the New York Academy of Sciences.. 2008 December 1148 :238-48. Epub 1900 01 01.

Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons.

Chen X, Xu L, Radcliffe P, Sun B, Tank AW

Molecular pharmacology.. 2008 June 73 (6):1816-28. Epub 03/18/2008.

Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo.

Chen X, Rzhetskaya M, Kareva T, Bland R, During MJ, Tank AW, Kholodilov N, Burke RE

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 January 1628 (3):672-80. Epub 1900 01 01.

Evidence for regulation of tyrosine hydroxylase mRNA translation by stress in rat adrenal medulla.

Xu L, Chen X, Sun B, Sterling C, Tank AW

Brain research.. 2007 July 161158 :1-10. Epub 05/10/2007.

Stress-induced catecholaminergic function: transcriptional and post-transcriptional control.

Wong DL, Tank AW

Stress : the international journal on the biology of stress.. 2007 June 10 (2):121-30. Epub 1900 01 01.

Mechanism of neurotrophic action of nobiletin in PC12D cells.

Nagase H, Yamakuni T, Matsuzaki K, Maruyama Y, Kasahara J, Hinohara Y, Kondo S, Mimaki Y, Sashida Y, Tank AW, Fukunaga K, Ohizumi Y

Biochemistry.. 2005 October 2544 (42):13683-91. Epub 1900 01 01.

Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity.

Osterhout CA, Sterling CR, Chikaraishi DM, Tank AW

Journal of neurochemistry.. 2005 August 94 (3):731-41. Epub 1900 01 01.

Chronic nicotine treatment leads to induction of tyrosine hydroxylase in locus ceruleus neurons: the role of transcriptional activation.

Sun B, Chen X, Xu L, Sterling C, Tank AW

Molecular pharmacology.. 2004 October 66 (4):1011-21. Epub 07/16/2004.

Nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla.

Yoshimura R, Xu L, Sun B, Tank AW

Brain research. Molecular brain research.. 2004 July 26126 (2):188-97. Epub 1900 01 01.

Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype.

Thiruchelvam M, McCormack A, Richfield EK, Baggs RB, Tank AW, Di Monte DA, Cory-Slechta DA

The European journal of neuroscience.. 2003 August 18 (3):589-600. Epub 1900 01 01.

c-Fos is essential for the response of the tyrosine hydroxylase gene to depolarization or phorbol ester.

Sun B, Tank AW

Journal of neurochemistry.. 2003 June 85 (6):1421-30. Epub 1900 01 01.

Chronic nicotine treatment leads to sustained stimulation of tyrosine hydroxylase gene transcription rate in rat adrenal medulla.

Sun B, Sterling CR, Tank AW

The Journal of pharmacology and experimental therapeutics.. 2003 February 304 (2):575-88. Epub 1900 01 01.

Overexpression of c-Fos is sufficient to stimulate tyrosine hydroxylase (TH) gene transcription in rat pheochromocytoma PC18 cells.

Sun B, Tank AW

Journal of neurochemistry.. 2002 January 80 (2):295-306. Epub 1900 01 01.

The cAMP responsive element and CREB partially mediate the response of the tyrosine hydroxylase gene to phorbol ester.

Piech-Dumas KM, Best JA, Chen Y, Nagamoto-Combs K, Osterhout CA, Tank AW

Journal of neurochemistry.. 2001 March 76 (5):1376-85. Epub 1900 01 01.

Adrenal tyrosine hydroxylase activity and gene expression are increased by intraventricular administration of nicotine.

Sterling CR, Tank AW

The Journal of pharmacology and experimental therapeutics.. 2001 January 296 (1):15-21. Epub 1900 01 01.

The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease.

Thiruchelvam M, Richfield EK, Baggs RB, Tank AW, Cory-Slechta DA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2000 December 1520 (24):9207-14. Epub 1900 01 01.

CREB mediates the cAMP-responsiveness of the tyrosine hydroxylase gene: use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines.

Piech-Dumas KM, Tank AW

Brain research. Molecular brain research.. 1999 July 570 (2):219-30. Epub 1900 01 01.

Regulation of tyrosine hydroxylase gene expression by muscarinic agonists in rat adrenal medulla.

Piech-Dumas KM, Sterling CR, Tank AW

Journal of neurochemistry.. 1999 July 73 (1):153-61. Epub 1900 01 01.

Transient or sustained transcriptional activation of the genes encoding rat adrenomedullary catecholamine biosynthetic enzymes by different durations of immobilization stress.

Nankova BB, Tank AW, Sabban EL

Neuroscience.. 1999 94 (3):803-8. Epub 1900 01 01.

The THCRE2 site in the rat tyrosine hydroxylase gene promoter is responsive to phorbol ester.

Best JA, Tank AW

Neuroscience letters.. 1998 December 24258 (3):131-4. Epub 1900 01 01.

Regulation of tyrosine hydroxylase activity by muscarinic agonists in rat adrenal medulla.

Tank AW, Osterhout CA, Sterling CR

The Journal of pharmacology and experimental therapeutics.. 1998 August 286 (2):848-54. Epub 1900 01 01.

Long-term effects of amphetamine neurotoxicity on tyrosine hydroxylase mRNA and protein in aged rats.

Bowyer JF, Frame LT, Clausing P, Nagamoto-Combs K, Osterhout CA, Sterling CR, Tank AW

The Journal of pharmacology and experimental therapeutics.. 1998 August 286 (2):1074-85. Epub 1900 01 01.

Regulation of tyrosine hydroxylase gene expression by transsynaptic mechanisms and cell-cell contact.

Tank AW, Piech KM, Osterhout CA, Sun B, Sterling C

Advances in pharmacology.. 1998 42 :25-9. Epub 1900 01 01.

Induction of tyrosine hydroxylase protein and a transgene containing tyrosine hydroxylase 5' flanking sequences by stress in mouse adrenal gland.

Osterhout CA, Chikaraishi DM, Tank AW

Journal of neurochemistry.. 1997 March 68 (3):1071-7. Epub 1900 01 01.

Tyrosine hydroxylase gene promoter activity is regulated by both cyclic AMP-responsive element and AP1 sites following calcium influx. Evidence for cyclic amp-responsive element binding protein-independent regulation.

Nagamoto-Combs K, Piech KM, Best JA, Sun B, Tank AW

The Journal of biological chemistry.. 1997 February 28272 (9):6051-8. Epub 1900 01 01.

Regulation of tyrosine hydroxylase gene expression by the m1 muscarinic acetylcholine receptor in rat pheochromocytoma cells.

Chen Y, Best JA, Nagamoto K, Tank AW

Brain research. Molecular brain research.. 1996 August 40 (1):42-54. Epub 1900 01 01.

The response of the tyrosine hydroxylase gene to cyclic AMP is mediated by two cyclic AMP-response elements.

Best JA, Chen Y, Piech KM, Tank AW

Journal of neurochemistry.. 1995 November 65 (5):1934-43. Epub 1900 01 01.

Increased cell-cell contact stimulates the transcription rate of the tyrosine hydroxylase gene in rat pheochromocytoma PC18 cells.

Carlson CD, Tank AW

Journal of neurochemistry.. 1994 March 62 (3):844-53. Epub 1900 01 01.

Regulation of tyrosine hydroxylase gene transcription rate and tyrosine hydroxylase mRNA stability by cyclic AMP and glucocorticoid.

Fossom LH, Sterling CR, Tank AW

Molecular pharmacology.. 1992 November 42 (5):898-908. Epub 1900 01 01.

Phosphorylation and activation of tyrosine hydroxylase in PC18 cells: a cell line derived from rat pheochromocytoma PC12 cells.

Bowyer JF, Nakanishi A, Houchi H, Dreyer E, Sterling C, Masserano JS, Tank AW, Weiner N

Brain research.. 1992 September 25591 (2):261-70. Epub 1900 01 01.

Molecular aspects of the regulation of tyrosine hydroxylase by testosterone.

Goldstein ME, Tank AW, Fossom LH, Hamill RW

Brain research. Molecular brain research.. 1992 June 14 (1-2):79-86. Epub 1900 01 01.

The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum.

Bowyer JF, Tank AW, Newport GD, Slikker W, Ali SF, Holson RR

The Journal of pharmacology and experimental therapeutics.. 1992 February 260 (2):817-24. Epub 1900 01 01.

Activation of tyrosine hydroxylase by nicotine in rat adrenal gland.

Fossom LH, Sterling C, Tank AW

Journal of neurochemistry.. 1991 December 57 (6):2070-7. Epub 1900 01 01.

Stimulation of tyrosine hydroxylase gene transcription rate by nicotine in rat adrenal medulla.

Fossom LH, Carlson CD, Tank AW

Molecular pharmacology.. 1991 August 40 (2):193-202. Epub 1900 01 01.

Tyrosine hydroxylase mRNA in the dopaminergic neurons of young adult and aged mice by in situ hybridization.

Gupta M, Stoler MH, Fossom LH, Tank AW

Neuroscience letters.. 1990 October 30119 (1):49-52. Epub 1900 01 01.

Tyrosine hydroxylase is activated and phosphorylated on different sites in rat pheochromocytoma PC12 cells treated with phorbol ester and forskolin.

Tachikawa E, Tank AW, Weiner DH, Mosimann WF, Yanagihara N, Weiner N

Journal of neurochemistry.. 1987 May 48 (5):1366-76. Epub 1900 01 01.

Tyrosine 3-monooxygenase from rat pheochromocytoma.

Tank AW, Weiner N

Methods in enzymology.. 1987 142 :71-82. Epub 1900 01 01.

Effects of induction of rat liver cytosolic aldehyde dehydrogenase on the oxidation of biogenic aldehydes.

Tank AW, Deitrich RA, Weiner H

Biochemical pharmacology.. 1986 December 1535 (24):4563-9. Epub 1900 01 01.

Induction of tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: effect of the inducing agents alone or in combination on the enzyme levels and rate of synthesis of tyrosine hydroxylase.

Tank AW, Ham L, Curella P

Molecular pharmacology.. 1986 November 30 (5):486-96. Epub 1900 01 01.

Phosphorylation of tyrosine hydroxylase on at least three sites in rat pheochromocytoma PC12 cells treated with 56 mM K+: determination of the sites on tyrosine hydroxylase phosphorylated by cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases.

Tachikawa E, Tank AW, Yanagihara N, Mosimann W, Weiner N

Molecular pharmacology.. 1986 November 30 (5):476-85. Epub 1900 01 01.

Induction of mRNA for tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: evidence for the regulation of tyrosine hydroxylase synthesis by multiple mechanisms in cells exposed to elevated levels of both inducing agents.

Tank AW, Curella P, Ham L

Molecular pharmacology.. 1986 November 30 (5):497-503. Epub 1900 01 01.

Enhanced phosphorylation of tyrosine hydroxylase at more than one site is induced by 56 mM K+ in rat pheochromocytoma PC12 cells in culture.

Yanagihara N, Tank AW, Langan TA, Weiner N

Journal of neurochemistry.. 1986 February 46 (2):562-8. Epub 1900 01 01.

Elevation of RNA coding for tyrosine hydroxylase in rat adrenal gland by reserpine treatment and exposure to cold.

Tank AW, Lewis EJ, Chikaraishi DM, Weiner N

Journal of neurochemistry.. 1985 October 45 (4):1030-3. Epub 1900 01 01.

Cyclic AMP-dependent protein kinase is not involved in the in vivo activation of tyrosine hydroxylase in the adrenal gland after decapitation.

Tank AW, Meligeni J, Weiner N

The Journal of biological chemistry.. 1984 July 25259 (14):9269-76. Epub 1900 01 01.

Relationship between activation and phosphorylation of tyrosine hydroxylase by 56 mm K+ in PC12 cells in culture.

Yanagihara N, Tank AW, Weiner N

Molecular pharmacology.. 1984 July 26 (1):141-7. Epub 1900 01 01.

Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. Isolation of a cDNA clone for tyrosine hydroxylase mRNA.

Lewis EJ, Tank AW, Weiner N, Chikaraishi DM

The Journal of biological chemistry.. 1983 December 10258 (23):14632-7. Epub 1900 01 01.

Induction of tyrosine hydroxylase by glucocorticoids in mouse neuroblastoma cells. Enhancement of the induction by cyclic AMP.

Tank AW, Weiner N

Molecular pharmacology.. 1982 September 22 (2):421-30. Epub 1900 01 01.

Enzymology and subcellular localization of aldehyde oxidation in rat liver. Oxidation of 3,4-dihydroxyphenylacetaldehyde derived from dopamine to 3,4-dihydroxyphenylacetic acid.

Tank AW, Weiner H, Thurman JA

Biochemical pharmacology.. 1981 December 1530 (24):3265-75. Epub 1900 01 01.

Effect of carbachol and 56 mm-potassium chloride on the cyclic AMP-mediated induction of tyrosine hydroxylase in neuroblastoma cells in culture.

Tank AW, Weiner N

Journal of neurochemistry.. 1981 February 36 (2):518-31. Epub 1900 01 01.

Ethanol-induced alteration of dopamine metabolism in rat liver.

Tank AW, Weiner H

Biochemical pharmacology.. 1979 October 1528 (20):3139-47. Epub 1900 01 01.

The effects of ethanol on dopamine metabolism in rat liver and brain.

Tank AW, Weiner H

Advances in experimental medicine and biology.. 1977 85A :473-83. Epub 1900 01 01.

Ethanol-induced alterations of dopamine metabolism in rat liver.

Tank AW, Weiner H, Thurman JA

Annals of the New York Academy of Sciences.. 1976 273 :219-26. Epub 1900 01 01.

Books

Stress: Neural, Endocrine and Molecular Studies (2002)

Chapter: Regulation of tyrosine hydroxylase gene transcription rate by stress: Use of transgenic mice.

Adv. Pharmacol. (1998)

Chapter: Regulation of tyrosine hydroxylase gene expression by transsynaptic mechanisms and cell-cell contact.

Stress: Molecular Genetic and Neurobiological Advances (1996)

Chapter: Regulation of tyrosine hydroxylase gene expression by multiple receptor-mediated pathways during stress or nicotine treatment.

Catecholamine Genes (1990)

Chapter: Regulation of tyrosine hydroxylase in rat pheochromocytoma cell lines.

Handbook of Exp. Pharmacol. (1989)

Chapter: The role of tyrosine hydroxylase in the regulation of catecholamine synthesis.

Methods in Enzymology (1987)

Chapter: Tyrosine hydroxylase from rat pheochromocytoma.

Catecholamines, Basic and Peripheral Mechanisms (1984)

Chapter: Studies on the mechanism of activation of tyrosine hydroxylase in situ in PC12 cells.

Neuronal and Extraneuronal Events in Autonomic Pharmacology (1984)

Chapter: Activation of tyrosine hydroxylase during K+-evoked depolarization of PC12 cells: Involvement of protein phosphorylation.

Synhesis, Storage and Secretion of Adrenal Catecholamine (1982)

Chapter: Activation of adrenal tyrosine hydroxylase following acute and chronic stress.

Cold Spring Harbor Conferences on Cell Proliferation (1981)

Chapter: In vivo phosphorylation of rat adrenal tyrosine hydroxylase during acute decapitation stress.

Regulation and Function of Monoamine Enzymes (1981)

Chapter: In situ phosphorylation of vas deferens tyrosine hydroxylase during hypogastric nerve stimulation.

Regulation and Function of Monoamine Enzymes (1981)

Chapter: Regulation of tyrosine hydroxylase by cyclic AMP and dexamethasone in mouse neuroblastoma cells.

Catecholamines: Basic & Clinical Frontiers, Proceedings of 4th Int. Symposium (1979)

Chapter: The effect of carbachol on cyclic AMP-mediated induction of tyrosine hydroxylase in neuroblastoma cells.

Alcohol Intoxication and Withdrawal IIIa (1977)

Chapter: The effects of ethanol on dopamine metabolism in rat liver and brain.

Alcohol and Aldehyde Metabolizing Systems II (1977)

Chapter: Intracellular location of 3,4-dihydroxyphenylacetaldehyde and acetaldehyde oxidation in rat liver.

Ethanol-induced alterations of dopa-mine metabolism in rat liver. (1976)