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Trevor J. Shuttleworth, Ph.D.

Trevor J. Shuttleworth, Ph.D.

About Me

Faculty Appointments

Professor Emeritus - Department of Pharmacology and Physiology (SMD)

Credentials

Post-doctoral Training & Residency

SRC Research Associate, Department of Biological Sciences, University of Lancaster, England 1972 - 1974

Education

PhD | New Zealand-Univ of Otago. Zoology/Comp. Physiology. 1972

BS | UK-Univ of London. Zoology. 1968

Awards

Chair and Organizer, Satellite Symposium on "Orai Channels--New Insights, New Ideas". 2012

Plenary Speaker, Ion Channel Signaling Mechanisms: from Basic Science to Clinical Applications. 2011 - 2011

Session Chair - Salivary Glands and Saliva. 2003

Session Chair - 5th UK Calcium Signalling Conference, Liverpool, England. 2003

Session Chair - Professor Sir Michael Berridge Retirement Conference, Cambridge, England. 2003

Session Chair - International Workshop on "Experimental and Theoretical Calcium Dynamics" Max-Planck institute for the Physics of Complex Systems, Dresden, Germany 2000

Session Chair - Experimental Biology 1993 (FASEB) meeting, New Orleans 1993

Session Chair - Joint Meeting of the APS, ASZ, CSZ and SEB, Cambridge, England 1992

Session Chair - International Symposium on "Mechanisms of Systemic Regulation in Lower Vertebrates", Göttingen, Germany 1990

Session Chair - Society for Experimental Biology Conference, York, U.K. 1987

Session Chair - IUPS International Congress, Vancouver, Canada 1986

Session Chair - IUPS Satellite Symposium on "Membrane Transport and Control: Comparative Mechanisms", Banff, Canada 1986

Session Chair - Society for Experimental Biology Conference, Bangor, U.K. 1985

Session Chair - Society for Experimental Biology Conference, Cardiff, U.K. 1984

Session Chair - Seminar Series Symposium of the Society for Experimental Biology, Durham, U.K. 1981

Session Chair - Society for Experimental Biology Conference, Lancaster, U.K. 1979

Science Research Council Fellowship (U.K.), University of Lancaster, England 1972 - 1974

University of Otago Teaching Fellowship, University of Otago, New Zealand 1969 - 1972

Research

The cellular actions of many neurotransmitters and hormones are dependent on receptor-activated increases in intracellular calcium concentrations in their target cells. In various secretory and other "non-excitable" cells, the physiologically relevant signals often take the form of a series of Ca2+ ...
The cellular actions of many neurotransmitters and hormones are dependent on receptor-activated increases in intracellular calcium concentrations in their target cells. In various secretory and other "non-excitable" cells, the physiologically relevant signals often take the form of a series of Ca2+ oscillations, and many critical cellular responses are tuned to respond to the specific frequency of such oscillations. A key factor in sustaining these signals and determining their frequency, is the receptor-activated entry of Ca2+ from the extracellular medium. Our research concerns the nature of the conductances responsible for this entry, and their specific roles in modulating the overall Ca2+ signal. Specifically, our recent research has focused on the ARC channel – a novel Ca2+ entry channel that is activated by the receptor-mediated generation of arachidonic acid, and which we first described a few years ago. Importantly, it is this channel that appears to play the major role in the entry of Ca2+ during the generation of the oscillatory Ca2+ signals in several cell types. We have recently characterized the key molecular components of this channel, revealing that it is a member of a new family of channels – the "Orai-based channels". This molecular characterization has opened up new opportunities for the analysis of its nature, mechanism of activation, and regulation. This, along with identifying how the Ca2+ entering via this channel acts to modulate the frequency of the agonist-induced Ca2+ oscillations, forms the major focus of our current research.

Techniques used include patch-clamp analysis of ion-channel activity, digital imaging, real-time confocal imaging, and photon-counting microfluorimetric measurements of intracellular Ca2+ concentrations in single cells, and biochemical and molecular studies of the proteins that form the channel and its regulators.

Publications

Journal Articles

Selective activation of distinct Orai channels by STIM1.

Shuttleworth TJ

Cell calcium.. 2017 May 63 :40-42. Epub 11/04/2016.

Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channel.

Thompson JL, Shuttleworth TJ

The Journal of physiology.. 2015 February 1593 (3):559-72. Epub 01/07/2015.

Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity.

Duquette M, Nadler M, Okuhara D, Thompson J, Shuttleworth T, Lawler J

Matrix biology : journal of the International Society for Matrix Biology.. 2014 July 37 :15-24. Epub 05/16/2014.

How many Orai's does it take to make a CRAC channel?

Thompson, JL; Shuttleworth, TJ.

Nature Scientific Reports. 2013; 3: 1961.

Molecular basis of activation of the arachidonate-regulated ARC channel, a store-independent Orai channel, by plasma membrane STIM1

Thompson, JL; Shuttleworth, TJ.

The Journal of Physiology. 2013; 591: 3507-3523.

Exploring the unique features of the ARC channel, a store-independent Orai channel

Thompson, JL.; Shuttleworth, TJ.

Channels. 2013; 7: 364-373.

The ARC channel--an endogenous store-independent Orai channel.

Thompson JL, Mignen O, Shuttleworth TJ

Current topics in membranes.. 2013 71 :125-48. Epub 1900 01 01.

Orai channels - new insights, new ideas.

Shuttleworth TJ

The Journal of physiology.. 2012 September 1590 (17):4155-6. Epub 1900 01 01.

Modelling the effects of calcium waves and oscillations on saliva secretion.

Palk L, Sneyd J, Patterson K, Shuttleworth TJ, Yule DI, Maclaren O, Crampin EJ

Journal of theoretical biology.. 2012 July 21305 :45-53. Epub 04/14/2012.

Orai3--the 'exceptional' Orai?

Shuttleworth TJ

The Journal of physiology.. 2012 January 15590 (2):241-57. Epub 10/31/2011.

STIM and Orai proteins and the non-capacitative ARC channels

Shuttleworth, TJ.

Frontiers in Bioscience. 2012; 17: 847-860.

A plasma membrane-targeted cytosolic domain of STIM1 selectively activates ARC channels, an arachidonate-regulated store-independent Orai channel.

Thompson JL, Shuttleworth TJ

Channels.. 2012 6 (5):370-8. Epub 09/01/2012.

Orai channel-dependent activation of phospholipase C-?: a novel mechanism for the effects of calcium entry on calcium oscillations.

Thompson JL, Shuttleworth TJ

The Journal of physiology.. 2011 November 1589 (Pt 21):5057-69. Epub 08/30/2011.

A dynamic model of saliva secretion.

Palk L, Sneyd J, Shuttleworth TJ, Yule DI, Crampin EJ

Journal of theoretical biology.. 2010 October 21266 (4):625-40. Epub 06/25/2010.

The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid.

Thompson JL, Mignen O, Shuttleworth TJ

Channels.. 2010 4 (5):398-410. Epub 09/01/2010.

The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits.

Mignen O, Thompson JL, Shuttleworth TJ

The Journal of physiology.. 2009 September 1587 (Pt 17):4181-97. Epub 07/21/2009.

Arachidonic acid, ARC channels, and Orai proteins.

Shuttleworth TJ

Cell calcium.. 2009 June 45 (6):602-10. Epub 03/17/2009.

The Orai1 severe combined immune deficiency mutation and calcium release-activated Ca2+ channel function in the heterozygous condition.

Thompson JL, Mignen O, Shuttleworth TJ

The Journal of biological chemistry.. 2009 March 13284 (11):6620-6. Epub 12/15/2008.

Orai1 subunit stoichiometry of the mammalian CRAC channel pore.

Mignen O, Thompson JL, Shuttleworth TJ

The Journal of physiology.. 2008 January 15586 (2):419-25. Epub 11/15/2007.

Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels.

Mignen O, Thompson JL, Shuttleworth TJ

The Journal of physiology.. 2008 January 1586 (1):185-95. Epub 11/08/2007.

STIM1 and the noncapacitative ARC channels.

Shuttleworth TJ, Thompson JL, Mignen O

Cell calcium.. 2007 August 42 (2):183-91. Epub 03/27/2007.

STIM1 regulates Ca2+ entry via arachidonate-regulated Ca2+-selective (ARC) channels without store depletion or translocation to the plasma membrane.

Mignen O, Thompson JL, Shuttleworth TJ

The Journal of physiology.. 2007 March 15579 (Pt 3):703-15. Epub 12/07/2006.

A mathematical model of fluid secretion from a parotid acinar cell.

Gin,E.; Crampin,E.J.; Brown,D.A.; Shuttleworth,T.J.; Yule,D.I.; and Snyd,J.

J.Theoret.Biol. 2007; 248: 64-80.

A critical analysis of carbonic anhydrase function, respiratory gas exchange, and the acid-base control of secretion in the rectal gland of Squalus acanthias.

Shuttleworth TJ, Thompson J, Munger RS, Wood CM

The Journal of experimental biology.. 2006 December 209 (Pt 23):4701-16. Epub 1900 01 01.

Carboxyamidotriazole-induced inhibition of mitochondrial calcium import blocks capacitative calcium entry and cell proliferation in HEK-293 cells.

Mignen O, Brink C, Enfissi A, Nadkarni A, Shuttleworth TJ, Giovannucci DR, Capiod T

Journal of cell science.. 2005 December 1118 (Pt 23):5615-23. Epub 1900 01 01.

Arachidonate-regulated Ca2+-selective (ARC) channel activity is modulated by phosphorylation and involves an A-kinase anchoring protein.

Mignen O, Thompson JL, Shuttleworth TJ

The Journal of physiology.. 2005 September 15567 (Pt 3):787-98. Epub 06/30/2005.

Agonist activation of arachidonate-regulated Ca2+-selective (ARC) channels in murine parotid and pancreatic acinar cells.

Mignen O, Thompson JL, Yule DI, Shuttleworth TJ

The Journal of physiology.. 2005 May 1564 (Pt 3):791-801. Epub 03/10/2005.

Regulation of fluid and electrolyte secretion in salivary gland acinar cells.

Melvin JE, Yule D, Shuttleworth T, Begenisich T

Annual review of physiology.. 2005 67 :445-69. Epub 1900 01 01.

ARC channels: a novel pathway for receptor-activated calcium entry.

Shuttleworth TJ, Thompson JL, Mignen O

Physiology.. 2004 December 19 :355-61. Epub 1900 01 01.

Receptor-activated calcium entry channels--who does what, and when?

Shuttleworth TJ

Science's STKE : signal transduction knowledge environment. 2004 July 202004 (243):pe40. Epub 07/20/2004.

Modulation of [Ca2+]i signaling dynamics and metabolism by perinuclear mitochondria in mouse parotid acinar cells.

Bruce JI, Giovannucci DR, Blinder G, Shuttleworth TJ, Yule DI

The Journal of biological chemistry.. 2004 March 26279 (13):12909-17. Epub 12/29/2003.

Control of calcium oscillations by membrane fluxes.

Yule DI, Sneyd J, Thompson JL, Tsaneva-Atanasova K, Shuttleworth TJ, Yule DI, Thompson JL, Shuttleworth TJ

Proceedings of the National Academy of Sciences of the United States of America.. 2004 February 3101 (5):1392-6. Epub 01/20/2004.

Calcineurin directs the reciprocal regulation of calcium entry pathways in nonexcitable cells.

Mignen O, Thompson JL, Shuttleworth TJ

The Journal of biological chemistry.. 2003 October 10278 (41):40088-96. Epub 07/21/2003.

Calcium entry and the control of calcium oscillations.

Shuttleworth TJ, Mignen O

Biochemical Society transactions.. 2003 October 31 (Pt 5):916-9. Epub 1900 01 01.

Ca2+ selectivity and fatty acid specificity of the noncapacitative, arachidonate-regulated Ca2+ (ARC) channels.

Mignen O, Thompson JL, Shuttleworth TJ

The Journal of biological chemistry.. 2003 March 21278 (12):10174-81. Epub 01/09/2003.

Ca2+-dependent protein kinase--a modulation of the plasma membrane Ca2+-ATPase in parotid acinar cells.

Bruce JI, Yule DI, Shuttleworth TJ

The Journal of biological chemistry.. 2002 December 13277 (50):48172-81. Epub 10/03/2002.

Cytosolic Ca(2+) and Ca(2+)-activated Cl(-) current dynamics: insights from two functionally distinct mouse exocrine cells.

Giovannucci DR, Bruce JI, Straub SV, Arreola J, Sneyd J, Shuttleworth TJ, Yule DI

The Journal of physiology.. 2002 April 15540 (Pt 2):469-84. Epub 1900 01 01.

Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling.

Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI

The Journal of biological chemistry.. 2002 January 11277 (2):1340-8. Epub 11/01/2001.

Reciprocal regulation of capacitative and arachidonate-regulated noncapacitative Ca2+ entry pathways.

Mignen O, Thompson JL, Shuttleworth TJ

The Journal of biological chemistry.. 2001 September 21276 (38):35676-83. Epub 07/24/2001.

Permeation of monovalent cations through the non-capacitative arachidonate-regulated Ca2+ channels in HEK293 cells. Comparison with endogenous store-operated channels.

Mignen O, Shuttleworth TJ

The Journal of biological chemistry.. 2001 June 15276 (24):21365-74. Epub 04/02/2001.

I(ARC), a novel arachidonate-regulated, noncapacitative Ca(2+) entry channel.

Mignen O, Shuttleworth TJ

The Journal of biological chemistry.. 2000 March 31275 (13):9114-9. Epub 1900 01 01.

A Ca(2+)-independent activation of a type IV cytosolic phospholipase A(2) underlies the receptor stimulation of arachidonic acid-dependent noncapacitative calcium entry.

Osterhout JL, Shuttleworth TJ

The Journal of biological chemistry.. 2000 March 17275 (11):8248-54. Epub 1900 01 01.

Discriminating between capacitative and arachidonate-activated Ca(2+) entry pathways in HEK293 cells.

Shuttleworth TJ, Thompson JL

The Journal of biological chemistry.. 1999 October 29274 (44):31174-8. Epub 1900 01 01.

Vertebrate salt glands: short- and long-term regulation of function.

Shuttleworth TJ, Hildebrandt JP

The Journal of experimental zoology.. 1999 June 1283 (7):689-701. Epub 1900 01 01.

What drives calcium entry during [Ca2+]i oscillations?--challenging the capacitative model.

Shuttleworth TJ

Cell calcium.. 1999 March 25 (3):237-46. Epub 1900 01 01.

Muscarinic receptor activation of arachidonate-mediated Ca2+ entry in HEK293 cells is independent of phospholipase C.

Shuttleworth TJ, Thompson JL

The Journal of biological chemistry.. 1998 December 4273 (49):32636-43. Epub 1900 01 01.

Intracellular Ca2+ signalling in secretory cells.

Shuttleworth TJ

The Journal of experimental biology.. 1997 January 200 (Pt 2):303-14. Epub 1900 01 01.

The control of fluid-secreting epithelia by VIP.

Martin SC, Shuttleworth TJ

Annals of the New York Academy of Sciences.. 1996 December 26805 :133-47; discussion 147-8. Epub 1900 01 01.

Clustered distribution of calcium sensitivities: an indication of hetero-tetrameric gating components in Ca2+-activated K+ channels reconstituted from avian nasal gland cells.

Wu JV, Shuttleworth TJ, Stampe P

The Journal of membrane biology.. 1996 December 154 (3):275-82. Epub 1900 01 01.

Arachidonic acid activates the noncapacitative entry of Ca2+ during [Ca2+]i oscillations.

Shuttleworth TJ

The Journal of biological chemistry.. 1996 September 6271 (36):21720-5. Epub 1900 01 01.

Evidence for a non-capacitative Ca2+ entry during [Ca2+] oscillations.

Shuttleworth TJ, Thompson JL

The Biochemical journal.. 1996 June 15316 ( Pt 3) (Pt 3):819-24. Epub 1900 01 01.

Ca2+ entry modulates oscillation frequency by triggering Ca2+ release.

Shuttleworth TJ, Thompson JL

The Biochemical journal.. 1996 February 1313 ( Pt 3) (Pt 3):815-9. Epub 1900 01 01.

A re-evaluation of the apparent effects of luminal Ca2+ on inositol 1,4,5-trisphosphate-induced Ca2+ release.

Shuttleworth TJ

Cell calcium.. 1995 June 17 (6):393-8. Epub 1900 01 01.

Activation by ATP of a P2U 'nucleotide' receptor in an exocrine cell.

Martin SC, Shuttleworth TJ

British journal of pharmacology.. 1995 May 115 (2):321-9. Epub 1900 01 01.

Ca2+ influx drives agonist-activated [Ca2+]i oscillations in an exocrine cell.

Martin SC, Shuttleworth TJ

FEBS letters.. 1994 September 19352 (1):32-6. Epub 1900 01 01.

Vasoactive intestinal peptide stimulates a cAMP-mediated Cl- current in avian salt gland cells.

Martin SC, Shuttleworth TJ

Regulatory peptides.. 1994 August 452 (3):205-14. Epub 1900 01 01.

Potentiation of Ca(2+)-activated secretory activity by a cAMP-mediated mechanism in avian salt gland cells.

Martin SC, Thompson J, Shuttleworth TJ

The American journal of physiology.. 1994 July 267 (1 Pt 1):C255-65. Epub 1900 01 01.

Temporal relationships between Ca2+ store mobilization and Ca2+ entry in an exocrine cell.

Shuttleworth TJ

Cell calcium.. 1994 June 15 (6):457-66. Epub 1900 01 01.

Muscarinic receptor characterization in differentiating avian exocrine cells.

Hildebrandt JP, Shuttleworth TJ

The American journal of physiology.. 1994 March 266 (3 Pt 2):R674-81. Epub 1900 01 01.

Muscarinic-receptor activation stimulates oscillations in K+ and Cl- currents which are acutely dependent on extracellular Ca2+ in avian salt gland cells.

Martin SC, Shuttleworth TJ

Pflu?gers Archiv : European journal of physiology.. 1994 February 426 (3-4):231-8. Epub 1900 01 01.

A Gq-type G protein couples muscarinic receptors to inositol phosphate and calcium signaling in exocrine cells from the avian salt gland.

Hildebrandt JP, Shuttleworth TJ

The Journal of membrane biology.. 1993 April 133 (2):183-90. Epub 1900 01 01.

Modulation of inositol(1,4,5)trisphosphate-sensitive calcium store content during continuous receptor activation and its effects on calcium entry.

Shuttleworth TJ, Thompson JL

Cell calcium.. 1992 October 13 (9):541-51. Epub 1900 01 01.

Calcium-sensitivity of inositol 1,4,5-trisphosphate metabolism in exocrine cells from the avian salt gland.

Hildebrandt JP, Shuttleworth TJ

The Biochemical journal.. 1992 March 15282 ( Pt 3) (Pt 3):703-10. Epub 1900 01 01.

Ca2+ release from inositol trisphosphate-sensitive stores is not modulated by intraluminal [Ca2+].

Shuttleworth TJ

The Journal of biological chemistry.. 1992 February 25267 (6):3573-6. Epub 1900 01 01.

Changes in pHi associated with activation of ion secretion in avian nasal salt gland cells.

Shuttleworth TJ, Wood CM

The American journal of physiology.. 1992 January 262 (1 Pt 1):C221-8. Epub 1900 01 01.

Inositol phosphates and [Ca2+]i signals in a differentiating exocrine cell.

Hildebrandt JP, Shuttleworth TJ

The American journal of physiology.. 1991 August 261 (2 Pt 1):C210-7. Epub 1900 01 01.

Effect of temperature on receptor-activated changes in [Ca2+]i and their determination using fluorescent probes.

Shuttleworth TJ, Thompson JL

The Journal of biological chemistry.. 1991 January 25266 (3):1410-4. Epub 1900 01 01.

Fluoroaluminate activation of different components of the calcium signal in an exocrine cell.

Shuttleworth TJ

The Biochemical journal.. 1990 July 15269 (2):417-22. Epub 1900 01 01.

Receptor-activated calcium entry in exocrine cells does not occur via agonist-sensitive intracellular pools.

Shuttleworth TJ

The Biochemical journal.. 1990 March 15266 (3):719-26. Epub 1900 01 01.

Intracellular [Ca2+] and inositol phosphates in avian nasal gland cells.

Shuttleworth TJ, Thompson JL

The American journal of physiology.. 1989 November 257 (5 Pt 1):C1020-9. Epub 1900 01 01.

Overview of epithelial ion-transport mechanisms.

Shuttleworth, T.J.

Can. J. Zool. 1989; 67: 3032-3038.

A novel vasoactive intestinal peptide (VIP) from elasmobranch intestine has full affinity for mammalian pancreatic VIP receptors.

Dimaline R, Young J, Thwaites DT, Lee CM, Shuttleworth TJ, Thorndyke MC

Biochimica et biophysica acta.. 1987 August 19930 (1):97-100. Epub 1900 01 01.

Potassium secretion by nasal salt glands of desert lizard Sauromalus obesus.

Shuttleworth TJ, Thompson JL, Dantzler WH

The American journal of physiology.. 1987 July 253 (1 Pt 2):R83-90. Epub 1900 01 01.

Secretory activity in salt glands of birds and turtles: stimulation via cyclic AMP.

Shuttleworth TJ, Thompson JL

The American journal of physiology.. 1987 February 252 (2 Pt 2):R428-32. Epub 1900 01 01.

Sites of interactions of surfactants with beta-adrenergic responses in trout (Salmo gairdneri) gills.

Stagg RM, Shuttleworth TJ

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.. 1987 157 (4):429-34. Epub 1900 01 01.

Mode of adrenergic and peptidergic inhibition of ion transport in flounder gill.

Davis MS, Shuttleworth TJ

The American journal of physiology.. 1986 December 251 (6 Pt 2):R1064-70. Epub 1900 01 01.

Perfusion-secretion relationships in the isolated elasmobranch rectal gland.

Shuttleworth TJ, Thompson JL

The Journal of experimental biology.. 1986 September 125 :373-84. Epub 1900 01 01.

Surfactant effects on adrenergic responses in the gills of the flounder (Platichthys flesus L.)

Stagg, R.M.; Shuttleworth, T.J.

J. Comp. Physiol. 1986; 156: 727-733.

Peptidergic and adrenergic regulation of electrogenic ion transport in isolated gills of the flounder (Platichthys flesus L.)

Davis, M.S.; Shuttleworth, T.J.

J. Comp. Physiol. 1985; : 471-478.

Distribution of intracellular sodium, potassium and chloride in Arenicola marina (L.) equilibrated to diluted sea water.

Freeman, R.F.H.; Shuttleworth, T.J.

J. Mar. Biol. Ass. U.K. 1985; 65: 395-413.

Pancreatic peptides regulate Cl- secretion in the marine teleost gill.

Davis MS, Shuttleworth TJ

Peptides.. 1985 6 Suppl 3 :379-82. Epub 1900 01 01.

Biochemical and physiological studies on peptides from the elasmobranch gut.

Thorndyke MC, Shuttleworth TJ

Peptides.. 1985 6 Suppl 3 :369-72. Epub 1900 01 01.

An endogenous peptide stimulates secretory activity in the elasmobranch rectal gland.

Shuttleworth TJ, Thorndyke MC

Science.. 1984 July 20225 (4659):319-21. Epub 1900 01 01.

Beta-alanine transport in the isolated hepatocytes of the elasmobranch Raja erinacea.

Shuttleworth TJ, Goldstein L

The Journal of experimental zoology.. 1984 July 231 (1):39-44. Epub 1900 01 01.

Hemodynamics and potentials in isolated flounder gills: effects of catecholamines.

Stagg RM, Shuttleworth TJ

The American journal of physiology.. 1984 February 246 (2 Pt 2):R211-20. Epub 1900 01 01.

Role of calcium in cAMP-mediated effects in the elasmobranch rectal gland.

Shuttleworth TJ

The American journal of physiology.. 1983 December 245 (6):R894-900. Epub 1900 01 01.

Haemodynamic effects of secretory agents on the isolated elasmobranch rectal gland.

Shuttleworth TJ

The Journal of experimental biology.. 1983 March 103 :193-204. Epub 1900 01 01.

Amphotericin B and the elasmobranch rectal gland: implications for the relationship between oxygen consumption and ion transport.

Shuttleworth TJ

The Journal of experimental zoology.. 1982 June 10221 (2):255-8. Epub 1900 01 01.

Na, K ATPase, ouabain binding and ouabain-sensitive oxygen consumption in gills from Platichthys flesus adapted to seawater and freshwater.

Stagg, R.M.; Shuttleworth, T.J.

J. Comp. Physiol. 1982; 147: 93-99.

The accumulation of copper in Platichthys flesus L. and its effects on plasma electrolyte concentrations.

Stagg, R.M.; Shuttleworth, T.J.

J. Fish Biol. 1982; : 491-500.

The mechanism of cyclic AMP stimulation of secretion in the dogfish rectal gland.

Shuttleworth, T.J.; Thompson, J.L.

J. Comp. Physiol. 1980; : 209-216.

Oxygen consumption in the rectal gland of the dogfish Scyliorhinus canicula and the effects of cyclic AMP.

Shuttleworth, T.J.; Thompson, J.L.

J. Comp. Physiol. 1980; 136: 39-43.

Cyclic AMP and ouabain-binding sites in the rectal gland of the dogfish Scyliorhinus canicula.

Shuttleworth, T.J.; Thompson, J.L.

J. Exp. Zool. 1978; 206: 297-302.

The effect of adrenaline on potentials in the isolated gills of the flounder (Platichthys flesus L.).

Shuttleworth, T.J.

J. Comp. Physiol. 1978; 124: 129-136.

Distribution of intracellular solutes in Arenicola marina (Polychaeta) equilibrated to diluted sea water.

Freeman, R.F.H.; Shuttleworth, T.J.

J. Mar. Biol. Ass. U.K. 1977; 57: 889-905.

Distribution of water in Arenicola marina (L.) equilibrated to diluted sea water.

Freeman, R.F.H.; Shuttleworth, T.J.

J. Mar. Biol. Ass. U.K. 1977; 57: 501-519.

Distribution of dry matter between the tissues and coelom in Arenicola marina (L.) equilibrated to dilute sea water.

Freeman, R.F.H.; Shuttleworth, T.J.

J. Mar. Biol. Ass. U.K. 1977; 57: 97-107.

Net fluxes of water in the isolated gills of Anguilla dieffenbachii.

Shuttleworth TJ, Freeman RF

The Journal of experimental biology.. 1974 June 60 (3):769-81. Epub 1900 01 01.

Bioelectric potentials in the gills of the flounder Platichthys flesus.

Shuttleworth, T.J., W.T.W. Potts and J.N. Harris.

J. Comp. Physiol. 1974; 94: 321-329.

Factors affecting the net fluxes of ions in the isolated perfused gills of freshwater Anguilla dieffenbachii.

Shuttleworth, T.J.; Freeman, R.F.H.

J. Comp. Physiol. 1974; 94: 297-307.

The role of the gills in seawater adaptation in Anguilla dieffenbachii. I. Osmotic and ionic composition of the blood and gill tissue.

Shuttleworth, T.J.; Freeman, R.F.H.

J. Comp. Physiol. 1973; 86: 239-313.

The role of the gills in seawater adaptation in Anguilla dieffenbachii. II. Net ion fluxes in isolated perfused gills.

Shuttleworth, T.J.; Freeman, R.F.H.

J. Comp. Physiol. 1973; 86: 315-321.

The role of the gills in seawater adaptation in Anguilla dieffenbachii. III. The relative significance of the gills.

Shuttleworth, T.J.; Freeman, R.F.H.

J. Comp. Physiol. 1973; 86: 323-330.

A new isolated perfused gill preparation for the study of the mechanisms of ionic regulation in teleosts.

Shuttleworth TJ

Comparative biochemistry and physiology. A, Comparative

Anchoring protein AKAP79-mediated PKA-phosphorylation of STIM1 determines selective activation of ARC channels, a store-independent Orai channel.

Thompson J.L.; Shuttleworth T.J.

The Journal of Physiology. .

Books

Ion Channels and Transporters in of Epithelia in Health and Disease (2016)

Chapter: Orai Channels

Authors: Shuttleworth, TJ

Publisher: Springer 2016

Current Topics in Membranes (2013)

Chapter: ARC channels – an endogenous store-independent Orai channel

Authors: Thompson, JL; Mignen, O; Shuttleworth, TJ

Publisher: Elsevier Press 2013

Handbook of Cell Signaling (2009)

Chapter: Arachidonic acid-regulated Ca2+ channel

Authors: Shuttleworth, TJ

Publisher: Academic Press 2009

Handbook of Cell Signaling, vol 2 (2003)

Chapter: Arachidonic acid-regulated Ca2+ channel.

Authors: Shuttleworth, T.J.

Publisher: Academic Press 2003

Ionic regulation in animals, (1997)

Chapter: Intracellular signalling in salt-secreting cells - recent advances in the avian nasal gland model

Authors: Shuttleworth, T.J., J.L. Thompson and S.C. Martin

Publisher: Springer Verlag, Berlin 1997

Cellular and Molecular Approaches to Fish Ionic Regulation (1995)

Authors: Wood, C.M., and T.J. Shuttleworth

Publisher: Academic Press, San Diego 1995

Mechanisms of Systemic Regulation: Vol II (1995)

Chapter: Intracellular signals controlling ionic and acid-base regulation in avian nasal gland cells

Authors: Shuttleworth, T.J.

Publisher: Springer Verlag 1995

Handbook of Membrane Channels: Molecular and Cellular Physiology (1994)

Chapter: InsP3 receptor and intracellular Ca2+ release

Authors: Shuttleworth, T.J.

Publisher: Academic Press 1994

Physiology of Elasmobranch Fishes (1988)

Authors: Shuttleworth, T.J

Publisher: Springer Verlag, Berlin. 1988

Physiology of Elasmobranch Fishes (1988)

Chapter: Salt and water balance - Extrarenal mechanisms.

Authors: Shuttleworth, T.J.

Publisher: Springer Verlag, Berlin 1988

Comparative Physiology: Life in Water and on Land (1987)

Chapter: Salt gland function in osmoregulation in terrestrial and aquatic environments.

Authors: Shuttleworth, T.J.

Publisher: Springer Verlag, New York 1987

Transport Processes, Iono- and Osmoregulation (1985)

Chapter: Peptidergic control of transport in the teleost gill

Authors: Shuttleworth, T.J.

Publisher: Springer Verlag, Berlin 1985

Biology in the 80's - Animal Physiology and Biochemistry (1984)

Chapter: Salt secretion and its regulation in vertebrates

Authors: Shuttleworth, T.J.

Publisher: University of Lancaster Press, Lancaster, UK 1984

Gills (1982)

Authors: Houlihan, D.F., J.C. Rankin and T.J. Shuttleworth

Publisher: Cambridge University Press, Cambridge, England. 1982