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Nicholas Jospe, M.D.

Nicholas Jospe, M.D.

About Me

Diabetes
Growth
Diabetes
Growth

Faculty Appointments

Professor Emeritus - Department of Pediatrics, Endocrinology (SMD)

Credentials

Post-doctoral Training & Residency

Pediatric Endocrinology Fellowship, The Johns Hopkins University, Baltimore, MD 1984 - 1988

Residency in Pediatrics, The Brookdale Hospital Medical Center, Brooklyn, NY 1981 - 1984

Education

MD | Free University of Brussels Medical School. Medicine. 1981

BA | Boston University. Biology. 1974

Awards

JDRF - Hope for a Cure Inspiration Award. 2015

Diabetes Award in Adolescent Health. 2003

American Diabetes Association Certificate of Recognition. 2002

JDRF "Inspiration Award". 2002

Research

Dr. Jospe is engaged in clinical research aimed at preventing Type 1 diabetes and studying the underlying mechanisms causing Type 1 diabetes. He is an investigator in "TrialNet", an international study funded by the NIH and other organizations, investigating the natural history of Type 1 diabetes an...
Dr. Jospe is engaged in clinical research aimed at preventing Type 1 diabetes and studying the underlying mechanisms causing Type 1 diabetes. He is an investigator in "TrialNet", an international study funded by the NIH and other organizations, investigating the natural history of Type 1 diabetes and possible interventions to prevent diabetes in individuals at high risk. He has partnered locally with the "Autoimmunity Center of Excellence" at the University of Rochester, as well as the Benaroya Research Institute, Virginia Mason Medical Center, Seattle WA, where he is currently on sabbatical. He is co-investigator in a multi-center industry sponsored study investigating the utility of continuous glucose sensor technology in the care of children with Type 1 diabetes.

Publications

Journal Articles

Antibody Response to Serpin B13 Induces Adaptive Changes in Mouse Pancreatic Islets and Slows Down the Decline in the Residual Beta Cell Function in Children with Recent Onset of Type 1 Diabetes Mellitus.

Kryvalap Y, Lo CW, Manuylova E, Baldzizhar R, Jospe N, Czyzyk J

The Journal of biological chemistry.. 2016 January 1291 (1):266-78. Epub 11/17/2015.

Avidity-dependent programming of autoreactive T cells in T1D.

Durinovic-Belló I, Gersuk VH, Ni C, Wu R, Thorpe J, Jospe N, Sanda S, Greenbaum CJ, Nepom GT

PloS one.. 2014 9 (5):e98074. Epub 05/20/2014.

Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative.

Mallone R, Scotto M, Janicki CN, James EA, Fitzgerald-Miller L, Wagner R, Gottlieb P, Thorpe J, Jospe N, Durinovic-Bellò I, Boitard C, Lou O, Dayan CM, Wong FS,

Diabetes/metabolism research and reviews.. 2011 November 27 (8):720-6. Epub 1900 01 01.

Immunology of Diabetes Society T-Cell Workshop: HLA class II tetramer-directed epitope validation initiative.

James EA, Mallone R, Schloot NC, Gagnerault MC, Thorpe J, Fitzgerald-Miller L, Reichow J, Wagner R, Pham MN, Jospe N, Lou O, Gottlieb PA, Brooks-Worrell BM, Durinovic-Belló I,

Diabetes/metabolism research and reviews.. 2011 November 27 (8):727-36. Epub 1900 01 01.

Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes.

Hughson A, Bromberg I, Johnson B, Quataert S, Jospe N, Fowell DJ

Diabetes.. 2011 August 60 (8):2125-33. Epub 06/29/2011.

Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial.

Skyler JS, Weinstock RS, Raskin P, Yale JF, Barrett E, Gerich JE, Gerstein HC,

Diabetes care.. 2005 July 28 (7):1630-5. Epub 1900 01 01.

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

Skyler JS, Krischer JP, Wolfsdorf J, Cowie C, Palmer JP, Greenbaum C, Cuthbertson D, Rafkin-Mervis LE, Chase HP, Leschek E

Diabetes care.. 2005 May 28 (5):1068-76. Epub 1900 01 01.

Continuous subcutaneous insulin infusion in toddlers and children with type 1 diabetes mellitus is safe and effective.

Mack-Fogg JE, Orlowski CC, Jospe N

Pediatric diabetes.. 2005 March 6 (1):17-21. Epub 1900 01 01.

Hermaphroditus in Greco-Roman myth: lessons and hypotheses for intersex today.

Jospe N, Florence M

Journal of pediatric endocrinology & metabolism : JPEM.. 2004 November 17 (11):1471-9. Epub 1900 01 01.

Comprehensive assessment of professional competence: the Rochester experiment.

Epstein RM, Dannefer EF, Nofziger AC, Hansen JT, Schultz SH, Jospe N, Connard LW, Meldrum SC, Henson LC

Teaching and learning in medicine.. 2004 16 (2):186-96. Epub 1900 01 01.

Effects of insulin in relatives of patients with type 1 diabetes mellitus.

The New England journal of medicine.. 2002 May 30346 (22):1685-91. Epub 1900 01 01.

Expression of GAD65 and islet cell antibody (ICA512) autoantibodies among cytoplasmic ICA+ relatives is associated with eligibility for the Diabetes Prevention Trial-Type 1.

Yu L, Cuthbertson DD, Maclaren N, Jackson R, Palmer JP, Orban T, Eisenbarth GS, Krischer JP,

Diabetes.. 2001 August 50 (8):1735-40. Epub 1900 01 01.

Third-year medical student survey of office preceptorships during the pediatric clerkship.

Jospe N, Kaplowitz PB, McCurdy FA, Gottlieb RP, Harris MA, Boyle R

Archives of pediatrics & adolescent medicine.. 2001 May 155 (5):592-6. Epub 1900 01 01.

First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes.

Chase HP, Cuthbertson DD, Dolan LM, Kaufman F, Krischer JP, Schatz DA, White NH, Wilson DM, Wolfsdorf J

The Journal of pediatrics.. 2001 February 138 (2):244-9. Epub 1900 01 01.

Type I diabetes manifested solely by 2-h oral glucose tolerance test criteria.

Greenbaum CJ, Cuthbertson D, Krischer JP,

Diabetes.. 2001 February 50 (2):470-6. Epub 1900 01 01.

Islet Cell Antibody-Positive Relatives With Human Leukocyte Antigen DQA1*0102, DQB1*0602: Identification by the Diabetes Prevention Trial-Type 1

Greenbaum CJ, Schatz DA, Cuthbertson D, Zeidler A, Eisenbarth GS, Krischer JP, The Diabetes Prevention TrialType 1 Study Group [Jospe N Study Group Member].

Journal of Clinical Endocrinology & Metabolism. 2000; 85((3)): 1255-1260.

Hyponatremia secondary to reset osmostat in a child with a central nervous system midline defect and a chromosomal abnormality.

Gupta P, Mick G, Fong CT, Jospe N, McCormick K

Journal of pediatric endocrinology & metabolism : JPEM.. 2000 13 (9):1637-41. Epub 1900 01 01.

Ambiguity of the external genitalia in an infant with Down syndrome: gender assignment and ethical implications.

Jospe N, Lane A, Greenlaw J, Sulkes SB

Mental retardation.. 1999 June 37 (3):232-6. Epub 1900 01 01.

Fluids and electrolytes--clinical aspects.

Jospe N, Forbes G

Pediatrics in review. 1996 November 17 (11):395-403; quiz 404. Epub 1900 01 01.

Homozygous nonsense mutation in the insulin receptor gene of a patient with severe congenital insulin resistance: leprechaunism and the role of the insulin-like growth factor receptor.

Jospe N, Kaplowitz PB, Furlanetto RW

Clinical endocrinology.. 1996 August 45 (2):229-35. Epub 1900 01 01.

Deletion of lysine 121 creates a temperature-sensitive alteration in insulin binding by the insulin receptor.

Liu R, Zhu J, Jospe N, Furlanetto RW, Bastian W, Livingston JN

The Journal of biological chemistry.. 1995 January 6270 (1):476-82. Epub 1900 01 01.

The Diabetes Prevention Trial-Type 1 Diabetes (DPT-1): Implementation of Screening and Staging of Relatives

DPT-1 Study Group; [Jospe N - Study Group Member].

Transplantation Proceedings (Diabetes Prevention Trial- type 1 Study Group References). 1995; 27((6)): 3377.

Comparison of transdermal and oral estrogen therapy in girls with Turner's syndrome.

Jospe N, Orlowski CC, Furlanetto RW

Journal of pediatric endocrinology & metabolism : JPEM.. 1995 8 (2):111-6. Epub 1900 01 01.

Deletion of 3 basepairs resulting in the loss of lysine-121 in the insulin receptor alpha-subunit in a patient with leprechaunism: binding, phosphorylation, and biological activity.

Jospe N, Zhu J, Liu R, Livingston JN, Furlanetto RW

The Journal of clinical endocrinology and metabolism.. 1994 November 79 (5):1294-302. Epub 1900 01 01.

Melanocytic nevi in Turner syndrome.

Becker B, Jospe N, Goldsmith LA

Pediatric dermatology.. 1994 June 11 (2):120-4. Epub 1900 01 01.

Temporal and individual variations in the dose of glucocorticoid used for the treatment of salt-losing congenital virilizing adrenal hyperplasia due to 21-hydroxylase deficiency.

Sandrini R, Jospe N, Migeon CJ

Acta paediatrica (Oslo, Norway : 1992). Supplement. 1993 March 388 :56-60; discussion 61. Epub 1900 01 01.

Steroid, 21-Hydroxylase

Sherer, D.M., Jospe, N., Abramowicz, J.S.

The Fetus. 1991; 1(5): 1-4.

Growth hormone deficiency in an 8-year-old girl with human immunodeficiency virus infection.

Jospe N, Powell KR

Pediatrics.. 1990 August 86 (2):309-12. Epub 1900 01 01.

Two distinct areas of unequal crossingover within the steroid 21-hydroxylase genes produce absence of CYP21B.

Donohoue PA, Jospe N, Migeon CJ, Van Dop C

Genomics.. 1989 October 5 (3):397-406. Epub 1900 01 01.

Factitious transient neonatal hyperthyrotropinemia.

Jospe N, Berkovitz GD, Corcoran LE, Humphrey RL

Journal of endocrinological investigation.. 1988 February 11 (2):129-32. Epub 1900 01 01.

Restriction fragment analysis of duplication of the fourth component of complement (C4A).

McLean RH, Donohoue PA, Jospe N, Bias WB, Van Dop C, Migeon CJ

Genomics.. 1988 January 2 (1):76-85. Epub 1900 01 01.

Prevalence of polymorphic 21-hydroxylase gene (CA21HB) mutations in salt-losing congenital adrenal hyperplasia.

Jospe N, Donohoue PA, Van Dop C, McLean RH, Bias WB, Migeon CJ

Biochemical and biophysical research communications.. 1987 February 13142 (3):798-804. Epub 1900 01 01.

Restriction maps and restriction fragment length polymorphisms of the human 21-hydroxylase genes.

Donohoue PA, Jospe N, Migeon CJ, McLean RH, Bias WB, White PC, Van Dop C

Biochemical and biophysical research communications.. 1986 April 29136 (2):722-9. Epub 1900 01 01.

Congenital adrenal hyperplasia: molecular mechanisms resulting in 21-hydroxylase deficiency.

Donohoue PA, Van Dop C, Jospe N, Migeon CJ

Acta endocrinologica. Supplementum. 1986 279 :315-20. Epub 1900 01 01.

Progressive Loss of Regulatory T cell Function in the first year from Diagnosis in Children with Type 1 Diabetes Mellitus.

Hughson, Angela; Bromberg, Irena; Johnson, Barbara; Fowell, Deborah PhD; Jospe, Nicholas MD.

Books

Nelson Textbook of Pediatric (2015)

Chapter: Section on Diabetes

Authors: Svoren B, Jospe N

Publisher: Elsevier, Philadelphia, PA 2015

Textbook of Pediatric Care (2015)

Chapter: Hyperthyroidism

Authors: McInerny, T

Publisher: Mosby Year Book Publishers, St. Louis 2015

Disorders of Pre pubertal breast development and abnormalities for periFACTS ob/gyn Academy, (2015)

Authors: Weber D, Jospe N

Publisher: Online Journal 2015

Textbook of Pediatric Care (2011)

Chapter: Hyperthyroidism

Authors: McInerny,T

Publisher: Mosby Year Book Publishers, St. Louis 2011

Nelson Essentials Sixth Edition (2009)

Chapter: Endocrinology

Authors: Jospe N

Publisher: Elsevier, Inc, Philadelphia, PA 2009

Merck Manual Edition 19 (2008)

Chapter: Metabolic, Electrolyte, and Toxic Disorders in Neonates.

Authors: Jospe N

Publisher: Merck Publishing Group, Rahway, NJ 2008

The Merck Manual of Medical Information (2008)

Chapter: Endocrine and Metabolic Disorders

Authors: Jospe, Nicholas MD

Publisher: Beers, MH, Rahway, NJ 2008

Nelson Essenttials of Pediatrics (2008)

Chapter: Section on Endocrinology

Authors: Jospe, Nichoals MD

Publisher: W. B. Saunders, Philadelphia, PA 2008

Mosby's Pediatric Clinical Advisor (2007)

Chapter: Diabetes Mellitus type 1

Authors: Jospe N

Publisher: Harcourt, Health Sciences, St Louis, MO 2007

Mosby's Pediatric Clinical Advisor (2007)

Chapter: Diabetes Mellitus type 2

Authors: Jospe N

Publisher: Harcourt, Health Sciences, St Louis, MO 2007

Mosby's Pediatric Clinical Advisor (2007)

Chapter: Diabetic ketoacidosis

Authors: Jospe N

Publisher: Harcourt, Health Sciences, St Louis, MO 2007

The Merck Manual of Medical Information (2007)

Chapter: Diabetes in Childhood and Adolescence

Authors: Jospe N

Publisher: Merck and Company, Rahway, NJ 2007

Pediatric Clerkship Guide: Essential Guide to the Pediatric Clerkship (2007)

Chapter: Endocrinology (in preparation)

Authors: Jospe N

Publisher: Mosby, St. Louis, MO 2007

The Merk Manual of Medical Infomation-Home Edition (2007)

Chapter: Endocrine and Metabolic Disorders: Pediatric Diabetes

Authors: Jospe, N

Publisher: Merk Research Laboratories, Rahway, NJ 2007

Primary Pediatric Care (2006)

Chapter: Hyperthyroidism (in preparation)

Authors: Jospe N

Publisher: Mosby Year Book Publishers, St. Louis, MO 2006

Computer-assisted Learning in Pediatrics Project (2005)

Authors: Jospe N

Publisher: CLIPP, Dartmouth, NH 2005

Nelson Essentials of Pediatrics (2005)

Chapter: Section on Endocrinology

Authors: Jospe N

Publisher: W.B. Saunders, Philadelphia, PA 2005

Mosby's Pediatric Clinical Advisor (2005)

Chapter: Ambiguous Genitalia

Authors: Jospe N

Publisher: Harcourt, Health Sciences, St Louis, MO 2005

The Merck Manual of Medical Information (2005)

Chapter: Endocrine and Metabolic Disorders

Authors: Jospe N

Publisher: Merck and Company, Rahway, NJ 2005

Pediatrics (2004)

Chapter: Disorders of Puberty

Authors: Jospe N

Publisher: McGraw-Hill Companies, Columbus, OH 2004

Pediatrics (2004)

Chapter: Disorders of Sexual Differentiation

Authors: Jospe N

Publisher: McGraw-Hill Companies, Columbus, OH 2004

Pediatrics (2004)

Chapter: Disorders of the Adrenal Gland

Authors: Jospe N

Publisher: McGraw-Hill Companies, Columbus, OH 2004

Pediatric Clerkship Guide: Essential Guide to the Pediatric Clerkship (2003)

Chapter: Endocrinology

Authors: Jospe N

Publisher: Mosby, St Louis, MO 2003

Pediatric Clerkship Guide: Essential Guide to the Pediatric Clerkship (2003)

Chapter: Growth problems

Authors: Jospe N

Publisher: Mosby, St Louis, MO 2003

Primary Pediatric Care (2001)

Chapter: Hyperthyroidism

Authors: Jospe N

Publisher: Mosby Year Book Publishers, St. Louis, MO 2001

Mosby's Pediatric Clinical Advisor (2001)

Chapter: Ambiguous Genitalia

Authors: Jospe N

Publisher: Harcourt, Health Sciences, St Louis, MO 2001

Mosby's Pediatric Clinical Advisor (2001)

Chapter: Diabetes Mellitus type 1

Authors: Jospe N

Publisher: Harcourt, Health Sciences, St Louis, MO 2001

Mosby's Pediatric Clinical Advisor (2001)

Chapter: Diabetes Mellitus type 2

Authors: Jospe N

Publisher: Harcourt, Health Sciences, St Louis, MO 2001

Mosby's Pediatric Clinical Advisor (2001)

Chapter: Diabetic ketoacidosis

Authors: Jospe N

Publisher: Harcourt, Health Sciences, St Louis, MO 2001

Primary Pediatric Care (1997)

Chapter: Hyperthyroidism

Authors: Jospe N

Publisher: Mosby Year Book Publishers, St. Louis, MO 1997

Endocrine and Metabolic Disorders (1997)

Chapter: The Merck Manual of Medical Information - Home Edition

Authors: Jospe N

Publisher: Merck and Company, Rahway, NJ 1997

The Merck Manual of Medical Information (1997)

Chapter: Endocrine Disorders

Authors: Jospe N

Publisher: Merck and Company, Rahway, NJ 1997

The Rochester Manual: practical patient Care, Medicine, Surgery, Pediatrics, OB- (1996)

Chapter: Pediatric Endocrinology

Authors: Jospe N (contributing editor)

Publisher: Laennec Publishing, Inc., Cedar Grove, NJ 1996

Locations

Golisano Childrens Hospital Pediatric Endocrinology

601 Elmwood Ave
Rochester, NY 14642

(585) 275-7744 Get Directions