Robert Glenn Quivey, Ph.D.
Contact
Robert Glenn Quivey, Ph.D.
About Me
Faculty Appointments
Professor - Department of Microbiology and Immunology (SMD)
Credentials
Post-doctoral Training & Residency
NIH/NIDR Postdoctoral Cariology Trainee, Department of Dental Research, University of Rochester 1985 - 1988
Postdoctoral Fellow, Department of Microbiology, University of Rochester 1984 - 1985
Education
PhD | Univ Texas-Austin. Microbiology. 1984
MS | Penn State University. Genetics. 1979
BS | Penn State University. Biology. 1977
BS | Penn State University. Biochemistry. 1977
Awards
IADR Councilor for the Microbiology & Immunology Research Group. 2009
President, Microbiology & Immunology Research Group. 2004
Graduate Alumni Award for Excellence in Graduate Education, University of Rochester Medical Center 2003
President Elect, Microbiology and Immunology Research Group. 2002 - 2004
Chairman, Fellowships Committee. 1996 - 1999
Phi Kappa Phi
Sigma Xi
Member- Pathogen Functional Genomics Research Advisory Committee.
Research
Results from our efforts have shown that S. mutans utilizes a number of discrete mechanisms to survive acidic environments. Interestingly, we've found that some of the mechanisms are shared with other streptococcal pathogens, and some are shared with streptococcal and staphylococcal pathogens. For example, we've shown that the central acid-protective enzyme, the F-ATPase, is transcriptionally up-regulated ("on") at low pH, which is characteristic shared with S. pneumoniae (Kuhnert et al., 2004). Our data has also shown that S. mutans must make major alterations to its membrane to survive low pH, requiring the action of an enzyme called FabM, a condition that is apparently shared in Staphylococcus aureus (Fozo and Quivey, 2004). Further evidence from our group has shown that resistance to acid-stress overlaps stress from oxidative agents, such as hydrogen peroxide, and that control of oxygen metabolism by an enzyme called NADH oxidase is mediated, in part, by novel mechanisms unique to S. mutans (Karrupaiah et al., 2005). In all of this work, we have focused on identifying those elements that might be useful targets for therapeutic intervention. Our results have shown that identification of unique regulatory schemes or novel enzyme mechanisms involved in stress responses in S. mutans also have a possible usefulness in other human pathogens. We are pursuing or basic science goals, with the inclusion of translational work. For example, we are exploring the use of metal ions, with knowledge gained from DNA repair studies, to develop new therapies for bacterial infection (Faustoferri et al., 2005). We have also begun the use of transgenic mice to study early infection processes (Culp et al., 2005). And, finally, we are developing new technology, in conjunction with the Optics Institute, to rapidly determine the bacterial composition of clinical biofilm samples (Zhu et al., 2004).
Publications
Journal Articles
Tinder EL, Faustoferri RC, Buckley AA, Quivey RG, Baker JL
mSystems.. 2022 April 267 (2):e0127221. Epub 03/15/2022.
Kopycka-Kedzierawski DT, Scott-Anne K, Ragusa PG, Cvetanovska M, Flint K, Feng C, Watson GE, Wong CL, Billings RJ, Quivey RJ, O'Connor TG
JDR clinical and translational research.. 2022 April 7 (2):163-173. Epub 03/10/2021.
Quivey RG, O'Connor TG, Gill SR, Kopycka-Kedzierawski DT
Molecular oral microbiology.. 2021 October 36 (5):255-257. Epub 08/06/2021.
Grier A, Myers JA, O'Connor TG, Quivey RG, Gill SR, Kopycka-Kedzierawski DT
Journal of dental research.. 2021 June 100 (6):599-607. Epub 12/24/2020.
Lindsay EL, Faustoferri RC, Quivey RG
FEMS microbiology letters.. 2021 February 12368 (3)Epub 1900 01 01.
Baker JL, Saputo S, Faustoferri RC, Quivey RG
Molecular oral microbiology.. 2020 June 35 (3):118-128. Epub 02/26/2020.
Bischer AP, Kovacs CJ, Faustoferri RC, Quivey RG
Journal of bacteriology.. 2020 February 25202 (6)Epub 02/25/2020.
Kovacs CJ, Faustoferri RC, Bischer AP, Quivey RG
Molecular microbiology.. 2019 September 112 (3):944-959. Epub 07/12/2019.
Castillo Pedraza MC, Rosalen PL, de Castilho ARF, Freires IA, de Sales Leite L, Faustoferri RC, Quivey RG, Klein MI
Journal of oral microbiology.. 2019 11 (1):1607505. Epub 05/09/2019.
Xiao J, Grier A, Faustoferri RC, Alzoubi S, Gill AL, Feng C, Liu Y, Quivey RG, Kopycka-Kedzierawski DT, Koo H, Gill SR
Journal of dental research.. 2018 December 97 (13):1468-1476. Epub 07/26/2018.
Wen ZT, Scott-Anne K, Liao S, De A, Luo M, Kovacs C, Narvaez BS, Faustoferri RC, Yu Q, Taylor CM, Quivey RG
Molecular oral microbiology.. 2018 October 33 (5):353-363. Epub 07/17/2018.
Baker JL, Lindsay EL, Faustoferri RC, To TT, Hendrickson EL, He X, Shi W, McLean JS, Quivey RG
Journal of bacteriology.. 2018 June 15200 (12)Epub 05/24/2018.
Herzog CR, Berzins DW, DenBesten P, Gregory RL, Hargreaves KM, Messer RLW, Mina M, Mooney MP, Paine ML, Phillips C, Presland RB, Quivey RG, Scannapieco FA, Sheridan JF, Svoboda KKH, Trackman PC, Walker MP, Walker SG, Wang CY, Hu JCC
Journal of dental research.. 2018 May 97 (5):483-491. Epub 01/12/2018.
Saputo S, Faustoferri RC, Quivey RG
Antimicrobial agents and chemotherapy.. 2018 January 62 (1)Epub 12/21/2017.
Saputo S, Faustoferri RC, Quivey RG
Antimicrobial agents and chemotherapy.. 2018 January 62 (1)Epub 12/21/2017.
Kovacs CJ, Faustoferri RC, Quivey RG
Journal of bacteriology.. 2017 December 15199 (24)Epub 11/14/2017.
Castillo Pedraza MC, Novais TF, Faustoferri RC, Quivey RG, Terekhov A, Hamaker BR, Klein MI
Biofouling.. 2017 October 33 (9):722-740. Epub 09/25/2017.
Solinski AE, Koval AB, Brzozowski RS, Morrison KR, Fraboni AJ, Carson CE, Eshraghi AR, Zhou G, Quivey RG, Voelz VA, Buttaro BA, Wuest WM
Journal of the American Chemical Society.. 2017 May 31139 (21):7188-7191. Epub 05/17/2017.
Baker JL, Faustoferri RC, Quivey RG
Molecular oral microbiology.. 2017 April 32 (2):107-117. Epub 06/21/2016.
Kiang A, Weinberg VK, Cheung KH, Shugard E, Chen J, Quivey JM, Yom SS
Radiation oncology.. 2016 September 2611 (1):127. Epub 09/26/2016.
Baker JL, Faustoferri RC, Quivey RG
Bio-protocol.. 2016 August 206 (16)Epub 1900 01 01.
Cross B, Garcia A, Faustoferri R, Quivey RG
Microbiology.. 2016 April 162 (4):662-671. Epub 02/05/2016.
Cross B, Faustoferri RC, Quivey RG
Current oral health reports.. 2016 March 3 (1):56-63. Epub 01/23/2016.
Xiao J, Moon Y, Li L, Rustchenko E, Wakabayashi H, Zhao X, Feng C, Gill SR, McLaren S, Malmstrom H, Ren Y, Quivey R, Koo H, Kopycka-Kedzierawski DT
PloS one.. 2016 11 (10):e0164242. Epub 10/14/2016.
Quivey RG, Grayhack EJ, Faustoferri RC, Hubbard CJ, Baldeck JD, Wolf AS, MacGilvray ME, Rosalen PL, Scott-Anne K, Santiago B, Gopal S, Payne J, Marquis RE
Molecular oral microbiology.. 2015 December 30 (6):474-95. Epub 06/19/2015.
Baker JL, Abranches J, Faustoferri RC, Hubbard CJ, Lemos JA, Courtney MA, Quivey R
Molecular oral microbiology.. 2015 December 30 (6):496-517. Epub 07/02/2015.
Baker JL, Derr AM, Faustoferri RC, Quivey RG
Journal of bacteriology.. 2015 December 197 (23):3645-57. Epub 09/08/2015.
Faustoferri RC, Hubbard CJ, Santiago B, Buckley AA, Seifert TB, Quivey RG
Molecular oral microbiology.. 2015 April 30 (2):128-46. Epub 10/27/2014.
Baker JL, Derr AM, Karuppaiah K, MacGilvray ME, Kajfasz JK, Faustoferri RC, Rivera-Ramos I, Bitoun JP, Lemos JA, Wen ZT, Quivey RG
Journal of bacteriology.. 2014 June 196 (12):2166-77. Epub 03/28/2014.
Buckley AA, Faustoferri RC, Quivey RG
Microbiology.. 2014 April 160 (Pt 4):818-827. Epub 02/07/2014.
Santiago B, Marek M, Faustoferri RC, Quivey RG
Journal of bacteriology.. 2013 August 195 (16):3552-62. Epub 06/07/2013.
Lemos JA, Quivey RG, Koo H, Abranches J
Microbiology.. 2013 March 159 (Pt 3):436-445. Epub 02/07/2013.
Macgilvray ME, Lapek JD, Friedman AE, Quivey RG
Microbiology.. 2012 August 158 (Pt 8):2133-2143. Epub 05/24/2012.
Beier BD, Quivey RG, Berger AJ
AMB Express.. 2012 July 132 (1):35. Epub 07/13/2012.
Gonzalez K, Faustoferri RC, Quivey RG
Molecular microbiology.. 2012 July 85 (2):361-77. Epub 06/15/2012.
Santiago B, MacGilvray M, Faustoferri RC, Quivey RG
Journal of bacteriology.. 2012 April 194 (8):2010-9. Epub 02/10/2012.
Derr AM, Faustoferri RC, Betzenhauser MJ, Gonzalez K, Marquis RE, Quivey RG
Applied and environmental microbiology.. 2012 February 78 (4):1215-27. Epub 12/16/2011.
Sheng J, Baldeck JD, Nguyen PT, Quivey RG, Marquis RE
Canadian journal of microbiology.. 2010 July 56 (7):539-47. Epub 1900 01 01.
Kajfasz JK, Rivera-Ramos I, Abranches J, Martinez AR, Rosalen PL, Derr AM, Quivey RG, Lemos JA
Journal of bacteriology.. 2010 May 192 (10):2546-56. Epub 03/16/2010.
Beier BD, Quivey RG, Berger AJ
Journal of biomedical optics.. 2010 15 (6):066001. Epub 1900 01 01.
Kajfasz JK, Martinez AR, Rivera-Ramos I, Abranches J, Koo H, Quivey RG, Lemos JA
Journal of bacteriology.. 2009 April 191 (7):2060-8. Epub 01/30/2009.
Zhu Q, Quivey RG, Berger AJ
Applied spectroscopy.. 2007 November 61 (11):1233-7. Epub 1900 01 01.
Fozo EM, Scott-Anne K, Koo H, Quivey RG
Infection and immunity.. 2007 March 75 (3):1537-9. Epub 01/12/2007.
Koo H, Seils J, Abranches J, Burne RA, Bowen WH, Quivey RG
Antimicrobial agents and chemotherapy.. 2006 February 50 (2):542-6. Epub 1900 01 01.
Faustoferri RC, Hahn K, Weiss K, Quivey RG
Journal of bacteriology.. 2005 April 187 (8):2705-14. Epub 1900 01 01.
Chatfield CH, Koo H, Quivey RG
Microbiology.. 2005 February 151 (Pt 2):625-631. Epub 1900 01 01.
Culp DJ, Quivey RQ, Bowen WH, Fallon MA, Pearson SK, Faustoferri R
Caries research.. 2005 39 (6):448-54. Epub 1900 01 01.
Kuhnert WL, Zheng G, Faustoferri RC, Quivey RG
Journal of bacteriology.. 2004 December 186 (24):8524-8. Epub 1900 01 01.
Fozo EM, Kajfasz JK, Quivey RG
FEMS microbiology letters.. 2004 September 15238 (2):291-5. Epub 1900 01 01.
Fozo EM, Quivey RG
Journal of bacteriology.. 2004 July 186 (13):4152-8. Epub 1900 01 01.
Fozo EM, Quivey RG
Applied and environmental microbiology.. 2004 February 70 (2):929-36. Epub 1900 01 01.
Zhu Q, Quivey RG, Berger AJ
Journal of biomedical optics.. 2004 9 (6):1182-6. Epub 1900 01 01.
Kuhnert WL, Quivey Jr RG
Journal of bacteriology.. 2003 March 185 (5):1525-33. Epub 1900 01 01.
Raman Spectroscopy of oral bacteria.
Berger, A.J.; Zhu, Q.; Quivey, R.G.
Diagnostic Optical Spectroscopy in Biomedicine II, (Georges A. Wagnieres; Ed.). 2003; Proc. SPIE.5141: 214-218.
Bowen WH, Quivey RG, Smith AV
Journal of dental research.. 2001 June 80 (6):1505-6. Epub 1900 01 01.
Quivey RG, Kuhnert WL, Hahn K
Critical reviews in oral biology and medicine : an official
Quivey RG, Faustoferri R, Monahan K, Marquis R
FEMS microbiology letters.. 2000 August 1189 (1):89-92. Epub 1900 01 01.
Quivey RG, Kuhnert WL, Hahn K
Advances in microbial physiology. 2000 42 :239-74. Epub 1900 01 01.
Hahn K, Faustoferri RC, Quivey RG
Molecular microbiology.. 1999 March 31 (5):1489-98. Epub 1900 01 01.
Burne RA, Quivey RG, Marquis RE
Methods in enzymology.. 1999 310 :441-60. Epub 1900 01 01.
A medium-copy-number plasmid insertional mutagenesis of S. mutans
Faustoferri, R.C.; Quivey, R.G.; Smith, A.J.; Sanchez, R.
Plasmid. 1998; : 40; 247-251.
Use of proteomics and PCR to elucidate changes in protein expression in oral streptococci
Quivey, R.G.: Kuhnert, W.L.: and Faustoferri, R.C.
Methods in Cell Sci. 1998; : 20: 165-179.
Smith AJ, Quivey RG, Faustoferri RC
Gene.. 1996 December 12183 (1-2):87-96. Epub 1900 01 01.
Vacca-Smith AM, Venkitaraman AR, Quivey RG, Bowen WH
Archives of oral biology.. 1996 March 41 (3):291-8. Epub 1900 01 01.
Quivey RG, Faustoferri RC, Clancy KA, Marquis RE
FEMS microbiology letters.. 1995 March 1126 (3):257-61. Epub 1900 01 01.
Role of models in assessing new agents for caries prevention-non-fluoride systems: reaction paper.
Quivey, R.G., Jr.; Smith, A.J.
Ad. Dent. Res. 1995; 9: 312-314.
Quivey RG, Faustoferri RC, Reyes SD
Developments in biological standardization. 1995 85 :393-8. Epub 1900 01 01.
Burne RA, Quivey RG
Methods in enzymology.. 1994 235 :405-26. Epub 1900 01 01.
Quivey RG, Kriger PS
FEMS microbiology letters.. 1993 September 15112 (3):307-12. Epub 1900 01 01.
Quivey RG, Faustoferri RC
Gene.. 1992 July 1116 (1):35-42. Epub 1900 01 01.
Quivey RG, Faustoferri RC, Belli WA, Flores JS
Gene.. 1991 January 297 (1):63-8. Epub 1900 01 01.
Quivey RG, Bowen WH
Caries research.. 1991 25 (3):191-6. Epub 1900 01 01.
Falcone DL, Quivey RG, Tabita FR
Journal of bacteriology.. 1988 January 170 (1):5-11. Epub 1900 01 01.
Le Sonde di DNA Nell Diagnosi e Nella Terapia Odontoiatrica.
Quivey, R.G., Jr.
Il Dentista Moderno. 1988; 9: 2065-2090.
Nucleotide and Deduced Amino Acid Sequence of the Rhodobacter sphaeroides Gene Encoding Form II Ribulose-1,5-bisphosphate Carboxylase/Oxygenase and Comparison with Other Deduced Form I and II Sequences.
Wagner, S.J.; Stevens, S.E. Jr.; Nixon, B.T.; Lambert, D.H.; Quivey, R.G. Jr.; Tabita, F.R.
FEMS Microbiol. Lett. 1988; 55: 217-222.
Quivey RG
Advances in dental research.. 1987 October 1 (1):99-108. Epub 1900 01 01.
Synthesis and assembly of a novel recombinant ribulose 1,5-bisphosphate carboxylase/oxygenase for structure function studies.
Tabita, F.R.; Gibson, J.L.; Mandy, W.J.; Quivey, R.G. Jr.
Nature BioTechnology. 1986; 4: 138-141.
Quivey RG, Tabita FR
Gene.. 1984 November 31 (1-3):91-101. Epub 1900 01 01.
Books
Methods in Cell Science (1999)
Chapter: Use of proteomics and degenerate PCR to elucidate virulence mechanisms in oral streptococci.
Authors: Quivey, R. G. Jr.; Kuhnert, W.L. ; Faustoferri, R.C.
Publisher: Invited for publication in a series of methods pertinent to streptococci. 1999
Bacterial Pathogenesis (the Work) (1997)
Chapter: Use of Transposons to Dissect Pathogenic Strategies of Gram-Positive Bacteria.
Authors: Quivey, R.G.
Publisher: (Selected Methods in Enzymology Series.) 1997
Cariology for the Nineties (1993)
Chapter: Genetic Manipulation of the Oral Streptococci
Authors: Quivey, R.G., Jr.; Faustoferri, R.C.; Kriger, P.S.
Publisher: University of Rochester Press, Rochester, NY. 1993
Microbiology-1983 (1984)
Chapter: Molecular Regulation, Mechanism, and Enzymology of Autotrophic Carbon Dioxide Fixation
Authors: Tabita, F.R.; Sarles, L.S.; Quivey, R.G.Jr., Weaver, K.E.; Wadill, F.E.
Publisher: ASM Press, Washington, D.C. 1984
Microbial Growth on C-1 Compounds (1984)
Chapter: Control of Carbon Dioxide Fixation
Authors: Tabita, F.R.; Martin, M.N.; Beudeker, R.F.; Quivey, R.G. Jr.; Sarles, L.S.; Weaver, K.E.
Publisher: ASM Press, Washington, D.C. 1984