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James Burchfiel, Ph.D.

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About Me
Credentials
Publications

About Me

James L. Burchfiel, Ph.D. is Professor of Neurology at the University of Rochester, New York. Director of the Strong Epilepsy Center 2000-2006 and Co-Director 1989-2000. His clinical interest is in the neurophysiology of epilepsy and other neurological disorders. His research interest is in the development of epilepsy in neonatal animal models.

Dr. Burchfiel received both his undergraduate (with honors) and graduate education at Stanford University. After serving for 2 years as a Captain in the US Army, working in the research laboratories of Edgewood Arsenal, Maryland, he joined the faculty of the Seizure Unit, Department of Neurology, Children's Hospital, Boston and the Harvard Medical School. There, he completed fellowship training in clinical neurophysiology and served as an attending clinical neurophysiologist. In addition, he conducted independent NIH-sponsored basic research in epilepsy.

In 1989, Dr. Burchfiel, with his long-time colleague Dr. Giuseppe Erba, moved to the University of Rochester to found the Strong Epilepsy Center. Dr. Burchfiel served as Co-Director with Dr. Erba until 2000 and was Director from 2000 to 2006.

Dr. Burchfiel has published over 50 peer-reviewed articles and reviews and continues to have an active interest in both basic and clinical research in epilepsy. Most recently, he has been working with basic researchers in the Department of Developmental Epileptology, Academy of Sciences of the Czech Republic.

He is an active member of the Eastern Association of Electroencephalographers, the American Clinical Neurophysiology Society and the American Epilepsy Society and has held offices and served on committees and boards for these organizations. In addition, he is a past member of an NIH grant review study section.

Faculty Appointments

Professor Emeritus - Department of Neurology, Epilepsy (SMD)

Credentials

Education

PhD | Stanford University. Pharmacology. 1969

BS | Stanford University. Chemistry. 1963

Awards

Practice of Clinical Neurophysiology Committee. 1996

Investigators' Workshop Committee. 1994 - 1997

Medical Instrumentation Committee. 1993 - 1995

Consultant, NINDS Neurological Disorders Program Project Review A Committee,. 1991

Childhood Epilepsy Committee. 1990 - 1992

Chair, Long-Range Planning Committee. 1990 - 1993

President, Eastern Association of Electroencephalographers. 1988 - 1989

President-Elect, Eastern Association of Electroencephalographers. 1986 - 1987

Chartered Member, Neurology A Study Section. 1986 - 1990

Program Committee. 1985 - 1986

Program Committee, Eastern Association of Electroencephalographers. 1985 - 1990

Special Reviewer, Neurological Sciences Study Section. 1983

Special Research Program Review Committee. 1983

Secretary/Treasurer. 1983 - 1986

Committee on Technical Matters, Long-term Monitoring. 1983 - 1990

Member, Site Visit Committee. 1982

Junior to Senior Councilor. 1982 - 1983

Member, Special Site Visit Study Section. 1981

Member, Special Study Section. 1981

Member, Special Study Section. 1980

Special Reviewer, Neurological Sciences Study Section. 1979

Publications

Journal Articles

Electrographic seizures induced by activation of ET and ET receptors following intrahippocampal infusion of endothelin-1 in immature rats occur by different mechanisms.

Vondrakova K, Novotny P, Kubova H, Posusta A, Boron J, Faberova V, Fabene PF, Burchfiel J, Tsenov G

Experimental neurology.. 2020 June 328 :113255. Epub 02/19/2020.

Electrographic seizures induced by activation of ETA and ETB receptors following intrahippocampal infusion of endothelin-1 in immature rats occur by different mechanisms.

Burchfiel, J.

Exp. Neurol. 2020; .

The Free Radical Scavenger N-Tert-Butyl-?-Phenylnitrone (PBN) Administered to Immature Rats During Status Epilepticus Alters Neurogenesis and Has Variable Effects, Both Beneficial and Detrimental, on Long-Term Outcomes.

Kubová H, Folbergrová J, Rejchrtová J, Tsenov G, Pa?ízková M, Burchfiel J, Mikulecká A, Mareš P

Frontiers in cellular neuroscience.. 2018 12 :266. Epub 08/28/2018.

Neurodevelopmental outcomes after neonatal cardiac surgery: Role of cortical isoelectric activity.

Seltzer L, Swartz MF, Kwon J, Burchfiel J, Cholette JM, Wang H, Sweeney D, Adams HR, Meagher C, Angona R, Guillet R, Alfieris GM

The Journal of thoracic and cardiovascular surgery.. 2016 April 151 (4):1137-42. Epub 10/27/2015.

Characteristic Features of the Interictal EEG Background in 2 Patients With Malignant Migrating Partial Epilepsy in Infancy.

Selioutski O, Seltzer LE, Burchfiel J, Paciorkowski AR, Erba G

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.. 2015 August 32 (4):e23-9. Epub 1900 01 01.

Activation of either the ETA or the ETB receptors is involved in the development of electrographic seizures following intrahippocampal infusion of the endothelin-1 in immature rats.

Tsenov G, Vondraková K, Otáhal J, Burchfiel J, Kubová H

Experimental neurology.. 2015 March 265 :40-7. Epub 12/24/2014.

Intraoperative electroencephalography predicts postoperative seizures in infants with congenital heart disease.

Seltzer LE, Swartz M, Kwon JM, Burchfiel J, Alfieris GM, Guillet R

Pediatric neurology.. 2014 April 50 (4):313-7. Epub 12/19/2013.

EEG changes during awake carotid endarterectomy.

Illig KA, Sternbach Y, Zhang R, Burchfiel J, Shortell CK, Rhodes JM, Davies MG, Lyden SP, Green RM

Annals of vascular surgery.. 2002 January 16 (1):6-11. Epub 01/16/2002.

Value of preoperative EEG for carotid endarterectomy.

Illig KA, Burchfiel JL, Ouriel K, DeWeese JA, Shortell CK, Green RM

Cardiovascular surgery : official journal of the International Society for Cardiovascular Surgery.. 1998 October 6 (5):490-5. Epub 1900 01 01.

EEG background as predictor of electrographic seizures in high-risk neonates.

Laroia N, Guillet R, Burchfiel J, McBride MC

Epilepsia.. 1998 May 39 (5):545-51. Epub 1900 01 01.

The effects of neonatal hypoxia on kindled seizure development and electroconvulsive shock profiles.

Applegate CD, Jensen F, Burchfiel JL, Lombroso C

Epilepsia.. 1996 August 37 (8):723-7. Epub 1900 01 01.

Ictal contralateral paresis in complex partial seizures.

Oestreich LJ, Berg MJ, Bachmann DL, Burchfiel J, Erba G

Epilepsia.. 1995 July 36 (7):671-5. Epub 1900 01 01.

Long-term monitoring for epilepsy. Report of an IFCN committee.

Engel J, Burchfiel J, Ebersole J, Gates J, Gotman J, Homan R, Ives J, King D, Lieb J, Sato S

Electroencephalography and clinical neurophysiology.. 1993 December 87 (6):437-58. Epub 1900 01 01.

Epileptogenic effect of hypoxia in the immature rodent brain.

Jensen FE, Applegate CD, Holtzman D, Belin TR, Burchfiel JL

Annals of neurology.. 1991 June 29 (6):629-37. Epub 1900 01 01.

Evidence for the interaction of brainstem systems mediating seizure expression in kindling and electroconvulsive shock seizure models.

Applegate CD, Samoriski GM, Burchfiel JL

Epilepsy research.. 1991 10 (2-3):142-7. Epub 1900 01 01.

Differential effects of perinatal hypoxia and anoxia on long term seizure susceptibility in the rat.

Jensen FE, Applegate C, Burchfiel J, Lombroso CT

Life sciences.. 1991 49 (5):399-407. Epub 1900 01 01.

Perinatal exposure to anoxia alone does not alter the susceptibility to amygdaloid-kindled seizures in the adult rabbit.

DeLeo JA, Applegate CD, Burchfiel JL, Lorenzo AV, Hsi DH

Brain research.. 1990 July 2522 (1):168-71. Epub 1900 01 01.

Evidence for a norepinephrine-dependent brain-stem substrate in the development of kindling antagonism.

Applegate CD, Burchfiel JL

Epilepsy research.. 1990 6 (1):23-32. Epub 1900 01 01.

Stepwise progression of kindling: perspectives from the kindling antagonism model.

Burchfiel JL, Applegate CD

Neuroscience and biobehavioral reviews.. 1989 13 (4):289-99. Epub 1900 01 01.

Microinjections of GABA agonists into the amygdala complex attenuates kindled seizure expression in the rat.

Applegate CD, Burchfiel JL

Experimental neurology.. 1988 November 102 (2):185-9. Epub 1900 01 01.

Kindling does not cause persistent changes in firing rates or transmitter sensitivities of substantia nigra pars reticulata neurons.

Waszczak BL, Applegate CD, Burchfiel JL

Brain research.. 1988 July 5455 (1):115-22. Epub 1900 01 01.

Kindling antagonism: a role for hindbrain norepinephrine in the development of site suppression following concurrent, alternate stimulation.

Applegate CD, Konkol RJ, Burchfiel JL

Brain research.. 1987 March 31407 (2):212-22. Epub 1900 01 01.

Etiologic and preventive aspects of epilepsy in the child--bridging the gap between laboratory and clinic.

Lombroso CT, Burchfiel JL

Epilepsia.. 1987 28 Suppl 1 :S25-35. Epub 1900 01 01.

The effects of chronic desmethylimipramine on entorhinal cortical kindling in rats.

Applegate CD, Flashman LA, Burchfiel JL

Brain research.. 1986 November 19398 (1):121-7. Epub 1900 01 01.

Kindling antagonism: effects of norepinephrine depletion on kindled seizure suppression after concurrent, alternate stimulation in rats.

Applegate CD, Burchfiel JL, Konkol RJ

Experimental neurology.. 1986 November 94 (2):379-90. Epub 1900 01 01.

Comparative pharmacological effects on visual cortical neurons in monocularly deprived cats.

Duffy FH, Burchfiel JL, Mower GD, Joy RM, Snodgrass SR

Brain research.. 1985 July 29339 (2):257-64. Epub 1900 01 01.

Microiontophoretic bicuculline restores binocular responses to visual cortical neurons in strabismic cats.

Mower GD, Christen WG, Burchfiel JL, Duffy FH

Brain research.. 1984 August 20309 (1):168-72. Epub 1900 01 01.

Extraction of clinical information from electroencephalographic background activity: the combined use of brain electrical activity mapping and intravenous sodium thiopental.

Duffy FH, Jensen F, Erba G, Burchfiel JL, Lombroso CT

Annals of neurology.. 1984 January 15 (1):22-30. Epub 1900 01 01.

Micoiontophoretic bicuculline restores binocular responsed to visual cortical neurons in strabismic cats.

Mower GD, Christen WG, Berry D, Burchfiel JL, Duffy FH.

Bran Res. 1984; 309: 168-172.

Extraction of clinical information from electroencephalographic background activity - the combined use of brain electrical activity mapping and intravenous sodium thiopental.

Duffy FH, Jensen F, Erba G, Burchfiel JL, Lombroso CT.

Ann. Neurology. 1984; 15: 22-30.

Organophosphate neurotoxicity: chronic effects of sarin on the electroencephalogram of monkey and man.

Burchfiel JL, Duffy FH.

Neurobehav. Toxicol. Teratol. 1983; 4: 767-778.

Animal models of strabismic amblyopia: physiological studies of visual cortex and the lateral geniculate nucleus.

Mower GD, Burchfiel JL, Duffy FH

Brain research.. 1982 November 281 (3):311-27. Epub 1900 01 01.

Kindling antagonism: interactions of dorsal and ventral entorhinal cortex with the septum during concurrent kindling.

Burchfiel JL, Serpa KA, Duffy FH

Brain research.. 1982 April 22238 (1):3-12. Epub 1900 01 01.

Further studies of antagonism of seizure development between concurrently developing kindled limbic foci in the rat.

Burchfiel JL, Serpa KA, Duffy FH

Experimental neurology.. 1982 February 75 (2):476-89. Epub 1900 01 01.

Animal models of strabismic amblyopia: Physiological studies of visual cortex and the lateral geniculate nucleus.

Mower GD, Berry D, Burchfiel JL, Duffy FH.

Dev. Brain Res. 1982; 5: 311-327.

Organophosphate neurotoxicity: chronic effects of sarin on the electroencephalogram of monkey and man.

Burchfiel JL, Duffy FH

Neurobehavioral toxicology and teratology. 1982 4 (6):767-78. Epub 1900 01 01.

Comparison of the effects of dark rearing and binocular suture on development and plasticity of cat visual cortex.

Mower GD, Berry D, Burchfiel JL, Duffy FH

Brain research.. 1981 September 14220 (2):255-67. Epub 1900 01 01.

The effects of dark-rearing on the development and plasticity of the lateral geniculate nucleus.

Mower GD, Burchfiel JL, Duffy FH

Brain research.. 1981 June 227 (3):418-24. Epub 1900 01 01.

Significance probability mapping: an aid in the topographic analysis of brain electrical activity.

Duffy FH, Bartels PH, Burchfiel JL

Electroencephalography and clinical neurophysiology.. 1981 May 51 (5):455-62. Epub 1900 01 01.

Facilitation and antagonism of kindled seizure development in the limbic system of the rat.

Duchowny MS, Burchfiel JL

Electroencephalography and clinical neurophysiology.. 1981 April 51 (4):403-16. Epub 1900 01 01.

Role of intracortical inhibition in deprivation amblyopia: reversal by microiontophoretic bicuculline.

Burchfiel JL, Duffy FH

Brain research.. 1981 February 16206 (2):479-84. Epub 1900 01 01.

Comparison of the effects of dark rearing and binocular suture on development and plasticity of cat visual corted.

Mower GD, Berry D, Burchfiel JL, Duffy FH.

Brain Res. 1981; 220: 225-267.

Kindling in the rat hippocampus: studies of neurotransmitter mechanisms and transfer mechanisms.

Burchfiel JL.

In: Wada JA, ed. Kindling 2. 1981; : 295-302.

The effects of dark-rearing on the development and plasticity of the lateral geniculate nucleus.

Mower GD, Burchfiel JL, Duffy FH.

Developmental Brain Res. 1981; 1: 418-424.

The combined discriminating power of quantitative electroencephalography and neuropsychologic measures in evaluating CNS effects of lead at low dose.In: Needleman HH, ed. Low Level Lead Exposure: The Clinical Implications of Curremt Research

Burchfiel JL, Duffy FH, Bartels PH, Needleman HH.

New York: Raven Press. 1980; : 75-89.

Long-term effects of the organophosphate sarin on EEGs in monkeys and human.

Dufrfy FH, Burchfiel JL.

Neurotoxicology. 1980; 1: 667-689.

Neuronal supersensitivity to acetylcholine induced by kindling in the rat hippocampus.

Burchfiel JL, Duchowny MS, Duffy FH

Science.. 1979 June 8204 (4397):1096-8. Epub 1900 01 01.

Brain electrical activity mapping (BEAM): a method for extending the clinical utility of EEG and evoked potential data.

Duffy FH, Burchfiel JL, Lombroso CT

Annals of neurology.. 1979 April 5 (4):309-21. Epub 1900 01 01.

Long-term effects of an organophosphate upon the human electroencephalogram.