Skip to content
Home
Stephen Dewhurst, Ph.D.

Stephen Dewhurst, Ph.D.

Contact

Office (585) 275-3216
Administrative (585) 275-3402

Connect with Stephen Dewhurst, Ph.D.

University of Rochester Appointment: Vice President for Research and Chief Research Officer

Looking for more Information?

Visit my lab website to learn more about my research, collaborators, latest news, etc.

Visit Research Lab Website

About Me

ADMINISTRATIVE EXPERIENCE

Dr. Dewhurst is Vice President for Research for the University of Rochester (UR) and Vice Dean for Research at the UR School of Medicine and Dentistry. He joined the faculty of UR in 1990, and previously served as Senior Associate Dean for Basic Research at the URS...
ADMINISTRATIVE EXPERIENCE

Dr. Dewhurst is Vice President for Research for the University of Rochester (UR) and Vice Dean for Research at the UR School of Medicine and Dentistry. He joined the faculty of UR in 1990, and previously served as Senior Associate Dean for Basic Research at the URSMD from 2007 to 2009.


EDUCATION AND MENTORING EXPERIENCE

Over the past 10 years, Dr. Dewhurst has mentored 12 doctoral students and 5 post-baccalaureate trainees. He presently mentors 4 doctoral trainees and 2 undergraduates. Many of his former trainees hold prestigious positions in industry and government; others are tenure-track academic faculty members. He has also received several mentoring awards, including the UR’s highest award for graduate education, the William H. Riker University Award for Graduate Teaching (2008), as well as the Graduate Student Society Faculty Teaching Award (1996), the Graduate Alumni Award for Excellence in Graduate Education (2001) and the Graduate Student Society Student Advocacy Award (2021).  In addition, he served as the communicating MPI of the UR’s NIH-funded “Broadening Experiences in Scientific Training (BEST)” program (2014-2021); this program has transformed institutional culture and practice in the area of graduate and postdoctoral education, by creating sustainable structures that support the exploration of diverse career options by PhD students and postdocs. 


CONTRIBUTIONS TO EQUITY AND INCLUSION

Dr. Dewhurst is the founding Director (and contact MPI) of the UR’s NIH-funded Rochester Partnership for Research and Academic Career Training of Deaf Postdoctoral Scholars.  This mentored postdoctoral research training program for Deaf and Hard-of-Hearing (D/HH) Scholars is the only program of its kind in the nation, and is a unique partnership between UR and the National Technical Institute for the Deaf (NTID) at the Rochester Institute of Technology (RIT). Dr. Dewhurst was also the founding Director for the UR's NIH funded Postbaccalaureate Research Education Program (PREP), which has supported over 100 postbacc trainees since its inception - all of whom are members of groups that have been historically excluded from the biomedical research enterprise. Over 75% of these individuals have gone on to successfully complete biomedical Ph.Ds.  Finally, he is a member of the UR’s Executive Committee on Diversity and Inclusion. 

Faculty Appointments

Professor - Department of Microbiology and Immunology (SMD)

Associate Vice President for Health Sciences Research - Office of Sr VP for Research (UR)

Credentials

Post-doctoral Training & Residency

Postdoctoral Fellow, Department of Cancer Biology, Harvard School of Public Health, Boston, MA. 1988 - 1990

Postdoctoral Fellow, Department of Medicine and Pediatrics, Columbia University, New York, NY. 1987 - 1988

Education

PhD | University of Nebraska. Molecular Biology. 1987

BS | Bristol University, UK. Biochemistry. 1984

Awards

Graduate Student Society Student Advocacy Award, UR School of Medicine and Dentistry. 2021 - 2021

Member, Scientific Advisory Board, Sensei Biotherapeutics. 2020

Albert and Phyllis Ritterson Professor of Microbiology and Immunology. 2020

Member, Scientific Advisory Board, Vaccitech. 2018

Member, HIV Immunopathogenesis and Vaccine Development (HIVD) Study Section, NIH. 2018 - 2021

Outstanding Training Program Director. 2015

William H. Riker Award for Graduate Education. 2008

Member, NIH Recombinant Advisory Committee (RAC). 2004 - 2008

University Dean's Award for Meritorious Service in Ph.D. Defenses. 2003

Chair, NIH/NIAID AIDSRRC Charter Study Section. 2003 - 2004

Graduate Alumni Award for Excellence in Graduate Education. 2002

Dean's Professor of Microbiology & Immunology. 2002 - 2019

Graduate Student Society (GSS) Faculty Teaching Award. 1996

Friend of Education Award. 1995

Research Career Development Award, NIH. 1994 - 1999

AIDS Research Scholar. 1988 - 1991

Research

Dr. Dewhurst has over 30 years’ experience in molecular virology research. He currently codirects the UR’s HIV Clinical Trials Unit (CTU), which conducts HIV vaccine and treatment trials and engages with communities affected by HIV. Other research interests include: (1) understanding the interactio...
Dr. Dewhurst has over 30 years’ experience in molecular virology research. He currently codirects the UR’s HIV Clinical Trials Unit (CTU), which conducts HIV vaccine and treatment trials and engages with communities affected by HIV. Other research interests include: (1) understanding the interaction of HIV with glial cells; (2) developing an improved live attenuated influenza vaccine (LAIV); (3) elucidating host cell response to infection by viral pathogens (with emphasis on SARS-CoV-2 and Adeno-associated virus, AAV).

Patents

Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof

Issue date: April 28, 2010

Patent #: 1346036

Country: Europe

Inventors: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof

Issue date: April 24, 2008

Patent #: 2002246625

Country: Australia

Inventors: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

avB3 Integrin-Binding Polypeptide Monobodies and Their Use

Issue date: July 07, 2009

Patent #: 7,556,925

Country: United States

Inventors: Stephen Dewhurst, Shohei Koide, Akiko Koide, Michelle L Miller, Julie Richards Gunzler

AVB3 Integrin-Binding Polypeptide Monobodies and Their Use

Issue date: May 17, 2007

Patent #: 2002307146

Country: Australia

Inventors: Stephen Dewhurst, Shohei Koide, Akiko Koide, Michelle L Miller, Julie Richards Gunzler

Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof

Issue date: February 21, 2012

Patent #: 8,119,118

Country: United States

Inventors: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Modified Phage for Displaying Post-Translationally Modified Proteins and Uses Thereof

Issue date: June 17, 2014

Patent #: 8,754,015

Country: United States

Inventors: Stephen Dewhurst, John J Treanor

Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof

Issue date: April 28, 2010

Patent #: IE1346036

Country: Ireland

Inventors: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof

Issue date: April 28, 2010

Patent #: GB1346036

Country: United Kingdom

Inventors: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof

Issue date: April 28, 2010

Patent #: DK1346036

Country: Denmark

Inventors: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof

Issue date: April 28, 2010

Patent #: BE1346036

Country: Belgium

Inventors: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Helper Virus-Free Herpesvirus Amplicon Particles and Uses Thereof

Issue date: April 28, 2010

Patent #: DE1346036

Country: Germany

Inventors: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Helper Virus-Free Herpesvirus Amplicon Particles and Uses Thereof

Issue date: April 28, 2010

Patent #: FR1346036

Country: France

Inventors: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

MLK Inhibitors and Methods of Use

Issue date: October 24, 2017

Patent #: 2,744,498

Country: Canada

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

MLK Inhibitors and Methods of Use

Issue date: November 04, 2015

Patent #: 2379561

Country: Europe

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

MLK Inhibitors and Methods of Use

Issue date: May 13, 2016

Patent #: 5930278

Country: Japan

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Substituted Pyrrolo [2,3-B] Pyridines as MLK Inhibitors

Issue date: November 04, 2014

Patent #: 8,877,772

Country: United States

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

MLK Inhibitors and Methods of Use

Issue date: February 11, 2015

Patent #: ZL200980152665.1

Country: China, People's Republic of

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

MLK Inhibitors and Methods of Use

Issue date: July 23, 2015

Patent #: 2009324894

Country: Australia

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Antigenic Mimics of Discontinuous Epitopes of Pathogens Recognized by Broadly Neutralizing Antibodies

Issue date: February 24, 2015

Patent #: 8,961,977

Country: United States

Inventors: Stephen Dewhurst, Mark A Sullivan

Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use

Issue date: March 30, 2017

Patent #: 2011258465

Country: Australia

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use

Issue date: August 28, 2018

Patent #: 2,800,176

Country: Canada

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use

Issue date: February 03, 2015

Patent #: 603644

Country: New Zealand

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use

Issue date: September 30, 2014

Patent #: 8,846,909

Country: United States

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use

Issue date: February 10, 2016

Patent #: ZL201180036376.2

Country: China, People's Republic of

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use

Issue date: February 10, 2017

Patent #: 6086326

Country: Japan

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

MLK Inhibitors and Methods of Use

Issue date: June 30, 2015

Patent #: 614904

Country: New Zealand

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Substituted Pyrrolo [2,3-B] Pyridines as MLK Inhibitors

Issue date: November 10, 2015

Patent #: 9,181,247

Country: United States

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

MLK Inhibitors and Methods of Use

Issue date: January 22, 2016

Patent #: 5873544

Country: Japan

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies

Issue date: August 10, 2018

Patent #: ZL201380060736.1

Country: China, People's Republic of

Inventors: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies

Issue date: January 09, 2019

Patent #: 2925319

Country: Europe

Inventors: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies

Issue date: November 26, 2019

Patent #: 10,485,800

Country: United States

Inventors: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

MLK Inhibitors and Methods of Use

Issue date: November 04, 2015

Patent #: FR2379561

Country: France

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

MLK Inhibitors and Methods of Use

Issue date: November 04, 2015

Patent #: DE2379561

Country: Germany

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

MLK Inhibitors and Methods of Use

Issue date: November 04, 2015

Patent #: IT2379561

Country: Italy

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

MLK Inhibitors and Methods of Use

Issue date: November 04, 2015

Patent #: ES2379561

Country: Spain

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

MLK Inhibitors and Methods of Use

Issue date: November 04, 2015

Patent #: GB2379561

Country: United Kingdom

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Attenuated Influenza Vaccines and Uses Thereof

Issue date: September 07, 2021

Patent #: 2,918,739

Country: Canada

Inventors: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Attenuated Influenza Vaccines and Uses Thereof

Issue date: April 28, 2020

Patent #: ZL201480045309.0

Country: China, People's Republic of

Inventors: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Attenuated Influenza Vaccines and Uses Thereof

Issue date: June 19, 2019

Patent #: 3022298

Country: Europe

Inventors: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Attenuated Influenza Vaccines and Uses Thereof

Issue date: January 30, 2018

Patent #: 9,878,032

Country: United States

Inventors: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Substituted Pyrrolo [2,3-b] Pyridines as MLK Inhibitors

Issue date: November 14, 2017

Patent #: 9,814,704

Country: United States

Inventors: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Attenuated Influenza Vaccines and Uses Thereof

Issue date: June 18, 2019

Patent #: 10,323,231

Country: United States

Inventors: Andrew Cox, Stephen Dewhurst, John J Treanor

Methods and Compositions Related to Increasing the Fidelity of Influenza A Virus for Vaccine Development

Issue date: December 10, 2019

Patent #: 10,500,268

Country: United States

Inventors: Andrew Cox, Stephen Dewhurst

Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies

Issue date: January 09, 2019

Patent #: FR2925319

Country: France

Inventors: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies

Issue date: January 09, 2019

Patent #: 602013049719.2

Country: Germany

Inventors: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies

Issue date: January 09, 2019

Patent #: GB2925319

Country: United Kingdom

Inventors: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Attenuated Influenza Vaccines and Uses Thereof

Issue date: June 19, 2019

Patent #: FR3022298

Country: France

Inventors: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Attenuated Influenza Vaccines and Uses Thereof

Issue date: June 19, 2019

Patent #: 602014048

Country: Germany

Inventors: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Attenuated Influenza Vaccines and Uses Thereof

Issue date: June 19, 2019

Patent #: GB3022298

Country: United Kingdom

Inventors: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Publications

Journal Articles

Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2-infected older mice with neurological signs.

Rahman SM, Buchholz DW, Imbiakha B, Jager MC, Leach J, Osborn RM, Birmingham AO, Dewhurst S, Aguilar HC, Luebke AE

Journal of virology.. 2024 July 2398 (7):e0006624. Epub 05/30/2024.

New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity.

Molina Vargas AM, Sinha S, Osborn R, Arantes PR, Patel A, Dewhurst S, Hardy DJ, Cameron A, Palermo G, O'Connell MR

Nucleic acids research.. 2024 January 2552 (2):921-939. Epub 1900 01 01.

Adaptive immune cells are necessary for SARS-CoV-2-induced pathology.

Imbiakha B, Sahler JM, Buchholz DW, Ezzatpour S, Jager M, Choi A, Monreal IA, Byun H, Adeleke RA, Leach J, Whittaker G, Dewhurst S, Rudd BD, Aguilar HC, August A

Science advances.. 2024 January 510 (1):eadg5461. Epub 01/03/2024.

Ventilation during COVID-19 in a school for students with intellectual and developmental disabilities (IDD).

Zand MS, Spallina S, Ross A, Zandi K, Pawlowski A, Seplaki CL, Herington J, Corbett AM, Kaukeinen K, Holden-Wiltse J, Freedman EG, Alcantara L, Li D, Cameron A, Beaumont N, Dozier A, Dewhurst S, Foxe JJ

PloS one.. 2024 19 (4):e0291840. Epub 04/03/2024.

Ventilation during COVID-19 in a school for students with intellectual and developmental disabilities (IDD).

Zand MS, Spallina S, Ross A, Zandi K, Pawlowski A, Seplaki CL, Herington J, Corbett AM, Kaukeinen K, Holden-Wiltse J, Freedman EG, Alcantara L, Li D, Cameron A, Beaumont N, Dozier A, Dewhurst S, Foxe JJ

medRxiv : the preprint server for health sciences.. 2023 September 20 Epub 09/20/2023.

Utilization and Impact of Symptomatic and Exposure SARS-CoV-2 Testing in K-12 Schools.

Schuster JE, Erickson TR, Goldman JL, Benjamin DK, Brookhart MA, Dewhurst S, Fist A, Foxe J, Godambe M, Gwynn L, Kiene SM, Keener Mast D, McDaniels-Davidson C, Newland JG, Oren E, Selvarangan R, Shinde N, Walsh T, Watterson T, Zand M, Zimmerman KO, Kalu IC

Pediatrics.. 2023 July 1152 (Suppl 1)Epub 1900 01 01.

Building School-Academic Partnerships to Implement COVID-19 Testing in Underserved Populations.

Goldman JL, Kalu IC, Schuster JE, Erickson T, Mast DK, Zimmerman K, Benjamin DK, Kalb LG, Gurnett C, Newland JG, Sherby M, Godambe M, Shinde N, Watterson T, Walsh T, Foxe J, Zand M, Dewhurst S, Coller R, DeMuri GP, Archuleta S, Ko LK, Inkelas M, Manuel V, Lee R, Oh H, Murugan V, Kramer J, Okihiro M, Gwynn L, Pulgaron E, McCulloh R, Broadhurst J, McDaniels-Davidson C, Kiene S, Oren E, Wu Y, Wetter DW, Stump T, Brookhart MA, Fist A, Haroz E

Pediatrics.. 2023 July 1152 (Suppl 1)Epub 1900 01 01.

Generation and Functional Analysis of Defective Viral Genomes during SARS-CoV-2 Infection.

Zhou T, Gilliam NJ, Li S, Spandau S, Osborn RM, Connor S, Anderson CS, Mariani TJ, Thakar J, Dewhurst S, Mathews DH, Huang L, Sun Y

mBio.. 2023 June 2714 (3):e0025023. Epub 04/19/2023.

Preparation of noninfectious scRNAseq samples from SARS-CoV-2-infected epithelial cells.

Osborn RM, Leach J, Zanche M, Ashton JM, Chu C, Thakar J, Dewhurst S, Rosenberger S, Pavelka M, Pryhuber GS, Mariani TJ, Anderson CS

PloS one.. 2023 18 (2):e0281898. Epub 02/24/2023.

Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection.

Zhou T, Gilliam NJ, Li S, Spaudau S, Osborn RM, Anderson CS, Mariani TJ, Thakar J, Dewhurst S, Mathews DH, Huang L, Sun Y

bioRxiv : the preprint server for biology.. 2022 September 23 Epub 09/23/2022.

Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine.

Nogales A, Steel J, Liu WC, Lowen AC, Rodriguez L, Chiem K, Cox A, García-Sastre A, Albrecht RA, Dewhurst S, Martínez-Sobrido L

Microbiology spectrum.. 2022 June 2910 (3):e0007822. Epub 05/18/2022.

Supporting COVID-19 School Safety for Children With Disabilities and Medical Complexity.

Sherby MR, Kalb LG, Coller RJ, DeMuri GP, Butteris S, Foxe JJ, Zand MS, Freedman EG, Dewhurst S, Newland JG, Gurnett CA

Pediatrics.. 2022 February 1149 (12 Suppl 2)Epub 1900 01 01.

Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro.

Raymonda MH, Ciesla JH, Monaghan M, Leach J, Asantewaa G, Smorodintsev-Schiller LA, Lutz MM, Schafer XL, Takimoto T, Dewhurst S, Munger J, Harris IS

Virology.. 2022 January 566 :60-68. Epub 11/27/2021.

Evaluating the Antimicrobial Properties of Commercial Hand Sanitizers.

Chojnacki M, Dobrotka C, Osborn R, Johnson W, Young M, Meyer B, Laskey E, Wozniak RAF, Dewhurst S, Dunman PM

mSphere.. 2021 March 36 (2)Epub 03/03/2021.

A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.

Cox A, Schmierer J, D'Angelo J, Smith A, Levenson D, Treanor J, Kim B, Dewhurst S

Viruses.. 2020 October 3112 (11)Epub 10/31/2020.

Platelets function as an acute viral reservoir during HIV-1 infection by harboring virus and T-cell complex formation.

Simpson SR, Singh MV, Dewhurst S, Schifitto G, Maggirwar SB

Blood advances.. 2020 September 224 (18):4512-4521. Epub 1900 01 01.

G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells.

Piekna-Przybylska D, Bambara RA, Maggirwar SB, Dewhurst S

Cell cycle.. 2020 September 19 (18):2298-2313. Epub 08/17/2020.

Effect of Dolutegravir and Sertraline on the Blood Brain Barrier (BBB).

Ma Q, Schifitto G, Venuto C, Ocque A, Dewhurst S, Morse GD, Aalinkeel R, Schwartz SA, Mahajan SD

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2020 March 15 (1):7-9. Epub 01/15/2020.

A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus.

Smith A, Rodriguez L, El Ghouayel M, Nogales A, Chamberlain JM, Sortino K, Reilly E, Feng C, Topham DJ, Martínez-Sobrido L, Dewhurst S

Journal of virology.. 2020 January 3194 (4)Epub 01/31/2020.

Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines.

Rodriguez L, Blanco-Lobo P, Reilly EC, Maehigashi T, Nogales A, Smith A, Topham DJ, Dewhurst S, Kim B, Martínez-Sobrido L

Viruses.. 2019 October 1011 (10)Epub 10/10/2019.

Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus.

Chamberlain J, Sortino K, Sethna P, Bae A, Lanier R, Bambara RA, Dewhurst S

Antimicrobial agents and chemotherapy.. 2019 January 63 (1)Epub 12/21/2018.

Display of the HIV envelope protein at the yeast cell surface for immunogen development.

Mathew E, Zhu H, Connelly SM, Sullivan MA, Brewer MG, Piepenbrink MS, Kobie JJ, Dewhurst S, Dumont ME

PloS one.. 2018 13 (10):e0205756. Epub 10/18/2018.

Natural Seminal Amyloids as Targets for Development of Synthetic Inhibitors of HIV Transmission.

Sheik DA, Dewhurst S, Yang J

Accounts of chemical research.. 2017 September 1950 (9):2159-2166. Epub 08/15/2017.

HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.

Hilimire TA, Chamberlain JM, Anokhina V, Bennett RP, Swart O, Myers JR, Ashton JM, Stewart RA, Featherston AL, Gates K, Helms ED, Smith HC, Dewhurst S, Miller BL

ACS chemical biology.. 2017 June 1612 (6):1674-1682. Epub 05/05/2017.

Hydrophobic Nanoparticles Reduce the ?-Sheet Content of SEVI Amyloid Fibrils and Inhibit SEVI-Enhanced HIV Infectivity.

Sheik DA, Chamberlain JM, Brooks L, Clark M, Kim YH, Leriche G, Kubiak CP, Dewhurst S, Yang J

Langmuir : the ACS journal of surfaces and colloids.. 2017 March 1433 (10):2596-2602. Epub 03/01/2017.

Nanoparticles decorated with viral antigens are more immunogenic at low surface density.

Brewer MG, DiPiazza A, Acklin J, Feng C, Sant AJ, Dewhurst S

Vaccine.. 2017 February 135 (5):774-781. Epub 01/03/2017.

Building community for deaf scientists.

Buckley G, Smith S, DeCaro J, Barnett S, Dewhurst S

Science.. 2017 January 20355 (6322):255. Epub 1900 01 01.

Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.

Mattiacio JL, Brewer M, Dewhurst S

Methods in molecular biology.. 2017 1581 :245-253. Epub 1900 01 01.

Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments.

Blanchard C, Brooks L, Beckley A, Colquhoun J, Dewhurst S, Dunman PM

Antimicrobial agents and chemotherapy.. 2016 February 60 (2):862-72. Epub 11/23/2015.

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation.

Nishimura C, Polesskaya O, Dewhurst S, Silva JN

Journal of visualized experiments : JoVE.. 2016 January 12 (107):e53582. Epub 01/12/2016.

Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment.

Blanchard C, Brooks L, Ebsworth-Mojica K, Didione L, Wucher B, Dewhurst S, Krysan D, Dunman PM, Wozniak RA

mSphere.. 2016 1 (5)Epub 09/14/2016.

A Single Mutation at PB1 Residue 319 Dramatically Increases the Safety of PR8 Live Attenuated Influenza Vaccine in a Murine Model without Compromising Vaccine Efficacy.

Cox A, Dewhurst S

Journal of virology.. 2015 December 1690 (5):2702-5. Epub 12/16/2015.

Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.

Puccini JM, Marker DF, Fitzgerald T, Barbieri J, Kim CS, Miller-Rhodes P, Lu SM, Dewhurst S, Gelbard HA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2015 April 135 (13):5271-83. Epub 1900 01 01.

Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine.

Cox A, Baker SF, Nogales A, Martínez-Sobrido L, Dewhurst S

Journal of virology.. 2015 March 89 (6):3421-6. Epub 12/31/2014.

Inhibition of the enhancement of infection of human immunodeficiency virus by semen-derived enhancer of virus infection using amyloid-targeting polymeric nanoparticles.

Sheik DA, Brooks L, Frantzen K, Dewhurst S, Yang J

ACS nano.. 2015 February 249 (2):1829-1836. Epub 02/02/2015.

Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters.

Ying B, Tollefson AE, Spencer JF, Balakrishnan L, Dewhurst S, Capella C, Buller RM, Toth K, Wold WS

Antimicrobial agents and chemotherapy.. 2014 December 58 (12):7171-81. Epub 09/15/2014.

Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity.

Silva JN, Polesskaya O, Wei HS, Rasheed IY, Chamberlain JM, Nishimura C, Feng C, Dewhurst S

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2014 October 21 (7):664-76. Epub 1900 01 01.

Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development.

Nogales A, Baker SF, Ortiz-Riaño E, Dewhurst S, Topham DJ, Martínez-Sobrido L

Journal of virology.. 2014 September 88 (18):10525-40. Epub 06/25/2014.

MLK3 regulates fMLP-stimulated neutrophil motility.

Polesskaya O, Wong C, Lebron L, Chamberlain JM, Gelbard HA, Goodfellow V, Kim M, Daiss JL, Dewhurst S

Molecular immunology.. 2014 April 58 (2):214-22. Epub 01/03/2014.

Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies.

Domm W, Brewer M, Baker SF, Feng C, Martínez-Sobrido L, Treanor J, Dewhurst S

Journal of virological methods.. 2014 March 197 :47-50. Epub 12/06/2013.

Theoretical model of critical issues in informed consent in HIV vaccine trials.

Lewis CA, Dewhurst S, McMahon JM, Bunce CA, Keefer MC, Alio AP

AIDS care.. 2014 26 (11):1452-60. Epub 05/28/2014.

Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model.

Rhoo KH, Granger M, Sur J, Feng C, Gelbard HA, Dewhurst S, Polesskaya O

PloS one.. 2014 9 (9):e108487. Epub 09/29/2014.

Fluorescence detection of cationic amyloid fibrils in human semen.

Easterhoff D, Dimaio JT, Liyanage W, Lo CW, Bae W, Doran TM, Smrcka A, Nilsson BL, Dewhurst S

Bioorganic & medicinal chemistry letters.. 2013 September 1523 (18):5199-202. Epub 07/08/2013.

Directional Histogram Ratio at Random Probes: A Local Thresholding Criterion for Capillary Images.

Lu N, Silva J, Gu Y, Gerber S, Wu H, Gelbard H, Dewhurst S, Miao H

Pattern recognition. 2013 July 146 (7):1933-1948. Epub 01/18/2013.

The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.

Marker DF, Tremblay ME, Puccini JM, Barbieri J, Gantz Marker MA, Loweth CJ, Muly EC, Lu SM, Goodfellow VS, Dewhurst S, Gelbard HA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 June 1233 (24):9998-10010. Epub 1900 01 01.

Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen.

Easterhoff D, Ontiveros F, Brooks LR, Kim Y, Ross B, Silva JN, Olsen JS, Feng C, Hardy DJ, Dunman PM, Dewhurst S

Antimicrobial agents and chemotherapy.. 2013 June 57 (6):2443-50. Epub 03/18/2013.

Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo.

Arany S, Benoit DS, Dewhurst S, Ovitt CE

Molecular therapy : the journal of the American Society of Gene Therapy.. 2013 June 21 (6):1182-94. Epub 03/19/2013.

Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.

Ma Q, Gelbard HA, Maggirwar SB, Dewhurst S, Gendelman HE, Peterson DR, Difrancesco R, Hochreiter JS, Morse GD, Schifitto G

Journal of neurovirology.. 2013 June 19 (3):254-60. Epub 06/05/2013.

Anti-idiotypic monobodies derived from a fibronectin scaffold.

Sullivan MA, Brooks LR, Weidenborner P, Domm W, Mattiacio J, Xu Q, Tiberio M, Wentworth T, Kobie J, Bryk P, Zheng B, Murphy M, Sanz I, Dewhurst S

Biochemistry.. 2013 March 1252 (10):1802-13. Epub 03/01/2013.

Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults.

Mapstone M, Hilton TN, Yang H, Guido JJ, Luque AE, Hall WJ, Dewhurst S, Shah K

Aging and disease.. 2013 4 (6):311-9. Epub 08/27/2013.

9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles.

Alcéna DC, Kobie JJ, Kaminski DA, Rosenberg AF, Mattiacio JL, Brewer M, Dewhurst S, Dykes C, Jin X, Keefer MC, Sanz I

PloS one.. 2013 8 (12):e85098. Epub 12/26/2013.

Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.

Silva J, Polesskaya O, Knight W, Zheng JT, Granger M, Lopez T, Ontiveros F, Feng C, Yan C, Kasischke KA, Dewhurst S

Journal of neuroinflammation.. 2012 November 209 :253. Epub 11/20/2012.

Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase.

Capella C, Beltejar MJ, Brown C, Fong V, Daddacha W, Kim B, Dewhurst S

Journal of virology.. 2012 October 86 (19):10484-93. Epub 07/18/2012.

Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures.

Arany S, Xu Q, Hernady E, Benoit DS, Dewhurst S, Ovitt CE

Journal of cellular biochemistry.. 2012 June 113 (6):1955-65. Epub 1900 01 01.

Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide.

Olsen JS, Dimaio JT, Doran TM, Brown C, Nilsson BL, Dewhurst S

The Journal of biological chemistry.. 2012 April 6287 (15):11842-9. Epub 02/21/2012.

Detection of microregional hypoxia in mouse cerebral cortex by two-photon imaging of endogenous NADH fluorescence.

Polesskaya O, Sun A, Salahura G, Silva JN, Dewhurst S, Kasischke K

Journal of visualized experiments : JoVE.. 2012 February 21 (60)Epub 02/21/2012.

9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity.

Kobie JJ, Alcena DC, Zheng B, Bryk P, Mattiacio JL, Brewer M, Labranche C, Young FM, Dewhurst S, Montefiori DC, Rosenberg AF, Feng C, Jin X, Keefer MC, Sanz I

PloS one.. 2012 7 (4):e35356. Epub 04/18/2012.

Advances in HIV microbicide development.

Olsen JS, Easterhoff D, Dewhurst S

Future medicinal chemistry.. 2011 December 3 (16):2101-16. Epub 1900 01 01.

Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.

Aggarwal S, Dewhurst S, Takimoto T, Kim B

The Journal of biological chemistry.. 2011 October 7286 (40):34504-13. Epub 08/04/2011.

CTSA-IP: a solution to identifying and aggregating intellectual property across the NIH Clinical Translational Science Award (CTSA) consortium of biomedical research institutes.

Hazard M, Steele S, Wang D, Pearson T, Scheideler M, Dewhurst S

Clinical and translational science.. 2011 October 4 (5):328-31. Epub 1900 01 01.

Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier.

Domm W, Brooks L, Chung HL, Feng C, Bowers WJ, Watson G, McGrath JL, Dewhurst S

Vaccine.. 2011 September 1629 (40):7080-9. Epub 07/27/2011.

PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells.

Bussey KA, Desmet EA, Mattiacio JL, Hamilton A, Bradel-Tretheway B, Bussey HE, Kim B, Dewhurst S, Takimoto T

Journal of virology.. 2011 July 85 (14):7020-8. Epub 05/11/2011.

Dazed and confused by HHV-6.

Caserta MT, Dewhurst S

Blood.. 2011 May 12117 (19):5016-8. Epub 1900 01 01.

Dense display of HIV-1 envelope spikes on the lambda phage scaffold does not result in the generation of improved antibody responses to HIV-1 Env.

Mattiacio J, Walter S, Brewer M, Domm W, Friedman AE, Dewhurst S

Vaccine.. 2011 March 2129 (14):2637-47. Epub 02/18/2011.

Enhancement of HIV-1 infectivity by simple, self-assembling modular peptides.

Easterhoff D, Dimaio JT, Doran TM, Dewhurst S, Nilsson BL

Biophysical journal.. 2011 March 2100 (5):1325-34. Epub 1900 01 01.

Methamphetamine causes sustained depression in cerebral blood flow.

Polesskaya O, Silva J, Sanfilippo C, Desrosiers T, Sun A, Shen J, Feng C, Polesskiy A, Deane R, Zlokovic B, Kasischke K, Dewhurst S

Brain research.. 2011 February 101373 :91-100. Epub 12/13/2010.

HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells.

Lu SM, Tremblay MÈ, King IL, Qi J, Reynolds HM, Marker DF, Varrone JJ, Majewska AK, Dewhurst S, Gelbard HA

PloS one.. 2011 6 (9):e23915. Epub 09/02/2011.

Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.

Fong V, Osterbur M, Capella C, Kim YE, Hine C, Gorbunova V, Seluanov A, Dewhurst S

PloS one.. 2011 6 (12):e28714. Epub 12/09/2011.

Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure.

Polesskaya O, Cunningham LL, Francis SP, Luebke AE, Zhu X, Collins D, Vasilyeva ON, Sahler J, Desmet EA, Gelbard HA, Maggirwar SB, Walton JP, Frisina RD, Dewhurst S

Hearing research.. 2010 December 1270 (1-2):21-7. Epub 10/27/2010.

Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection.

Olsen JS, Brown C, Capule CC, Rubinshtein M, Doran TM, Srivastava RK, Feng C, Nilsson BL, Yang J, Dewhurst S

The Journal of biological chemistry.. 2010 November 12285 (46):35488-96. Epub 09/10/2010.

Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase.

Gelbard HA, Dewhurst S, Maggirwar SB, Kiebala M, Polesskaya O, Gendelman HE

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2010 October 7 (4):392-8. Epub 1900 01 01.

CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.

Gorantla S, Makarov E, Finke-Dwyer J, Gebhart CL, Domm W, Dewhurst S, Gendelman HE, Poluektova LY

The Journal of immunology : official journal of the American Association of Immunologists.. 2010 June 15184 (12):7082-91. Epub 05/21/2010.

Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequences.

Love TM, Thurston SW, Keefer MC, Dewhurst S, Lee HY

Journal of virology.. 2010 June 84 (11):5802-14. Epub 03/24/2010.

Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.

Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB

Virology.. 2010 May 10400 (2):224-32. Epub 02/25/2010.

Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.

Aggarwal S, Bradel-Tretheway B, Takimoto T, Dewhurst S, Kim B

PloS one.. 2010 April 295 (4):e10372. Epub 04/29/2010.

Neuroprotective activities of CEP-1347 in models of neuroAIDS.

Eggert D, Dash PK, Gorantla S, Dou H, Schifitto G, Maggirwar SB, Dewhurst S, Poluektova L, Gelbard HA, Gendelman HE

The Journal of immunology : official journal of the American Association of Immunologists.. 2010 January 15184 (2):746-56. Epub 12/04/2009.

The mechanistic architecture of thermostable Pyrococcus furiosus family B DNA polymerase motif A and its interaction with the dNTP substrate.

Kennedy EM, Hergott C, Dewhurst S, Kim B

Biochemistry.. 2009 December 148 (47):11161-8. Epub 1900 01 01.

Nef gene evolution from a single transmitted strain in acute SIV infection.

Bimber BN, Chugh P, Giorgi EE, Kim B, Almudevar AL, Dewhurst S, O'Connor DH, Lee HY

Retrovirology.. 2009 June 86 :57. Epub 06/08/2009.

Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.

Schifitto G, Zhong J, Gill D, Peterson DR, Gaugh MD, Zhu T, Tivarus M, Cruttenden K, Maggirwar SB, Gendelman HE, Dewhurst S, Gelbard HA

Journal of neurovirology.. 2009 April 15 (2):176-86. Epub 1900 01 01.

Proteasome inhibitors enhance bacteriophage lambda (lambda) mediated gene transfer in mammalian cells.

Volcy K, Dewhurst S

Virology.. 2009 February 5384 (1):77-87. Epub 12/06/2008.

The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit.

Bradel-Tretheway BG, Kelley Z, Chakraborty-Sett S, Takimoto T, Kim B, Dewhurst S

The Journal of general virology.. 2008 December 89 (Pt 12):2923-2932. Epub 1900 01 01.

Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells.

Sapinoro R, Volcy K, Rodrigo WW, Schlesinger JJ, Dewhurst S

Virology.. 2008 April 10373 (2):274-86. Epub 01/14/2008.

Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.

Chugh P, Bradel-Tretheway B, Monteiro-Filho CM, Planelles V, Maggirwar SB, Dewhurst S, Kim B

Retrovirology.. 2008 January 315 :11. Epub 01/31/2008.

Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death.

Taylor SR, Gonzalez-Begne M, Dewhurst S, Chimini G, Higgins CF, Melvin JE, Elliott JI

The Journal of immunology : official journal of the American Association of Immunologists.. 2008 January 1180 (1):300-8. Epub 1900 01 01.

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

Norman JP, Perry SW, Reynolds HM, Kiebala M, De Mesy Bentley KL, Trejo M, Volsky DJ, Maggirwar SB, Dewhurst S, Masliah E, Gelbard HA

PloS one.. 2008 3 (11):e3731. Epub 11/14/2008.

Enhanced transduction of dendritic cells by FcgammaRI-targeted adenovirus vectors.

Sapinoro R, Maguire CA, Burgess A, Dewhurst S

The journal of gene medicine.. 2007 December 9 (12):1033-45. Epub 1900 01 01.

HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime.

Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ, Dewhurst S

Vaccine.. 2007 October 1625 (42):7410-21. Epub 08/30/2007.

Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging.

Santos K, Sanfilippo CM, Narrow WC, Casey AE, Rodriguez-Colon SM, McDermott MP, Federoff HJ, Bowers WJ, Dewhurst S

Journal of virological methods.. 2007 October 145 (1):37-46. Epub 07/02/2007.

In vivo gene delivery and expression by bacteriophage lambda vectors.

Lankes HA, Zanghi CN, Santos K, Capella C, Duke CM, Dewhurst S

Journal of applied microbiology.. 2007 May 102 (5):1337-49. Epub 1900 01 01.

Human papillomavirus-like particles mediate functional delivery of plasmid DNA to antigen presenting cells in vivo.

Malboeuf CM, Simon DA, Lee YE, Lankes HA, Dewhurst S, Frelinger JG, Rose RC

Vaccine.. 2007 April 3025 (17):3270-6. Epub 01/22/2007.

Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia.

Sui Z, Sniderhan LF, Schifitto G, Phipps RP, Gelbard HA, Dewhurst S, Maggirwar SB

The Journal of immunology : official journal of the American Association of Immunologists.. 2007 March 1178 (5):3226-36. Epub 1900 01 01.

Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice.

Gorantla S, Sneller H, Walters L, Sharp JG, Pirruccello SJ, West JT, Wood C, Dewhurst S, Gendelman HE, Poluektova L

Journal of virology.. 2007 March 81 (6):2700-12. Epub 12/20/2006.

Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.

Dewhurst S, Maggirwar SB, Schifitto G, Gendelman HE, Gelbard HA

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2007 March 2 (1):93-6. Epub 12/16/2006.

Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag.

Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S

Vaccine.. 2007 February 1925 (9):1634-46. Epub 11/15/2006.

Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.

Chugh P, Fan S, Planelles V, Maggirwar SB, Dewhurst S, Kim B

Journal of molecular biology.. 2007 February 9366 (1):67-81. Epub 11/10/2006.

Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors.

Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff HJ, Dewhurst S, Frelinger JG

Human gene therapy.. 2007 February 18 (2):93-105. Epub 1900 01 01.

A new paradigm for studies of HIV-1 pathobiology in humanized Balb/c-Rag2-/-?c-/- mice. J. Virol. PMCID: PMC1865995

Gorantla, S., Sneller, H., Walters, L., Sharp, J.G., Pirruccello, S.J., West, J., Wood, C., Dewhurst, S., Gendelman, H.E., Poluektova, L.

2007; : 81:2700-2712.

A tractable method for simultaneous modifications to the head and tail of bacteriophage lambda and its application to enhancing phage-mediated gene delivery.

Zanghi CN, Sapinoro R, Bradel-Tretheway B, Dewhurst S

Nucleic acids research.. 2007 35 (8):e59. Epub 03/28/2007.

Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation.

Sui Z, Fan S, Sniderhan L, Reisinger E, Litzburg A, Schifitto G, Gelbard HA, Dewhurst S, Maggirwar SB

The Journal of immunology : official journal of the American Association of Immunologists.. 2006 July 1177 (1):702-11. Epub 1900 01 01.

Amplicons as vaccine vectors.

Santos K, Duke CM, Dewhurst S

Current gene therapy.. 2006 June 6 (3):383-92. Epub 1900 01 01.

Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons.

Sui Z, Sniderhan LF, Fan S, Kazmierczak K, Reisinger E, Kovács AD, Potash MJ, Dewhurst S, Gelbard HA, Maggirwar SB

The European journal of neuroscience.. 2006 May 23 (10):2623-34. Epub 1900 01 01.

Characteristics and acquisition of human herpesvirus (HHV) 7 infections in relation to infection with HHV-6.

Hall CB, Caserta MT, Schnabel KC, McDermott MP, Lofthus GK, Carnahan JA, Gilbert LM, Dewhurst S

The Journal of infectious diseases.. 2006 April 15193 (8):1063-9. Epub 03/06/2006.

Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigens.

Maguire CA, Sapinoro R, Girgis N, Rodriguez-Colon SM, Ramirez SH, Williams J, Dewhurst S

Vaccine.. 2006 January 3024 (5):671-82. Epub 08/24/2005.

HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1.

Zeng L, Planelles V, Sui Z, Gartner S, Maggirwar SB, Dewhurst S, Ye L, Nerurkar VR, Yanagihara R, Lu Y

The journal of gene medicine.. 2006 January 8 (1):18-28. Epub 1900 01 01.

A simple method for displaying recalcitrant proteins on the surface of bacteriophage lambda.

Zanghi CN, Lankes HA, Bradel-Tretheway B, Wegman J, Dewhurst S

Nucleic acids research.. 2005 October 1333 (18):e160. Epub 10/13/2005.

Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis.

Dou H, Ellison B, Bradley J, Kasiyanov A, Poluektova LY, Xiong H, Maggirwar S, Dewhurst S, Gelbard HA, Gendelman HE

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2005 September 1425 (37):8375-85. Epub 1900 01 01.

The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro.

Zhen Z, Bradel-Tretheway B, Sumagin S, Bidlack JM, Dewhurst S

Journal of virology.. 2005 September 79 (18):11914-24. Epub 1900 01 01.

HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis.

Perry SW, Norman JP, Litzburg A, Zhang D, Dewhurst S, Gelbard HA

The Journal of immunology : official journal of the American Association of Immunologists.. 2005 April 1174 (7):4333-44. Epub 1900 01 01.

Valproic acid enhances gene expression from viral gene transfer vectors.

Fan S, Maguire CA, Ramirez SH, Bradel-Tretheway B, Sapinoro R, Sui Z, Chakraborty-Sett S, Dewhurst S

Journal of virological methods.. 2005 April 125 (1):23-33. Epub 01/16/2005.

Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death.

Jin N, Kovács AD, Sui Z, Dewhurst S, Maggirwar SB

Neuropharmacology.. 2005 March 48 (4):576-83. Epub 01/25/2005.

Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge.

Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff HJ, Gendelman HE, Poluektova L

Journal of virology.. 2005 February 79 (4):2124-32. Epub 1900 01 01.

Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway.

Fan S, Ramirez SH, Garcia TM, Dewhurst S

Brain research. Molecular brain research.. 2004 December 6132 (1):38-50. Epub 1900 01 01.

Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase.

Diamond TL, Roshal M, Jamburuthugoda VK, Reynolds HM, Merriam AR, Lee KY, Balakrishnan M, Bambara RA, Planelles V, Dewhurst S, Kim B

The Journal of biological chemistry.. 2004 December 3279 (49):51545-53. Epub 09/26/2004.

Inhibition of HIV type 1 replication using lentiviral-mediated delivery of mutant tRNA(Lys3)A58U.

Renda MJ, Bradel-Tretheway B, Planelles V, Bambara RA, Dewhurst S

AIDS research and human retroviruses.. 2004 December 20 (12):1324-34. Epub 1900 01 01.

Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7).

Hall CB, Caserta MT, Schnabel KC, Boettrich C, McDermott MP, Lofthus GK, Carnahan JA, Dewhurst S

The Journal of pediatrics.. 2004 October 145 (4):472-7. Epub 1900 01 01.

Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children.

Caserta MT, McDermott MP, Dewhurst S, Schnabel K, Carnahan JA, Gilbert L, Lathan G, Lofthus GK, Hall CB

The Journal of pediatrics.. 2004 October 145 (4):478-84. Epub 1900 01 01.

Transient overexpression of kappa and mu opioid receptors using recombinant adenovirus vectors.

Zhen Z, Bradel-Tretheway BG, Dewhurst S, Bidlack JM

Journal of neuroscience methods.. 2004 July 30136 (2):133-9. Epub 1900 01 01.

Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal.

Ramirez SH, Fan S, Maguire CA, Perry S, Hardiek K, Ramkumar V, Gelbard HA, Dewhurst S, Maggirwar SB

Journal of neuroscience research.. 2004 July 1577 (2):258-69. Epub 1900 01 01.

Human herpesvirus type 6 and human herpesvirus type 7 infections of the central nervous system.

Dewhurst S

Herpes : the journal of the IHMF.. 2004 June 11 Suppl 2 :105A-111A. Epub 1900 01 01.

Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands.

Latchney LR, Fallon MA, Culp DJ, Gelbard HA, Dewhurst S

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.. 2004 May 52 (5):671-81. Epub 1900 01 01.

Efficient gene transfer into human monocyte-derived macrophages using defective lentiviral vectors.

Lu Y, Liu C, Zeng L, Lin Z, Dewhurst S, Gartner S, Planelles V

Cellular and molecular biology.. 2003 November 49 (7):1151-6. Epub 1900 01 01.

Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis.

Dou H, Birusingh K, Faraci J, Gorantla S, Poluektova LY, Maggirwar SB, Dewhurst S, Gelbard HA, Gendelman HE

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 October 823 (27):9162-70. Epub 1900 01 01.

Mechanistic understanding of an altered fidelity simian immunodeficiency virus reverse transcriptase mutation, V148I, identified in a pig-tailed macaque.

Diamond TL, Souroullas G, Weiss KK, Lee KY, Bambara RA, Dewhurst S, Kim B

The Journal of biological chemistry.. 2003 August 8278 (32):29913-24. Epub 05/08/2003.

Effects of codon-optimization on protein expression by the human herpesvirus 6 and 7 U51 open reading frame.

Bradel-Tretheway BG, Zhen Z, Dewhurst S

Journal of virological methods.. 2003 August 111 (2):145-56. Epub 1900 01 01.

Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes.

Wang X, Messerle M, Sapinoro R, Santos K, Hocknell PK, Jin X, Dewhurst S

Journal of virology.. 2003 July 77 (13):7182-92. Epub 1900 01 01.

Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming.

Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S

Vaccine.. 2003 June 221 (19-20):2288-97. Epub 1900 01 01.

A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells.

Richards JL, Abend JR, Miller ML, Chakraborty-Sett S, Dewhurst S, Whetter LE

European journal of biochemistry. 2003 May 270 (10):2287-94. Epub 1900 01 01.

Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin.

Richards J, Miller M, Abend J, Koide A, Koide S, Dewhurst S

Journal of molecular biology.. 2003 March 7326 (5):1475-88. Epub 1900 01 01.

Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk?

Perry SW, Dewhurst S, Bellizzi MJ, Gelbard HA

Journal of neurovirology.. 2002 December 8 (6):611-24. Epub 1900 01 01.

Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses.

Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst S

Journal of virology.. 2002 June 76 (11):5565-80. Epub 1900 01 01.

Human herpesvirus 6.

Caserta MT, Mock DJ, Dewhurst S

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2001 September 1533 (6):829-33. Epub 08/10/2001.

Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism.

Ramirez SH, Sanchez JF, Dimitri CA, Gelbard HA, Dewhurst S, Maggirwar SB

Journal of neurochemistry.. 2001 August 78 (4):874-89. Epub 1900 01 01.

Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons.

Tong N, Sanchez JF, Maggirwar SB, Ramirez SH, Guo H, Dewhurst S, Gelbard HA

The European journal of neuroscience.. 2001 May 13 (10):1913-22. Epub 1900 01 01.

Epitope mapping of human herpesvirus-7 gp65 using monoclonal antibodies.

Skrincosky D, Willis RA, Hocknell PK, Frelinger JG, Mirandola P, Wang X, Dewhurst S

Archives of virology.. 2001 146 (9):1705-22. Epub 1900 01 01.

Adenovirus type 7 penton purification of soluble pentamers from Escherichia coli and development of an integrin-dependent gene delivery system.

Bal HP, Chroboczek J, Schoehn G, Ruigrok RW, Dewhurst S

European journal of biochemistry. 2000 October 267 (19):6074-81. Epub 1900 01 01.

Identification and analysis of a novel heparin-binding glycoprotein encoded by human herpesvirus 7.

Skrincosky D, Hocknell P, Whetter L, Secchiero P, Chandran B, Dewhurst S

Journal of virology.. 2000 May 74 (10):4530-40. Epub 1900 01 01.

Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system.

Tong N, Perry SW, Zhang Q, James HJ, Guo H, Brooks A, Bal H, Kinnear SA, Fine S, Epstein LG, Dairaghi D, Schall TJ, Gendelman HE, Dewhurst S, Sharer LR, Gelbard HA

The Journal of immunology : official journal of the American Association of Immunologists.. 2000 February 1164 (3):1333-9. Epub 1900 01 01.

Functional interplay between nuclear factor-kappaB and c-Jun integrated by coactivator p300 determines the survival of nerve growth factor-dependent PC12 cells.

Maggirwar SB, Ramirez S, Tong N, Gelbard HA, Dewhurst S

Journal of neurochemistry.. 2000 February 74 (2):527-39. Epub 1900 01 01.

Pathogenesis and treatment of HIV-1 infection: recent developments (Y2K update).

Dewhurst SL, da Cruz RL, Whetter L

Frontiers in bioscience : a journal and virtual library.. 2000 January 15 :D30-49. Epub 01/01/2000.

Detection of human herpesvirus 6 by reverse transcription-PCR.

Norton RA, Caserta MT, Hall CB, Schnabel K, Hocknell P, Dewhurst S

Journal of clinical microbiology.. 1999 November 37 (11):3672-5. Epub 1900 01 01.

Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A.

Dominguez G, Dambaugh TR, Stamey FR, Dewhurst S, Inoue N, Pellett PE

Journal of virology.. 1999 October 73 (10):8040-52. Epub 1900 01 01.

Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj.

Hodge S, de Rosayro J, Glenn A, Ojukwu IC, Dewhurst S, McClure HM, Bischofberger N, Anderson DC, Klumpp SA, Novembre FJ

Journal of virology.. 1999 October 73 (10):8630-9. Epub 1900 01 01.

HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity.

Maggirwar SB, Tong N, Ramirez S, Gelbard HA, Dewhurst S

Journal of neurochemistry.. 1999 August 73 (2):578-86. Epub 1900 01 01.

Psychological predictors of single and recurrent major depressive episodes.

Wilhelm K, Parker G, Dewhurst-Savellis J, Asghari A

Journal of affective disorders.. 1999 July 54 (1-2):139-47. Epub 1900 01 01.

Pathogenesis of simian immunodeficiency virus infection.

Whetter LE, Ojukwu IC, Novembre FJ, Dewhurst S

The Journal of general virology.. 1999 July 80 ( Pt 7) :1557-1568. Epub 1900 01 01.

Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia.

Fine SM, Maggirwar SB, Elliott PR, Epstein LG, Gelbard HA, Dewhurst S

Journal of neuroimmunology.. 1999 March 195 (1-2):55-64. Epub 1900 01 01.

Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14.

Hodge S, Novembre FJ, Whetter L, Gelbard HA, Dewhurst S

Virology.. 1998 December 20252 (2):354-63. Epub 1900 01 01.

Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons.

Maggirwar SB, Sarmiere PD, Dewhurst S, Freeman RS

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1998 December 1518 (24):10356-65. Epub 1900 01 01.

U94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture.

Rotola A, Ravaioli T, Gonelli A, Dewhurst S, Cassai E, Di Luca D

Proceedings of the National Academy of Sciences of the United States of America.. 1998 November 1095 (23):13911-6. Epub 1900 01 01.

Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption.

Deng SX, Panahian N, James H, Gelbard HA, Federoff HJ, Dewhurst S, Epstein LG

Journal of neuroscience methods.. 1998 September 183 (2):159-64. Epub 1900 01 01.

Endogenous tumor necrosis factor-alpha contributes to lymphoproliferation induced by simian immunodeficiency virus variant, SIVsmmPBj14.

Hodge S, Novembre FJ, Dewhurst S

Immunology letters.. 1998 August 63 (1):49-51. Epub 1900 01 01.

Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis.

Perry SW, Hamilton JA, Tjoelker LW, Dbaibo G, Dzenko KA, Epstein LG, Hannun Y, Whittaker JS, Dewhurst S, Gelbard HA

The Journal of biological chemistry.. 1998 July 10273 (28):17660-4. Epub 1900 01 01.

HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism.

New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA

The Journal of biological chemistry.. 1998 July 10273 (28):17852-8. Epub 1900 01 01.

Costimulatory pathways in lymphocyte proliferation induced by the simian immunodeficiency virus SIVsmmPBj14.

Whetter L, Novembre FJ, Saucier M, Gummuluru S, Dewhurst S

Journal of virology.. 1998 July 72 (7):6155-8. Epub 1900 01 01.

The tyrosine-17 residue of Nef in SIVsmmPBj14 is required for acute pathogenesis and contributes to replication in macrophages.

Saucier M, Hodge S, Dewhurst S, Gibson T, Gibson JP, McClure HM, Novembre FJ

Virology.. 1998 May 10244 (2):261-72. Epub 1900 01 01.

Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6.

Deng H, Dewhurst S

Journal of virology.. 1998 January 72 (1):320-9. Epub 1900 01 01.

Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A.

Hall CB, Caserta MT, Schnabel KC, Long C, Epstein LG, Insel RA, Dewhurst S

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 1998 January 26 (1):132-7. Epub 1900 01 01.

Telomeric sequences from human herpesvirus 6 do not mediate nuclear retention of episomal DNA in human cells.

Bulboaca GH, Deng H, Dewhurst S, Calos MP

Archives of virology.. 1998 143 (3):563-70. Epub 1900 01 01.

Distribution of glutamate transporter subtypes during human brain development.

Bar-Peled O, Ben-Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A, Rothstein JD

Journal of neurochemistry.. 1997 December 69 (6):2571-80. Epub 1900 01 01.

Human herpesvirus 7.

Dewhurst S, Skrincosky D, van Loon N

Expert reviews in molecular medicine.. 1997 November 181997 :1-10. Epub 11/18/1997.

Human herpesvirus 6.

Dewhurst S, Skrincosky D, van Loon N

Expert reviews in molecular medicine.. 1997 November 51997 :1-17. Epub 11/05/1997.

The representation of nonstructural information in visual memory: evidence from image combination.

Walker P, Hitch GJ, Dewhurst SA, Whiteley HE, Brandimonte MA

Memory & cognition.. 1997 July 25 (4):484-91. Epub 1900 01 01.

Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis.

Krajewski S, James HJ, Ross J, Blumberg BM, Epstein LG, Gendelman HE, Gummuluru S, Dewhurst S, Sharer LR, Reed JC, Gelbard HA

Neuropathology and applied neurobiology.. 1997 June 23 (3):242-53. Epub 1900 01 01.

Stringent structural and sequence requirements of the human herpesvirus 6B lytic-phase origin of DNA replication.

Dykes C, Chan H, Krenitsky DM, Dewhurst S

The Journal of general virology.. 1997 May 78 ( Pt 5) :1125-9. Epub 1900 01 01.

Identification and analysis of a lytic-phase origin of DNA replication in human herpesvirus 7.

van Loon N, Dykes C, Deng H, Dominguez G, Nicholas J, Dewhurst S

Journal of virology.. 1997 April 71 (4):3279-84. Epub 1900 01 01.

Pathogenesis and treatment of HIV-1 infection: recent developments.

Dewhurst S, Whetter L

Frontiers in bioscience : a journal and virtual library.. 1997 March 12 :d147-59. Epub 03/01/1997.

Apoptosis correlates with immune activation in intestinal lymphoid tissue from macaques acutely infected by a highly enteropathic simian immunodeficiency virus, SIVsmmPBj14.

Gummuluru S, Novembre FJ, Lewis M, Gelbard HA, Dewhurst S

Virology.. 1996 November 1225 (1):21-32. Epub 1900 01 01.

Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia.

Fine SM, Angel RA, Perry SW, Epstein LG, Rothstein JD, Dewhurst S, Gelbard HA

The Journal of biological chemistry.. 1996 June 28271 (26):15303-6. Epub 1900 01 01.

Resources for HIV/AIDS on the Internet.

Dewhurst S, Sander DM, Sgro JY

Molecular medicine today. 1996 February 2 (2):52-7. Epub 1900 01 01.

SIVsmmPBj14 induces expression of a mucosal integrin on macaque lymphocytes.

Gummuluru S, Novembre FJ, Seshi B, Dewhurst S

Virology.. 1996 January 1215 (1):97-100. Epub 1900 01 01.

Neuropathogenesis of AIDS.

Dewhurst S, Gelbard HA, Fine SM

Molecular medicine today. 1996 January 2 (1):16-23. Epub 1900 01 01.

Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: structural analysis and heterogeneity.

Secchiero P, Nicholas J, Deng H, Xiaopeng T, van Loon N, Ruvolo VR, Berneman ZN, Reitz MS, Dewhurst S

Journal of virology.. 1995 December 69 (12):8041-5. Epub 1900 01 01.

Activation of nuclear factor kappa B in brains from children with HIV-1 encephalitis.

Dollard SC, James HJ, Sharer LR, Epstein LG, Gelbard HA, Dewhurst S

Neuropathology and applied neurobiology.. 1995 December 21 (6):518-28. Epub 1900 01 01.

Direct sequence analysis of human herpesvirus 6 (HHV-6) sequences from infants and comparison of HHV-6 sequences from mother/infant pairs.

van Loon NM, Gummuluru S, Sherwood DJ, Marentes R, Hall CB, Dewhurst S

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 1995 October 21 (4):1017-9. Epub 1900 01 01.

Effects of zidovudine use during pregnancy on resistance and vertical transmission of human immunodeficiency virus type 1.

Frenkel LM, Wagner LE, Demeter LM, Dewhurst S, Coombs RW, Murante BL, Reichman RC

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 1995 May 20 (5):1321-6. Epub 1900 01 01.

Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA.

Talley AK, Dewhurst S, Perry SW, Dollard SC, Gummuluru S, Fine SM, New D, Epstein LG, Gendelman HE, Gelbard HA

Molecular and cellular biology.. 1995 May 15 (5):2359-66. Epub 1900 01 01.

Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy.

Saito Y, Sharer LR, Dewhurst S, Blumberg BM, Hall CB, Epstein LG

Journal of neurovirology.. 1995 March 1 (1):30-9. Epub 1900 01 01.

Specific, sensitive, and rapid assay for human immunodeficiency virus type 1 pol mutations associated with resistance to zidovudine and didanosine.

Frenkel LM, Wagner LE, Atwood SM, Cummins TJ, Dewhurst S

Journal of clinical microbiology.. 1995 February 33 (2):342-7. Epub 1900 01 01.

Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.

Dollard SC, Gummuluru S, Tsang S, Fultz PN, Dewhurst S

Journal of virology.. 1994 December 68 (12):7800-9. Epub 1900 01 01.

Neuroinvasion and persistence of human herpesvirus 6 in children.

Caserta MT, Hall CB, Schnabel K, McIntyre K, Long C, Costanzo M, Dewhurst S, Insel R, Epstein LG

The Journal of infectious diseases.. 1994 December 170 (6):1586-9. Epub 1900 01 01.

Human herpesvirus 6B origin: sequence diversity, requirement for two binding sites for origin-binding protein, and enhanced replication from origin multimers.

Dewhurst S, Krenitsky DM, Dykes C

Journal of virology.. 1994 October 68 (10):6799-803. Epub 1900 01 01.

Human herpesvirus-6 infection in children. A prospective study of complications and reactivation.

Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, Knott A, Dewhurst S, Insel RA, Epstein LG

The New England journal of medicine.. 1994 August 18331 (7):432-8. Epub 1900 01 01.

Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini.

Thomson BJ, Dewhurst S, Gray D

Journal of virology.. 1994 May 68 (5):3007-14. Epub 1900 01 01.

Identification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29.

Dewhurst S, Dollard SC, Pellett PE, Dambaugh TR

Journal of virology.. 1993 December 67 (12):7680-3. Epub 1900 01 01.

Transcomplementation of simian immunodeficiency virus Rev with human T-cell leukemia virus type I Rex.

Krohn KJ, Hakkarainen K, Aavik E, Dewhurst S, Sadaie R, Mullins JI

Journal of virology.. 1993 September 67 (9):5681-4. Epub 1900 01 01.

Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants.

Dewhurst S, McIntyre K, Schnabel K, Hall CB

Journal of clinical microbiology.. 1993 February 31 (2):416-8. Epub 1900 01 01.

Phenotypic and genetic polymorphisms among human herpesvirus-6 isolates from North American infants.

Dewhurst S, Chandran B, McIntyre K, Schnabel K, Hall CB

Virology.. 1992 September 190 (1):490-3. Epub 1900 01 01.

Molecular clones from a non-acutely pathogenic derivative of SIVsmmPBj14: characterization and comparison to acutely pathogenic clones.

Dewhurst S, Embretson JE, Fultz PN, Mullins JI

AIDS research and human retroviruses.. 1992 June 8 (6):1179-87. Epub 1900 01 01.

Cellular mono(ADP-ribosyl) transferase inhibits protein synthesis.

Iglewski WJ, Dewhurst S

FEBS letters.. 1991 June 3283 (2):235-8. Epub 1900 01 01.

Sequence analysis and acute pathogenicity of molecularly cloned SIVSMM-PBj14.

Dewhurst S, Embretson JE, Anderson DC, Mullins JI, Fultz PN

Nature.. 1990 June 14345 (6276):636-40. Epub 1900 01 01.

Quantitative distribution of 131I-labelled monoclonal antibodies administered by the intra-ventricular route.

Smith DB, Mosely RP, Begent RH, Coakham HB, Glaser MG, Dewhurst S, Kelly A, Bagshawe KD

European journal of cancer : official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR).. 1990 February 26 (2):129-36. Epub 1900 01 01.

SIVsmm infection of macaque and mangabey monkeys: correlation between in vivo and in vitro properties of different isolates.

Fultz PN, Anderson DC, McClure HM, Dewhurst S, Mullins JI

Developments in biological standardization. 1990 72 :253-8. Epub 1900 01 01.

The FeLV and SIV AIDS pathogenesis models: search for and analysis of molecularly defined pathogens.

Mullins JI, Hoover EA, Donahue PR, Dewhurst S, Quackenbush SL, Murphey-Corb M, Martin LN, Fultz PN, Gallo MV, Reinhart TA

Developments in biological standardization. 1990 72 :167-71. Epub 1900 01 01.

Accurate quantification of 131I distribution by gamma camera imaging.

Green AJ, Dewhurst SE, Begent RH, Bagshawe KD, Riggs SJ

European journal of nuclear medicine.. 1990 16 (4-6):361-5. Epub 1900 01 01.

Differences in cytopathogenicity and host cell range among infectious molecular clones of human immunodeficiency virus type 1 simultaneously isolated from an individual.

Sakai K, Dewhurst S, Ma XY, Volsky DJ

Journal of virology.. 1988 November 62 (11):4078-85. Epub 1900 01 01.

Establishment of human glial cell lines chronically infected with the human immunodeficiency virus.

Dewhurst S, Sakai K, Zhang XH, Wasiak A, Volsky DJ

Virology.. 1988 January 162 (1):151-9. Epub 1900 01 01.

Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV.

Dewhurst S, Sakai K, Bresser J, Stevenson M, Evinger-Hodges MJ, Volsky DJ

Journal of virology.. 1987 December 61 (12):3774-82. Epub 1900 01 01.

Expression of the T4 molecule (AIDS virus receptor) by human brain-derived cells.

Dewhurst S, Stevenson M, Volsky DJ

FEBS letters.. 1987 March 9213 (1):133-7. Epub 1900 01 01.

Susceptibility of human glial cells to infection with human immunodeficiency virus (HIV).

Dewhurst S, Bresser J, Stevenson M, Sakai K, Evinger-Hodges MJ, Volsky DJ

FEBS letters.. 1987 March 9213 (1):138-43. Epub 1900 01 01.

Expression of glial fibrillary acidic protein in human glioma cell lines as detected by molecular hybridization.

Dewhurst S, Stevenson M, McComb RD, Volsky DJ

Acta neuropathologica.. 1987 73 (4):383-6. Epub 1900 01 01.

False-positive enzyme-linked immunosorbent assay reactions for antibody to human immunodeficiency virus in a population of midwestern patients with congenital bleeding disorders.

Smith DM, Dewhurst S, Shepherd S, Volsky DJ, Goldsmith JC

Transfusion.. 1987 27 (1):112. Epub 1900 01 01.

Retroviral etiology of the acquired immune deficiency syndrome (AIDS).

Volsky DJ, Sakai K, Stevenson M, Dewhurst S

AIDS research. 1986 December 2 Suppl 1 :S35-48. Epub 1900 01 01.

High prevalence and high titers of LAV/HTLV-III antibodies in healthy hemophiliacs in the midwestern United States.

Goldsmith JC, Dewhurst S, Hedenskog M, Casareale D, Volsky DJ

The American journal of medicine.. 1986 October 81 (4):579-83. Epub 1900 01 01.

Testing for antibodies to AIDS-associated retrovirus (HTLV-III/LAV) by indirect fixed cell immunofluorescence: specificity, sensitivity, and applications.

Hedenskog M, Dewhurst S, Ludvigsen C, Sinangil F, Rodriguez L, Wu YT, Volsky DJ

Journal of medical virology.. 1986 August 19 (4):325-34. Epub 1900 01 01.

A simple method for the production of specific antiserum to the second nuclear antigen (EBNA-2) of Epstein-Barr virus (EBV).

Dewhurst S, Volsky DJ

Journal of immunological methods.. 1986 March 1387 (2):283-7. Epub 1900 01 01.

Antibodies to HTLV-III/LAV in Venezuelan patients with acute malarial infections.

Volsky DJ, Wu YT, Stevenson M, Dewhurst S, Sinangil F, Merino F, Rodriguez L, Godoy G

The New England journal of medicine.. 1986 March 6314 (10):647-8. Epub 1900 01 01.

Antibodies to acquired immune deficiency syndrome (AIDS)-associated virus (HTLV-III/LAV) in Venezuelan populations.

Volsky DJ, Rodriguez L, Dewhurst S, Sinangil F, Sakai K, Merino F, Esparza B, De Salvo L

AIDS research. 1986 2 (2):79-92. Epub 1900 01 01.

Antibodies to HTLV-III/LAV among aboriginal Amazonian Indians in Venezuela.

Rodriquez L, Dewhurst S, Sinangil F, Merino F, Godoy G, Volsky DJ

Lancet.. 1985 November 162 (8464):1098-100. Epub 1900 01 01.

Prevalence of AIDS-associated retrovirus and antibodies among male homosexuals at risk for AIDS in Greenwich Village.

Casareale D, Dewhurst S, Sonnabend J, Sinangil F, Purtilo DT, Volsky DJ

AIDS research. 1984 1 (6):407-21. Epub 1900 01 01.