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Robert Alan Gross, M.D., Ph.D.

Robert Alan Gross, M.D., Ph.D.

About Me

Robert A. Gross MD, PhD, FANA, FAAN graduated from Harvard College with an AB in Biology, summa cum laude, in 1975. He entered the Medical Scientist Training Program at Washington University, St. Louis, earning the MD and PhD (Pharmacology) degrees (1981). He interned in Medicine at the Jewish Hosp...
Robert A. Gross MD, PhD, FANA, FAAN graduated from Harvard College with an AB in Biology, summa cum laude, in 1975. He entered the Medical Scientist Training Program at Washington University, St. Louis, earning the MD and PhD (Pharmacology) degrees (1981). He interned in Medicine at the Jewish Hospital in St. Louis and completed residency in Neurology at the Massachusetts General Hospital, where he served as Chief Resident. Faculty positions followed at the University of Michigan (1985-1991) and the University of Minnesota (1991-1994). Dr. Gross joined the faculty of the University of Rochester Medical Center (URMC) in 1994, where he is Associate Chair for Academic Affairs (Neurology). He sees patients in the Strong Epilepsy Center, with a particular interest in the pharmacology of anti-seizure drugs.

Research interests have centered on various aspects of cellular neuropharmacology (regulation of voltage-gated Ca channels by neurotransmitters and therapeutic compounds, regulation of hippocampal neurogenesis by seizures and chemotherapeutic drugs). Collaborative efforts have focused on mechanisms of excitotoxicity. He was involved in several clinical trials of novel anticonvulsants and served on a multi-center task force to design trials to compare brand to generic AEDs. He was the recipient of the S. Weir Mitchell Award of the American Academy of Neurology (AAN) in 1988.

Dr. Gross' educational efforts are diverse. A former director of the interdepartmental Graduate Program in Neuroscience at the University of Rochester, he is the founding and current Director of the Academic Research Track, an innovative program for medical students that centers on a year-out experience in medical research, often concurrent with Masters degree preparation. This program is funded by URMC's Clinical and Translational Science Award and he is a member of the grant's Research, Educational and Career Development Directorate. He serves on the design committee for the medical student course "Mind, Brain and Behavior" for which he provides 9 hours of lecture in neuropharmacology. He is the Director of a novel basic science course for fourth year medical students, the month-long "Process of Discovery," in which students design cutting-edge research programs to effect changes in clinical care over a decade. He teaches in AAN Annual Meeting courses, including the Career Development course. He has developed mentoring programs for residents, fellows and faculty in the Department of Neurology.

He served as an Associate Editor of Neurology® for 8 years, two of which were as Deputy Editor. He is the current Editor-in-Chief of the Neurology® journals.

He is a fellow of the ANA and AAN, and a member of the American Epilepsy Society. Dr. Gross was active in the Epilepsy Foundation of the Rochester, Syracuse and Binghamton regions (currently Epilepsy-Pralid, Inc.), and was a past President of the Board.

He has appeared on the PBS program "Second Opinion" and on local radio shows on the topic of epilepsy.

Faculty Appointments

Professor Emeritus - Department of Neurology, Epilepsy (SMD)

Credentials

Post-doctoral Training & Residency

Chief Resident, Neurology Service, Massachusetts General Hospital 1984 - 1985

Resident in Neurology, Massachusetts General Hospital 1982 - 1985

Intern in Medicine, Jewish Hospital of St. Louis
(at Washington University) 1981 - 1982

Education

MD | Washington U Medical Center. Medicine. 1981

PhD | Washington U Medical Center. Pharmacology. 1981

AB | Harvard College. Biology. 1975

Awards

Buswell Fellow. 1997

S. Weir Mitchell Award. 1987

Irwin S. Levy Prize in Neurology. 1981

Election to Alpha Omega Alpha. 1981

Cowdry Prize in Microscopic Anatomy. 1976

A.B. in Biology, summa cum laude. 1975

Publications

Journal Articles

Comment: Introducing Neurology Education in 2035.

Jones LK, Gross RA

Neurology.. 2023 March 21100 (12):578. Epub 12/23/2022.

Comment: Introducing the US Health Care System in 2035: The Neurology Future Forecasting Series.

Gross RA, Jones LK

Neurology.. 2022 March 898 (10):401. Epub 1900 01 01.

Comment: Introducing Artificial Intelligence and the Practice of Neurology in 2035.

Jones LK, Gross RA

Neurology.. 2022 February 898 (6):237. Epub 1900 01 01.

Comment: Introducing Neuromodulation in 2035: Future Forecasting Series.

Jones LK, Gross RA

Neurology.. 2022 January 1198 (2):64. Epub 1900 01 01.

Comment: Introducing Neurologic Therapeutics in 2035.

Jones LK, Gross RA

Neurology.. 2021 December 1497 (24):1120. Epub 1900 01 01.

An Appreciation: John Corboy, MD, FAAN.

Gross RA

Neurology. Clinical practice.. 2021 December 11 (6):455-456. Epub 1900 01 01.

Improved ictal assessment performance in the epilepsy monitoring unit via standardization.

Hanrahan B, Gross RA, Wychowski T, Erba G, Birbeck GL, Liu L

Epilepsy & behavior : E&B.. 2021 September 122 :108067. Epub 06/17/2021.

Author Response: Leadership, Recognition Awards, and Publication by Men and Women in the American Academy of Neurology.

Keran C, Gross RA, Yuan Y, Miyasaki JM

Neurology.. 2021 July 2797 (4):201. Epub 1900 01 01.

Author Response: Leadership, Recognition Awards, and Publication by Men and Women in the American Academy of Neurology.

Gross RA, Yuan Y, Keran C, Miyasaki JM

Neurology.. 2021 July 2797 (4):203. Epub 1900 01 01.

Futures Planning at the AAN: Approach and Initial Outcome.

Jackson CE, Jones LK, Klein BC, Rost NR, Benish SM, Levi BT, Gross RA,

Neurology.. 2021 June 196 (22):1032-1040. Epub 1900 01 01.

Leadership, recognition awards, and publication by men and women in the American Academy of Neurology.

Miyasaki JM, Maplethorpe E, Yuan Y, Keran C, Gross RA

Neurology.. 2020 December 1595 (24):e3313-e3320. Epub 09/15/2020.

Standing down, being relieved: Transitioning to a new editorial team.

Gross RA

Neurology.. 2020 March 3194 (13):553-554. Epub 1900 01 01.

Efforts by the journal to promote perspectives of equity, diversity, and inclusion and address disparities.

Baskin PK, Pieper KM, Gross RA

Neurology.. 2019 September 1793 (12):521-522. Epub 07/31/2019.

Reporting null results and advancing science.

Petty SJ, Gross RA

Neurology.. 2019 April 3092 (18):827-828. Epub 03/29/2019.

Checklist for the preparation and review of pain clinical trial publications: a pain-specific supplement to CONSORT.

Gewandter JS, Eisenach JC, Gross RA, Jensen MP, Keefe FJ, Lee DA, Turk DC

Pain reports.. 2019 4 (3):e621. Epub 09/13/2017.

Preprints and the implications for subsequent peer review and publishing.

Gross RA

Neurology.. 2018 November 691 (19):855-856. Epub 09/07/2018.

® null hypothesis: A special supplement for negative, inconclusive, or confirmatory studies.

Petty S, Gross RA

Neurology.. 2018 July 391 (1):12-13. Epub 06/08/2018.

Updating ® authorship criteria: Ensuring inclusion of those making valuable intellectual contributions.

Amato AA, Baskin PK, Gross RA

Neurology.. 2018 May 890 (19):865-866. Epub 04/11/2018.

The new : Designed for reader engagement and increased depth of research reporting.

Baskin PK, Gross RA

Neurology.. 2018 January 290 (1):12-13. Epub 1900 01 01.

Risk of cardiac events in Long QT syndrome patients when taking antiseizure medications.

Auerbach DS, Biton Y, Polonsky B, McNitt S, Gross RA, Dirksen RT, Moss AJ

Translational research : the journal of laboratory and clinical medicine.. 2018 January 191 :81-92.e7. Epub 10/20/2017.

The new : Redesigns, short articles for print, full articles online, and data availability policies.

Baskin PK, Gross RA

Neurology.. 2017 November 1489 (20):2026-2028. Epub 10/25/2017.

Evaluation of phenytoin serum levels following a loading dose in the acute hospital setting.

Selioutski O, Grzesik K, Vasilyeva ON, Hilmarsson Á, Fessler AJ, Liu L, Gross RA

Seizure.. 2017 November 52 :199-204. Epub 10/16/2017.

Interpretation of CIs in clinical trials with non-significant results: systematic review and recommendations.

Gewandter JS, McDermott MP, Kitt RA, Chaudari J, Koch JG, Evans SR, Gross RA, Markman JD, Turk DC, Dworkin RH

BMJ open.. 2017 July 187 (7):e017288. Epub 07/18/2017.

Spotlight on the July 11 issue.

Gross RA

Neurology.. 2017 July 1189 (2):109. Epub 1900 01 01.

Spotlight on the July 4 issue.

Gross RA

Neurology.. 2017 July 489 (1):1. Epub 1900 01 01.

Message from the Editors to our Reviewers.

Gross RA, Worrall BB, Amato AA, Cascino GD, Ciccarelli O, Corboy JR, Dalmau JO, Gottesman RF, Grossman M, Millichap JJ, Mink JW, Pulst SM, Uitti RJ

Neurology.. 2017 July 489 (1):2-10. Epub 1900 01 01.

Correcting honest pervasive errors in the scientific literature: Retractions without stigma.

Baskin PK, Mink JW, Gross RA

Neurology.. 2017 July 489 (1):11-13. Epub 1900 01 01.

Spotlight on the June 13 issue.

Gross RA

Neurology.. 2017 June 1388 (24):2241. Epub 1900 01 01.

Spotlight on the June 6 issue.

Gross RA

Neurology.. 2017 June 688 (23):2157. Epub 1900 01 01.

Spotlight on the May 30 issue.

Gross RA

Neurology.. 2017 May 3088 (22):2069. Epub 1900 01 01.

Spotlight on the May 23 issue.

Gross RA

Neurology.. 2017 May 2388 (21):1981. Epub 1900 01 01.

Spotlight on the May 16 issue.

Gross RA

Neurology.. 2017 May 1688 (20):1877. Epub 1900 01 01.

Spotlight on the May 9 issue.

Gross RA

Neurology.. 2017 May 988 (19):1779. Epub 1900 01 01.

Spotlight on the May 2 issue.

Gross RA

Neurology.. 2017 May 288 (18):1685. Epub 1900 01 01.

Spotlight on the April 25 issue.

Gross RA

Neurology.. 2017 April 2588 (17):1593. Epub 1900 01 01.

Spotlight on the April 18 issue.

Gross RA

Neurology.. 2017 April 1888 (16):1485. Epub 1900 01 01.

Spotlight on the April 11 issue.

Gross RA

Neurology.. 2017 April 1188 (15):1385. Epub 1900 01 01.

Spotlight on the April 4 issue.

Gross RA

Neurology.. 2017 April 488 (14):1299. Epub 1900 01 01.

Junior faculty core curriculum to enhance faculty development.

Guillet R, Holloway RG, Gross RA, Libby K, Shapiro JR

Journal of clinical and translational science.. 2017 April 1 (2):77-82. Epub 02/27/2017.

Spotlight on the March 28 issue.

Gross RA

Neurology.. 2017 March 2888 (13):1213. Epub 1900 01 01.

Spotlight on the March 21 issue.

Gross RA

Neurology.. 2017 March 2188 (12):1105. Epub 1900 01 01.

Spotlight on the March 14 issue.

Gross RA

Neurology.. 2017 March 1488 (11):1009. Epub 1900 01 01.

Spotlight on the March 7 issue.

Gross RA

Neurology.. 2017 March 788 (10):921. Epub 1900 01 01.

Reporting of data monitoring boards in publications of randomized clinical trials is often deficient: ACTTION systematic review.

Gewandter JS, Kitt RA, Hunsinger MR, Poku J, Lozano J, Chaudari J, Evans S, Gross RA, McDermott MP, Rowbotham MC, Turk DC, Dworkin RH

Journal of clinical epidemiology.. 2017 March 83 :101-107. Epub 01/23/2017.

Spotlight on the February 28 Issue.

Gross RA

Neurology.. 2017 February 2888 (9):815. Epub 1900 01 01.

Spotlight on the February 21 issue.

Gross RA

Neurology.. 2017 February 2188 (8):723. Epub 1900 01 01.

Spotlight on the February 14 Issue.

Gross RA

Neurology.. 2017 February 1488 (7):609. Epub 1900 01 01.

Spotlight on the February 7 issue.

Gross RA

Neurology.. 2017 February 788 (6):507. Epub 1900 01 01.

Spotlight on the January 31 Issue.

Gross RA

Neurology.. 2017 January 3188 (5):419. Epub 1900 01 01.

Spotlight on the January 24 Issue.

Gross RA

Neurology.. 2017 January 2488 (4):337. Epub 1900 01 01.

Spotlight on the January 17 Issue.

Gross RA

Neurology.. 2017 January 1788 (3):223. Epub 1900 01 01.

Spotlight on the January 10 Issue.

Gross RA

Neurology.. 2017 January 1088 (2):113. Epub 1900 01 01.

Editor Response: Retraction: Risedronate Therapy For Prevention Of Hip Fracture After Stroke In Elderly Women; Risedronate Therapy For Prevention Of Hip Fracture After Stroke In Elderly Women: Reply From The Authors.

Gross RA, Griggs RC

Neurology.. 2017 January 1088 (2):221. Epub 1900 01 01.

Spotlight on the January 3 Issue.

Gross RA

Neurology.. 2017 January 388 (1):1. Epub 1900 01 01.

Message from the Editors to our Reviewers.

Gross RA, Worrall BB, Amato AA, Cascino GD, Ciccarelli O, Corboy JR, Dalmau JO, Gottesman RF, Grossman M, Millichap JJ, Mink JW, Pulst SM, Uitti RJ

Neurology.. 2017 January 388 (1):2-10. Epub 1900 01 01.

Spotlight on the December 13 Issue.

Gross RA

Neurology.. 2016 December 1387 (24):2501. Epub 1900 01 01.

Spotlight on the December 6 issue.

Gross RA

Neurology.. 2016 December 687 (23):2387. Epub 1900 01 01.

Statistics and the detection of scientific misconduct.

Gross RA,

Neurology.. 2016 December 687 (23):2388. Epub 11/09/2016.

Spotlight on the November 29 Issue.

Gross RA

Neurology.. 2016 November 2987 (22):2285. Epub 1900 01 01.

Spotlight on the November 22 issue.

Gross RA

Neurology.. 2016 November 2287 (21):2177. Epub 1900 01 01.

Spotlight on the November 15 issue.

Gross RA

Neurology.. 2016 November 1587 (20):2069. Epub 1900 01 01.

Genetic biomarkers for the risk of seizures in long QT syndrome.

Auerbach DS, McNitt S, Gross RA, Zareba W, Dirksen RT, Moss AJ

Neurology.. 2016 October 1887 (16):1660-1668. Epub 07/27/2016.

Designing the reader's journal.

Gross RA

Neurology.. 2016 September 687 (10):962-9. Epub 1900 01 01.

A clinically relevant dose of cyclophosphamide chemotherapy impairs memory performance on the delayed spatial alternation task that is sustained over time as mice age.

Janelsins MC, Heckler CE, Thompson BD, Gross RA, Opanashuk LA, Cory-Slechta DA

Neurotoxicology.. 2016 September 56 :287-293. Epub 06/28/2016.

Contemplations on an unfolding future: Journal designs and standards.

Baskin PK, Gross RA

Neurology.. 2016 July 587 (1):11-2. Epub 1900 01 01.

Fingolimod-associated PML in a patient with prior immunosuppression.

Gyang TV, Hamel J, Goodman AD, Gross RA, Samkoff L

Neurology.. 2016 May 1086 (19):1843-5. Epub 04/13/2016.

Neurology mini-sites: New content and re-use of previously published Neurology content.

Baskin PK, Gross RA

Neurology.. 2016 January 586 (1):11-2. Epub 1900 01 01.

Style, spin, and science.

Gross RA

Neurology.. 2015 July 785 (1):10-1. Epub 1900 01 01.

Reporting of adverse events and statistical details of efficacy estimates in randomized clinical trials of pain in temporomandibular disorders: Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks systematic review.

Gewandter JS, Smith SM, McKeown A, Edwards K, Narula A, Pawlowski JR, Rothstein D, Desjardins PJ, Dworkin SF, Gross RA, Ohrbach R, Rappaport BA, Sessle BJ, Turk DC, Dworkin RH

The Journal of the American Dental Association.. 2015 April 146 (4):246-54.e6. Epub 1900 01 01.

Tools for readers: Getting the most from the Neurology electronic platforms.

Baskin PK, Gross RA

Neurology.. 2015 January 684 (1):11-2. Epub 1900 01 01.

Data interpretation in analgesic clinical trials with statistically nonsignificant primary analyses: an ACTTION systematic review.

Gewandter JS, McKeown A, McDermott MP, Dworkin JD, Smith SM, Gross RA, Hunsinger M, Lin AH, Rappaport BA, Rice AS, Rowbotham MC, Williams MR, Turk DC, Dworkin RH

The journal of pain.. 2015 January 16 (1):3-10. Epub 10/23/2014.

Molecular and functional identification of a mitochondrial ryanodine receptor in neurons.

Jakob R, Beutner G, Sharma VK, Duan Y, Gross RA, Hurst S, Jhun BS, O-Uchi J, Sheu SS

Neuroscience letters.. 2014 July 11575 :7-12. Epub 05/23/2014.

Disclosure of authorship contributions in analgesic clinical trials and related publications: ACTTION systematic review and recommendations.

Hunsinger M, Smith SM, McKeown A, Parkhurst M, Gross RA, Lin AH, McDermott MP, Rappaport BA, Turk DC, Dworkin RH

Pain.. 2014 June 155 (6):1059-1063. Epub 12/12/2013.

A call for "negative" outcome studies.

Knopman DK, Gross RA

Neurology.. 2014 January 782 (1):11-2. Epub 1900 01 01.

Mouse brain kaleidoscope.

Brenner SR, Calamante F, Gross RA

Neurology.. 2013 April 3080 (18):1720. Epub 1900 01 01.

Suicidality associated with antiepileptic drugs: implications for the treatment of neuropathic pain and fibromyalgia.

Pereira A, Gitlin MJ, Gross RA, Posner K, Dworkin RH

Pain.. 2013 March 154 (3):345-349. Epub 01/11/2013.

A call for transparent reporting to optimize the predictive value of preclinical research.

Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD

Nature.. 2012 October 11490 (7419):187-91. Epub 1900 01 01.

Honorary and ghost authorship.

Baskin PK, Gross RA

BMJ : British medical journal. 2011 October 25343 :d6223. Epub 10/25/2011.

Process of discovery: a fourth-year translational science course.

Digiovanni BF, Ward DS, O'Donnell SM, Fong CT, Gross RA, Grady-Weliky T, Lambert DR

Medical education online.. 2011 16 Epub 12/05/2011.

Three flasks.

Gross RA

Neurology.. 2010 July 675 (1):92. Epub 1900 01 01.

IGF-1 partially restores chemotherapy-induced reductions in neural cell proliferation in adult C57BL/6 mice.

Janelsins MC, Roscoe JA, Berg MJ, Thompson BD, Gallagher MJ, Morrow GR, Heckler CE, Jean-Pierre P, Opanashuk LA, Gross RA

Cancer investigation.. 2010 June 28 (5):544-53. Epub 1900 01 01.

Conflicts of interest, authorship, and disclosures in industry-related scientific publications.

Baskin PK, Knopman DS, Gross RA

Mayo Clinic proceedings.. 2010 February 85 (2):196-7; author 201-4. Epub 1900 01 01.

Mission: neurology(r).

Gross RA

Neurology.. 2010 January 574 (1):10-2. Epub 1900 01 01.

Levels of evidence: Taking Neurology to the next level.

Gross RA, Johnston KC

Neurology.. 2009 January 672 (1):8-10. Epub 1900 01 01.

Citation and readership metrics: how does Neurology measure up?

Noseworthy JH, Gross RA

Neurology.. 2008 December 271 (23):1846-7. Epub 1900 01 01.

Generic substitution in the treatment of epilepsy: patient and physician perceptions.

Berg MJ, Gross RA, Haskins LS, Zingaro WM, Tomaszewski KJ

Epilepsy & behavior : E&B.. 2008 November 13 (4):693-9. Epub 09/10/2008.

Translating research into treatments.

Noseworthy JH, Gross RA, Engel AG, Johnston KC, Knopman DS, Mink JW, Ransohoff RM, Uitti RJ

Neurology.. 2008 July 2271 (4):232-3. Epub 06/04/2008.

Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity.

Duan Y, Gross RA, Sheu SS

The Journal of physiology.. 2007 December 15585 (Pt 3):741-58. Epub 10/18/2007.

The profusion of genotypes and phenotypes in "idiopathic" generalized epilepsies.

Gross RA

Neurology.. 2005 August 2365 (4):503. Epub 1900 01 01.

Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy.

Beydoun A, Uthman BM, Kugler AR, Greiner MJ, Knapp LE, Garofalo EA,

Neurology.. 2005 February 864 (3):475-80. Epub 1900 01 01.

(Editorial Comment on Cody C. Eiberg, Ilo E. Leppik, Reed Perron, Ilo E. Leppik, James C. Clyod III, Lower Phenytoin serum levels in persons switched from brand to generic pheytoin).

Schwid SR, Gross RA, Mink JW and Griggs RC.

Neurology. 2005; 64: 1485-1486.

Bias, not conflict of interest, is the enemy. (Editorial).

Schwid SR and Gross RA.

Neurology. 2005; 64: 1830-1831.

Patient page. Antiseizure drugs and reduced bone density.

Gross RA, Gidal BE, Pack AM

Neurology.. 2004 June 862 (11):E24-5. Epub 1900 01 01.

Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua.

Takahashi Y, Mori H, Mishina M, Watanabe M, Fujiwara T, Shimomura J, Aiba H, Miyajima T, Saito Y, Nezu A, Nishida H, Imai K, Sakaguchi N, Kondo N

Neurology.. 2003 October 1461 (7):891-6. Epub 1900 01 01.

DC-EEG recording: a paradigm shift in seizure localization?

Lagerlund TD, Gross RA

Neurology.. 2003 April 860 (7):1062-3. Epub 1900 01 01.

The effects of brain-irradiation-induced decreases in hippocampal mitotic activity on flurothyl-induced epileptogenesis in adult C57BL/6J mice.

Ferland RJ, Williams JP, Gross RA, Applegate CD

Experimental neurology.. 2003 January 179 (1):71-82. Epub 1900 01 01.

The effects of brain irradiation-induced decreases in hippocampal mitotic activity on flurothyl-induced epileptogenesis in adult C57BL/6J.

Ferland RJ, William JP, Gross RA and Applegate CD.

Experimental Neurology. 2003; 64: 71-82.

Differences in hippocampal mitotic activity within the dorsal and ventral hippocampus following flurothyl seizures in mice.

Ferland RJ, Gross RA, Applegate CD

Neuroscience letters.. 2002 October 31332 (2):131-5. Epub 1900 01 01.

Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation.

Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS

Journal of neurochemistry.. 2002 February 80 (3):531-8. Epub 1900 01 01.

Increased mitotic activity in the dentate gyrus of the hippocampus of adult C57BL/6J mice exposed to the flurothyl kindling model of epileptogenesis.

Ferland RJ, Gross RA, Applegate CD

Neuroscience.. 2002 115 (3):669-83. Epub 1900 01 01.

Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors.

Scott JK, Huang SF, Gangadhar BP, Samoriski GM, Clapp P, Gross RA, Taussig R, Smrcka AV

The EMBO journal.. 2001 February 1520 (4):767-76. Epub 1900 01 01.

Advances in Neurology, vol. 84: Neocortical Epilepsies, by P. D. Williamson et al. (Book review).

Gross RA.

Neurology. 2001; 56: 1251.

Functional compartmentalization of opioid desensitization in primary sensory neurons.

Samoriski GM, Gross RA

The Journal of pharmacology and experimental therapeutics.. 2000 August 294 (2):500-9. Epub 1900 01 01.

Genetic alteration of PLC B3 expression modulates behavioral and cellular Response to u opiods.

Xie W., Samoriski G, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D.

Proceedings of the National academy of Sciences. 1999; 96: 10385-10390.

"The seat of the discharge" and the molecules that goven seizures> (Editorial).

Gross RA and Theodore WH.

Neruolgoy. 1999; 52: 441-443.

3-Nitropropionic acid exacerbates N-methyl-D-aspartate toxicity in striatal culture by multiple mechanisms.

Greene JG, Sheu SS, Gross RA, Greenamyre JT

Neuroscience.. 1998 May 84 (2):503-10. Epub 1900 01 01.

Epilepsy. A Comprehensive Testbook, by Engel & Pedley (book review).

Gross RA.

Archives of Neurology. 1998; 55: 1373-1374.

Epilepsy. A Comprehensive Textbook, by Engel & Pedley (book review).

Gross RA.

Archives of Neurology. 1998; 55: 1373-1374.

Dynorphin A-mediated reduction in multiple calcium currents involves a G(o) alpha-subtype G protein in rat primary afferent neurons.

Wiley JW, Moises HC, Gross RA, MacDonald RL

Journal of neurophysiology.. 1997 March 77 (3):1338-48. Epub 1900 01 01.

Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones.

Gross RA, Covey DF, Ferrendelli JA

The Journal of pharmacology and experimental therapeutics.. 1997 February 280 (2):686-94. Epub 1900 01 01.

Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells.

Gross RA, Huggenvik J, Massa E, Allen RG, Uhler MD

Molecular endocrinology.. 1994 August 8 (8):970-82. Epub 1900 01 01.

Seized, by Eve LaPlante (book review).

Gross RA.

Neurology. 1994; 44: 2220-2221.

Agonists for neuropeptide Y receptor subtypes NPY-1 and NPY-2 have opposite actions on rat nodose neuron calcium currents.

Wiley JW, Gross RA, MacDonald RL

Journal of neurophysiology.. 1993 July 70 (1):324-30. Epub 1900 01 01.

A brief history of epilepsy and its therapy in the Western Hemisphere.

Gross RA

Epilepsy research.. 1992 July 12 (2):65-74. Epub 1900 01 01.

The peptide calcitonin gene-related peptide increase a high threshold Ca2+ current in rat nodose neurons via a pertussis toxin-sensitive pathway.

Wiley JW, Gross RA and Macdonald RL.

Journal of Physiology (London). 1992; 455.

Een korte geschiendenis van epilepsie en haar therapeutische benadering in het Westelijk Halfron (translation of number 26 above).

Gross RA.

Acta Antwerpiensia. 1992; 9: 10-23.

Tetrahydroaminoacridine reduces voltage-dependent calcium currents in rat sensory neurons.

Kelly KM, Gross RA and Macdonald RL.

Neuroscience Letters. 1991; 132: 367-381.

Vertigo: Its Multisensory Syndromes.

Gross, RA.

The New England Journal of Medicine. 1991; 325: 1258.

The reduction of neuronal calcium currents by ATP-gamma-S is mediated by a G protein and occurs independently of cyclic AMP-dependent protein kinase.

Gross RA, Uhler MD, Macdonald RL

Brain research.. 1990 December 10535 (2):214-20. Epub 1900 01 01.

Neuropeptide Y reduces calcium current and inhibits acetylcholine release in nodose neurons via a pertussis toxin-sensitive mechanism.

Wiley JW, Gross RA, Lu YX, Macdonald RL

Journal of neurophysiology.. 1990 June 63 (6):1499-507. Epub 1900 01 01.

Regulation by GTP and its stable thiol derivatives of calcium current components in rat nodose ganglion neurons.

Gross RA, Wiley JW, Ryan-Jastrow T, Macdonald RL

Molecular pharmacology.. 1990 April 37 (4):546-53. Epub 1900 01 01.

Valproic acid selectively reudces the low-threshold (T) calcium current in rat nodose neurons.

Gross RA, Moises HC, Uhler MD and Macdonald RL.

Proceedings of the National academy of Sciences USA. 1990; 87: 7025-7029.

The cyclic AMP-dependent protein kinase catalytic subunit selectively enhances calcium currents in rat nodose neurones.

Gross RA, Uhler MD and Macdonald RL.

Journal of Physiology (London). 1990; 429: 483-496.

Activators of protein kinase C selectively enhance inactivation of a calcium current component of cultured sensory neurons in a pertussis toxin-sensitive manner.

Gross RA, MacDonald RL

Journal of neurophysiology.. 1989 June 61 (6):1259-69. Epub 1900 01 01.

Cyclic AMP selectively reduces the N-type calcium current component of mouse sensory neurons in culture by enhancing inactivation.

Gross RA, Macdonald RL

Journal of neurophysiology.. 1989 January 61 (1):97-105. Epub 1900 01 01.

2-chloroadenosine selectively reduces the N-type calcium current of mouse dorsal root ganglion neurones in a pertussis toxin sensitive manner.

Gross RA, Macdonald RL and Ryan-Jastrow T.

Journal of Physiology (London). 1989; 411: 585-595.

Reduction of the same calcium current component by A and C kinases: differential pertussis toxin sensitivity.

Gross RA, Macdonald RL

Neuroscience letters.. 1988 May 1688 (1):50-6. Epub 1900 01 01.

Barbiturates and nifedipine have different and selective effects on calcium currents of mouse DRG neurons in culture: a possible basis for differing clinical actions. The 1987 S. Weir Mitchell award.

Gross RA, Macdonald RL

Neurology.. 1988 March 38 (3):443-51. Epub 1900 01 01.

A maniclike illness associated with right frontal arteriovenous malformation.

Gross RA, Herridge P

The Journal of clinical psychiatry.. 1988 March 49 (3):119-20. Epub 1900 01 01.

Differential actions of pentobarbitone on calcium current components of mouse sensory neurones in culture.

Gross RA and Macdonald RL.

Journal of Physiology (London). 1988; : 187-203.

The suprachiasmatic nuclei contain a tetrodotoxin-resistant circadian pacemaker.

Schwartz WJ, Gross RA and Morton MT.

Proceedings of the National Academy of Sciences USA. 1987; 84: 1694-1698.

Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture.

Gross RA and Macdonald RL.

Proceedings of the National Academy of Sciences USA. 1987; 84: 5469-5473.

Unusual viral causes of transverse myelitis: hepatitis A virus and cytomegalovirus.

Tyler KL, Gross RA, Cascino GD

Neurology.. 1986 June 36 (6):855-8. Epub 1900 01 01.

Meningeal gliomatosis with "negative" CSF cytology: the value of GFAP staining.

Wechsler LR, Gross RA, Miller DC

Neurology.. 1984 December 34 (12):1611-5. Epub 1900 01 01.

Relationships between norepinephrine and cyclic nucleotides in brain and seizure activity.

Gross RA, Ferrendelli JA

Neuropharmacology.. 1982 July 21 (7):655-61. Epub 1900 01 01.

Relationships between seizure activity and cyclic nucleotide levels in brain.

Ferrendelli JA, Blank AC, Gross RA

Brain research.. 1980 October 27200 (1):93-103. Epub 1900 01 01.

Mechanisms of cyclic AMP regulation in cerebral anoxia and their relationship to glycogenolysis.

Gross RA, Ferrendelli JA

Journal of neurochemistry.. 1980 May 34 (5):1309-18. Epub 1900 01 01.

Effects of reserpine, propranolol, and aminophylline on seizure activity and CNS cyclic nucleotides.

Gross RA, Ferrendelli JA

Annals of neurology.. 1979 October 6 (4):296-301. Epub 1900 01 01.

Regulation of adenosine 3',5'-monophosphate content in human astrocytoma cells by isoproterenol and carbachol.

Gross RA, Clark RB

Molecular pharmacology.. 1977 March 13 (2):242-50. Epub 1900 01 01.

Regulation of adenosine 3':5'-monophosphate content in human astrocytoma cells by adenosine and the adenine nucleotides.

Clark RB, Gross R, Su YF, Perkins JP

The Journal of biological chemistry.. 1974 August 25249 (16):5296-303. Epub 1900 01 01.

Books

Pharmacotherapeutics (1998)

Chapter: "Neurologic Disorders".

Authors: Drew-Cates J and Gross RA.

Publisher: Appleton & Lange, Stamford, CT. 1998

GABAergic Transmission and Anxiety, Advances in Biochemical Psychopharmacology (1986)

Chapter: "Benzodiazepine, B-carboline and barbiturate actions on GABA responses".

Authors: Macdonald RL, Weddle MG and Gross RA.

Publisher: Raven Press, New York 1986

Cerebral Metabolism and Neural Function. (1980)

Chapter: "Cerebral metabolism during seizures: Regulation and role of cyclic AMP in epileptic brain".

Authors: Gross RA and Ferrendelli JA.

Publisher: Williams and Wilkins, Baltimore 1980

Neuropharmacology of Cyclic Nucleotides (1979)

Chapter: "Effects of seizures and anticonvulsant drugs on cyclic nucleotide regulation in the CNS".

Authors: Ferrendelli JA, Gross RA, Kinscherf DA and Rubin EH.

Publisher: Urban and Schwarzenberg, Baltimore 1979

Locations

Clinton Crossings

919 Westfall Rd, Bldg C, Ste 220
Rochester, NY 14618-2628

(585) 341-7500 Get Directions